Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 18 de 18
Filtrar
Mais filtros












Base de dados
Intervalo de ano de publicação
1.
BMC Med Imaging ; 19(1): 26, 2019 04 03.
Artigo em Inglês | MEDLINE | ID: mdl-30943911

RESUMO

BACKGROUND: Initial reports of 23Na magnetic resonance imaging (MRI) date back to the 1970s. However, methodological challenges of the technique hampered its widespread adoption for many years. Recent technical developments have overcome some of these limitations and have led to more optimal conditions for 23Na-MR imaging. In order to serve as a reliable tool for the assessment of clinical stroke or brain tumor patients, we investigated the repeatability and reproducibility of cerebral sodium (23Na) imaging in healthy subjects. METHODS: In this prospective, IRB approved study 12 consecutive healthy volunteers (8 female, age 31 ± 8.3) underwent three cerebral 23Na-MRI examinations at 3.0 T (TimTrio, Siemens Healthineers) distributed between two separate visits with an 8 day interval. For each scan a T1w MP-RAGE sequence for anatomical referencing and a 3D-density-adapted, radial GRE-sequence for 23Na-imaging were acquired using a dual-tuned (23Na/1H) head-coil. On 1 day, these scans were repeated consecutively; on the other day, the scans were performed once. 23Na-sequences were reconstructed according to the MP-RAGE sequence, allowing direct cross-referencing of ROIs. Circular ROIs were placed in predetermined anatomic regions: gray and white matter (GM, WM), head of the caudate nucleus (HCN), pons, and cerebellum. External 23Na-reference phantoms were used to calculate the tissue sodium content. RESULTS: Excellent correlation was found between repeated measurements on the same day (r2 = 0.94), as well as on a different day (r2 = 0.86). No significant differences were found based on laterality other than in the HCN (63.1 vs. 58.7 mmol/kg WW on the right (p = 0.01)). Pronounced inter-individual differences were identified in all anatomic regions. Moderate to good correlation (0.310 to 0.701) was found between the readers. CONCLUSION: Our study has shown that intra-individual 23Na-concentrations in healthy subjects do not significantly differ after repeated scans on the same day and a pre-set time interval. This confirms the repeatability and reproducibility of cerebral 23Na-imaging. However, with manual ROI placement in predetermined anatomic landmarks, fluctuations in 23Na-concentrations can be observed.


Assuntos
Encéfalo/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Sódio/administração & dosagem , Adulto , Núcleo Caudado/diagnóstico por imagem , Feminino , Substância Cinzenta/diagnóstico por imagem , Voluntários Saudáveis , Humanos , Imageamento por Ressonância Magnética/instrumentação , Masculino , Variações Dependentes do Observador , Imagens de Fantasmas , Ponte/diagnóstico por imagem , Estudos Prospectivos , Reprodutibilidade dos Testes , Substância Branca/diagnóstico por imagem , Adulto Jovem
2.
Int J Geriatr Psychiatry ; 32(4): 446-454, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-27113993

RESUMO

OBJECTIVE: Age-related white matter lesions (ARWMLs) have been identified in various clinical conditions such as reduced gait speed, cognitive impairment, urogenital dysfunction, and mood disturbances. Previous studies indicated an association between ARWML and late-onset major depression. However, most of these focused on the extent of supratentorial ARWML and neglected presence and degree of infratentorial lesions. METHODS: In 45 patients (mean age 73.7 ± 6.3 years, 17 (37.8%) men, 28 (62.2%) women) with late-onset major depression, MRI findings (3.0-T MR system, Magnetom Trio, Siemens Medical Systems, Erlangen, Germany) were analyzed with emphasis on the extent of supratentorial and infratentorial, as well as brainstem ARWMLs, and compared with control subjects. ARWMLs were determined by semiquantitative rating scales (modified Fazekas rating scale, Scheltens' rating scale), as well as a semiautomatic volumetric assessment, using a specific software (MRIcron). Supratentorial and infratentorial, as well as brainstem ARWMLs, were assessed both on fluid attenuated inversion recovery and T2-weighted images. RESULTS: Patients with late-onset major depression had significantly higher infratentorial ARWML rating scores (5 (5-7) vs 4.5 (3-6), p = 0.003) on T2-weighted images and volumes (1.58 ± 1.35 mL vs 1.05 ± 0.81 mL, p = 0.03) on T2-weighted images, as well as fluid attenuated inversion recovery images (2.07 ± 1.35 mL vs 1.52 ± 1.10 mL, p = 0.04), than normal controls. In more detail, in particular, the pontine ARWML rating subscore was significantly higher in patients with late-onset major depression (1 (1-2) vs 1 (1-1), p = 0.004). CONCLUSIONS: The extent and localization of brainstem ARWML might be of importance for the pathophysiology of late-onset major depression. In particular, this may hold true for pontine ARWML. Copyright © 2016 John Wiley & Sons, Ltd.


