Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 854
Filtrar
1.
Artigo em Inglês | MEDLINE | ID: mdl-39367661

RESUMO

AIMS: To explore the mediating role of relationship satisfaction between communication patterns and benefit findings in stroke couples using the actor-partner interdependence mediation model. METHODS AND RESULTS: A cross-sectional study was conducted from October 2022 to April 2023 in China. Based on the actor-partner interdependence mediation model, we used structural equation modeling to explore the mediating role of relationship satisfaction of stroke patients and their spouses in communication patterns and benefit findings. A total of 381 stroke couples (patients: 61.4% male, mean age 54.06; caregivers: mean age 53.58) were included in the data analysis. Actor effects showed that stroke couples' relationship satisfaction mediated each of their own three communication patterns (constructive communication, demand/withdraw communication, and mutual avoidance) and benefit findings. In addition, patients' relationship satisfaction mediated patient demand-spouse withdraw and spouses' benefit findings. Partner effect showed that patients' relationship satisfaction mediated the association between their own three communication patterns and spouses' benefit findings. Patients' relationship satisfaction mediated the association between patient demand-spouse withdraw and patients' benefit findings. Moreover, spouses' relationship satisfaction mediated the association between the two communication avoidance patterns exhibited by patients (spouse demand-patient withdraw and mutual avoidance) and the spouses' benefit findings. CONCLUSION: The results have demonstrated a reciprocal influence on benefit findings between stroke patients and their spouses. The communication patterns within these couples have impacted not only their own benefit findings but also those of their spouses, with relationship satisfaction playing a mediating role.

2.
Sci Total Environ ; 954: 176652, 2024 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-39362537

RESUMO

The Tibetan Plateau is one of the highest and most pristine plateaus in the world, and its ecological environment has a significant impact on global climate and the distribution of water resources. Mercury (Hg), as a toxic metal pollutant, can have a severe impact on the health of living organisms and the ecosystem due to its presence in the environment. This study collected 336 soil samples from 28 sites across four typical surface vegetation landscapes (meadow, grassland, desert, and forest) on the Tibetan Plateau to measure soil THg (Total Hg) concentrations. The research aimed to explore the factors influencing soil THg levels, analyze pollution and environmental risks of THg in the surface soil, and evaluate the associated health risks to the local population. The results indicate that the mean soil THg concentration (31.84 ± 32.58 ng·g-1) of this study is compared to the background value of THg in Tibetan Plateau soils (37.0 ng·g-1), but there are significant differences in THg concentration among soils with different surface vegetation landscapes. The mean THg concentration in soils of forest vegetation types (74.42 ± 41.19 ng·g-1) is approximately twice the background value of Tibetan Plateau soils. In the forested regions of the southeastern, eastern, and southern Tibetan Plateau, soil concentrations of total mercury are relatively high, whereas in the desert areas of the northern, northwestern, and northeastern Tibetan Plateau, the concentrations are lower. Organic matter (soil organic carbon) being an important factor influencing the soil THg. Based on existing surface soil THg data from this and previous research in Tibetan Plateau (n = 477), 34.2 % of the samples show Hg pollution and potential ecological risks. However, the health risks of soil Hg to both adults and children are not significant.

3.
Ecotoxicol Environ Saf ; 285: 117136, 2024 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-39353373

RESUMO

Bisphenol S (BPS) is widely presented and affects aging with unclear mechanisms. Here, we applied C. elegans to evaluate the effects of BPS on lifespan and healthspan and to investigate the underlying mechanisms. Both early-life and whole-life exposure to BPS at environmentally relevant doses (0.6, 6, 60 µg/L) significantly decreased lifespan, and healthspan (body bend, pharyngeal pumping, and lipofuscin accumulation). BPS exposure impaired mitochondrial structure and function, which promoted ROS production to induce oxidative stress. Furthermore, BPS increased expressions of the insulin/IGF-like signaling (IIS). Also, BPS inhibited expression of the IIS transcription factor daf-16 and its downstream anti-oxidative genes. Quercetin effectively improved BPS-induced oxidative stress byreversing BPS-regulated IIS/daf-16 pathway and anti-oxidative gene expressions. In daf-2 and daf-16 mutants, the effects of BPS and quercetin on lifespan, healthspan, oxidative stress, and anti-oxidative genes expressions were reversed, demonstrating the requirement of IIS/daf-16 for aging regulation. Molecular docking and molecular dynamics simulations confirmed the stable interaction between DAF-2 and BPS mainly via three residues (VAL1260, GLU1329, and MET1395), which was attenuated by quercetin. Our results highlighted that adverse effects of BPS on impairing lifespan and healthspan by affecting IIS/daf-16 function against mitochondrial stress, which could be inhibited by quercetin treatment. Thus, we first revealed the underlying mechanisms of BPS-induced aging and the potential treatment.


