Preliminary study of clinical outcomes for single implant-retained mandibular overdentures.

This study evaluated marginal bone loss and prosthetic complications associated with single implant-retained mandibular overdentures (1-IODs) with locator attachments. The 1-IOD was placed in the mandibular midline by using a conventional loading protocol in 22 patients with an edentulous mandible. Marginal bone loss at the start of loading and 12 months postoperatively was assessed by radiographic and crestal bone evaluation. The crestal bone was defined as the distance between the customized abutment shoulder and the top of the bone, as indicated by probing. In addition, implant stability quotient and prosthetic complications were recorded. The cumulative implant survival rate was 95.5%. Median implant stability quotient remained greater than 80, and median radiographic bone loss was 0.56 mm. Crestal measurement showed a median crestal bone loss of 0.16, 0.43, 0.39, and 0.52 mm on the buccal, right, lingual, and left sides, respectively. Both radiographic and crestal bone loss values significantly differed between the start of implant loading and 12 months postoperatively (except on the buccal and lingual sides; P < 0.05). The need to replace the nylon insert was the most common complication. Conventional loading of a 1-IOD with a locator attachment resulted in a high survival rate, good implant stability, and acceptable marginal bone loss.

Linkage study of cancer risk among lead-exposed workers in New Jersey.

OBJECTIVES: Epidemiologic studies have illustrated a possible association between occupational exposure to lead and cancer, specifically cancers of the kidney, lung, stomach, and nervous system. We performed a linkage between two New Jersey databases: the Adult Blood Lead Epidemiology and Surveillance System (ABLES) and the New Jersey State Cancer Registry (NJSCR) for 1985-2001 to ascertain the risk of cancer in lead-exposed workers and to evaluate the usefulness of this type of linkage. METHODS: A cohort of 3192 men from the ABLES database met the selection criteria before the linkage. AUTOMATCH was used to link the two databases. Person-time was stratified for each worker by five-year age group and calendar year. A standardized incidence ratios (SIR) analysis was performed. RESULTS: 83 cases of cancer were found among 3165 men after all exclusions were made. Workers were followed for an average of ten years and contributed 30,401 person-years. The SIR analysis showed a large overall deficit of cancer (SIR=0.51; 95% CI 0.41 to 0.62). Cancers of the stomach, breast, larynx, intrahepatic bile duct, and chronic myeloid leukemia were non-significantly elevated. Prostate cancer showed the only statistically significant result, a deficit with an SIR of 0.35 (95% CI 0.20 to 0.57). Deficits also occurred in cancers of the lung, kidney, and brain. CONCLUSIONS: The results do not indicate that occupational exposure to lead is associated with cancer. However, firm conclusions are not possible because of various study limitations, including small numbers, a large percentage of workers without age information, short follow-up time, and lack of vital status information. Cancer incidence in this cohort was expected to be low due to the Healthy Worker Effect and young age. Further follow-up of this cohort may be warranted since additional cancers may accrue as time from first exposure increases. Increased worker cohort information would also improve this type of study.