Assuntos
Tronco Encefálico/patologia , Transtorno Depressivo Maior/patologia , Substância Branca/patologia , Idade de Início , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Alemanha , Humanos , Modelos Logísticos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade
3.
J Cereb Blood Flow Metab ; 36(10): 1744-1754, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-26661161

RESUMO

Although lacunar infarction accounts for approximately 25% of ischemic strokes, collateral blood flow through anastomoses is not well evaluated in lacunar infarction. In 111 lacunar infarction patients, we analyzed diffusion-weighted images, perfusion-weighted images, and blood flow on dynamic four-dimensional angiograms generated by use of Signal Processing In NMR-Software. Blood flow was classified as absent (type 1), from periphery to center (type 2), from center to periphery (type 3), and combination of type 2 and 3 (type 4). On diffusion-weighted images, lacunar infarction was found in the basal ganglia (11.7%), internal capsule (24.3%), corona radiata (30.6%), thalamus (24.3%), and brainstem (9.0%). In 58 (52.2%) patients, perfusion-weighted image showed a circumscribed hypoperfusion, in one (0.9%) a circumscribed hyperperfusion, whereas the remainder was normal. In 36 (62.1%) patients, a larger perfusion deficit (>7 mm) was observed. In these, blood flow was classified type 1 in four (11.1%), 2 in 17 (47.2%), 3 in 9 (25.0%), and 4 in six (16.7%) patients. Patients with lacunar infarction in the posterior circulation more often demonstrated blood flow type 2 and less often type 3 (p = 0.01). Detailed examination and graduation of blood flow in lacunar infarction by use of dynamic four-dimensional angiograms is feasible and may serve for a better characterization of this stroke subtype.


Assuntos
Capilares/diagnóstico por imagem , Angiografia Cerebral/métodos , Circulação Cerebrovascular/fisiologia , Circulação Colateral/fisiologia , Angiografia por Ressonância Magnética/métodos , Acidente Vascular Cerebral Lacunar/diagnóstico por imagem , Idoso , Velocidade do Fluxo Sanguíneo/fisiologia , Capilares/fisiopatologia , Artérias Cerebrais/diagnóstico por imagem , Artérias Cerebrais/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Acidente Vascular Cerebral Lacunar/fisiopatologia
4.
Int J Stroke ; 10(8): 1287-93, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26045188

RESUMO

BACKGROUND: In acute posterior cerebral artery, occlusion involvement of the hippocampus is a common finding. Nevertheless, until today, infarction and ischemic lesion evolution in the hippocampus has not been studied systematically. AIM: Evaluation of hippocampal infarction patterns in posterior cerebral artery occlusion in the very early phase (≤six-hours) and ischemic lesion evolution on follow-up magnetic resonance imaging in relation to collateral blood flow assessed by a magnetic resonance imaging-based approach was conducted. METHODS: In 28 patients [mean age 69·4 ± 13·8 years, 19 (67·9%) males, 10 (32·1%) females] with proximal posterior cerebral artery occlusion, magnetic resonance imaging findings were analyzed, with emphasis on hippocampal infarction patterns on diffusion-weighted images and collateralization on dynamic 4D angiograms derived from perfusion-weighted raw images. RESULTS: On initial diffusion-weighted images, we identified all known hippocampal infarction patterns: type 1 (complete) in 6/18 (33·3%) patients, type 2 (lateral) in 10/18 (55·6%) patients, and type 3 (dorsal) and type 4 (circumscribed) in 1/18 (5·6%) patient respectively. On dynamic 4D angiograms, the grade of collateralization was classified as 1 in 9 (32·1%), 2 in 1 (3·6%), 3 in 10 (35·7%), and 4 in 8 (28·6%) patients. On follow-up diffusion-weighted images, we found new ischemic lesions in three and infarction growth in the hippocampus in five patients. Patients with better collateralization (grades 3 and 4) less often had hippocampal infarctions on initial (P = 0·003)/follow-up diffusion-weighted images (P = 0·046) as well as type 1 on initial (P = 0·007)/follow-up diffusion-weighted images (P = 0·005). CONCLUSIONS: Involvement of the hippocampus in proximal posterior cerebral artery occlusion is frequently but not obligatorily observed and highly dependent on the extent of collateralization. The same holds true for hippocampal infarction patterns.


