Experimental demonstration of accurate Bragg peak localization with ionoacoustic tandem phase detection (iTPD).

Accurate knowledge of the exact stopping location of ions inside the patient would allow full exploitation of their ballistic properties for patient treatment. The localized energy deposition of a pulsed particle beam induces a rapid temperature increase of the irradiated volume and leads to the emission of ionoacoustic (IA) waves. Detecting the time-of-flight (ToF) of the IA wave allows inferring information on the Bragg peak location and can henceforth be used forin-vivorange verification. A challenge for IA is the poor signal-to-noise ratio at clinically relevant doses and viable machines. We present a frequency-based measurement technique, labeled as ionoacoustic tandem phase detection (iTPD) utilizing lock-in amplifiers. The phase shift of the IA signal to a reference signal is measured to derive theToF. Experimental IA measurements with a 3.5 MHz lead zirconate titanate (PZT) transducer and lock-in amplifiers were performed in water using 22 MeV proton bursts. A digital iTPD was performedin-silicoat clinical dose levels on experimental data obtained from a clinical facility and secondly, on simulations emulating a heterogeneous geometry. For the experimental setup using 22 MeV protons, a localization accuracy and precision obtained through iTPD deviates from a time-based reference analysis by less than 15µm. Several methodological aspects were investigated experimentally in systematic manner. Lastly, iTPD was evaluatedin-silicofor clinical beam energies indicating that iTPD is in reach of sub-mm accuracy for fractionated doses < 5 Gy. iTPD can be used to accurately measure theToFof IA signals online via its phase shift in frequency domain. An application of iTPD to the clinical scenario using a single pulsed beam is feasible but requires further development to reach <1 Gy detection capabilities.

Investigation of ultrasonic absorption in the MHz frequency range by silicon substrates with a built-in porous silicon layer.

The present study is focused on the development and characterization of an innovative substrate to optimize the axial resolution of ultrasonic transducers on a silicon substrate that is dedicated to ultrasound imaging. The substrate must efficiently dampen wave propagation to avoid degradation of the axial resolution of ultrasound images. In this study, the proposed approach implements a silicon substrate with a built-in acoustic damping layer composed of porous silicon. Porous silicon layers with thicknesses of less than 100 µm and porosities varying from 27% to 62% were fabricated, and their substrate resonances were characterized. The experimental results obtained in the frequency range from 6 MHz to 10 MHz show that the substrate acoustic damping is controlled by adjusting the characteristics of the porous silicon layer; a significant damping of 70% is demonstrated with only 70 µm of porous silicon.