Assuntos
Proteínas de Caenorhabditis elegans , Caenorhabditis elegans , Fator de Crescimento Insulin-Like I , Insulina , Longevidade , Mitocôndrias , Estresse Oxidativo , Fenóis , Transdução de Sinais , Sulfonas , Animais , Caenorhabditis elegans/efeitos dos fármacos , Caenorhabditis elegans/fisiologia , Caenorhabditis elegans/genética , Fenóis/toxicidade , Longevidade/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Mitocôndrias/efeitos dos fármacos , Mitocôndrias/metabolismo , Transdução de Sinais/efeitos dos fármacos , Proteínas de Caenorhabditis elegans/genética , Proteínas de Caenorhabditis elegans/metabolismo , Insulina/metabolismo , Sulfonas/toxicidade , Sulfonas/farmacologia , Fatores de Transcrição Forkhead/metabolismo , Fatores de Transcrição Forkhead/genética , Simulação de Acoplamento Molecular , Espécies Reativas de Oxigênio/metabolismo
4.
Int J Biol Macromol ; : 136056, 2024 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-39443178

RESUMO

The widespread application of organophosphorus pesticides (OPs) has inflicted significant damage on human well-being and food security. Hence, it is imperative to develop a friendly and accessible biosensor for the detection of OPs. Herein, apple polysaccharide (AP) stabilized palladium nanoparticles (AP-PdnNPs) with a particle size of 2.75-5.95 nm were prepared using AP as a stabilizer and reducing agent. AP-Pd30NPs exhibited good peroxidase-like activity and effectively decomposed H2O2 to ·OH, which catalyzed the 3,3',5,5'-tetramethylbenzidine system to become blue. The catalytic kinetics of AP-Pd30NPs conformed to the typical Michelis-Menten equation. Furthermore, OPs directly inhibited the peroxidase-like activity of AP-Pd30NPs. Thus, a highly effective colorimetric biosensor was developed for the detection of OPs. The detection range of the biosensor was 0.050 µg/L - 200 mg/L, and the limit of detection was extremely low to 0.010 µg/L. Compared with other nanomaterials, the detection platform based on AP-Pd30NPs can effectively detect organophosphorus pesticides without coupling natural enzymes;this method is more economical and practical. Therefore, this established method explores good perspective for the detection of OPs.

5.
Sci Adv ; 10(43): eadr1607, 2024 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-39453994

RESUMO

The ability to move backward is crucial for millimeter-scale microrobots to navigate dead-end tunnels that are too narrow to allow for turning maneuvers. In this study, we introduce a 15-mm-long legged microrobot, BHMbot-B, which is capable of rapid forward and backward locomotion through vibration mode transition control. By properly arranging the vibratory motions of the magnet, cantilever, and linkages, the pitching movement of the body and the vibration of the forelegs are in phase during the first-order vibration mode of the cantilever and in antiphase during the second-order mode, which induces the forward and backward movement of the microrobot. Owing to its outstanding load-bearing capacity, the BHMbot-B equipped with dual electromagnetic actuators, an onboard battery, and a control circuit, can execute complex running trajectories under wireless command. Its maximum untethered running speeds are evaluated as 18.0 BL/s (360 mm/s) in the forward direction and 16.9 BL/s (338 mm/s) in the backward direction.

6.
J Clin Oncol ; : JCO2301296, 2024 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-39353160

RESUMO

PURPOSE: Screening for nasopharyngeal carcinoma (NPC) has shown an improvement in early detection and survival rates of NPC in endemic regions. It is critical to evaluate whether NPC screening can reduce NPC-specific mortality in the population. METHODS: Sixteen towns in Sihui and Zhongshan cities, China, were selected; eight were randomly allocated to the screening group and eight to the control group. Residents age 30-69 years with no history of NPC were included from January 1, 2008, to December 31, 2015. Residents in the screening towns were invited to undergo serum Epstein-Barr virus (EBV) viral capsid antigen/nuclear antigen 1-immunoglobulin A antibody tests; others received no intervention. The population was followed until December 31, 2019. Nonparametric tests and Poisson regression models were used to estimate the screening effect on NPC mortality, accounting for the cluster-randomized design. The trial is registered with ClinicalTrials.gov (identifier: NCT00941538). RESULTS: A total of 174,943 residents in the screening group and 186,263 residents in the control group were included. NPC incidence and overall mortality were similar between the two groups. A total of 52,498 (30.0% of 174,943) residents participated in the serum EBV antibody test. The overall compliance rate for endoscopic examination and/or biopsies among baseline and ever-classified high-risk participants was 65.9% (1,110 of 1,685) and 67.6% (1,703 of 2,518), respectively. A significant 30% reduction in NPC mortality was observed in the screening group compared with the control group (standardized NPC-specific mortality rate of 8.2 NPC deaths per 1,000 person-years versus 12.5; adjusted rate ratio [RR], 0.70 [95% CI, 0.49 to 0.997]; P = .048). This benefit was most evident among individuals age 50 years and older (RR, 0.56 [95% CI, 0.37 to 0.85]; P = .007) compared with those younger than 50 years (RR, 0.96 [95% CI, 0.64 to 1.46]; P = .856). CONCLUSION: In this 12-year trial, EBV antibody testing resulted in a significant reduction in NPC mortality.