Assuntos
Isquemia Encefálica/fisiopatologia , Circulação Cerebrovascular/fisiologia , Hipocampo/patologia , Infarto da Artéria Cerebral Posterior/fisiopatologia , Artéria Cerebral Posterior/fisiopatologia , Idoso , Isquemia Encefálica/patologia , Angiografia Cerebral , Imagem de Difusão por Ressonância Magnética , Feminino , Seguimentos , Hipocampo/irrigação sanguínea , Hipocampo/fisiopatologia , Humanos , Infarto da Artéria Cerebral Posterior/patologia , Angiografia por Ressonância Magnética , Masculino
5.
PLoS One ; 10(3): e0122537, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25803440

RESUMO

PURPOSE: Transient global amnesia (TGA) is a transitory, short-lasting neurological disorder characterized by a sudden onset of antero- and retrograde amnesia. Perfusion abnormalities in TGA have been evaluated mainly by use of positron emission tomography (PET) or single-photon emission computed tomography (SPECT). In the present study we explore the value of dynamic susceptibility contrast perfusion-weighted MRI (PWI) in TGA in the acute phase. METHODS: From a MRI report database we identified TGA patients who underwent MRI including PWI in the acute phase and compared these to control subjects. Quantitative perfusion maps (cerebral blood flow (CBF) and volume (CBV)) were generated and analyzed by use of Signal Processing In NMR-Software (SPIN). CBF and CBV values in subcortical brain regions were assessed by use of VOI created in FIRST, a model-based segmentation tool in the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library (FSL). RESULTS: Five TGA patients were included (2 men, 3 women). On PWI, no relevant perfusion alterations were found by visual inspection in TGA patients. Group comparisons for possible differences between TGA patients and control subjects showed significant lower rCBF values bilaterally in the hippocampus, in the left thalamus and globus pallidus as well as bilaterally in the putamen and the left caudate nucleus. Correspondingly, significant lower rCBV values were observed bilaterally in the hippocampus and the putamen as well as in the left caudate nucleus. Group comparisons for possible side differences in rCBF and rCBV values in TGA patients revealed a significant lower rCBV value in the left caudate nucleus. CONCLUSIONS: Mere visual inspection of PWI is not sufficient for the assessment of perfusion changes in TGA in the acute phase. Group comparisons with healthy control subjects might be useful to detect subtle perfusion changes on PWI in TGA patients. However, this should be confirmed in larger data sets and serial PWI examinations.


Assuntos
Amnésia Global Transitória/diagnóstico , Amnésia Global Transitória/patologia , Angiografia por Ressonância Magnética/métodos , Volume Sanguíneo/fisiologia , Circulação Cerebrovascular/fisiologia , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Masculino , Software , Estatísticas não Paramétricas
6.
J Neuroimaging ; 25(6): 983-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25786673

RESUMO

BACKGROUND AND PURPOSE: To characterize relations between configurations of the posterior part of the Circle of Willis (CoW) and the occurrence of unilateral thalamic infarction. METHODS: From a magnetic resonance imaging report database, we identified and analyzed 111 patients with acute isolated unilateral thalamic infarction on diffusion-weighted imaging (DWI). Vascular pathologies were noted on magnetic resonance angiography (MRA) and the diameter of the posterior communicating artery (PComA) and the P1 and P2 segments of the posterior cerebral artery determined. RESULTS: Most infarctions were observed in the territory of the inferolateral arteries (70.2%), followed by the paramedian (16.3%), tuberothalamic (8.7%), and posterior choroidal arteries (4.8%). Relevant vascular pathologies included stenosis of the basilar artery (4.5%), P1 segment stenosis (4.5%)/occlusion (.9%), and P2 segment stenosis (14.4%)/occlusion (4.5%). Paramedian thalamic infarction was associated with ipsilateral P1 segment hypoplasia/absence (P < .001); tuberothalamic infarction with ipsilateral PComA hypoplasia/absence (P = .08). Furthermore, the diameter of the relevant CoW segment was smaller in patients with ipsilateral thalamic infarction. CONCLUSIONS: Assessment of CoW configuration on MRA may be helpful to understand the appearance of unilateral thalamic stroke independent from stroke etiology. A smaller diameter of the relevant CoW segment might be a risk factor for ipsilateral thalamic stroke in the corresponding thalamic vascular territory.


Assuntos
Infarto Encefálico/patologia , Circulação Cerebrovascular , Círculo Arterial do Cérebro/patologia , Tálamo/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Infarto Encefálico/diagnóstico por imagem , Círculo Arterial do Cérebro/diagnóstico por imagem , Bases de Dados Factuais , Feminino , Humanos , Angiografia por Ressonância Magnética , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Tálamo/diagnóstico por imagem , Adulto Jovem
7.
J Neurooncol ; 122(2): 245-54, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25605299

