A Review of EMG-, FMG-, and EIT-Based Biosensors and Relevant Human-Machine Interactivities and Biomedical Applications.

Wearables developed for human body signal detection receive increasing attention in the current decade. Compared to implantable sensors, wearables are more focused on body motion detection, which can support human-machine interaction (HMI) and biomedical applications. In wearables, electromyography (EMG)-, force myography (FMG)-, and electrical impedance tomography (EIT)-based body information monitoring technologies are broadly presented. In the literature, all of them have been adopted for many similar application scenarios, which easily confuses researchers when they start to explore the area. Hence, in this article, we review the three technologies in detail, from basics including working principles, device architectures, interpretation algorithms, application examples, merits and drawbacks, to state-of-the-art works, challenges remaining to be solved and the outlook of the field. We believe the content in this paper could help readers create a whole image of designing and applying the three technologies in relevant scenarios.

Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity.

The Tat protein of HIV-1 has several well-known properties, such as nucleocytoplasmic trafficking, transactivation of transcription, interaction with tubulin, regulation of mitotic progression, and induction of apoptosis. Previous studies have identified a couple of lysine residues in Tat that are essential for its functions. In order to analyze the functions of all the lysine residues in Tat, we mutated them individually to alanine, glutamine, and arginine. Through systematic analysis of the lysine mutants, we discovered several previously unidentified characteristics of Tat. We found that lysine acetylation could modulate the subcellular localization of Tat, in addition to the regulation of its transactivation activity. Our data also revealed that lysine mutations had distinct effects on microtubule assembly and Tat binding to bromodomain proteins. By correlation analysis, we further found that the effects of Tat on apoptosis and mitotic progression were not entirely attributed to its effect on microtubule assembly. Our findings suggest that Tat may regulate diverse cellular activities through binding to different proteins and that the acetylation of distinct lysine residues in Tat may modulate its interaction with various partners.