RESUMO

Small animal imaging is of increasing relevance in biomedical research. Studies systematically assessing the diagnostic accuracy of contrast-enhanced in vivo micro-CT of orthotopic glioma xenografts in mice do not exist. NOD/SCID/γc(-/-) mice (n = 27) underwent intracerebral implantation of 2.5 × 10(6) GFP-Luciferase-transduced U87MG cells. Mice underwent bioluminescence imaging (BLI) to detect tumor growth and afterwards repeated contrast-enhanced (300 µl Iomeprol i.v.) micro-CT imaging (80 kV, 75 µAs, 360° rotation, 1,000 projections, 33 s scan time, resolution 40 × 40 × 53 µm, 0.5 Gy/scan). Presence of tumors, tumor diameter and tumor volume in micro-CT were rated by two independent readers. Results were compared with histological analyses. Six mice with tumors confirmed by micro-CT received fractionated irradiation (3 × 5 Gy every other day) using the micro-CT (5 mm pencil beam geometry). Repeated micro-CT scans were tolerated well. Tumor engraftment rate was 74 % (n = 20). In micro-CT, mean tumor volume was 30 ± 33 mm(3), and the smallest detectable tumor measured 360 × 620 µm. The inter-rater agreement (n = 51 micro-CT scans) for the item tumor yes/no was excellent (Spearman-Rho = 0.862, p < 0.001). Sensitivity and specificity of micro-CT were 0.95 and 0.71, respectively (PPV = 0.91, NPV = 0.83). BLI on day 21 after tumor implantation had a sensitivity and specificity of 0.90 and 1.0, respectively (PPV = 1.0, NPV = 0.5). Maximum tumor diameter and volume in micro-CT and histology correlated excellently (tumor diameter: 0.929, p < 0.001; tumor volume: 0.969, p < 0.001, n = 17). Irradiated animals showed a large central tumor necrosis. Longitudinal contrast enhanced micro-CT imaging of brain tumor growth in live mice is feasible at high sensitivity levels and with excellent inter-rater agreement and allows visualization of radiation effects.


Assuntos
Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/radioterapia , Glioblastoma/diagnóstico por imagem , Glioblastoma/radioterapia , Microtomografia por Raio-X/métodos , Animais , Encéfalo/diagnóstico por imagem , Encéfalo/efeitos da radiação , Linhagem Celular Tumoral , Meios de Contraste , Fracionamento da Dose de Radiação , Estudos de Viabilidade , Feminino , Humanos , Masculino , Camundongos Endogâmicos NOD , Camundongos Knockout , Camundongos SCID , Transplante de Neoplasias , Sensibilidade e Especificidade , Carga Tumoral
8.
J Neuroimaging ; 25(4): 608-13, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25327142

RESUMO

BACKGROUND AND PURPOSE: Vertebrobasilar dolichoectasia (VBD) is a dilatative arteriopathy associated with a decreased blood flow velocity. Fluid attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) is a phenomenon most likely representing slow arterial blood flow. We sought to examine the frequency and extent of FVH in VBD. METHODS: We analyzed magnetic resonance imaging (MRI) findings in 77 VBD patients with special emphasis on FVH in relation to the diagnostic MRI criteria of VBD and the etiology in symptomatic patients. RESULTS: In 49 (63.6%) VBD patients, FVH could be detected: in 22 (44.9%) a small hyperintense rim near the vessel wall (grade 1), in 20 (40.8%) a strong hyperintense rim near the vessel wall (grade 2), and in 7 (14.3%) the hyperintense signal filled the complete vessel lumen (grade 3). The diameter of the basilar artery moderately correlated with the extent of FVH. A higher FVH grade (2 and 3) was more common in patients with TIA/stroke related to VBD (9/16 [56.3%]) in comparison to patients with other etiology and asymptomatic patients (18/61 [29.5%]; P = .046). CONCLUSIONS: FVH may be useful to demonstrate the decreased blood flow velocity in VBD. More pronounced FVH in patients with posterior circulation TIA/stroke might reflect the underlying stroke pathomechanism.


Assuntos
Artéria Basilar/fisiopatologia , Velocidade do Fluxo Sanguíneo , Circulação Cerebrovascular , Angiografia por Ressonância Magnética/métodos , Artéria Vertebral/fisiopatologia , Insuficiência Vertebrobasilar/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Interpretação de Imagem Assistida por Computador/métodos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
9.
Neurosurgery ; 74(3): 321-34; discussion 334, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24549048

RESUMO

BACKGROUND: Flow-diverting stent (FDS) implantation is an endovascular treatment option for intracranial aneurysms. However, little is known about the hemodynamic effects. OBJECTIVE: To assess the effect of stent compression on FDS porosity, to evaluate the influence of single and overlapping implantation of FDS on intra-aneurysmal flow profiles, and to correlate stent porosity with changes in static mean intra-aneurysmal pressure. METHODS: Intra-aneurysmal time-density curves were recorded in a pulsatile in vitro flow model before and after implantation of FDSs (Pipeline Embolization Device; ev3) in 7 different types of aneurysm models. Reductions in the maximum contrast inflow and time to maximum intra-aneurysmal contrast were calculated. Micro--computed tomography was performed, and compression-related FDS porosity was measured. The influence of FDS placement on mean static intra-aneurysmal pressure was measured. RESULTS: FDS compression resulted in an almost linear reduction in stent porosity. Stent porosity (struts per 1 mm) correlated significantly with the reduction of aneurysm contrast inflow (R = 0.81, P < .001) and delay until maximum contrast (R = 0.34, P = .001). Circulating intra-aneurysmal high-velocity flow was terminated in all sidewall models after implantation of a single stent. Superimposition of 2 stents reduced maximum intra-aneurysmal contrast by 69.1 ± 3.1% (mean ± SD) in narrow-necked sidewall aneurysm models, whereas no substantial reduction in maximum intra-aneurysmal contrast was observed in wide-necked sidewall aneurysm models. Intra-aneurysmal mean static pressure did not correlate with FDS porosity or number of implanted stents. CONCLUSION: Implantation of FDS effectively reduces aneurysm inflow in a porosity-dependent way without relevantly affecting static mean intra-aneurysmal pressure. ABBREVIATIONS: FDS, flow-diverting stentMAP, mean arterial pressurePED, Pipeline Embolization Device.


Assuntos
Implante de Prótese Vascular/instrumentação , Implante de Prótese Vascular/métodos , Aneurisma Intracraniano/terapia , Stents , Velocidade do Fluxo Sanguíneo , Implante de Prótese Vascular/efeitos adversos , Circulação Cerebrovascular , Feminino , Hemodinâmica , Humanos , Masculino , Modelos Cardiovasculares , Fatores de Tempo , Resultado do Tratamento
10.
Cephalalgia ; 34(11): 870-6, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24554619

RESUMO

OBJECTIVES: Migraine with aura is a common neurological disorder, and differentiation from transient ischemic attack or stroke based on clinical symptoms may be difficult. METHODS: From an MRI report database we identified 33 patients with migraine with aura and compared these to 33 age-matched ischemic stroke patients regarding perfusion patterns on perfusion-weighted imaging (PWI)-derived maps: time to peak (TTP), mean transit time (MTT), and cerebral blood flow and volume (CBF, CBV). RESULTS: In 18/33 (54.5%) patients with migraine with aura, TTP showed areas of hypoperfusion, most of these not limited to the territory of a specific artery but affecting two or more vascular territories. In patients with migraine with aura, TTP (1.09 ± 0.05 vs. 1.47 ± 0.40, p < 0.001) and MTT ratios (1.01 ± 0.10 vs. 1.19 ± 0.21, p = 0.003) were significantly lower compared to patients with ischemic stroke. In contrast to this, CBF and CBV ratios did not differ significantly between both groups. CONCLUSIONS: Migraine aura is usually associated with a perfusion deficit not limited to a specific vascular territory, and only a moderate increase of TTP. Thus, hypoperfusion restricted to a single vascular territory in combination with a marked increase of TTP or MTT may be regarded as atypical for migraine aura and suggestive of acute ischemic stroke.


Assuntos
Encéfalo/irrigação sanguínea , Circulação Cerebrovascular , Interpretação de Imagem Assistida por Computador/métodos , Enxaqueca com Aura/diagnóstico , Acidente Vascular Cerebral/diagnóstico , Adolescente , Adulto , Idoso , Diagnóstico Diferencial , Imagem de Difusão por Ressonância Magnética , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
11.
PLoS One ; 9(2): e88044, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24505372

RESUMO

PURPOSE: Crossed cerebellar diaschisis (CCD) is a state of neural depression caused by loss of connections to injured neural structures remote from the cerebellum usually evaluated by positron emission tomography. Recently it has been shown that dynamic susceptibility contrast perfusion weighted MRI (PWI) may also be feasible to detect the phenomenon. In this study we aimed to assess the frequency of CCD on PWI in patients with acute thalamic infarction. METHODS: From a MRI report database we identified patients with acute isolated thalamic infarction. Contralateral cerebellar hypoperfusion was identified by inspection of time to peak (TTP) maps and evaluated quantitatively on TTP, mean transit time (MTT), cerebral blood flow and volume (CBF, CBV) maps. A competing cerebellar pathology or an underlying vascular pathology were excluded. RESULTS: A total of 39 patients was included. Common symptoms were hemiparesis (53.8%), hemihypaesthesia (38.5%), dysarthria (30.8%), aphasia (17.9%), and ataxia (15.4%). In 9 patients (23.1%) PWI showed hypoperfusion in the contralateral cerebellar hemisphere. All of these had lesions in the territory of the tuberothalamic, paramedian, or inferolateral arteries. Dysarthria was observed more frequently in patients with CCD (6/9 vs. 6/30; OR 8.00; 95%CI 1.54-41.64, p = 0.01). In patients with CCD, the median ischemic lesion volume on DWI (0.91 cm³), IQR 0.49-1.54 cm³) was larger compared to patients with unremarkable PWI (0.51 cm³, IQR 0.32-0.74, p = 0.05). The most pronounced changes were found in CBF (0.94±0.11) and MTT (1.06±0.13) signal ratios, followed by TTP (1.05±0.02). CONCLUSIONS: Multimodal MRI demonstrates CCD in about 20% of acute isolated thalamic infarction patients. Lesion size seems to be a relevant factor in its pathophysiology.


Assuntos
Cerebelo/irrigação sanguínea , Cerebelo/patologia , Infarto Cerebral/patologia , Angiografia por Ressonância Magnética , Idoso , Idoso de 80 Anos ou mais , Circulação Cerebrovascular , Feminino , Humanos , Angiografia por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade
12.
J Neuroimaging ; 24(4): 325-30, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-23621712

RESUMO

BACKGROUND AND PURPOSE: Bilateral paramedian thalamic infarction is a rare subtype of stroke the etiology of which still remains undetermined in many patients. METHODS: From a computed tomography (CT)/magnetic resonance imaging report database, we identified and analyzed 48 patients with bilateral paramedian thalamic infarction on diffusion-weighted imaging. Vascular pathologies were noted on CT angiography (CTA)/magnetic resonance angiography (MRA) and the P1 segments of the posterior cerebral artery (PCA) described as normal, hypoplastic, or absent. RESULTS: Vascular imaging revealed top of the basilar artery (BA) occlusion in 6 (12.5%), BA occlusion in 4 (8.3%), BA stenosis in 1 (2.1%), and BA hypoplasia in 3 (6.3%), PCA occlusion in 4 (8.3%), and PCA stenosis in 4 (8.3%) patients. In 18 (37.5%) patients, one or both P1 segments of the PCA were hypoplastic or absent. Patients with hypoplastic/absent P1 segments were more likely to have exclusively bilateral paramedian thalamic lesions (P < .001). An embolic source could be identified in 25 (55.6%) patients; there were no significant differences between both groups. CONCLUSIONS: Vascular imaging is useful to determine underlying vascular pathologies and may support the diagnosis of small vessel disease in those patients with isolated bilateral paramedian thalamic infarction, hypoplastic/absent P1 segment of the PCA, and lack of vascular pathology.


Assuntos
Angiografia Cerebral/métodos , Doenças Arteriais Cerebrais/diagnóstico , Infarto Cerebral/diagnóstico , Círculo Arterial do Cérebro/diagnóstico por imagem , Círculo Arterial do Cérebro/patologia , Tálamo/irrigação sanguínea , Adulto , Idoso , Idoso de 80 Anos ou mais , Doenças Arteriais Cerebrais/complicações , Infarto Cerebral/etiologia , Círculo Arterial do Cérebro/anormalidades , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Tálamo/diagnóstico por imagem , Tálamo/patologia , Tomografia Computadorizada por Raios X/métodos
13.
PLoS One ; 8(7): e69311, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23894448

RESUMO

BACKGROUND: Cervical selective nerve root block (CSNRB) is a well-established, minimally invasive procedure to treat radicular cervical pain. However, the procedure is technically challenging and might lead to major complications. The objective of this study was to evaluate the feasibility of a three-dimensional puncture planning and two-dimensional laser-guidance system for CSNRB in an ex-vivo model. METHODS: Dyna-CT of the cervical spine of an ex-vivo lamb model was performed with the Artis Zee® Ceiling (Siemens Medical Solutions, Erlangen, Germany) to acquire multiplanar reconstruction images. 15 cervical nerve root punctures were planned and conducted with the syngo iGuide® laser-guidance system. Needle tip location and contrast dye distribution were analyzed by two independent investigators. Procedural, planning, and fluoroscopic time, tract length, and dose area product (DAP) were acquired for each puncture. RESULTS: All 15 punctures were rated as successful with 12 punctures on the first attempt. Total procedural time was approximately 5 minutes. Mean planning time for the puncture was 2.03 (±0.39) min. Mean puncture time was 2.16 (±0.32) min, while mean fluoroscopy time was 0.17 (±0.06) min. Mean tract length was 2.68 (±0.23) cm. Mean total DAP was 397.45 (±15.63) µGy m(2). CONCLUSION: CSNRB performed with Dyna-CT and the tested laser guidance system is feasible. 3D pre-puncture planning is easy and fast and the laser-guiding system ensures very accurate and intuitive puncture control.


Assuntos
Vértebras Cervicais , Bloqueio Nervoso/métodos , Punções/métodos , Raízes Nervosas Espinhais , Tomografia Computadorizada por Raios X/métodos , Animais , Vértebras Cervicais/diagnóstico por imagem , Meios de Contraste , Fluoroscopia , Lasers , Agulhas
14.
World J Radiol ; 5(1): 5-16, 2013 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-23494089

RESUMO

AIM: To evaluate different promising magnetic resonance imaging (MRI) methods at 7.0 Tesla (T) for the pre-stereotactic visualization of the zona incerta (ZI). METHODS: Two neuroradiologists qualitatively and quantitatively examined T2-turbo spin-echo (T2-TSE), T1-weighted gradient-echo, as well as FLASH2D-T2Star and susceptibility-weighted imaging (SWI) for the visualization of the ZI at 7.0 T MRI. Delineation and image quality for the ZI were independently examined using a 6-scale grading system. Inter-rater reliability using Cohen's kappa coefficient (κ) were assessed. Contrast-to-noise ratios (CNR), and signal-to-noise ratios (SNR) for the ZI were calculated for all sequences. Differences in delineation, SNR, and CNR between the sequences were statistically assessed using a paired t-test. For the anatomic validation the coronal FLASH2D-T2Star images were co-registered with a stereotactic atlas (Schaltenbrand-Wahren). RESULTS: The rostral part of the ZI (rZI) could easily be identified and was best and reliably visualized in the coronal FLASH2D-T2Star images. The caudal part was not definable in any of the sequences. No major artifacts in the rZI were observed in any of the scans. FLASH2D-T2Star and SWI imaging offered significant higher CNR values for the rZI compared to T2-TSE images (P > 0.05). The co-registration of the coronal FLASH2D-T2Star images with the stereotactic atlas schema (Schaltenbrand-Wahren) confirmed the correct localization of the ZI in all cases. CONCLUSION: FLASH2D-T2Star imaging (particularly coronal view) provides the reliable and currently optimal visualization of the rZI at 7.0 T. These results can facilitate a better and more precise targeting of the caudal part of the ZI than ever before.

15.
Exp Dermatol ; 21(11): 837-41, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23163648

RESUMO

Spontaneous melanoma models in transgenic mice are increasingly used in preclinical research as they most closely match the progression of melanoma in humans. While optical inspection only allows analysis of tumors located on the skin, the accurate measurement and growth of subcutaneous tumors have not been adequately assessed. To improve the measurement accuracy of melanoma tumors, we used a fast single-sequence MRI protocol at 9.4 Tesla for longitudinal characterization of a ret-transgenic mouse model. Repeated MRI (average acquisition time 30 min per animal) of the trunk (excluding head and distal limbs) in six siblings revealed an increase in the mean total tumor volume (TTV) from 102.0 ± 80.5 mm(3) at 35 days of age to 434.8 ± 154.9 mm(3) by 77 days. The main tumor load was located within the pelvis (>40%), followed by the proximal hind limbs and groins (>30%). The smallest detectable tumor measured 0.07 mm(3). Inter-rater reliability between a radiologist and a veterinarian analysing MRI data was 0.993 for TTV and 0.840 for number of tumors (both p < 0.001). We thus conclude that because of the high variance of TTV of same-aged mice, MRI should be used (i) to establish treatment groups matched for TTV and (ii) for longitudinal examination of the TTV in mice over the course of treatments.


Assuntos
Proliferação de Células , Progressão da Doença , Imageamento por Ressonância Magnética/métodos , Melanoma/patologia , Proteínas Proto-Oncogênicas c-ret/genética , Neoplasias Cutâneas/patologia , Animais , Modelos Animais de Doenças , Feminino , Estudos Longitudinais , Masculino , Melanoma/genética , Melanoma/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Transgênicos , Variações Dependentes do Observador , Proteínas Proto-Oncogênicas c-ret/metabolismo , Reprodutibilidade dos Testes , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/metabolismo , Carga Tumoral
16.
J Neurosurg ; 117(6): 1155-65, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23039154

RESUMO

OBJECT: Reliable visualization of the subthalamic nucleus (STN) is indispensable for accurate placement of electrodes in deep brain stimulation (DBS) surgery for patients with Parkinson disease (PD). The aim of the study was to evaluate different promising new MRI methods at 3.0 T for preoperative visualization of the STN using a standard installation protocol. METHODS: Magnetic resonance imaging studies (T2-FLAIR, T1-MPRAGE, T2*-FLASH2D, T2-SPACE, and susceptibility-weighted imaging sequences) obtained in 9 healthy volunteers and in 1 patient with PD were acquired. Two neuroradiologists independently analyzed image quality and visualization of the STN using a 6-point scale. Interrater reliability, contrast-to-noise ratios, and signal-to-noise ratios for the STN were calculated. For illustration of the anatomical accuracy, coronal T2*-FLASH2D images were fused with the corresponding coronal section schema of the Schaltenbrand and Wahren stereotactic atlas. RESULTS: The STN was best and reliably visualized on T2*-FLASH2D imaging (in particular, the coronal view). No major artifacts in the STN were observed in any of the sequences. Susceptibility-weighted, T2-SPACE, and T2*-FLASH2D imaging provided significantly higher contrast-to-noise ratio values for the STN than standard T2-weighted imaging. Fusion of the coronal T2*-FLASH2D and the digitized coronal atlas view projected the STN clearly within the boundaries of the STN found in anatomical sections. CONCLUSIONS: For 3.0-T MRI, T2*-FLASH2D (particularly the coronal view) provides optimal delineation of the STN using a standard installation protocol.


Assuntos
Estimulação Encefálica Profunda/métodos , Doença de Parkinson/terapia , Núcleo Subtalâmico , Adulto , Idoso , Antiparkinsonianos/administração & dosagem , Artefatos , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Procedimentos Neurocirúrgicos/instrumentação , Procedimentos Neurocirúrgicos/métodos , Variações Dependentes do Observador , Doença de Parkinson/tratamento farmacológico , Doença de Parkinson/cirurgia , Valores de Referência , Técnicas Estereotáxicas , Tomografia Computadorizada Espiral
17.
Acta Neurochir (Wien) ; 154(11): 2051-62, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22930282

RESUMO

BACKGROUND: Deep-brain stimulation (DBS) of the subthalamic nucleus (STN) is an accepted neurosurgical technique for the treatment of medication-resistant Parkinson's disease and other neurological disorders. The accurate targeting of the STN is facilitated by precise and reliable identification in pre-stereotactic magnetic resonance imaging (MRI). The aim of the study was to compare and evaluate different promising MRI methods at 7.0 T for the pre-stereotactic visualisation of the STN METHODS: MRI (T2-turbo spin-echo [TSE], T1-gradient echo [GRE], fast low-angle shot [FLASH] two-dimensional [2D] T2* and susceptibility-weighted imaging [SWI]) was performed in nine healthy volunteers. Delineation and image quality for the STN were independently evaluated by two neuroradiologists using a six-point grading system. Inter-rater reliability, contrast-to-noise ratios (CNRs) and signal-to-noise ratios (SNRs) for the STN were calculated. For the anatomical validation, the coronal FLASH 2D T2* images were co-registered with a stereotactic atlas (Schaltenbrand-Wahren). RESULTS: The STN was clearly and reliably visualised in FLASH 2D T2* imaging (particularly coronal view), with a sharp delineation between the STN, the substantia nigra and the zona incerta. No major artefacts in the STN were observed in any of the sequences. FLASH 2D T2* and SWI images offered significantly higher CNR for the STN compared with T2-TSE. The co-registration of the coronal FLASH 2D T2* images with the stereotactic atlas affirmed the correct localisation of the STN in all cases. CONCLUSION: The STN is best and reliably visualised in FLASH 2D T2* imaging (particularly coronal orientation) at 7.0-T MRI.


Assuntos
Estimulação Encefálica Profunda/métodos , Núcleo Subtalâmico/fisiologia , Adulto , Encéfalo/patologia , Mapeamento Encefálico/métodos , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Neuroimagem/métodos , Razão Sinal-Ruído , Resultado do Tratamento , Adulto Jovem
18.
Acta Neurochir (Wien) ; 154(3): 481-94, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22167532

RESUMO

BACKGROUND: Deep-brain stimulation (DBS) of the internal globus pallidus (GPi) has shown remarkable therapeutic benefits for treatment-resistant neurological disorders including dystonia and Parkinson's disease (PD). The success of the DBS is critically dependent on the reliable visualization of the GPi. The aim of the study was to evaluate promising 3.0 Tesla magnetic resonance imaging (MRI) methods for pre-stereotactic visualization of the GPi using a standard installation protocol. METHODS: MRI at 3.0 T of nine healthy individuals and of one patient with PD was acquired (FLAIR, T1-MPRAGE, T2-SPACE, T2*-FLASH2D, susceptibility-weighted imaging mapping (SWI)). Image quality and visualization of the GPi for each sequence were assessed by two neuroradiologists independently using a 6-point scale. Axial, coronal, and sagittal planes of the T2*-FLASH2D images were compared. Inter-rater reliability, contrast-to-noise ratios (CNR) and signal-to-noise ratios (SNR) for the GPi were determined. For illustration, axial T2*-FLASH2D images were fused with a section schema of the Schaltenbrand-Wahren stereotactic atlas. RESULTS: The GPi was best and reliably visualized in axial and to a lesser degree on coronal T2*-FLASH2D images. No major artifacts in the GPi were observed in any of the sequences. SWI offered a significantly higher CNR for the GPi compared to standard T2-weighted imaging using the standard parameters. The fusion of the axial T2*-FLASH2D images and the atlas projected the GPi clearly in the boundaries of the section schema. CONCLUSIONS: Using a standard installation protocol at 3.0 T T2*-FLASH2D imaging (particularly axial view) provides optimal and reliable delineation of the GPi.


Assuntos
Estimulação Encefálica Profunda/métodos , Globo Pálido/cirurgia , Imageamento por Ressonância Magnética/métodos , Neuronavegação/métodos , Cuidados Pré-Operatórios/métodos , Cuidados Pré-Operatórios/normas , Adulto , Idoso , Feminino , Humanos , Imageamento por Ressonância Magnética/normas , Masculino , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...