7.
Angew Chem Int Ed Engl ; : e202416790, 2024 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-39404029

RESUMO

Covalent polymer networks find wide utility in diverse engineering applications owing to their desirable stiffness and resilience. However, the rigid covalent chemical structure between crosslinking points imposes limitations on enhancing their toughness. Although the incorporation of sacrificial chemical bonds has shown promise in improving toughness through energy dissipation, composite networks struggle to maintain both rapid recovery and stiffness. Consequently, a significant challenge persists in achieving a covalent network that combines high strength, stiffness, toughness, and fast recovery performance. To address this challenge, we propose a novel sacrificial structure termed "sacrificial conformation." In this approach, ß-cyclodextrin is covalently embedded into the network skeleton as the sacrificial conformation element.  Compared to traditional covalent networks (LCN), well-designed cyclodextrin-embedded covalent network (CCN) exhibit a 100-fold increase in Young's modulus and a 60-fold increase in toughness. Importantly, CCN maintains excellent elasticity, ensuring swift recovery after deformation. This sacrificial conformational strategy enables efficient energy dissipation without necessitating the rupture of chemical bonds, thereby overcoming the limitations of traditional approaches. This advancement holds great promise for the design and fabrication of advanced elastomers and hydrogels with superior mechanical properties and dynamic behavior.

8.
Sci Rep ; 14(1): 24112, 2024 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-39406945

RESUMO

Depressive disorder is a significant public health problem worldwide, which adversely affects children and adolescents' health. Impaired fasting blood glucose (IFG) is more common in depressive disorder, which becomes a clinical problem that needs to be focused on. The study purposed to determine the prevalence and related factors of IFG in Chinese children and adolescents with depressive disorder and the relationship between triglyceride and high-density lipoprotein cholesterol (TG/HDL-C) ratio and IFG. This research encompassed 756 individuals aged 8 to 18 with major depressive disorders, all diagnosed under DSM-5 criteria at the Third People's Hospital of Fuyang from January 2020 to December 2021. We detected fasting blood glucose (FBG) and lipid levels and assessed the suicidal behaviors and depressive symptoms severity of each participant. The sociodemographic and included study variables were collected and analyzed. Our study employed multiple logistic regression to discern independent factors affecting IFG in conjunction with depressive disorders among children and adolescents. The prevalence of IFG was 6.5% (49/756). IFG was positively correlated with FBG, BMI, TG, TG/HDL-C, and was negatively correlated with gender and the type of antidepressant drug taken. Binary logistic analysis showed that male (OR = 2.57, 95% CI: 1.43-4.63, P = 0.002) and higher levels of TG (OR = 1.63, 95% CI: 1.11-2.38, P = 0.013) were independently associated with IFG in children and adolescents with depressive disorder. The incidence of IFG in children and adolescents with depressive disorder was high and was positively related to the TG/HDL-C ratio. The evaluation and management of IFG in pediatric depression should extend beyond pharmacological interventions. Comprehensive strategies in both assessment and management of IFG are essential to address this condition effectively in young patients facing depressive disorders.


Assuntos
Glicemia , Jejum , Triglicerídeos , Humanos , Adolescente , Masculino , Feminino , Criança , Prevalência , Triglicerídeos/sangue , Glicemia/análise , Jejum/sangue , Transtorno Depressivo Maior/epidemiologia , Transtorno Depressivo Maior/sangue , China/epidemiologia , Lipoproteínas HDL/sangue , HDL-Colesterol/sangue , Transtorno Depressivo/epidemiologia , Transtorno Depressivo/sangue , Fatores de Risco
9.
Front Nutr ; 11: 1469601, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39371945

RESUMO

Background: Increasing cardiac, hepatic, and metabolic diseases have raised the need to modify our contemporary lifestyles toward balancing and diversifying the nutrients in our daily diet. Objective: Dietary fats should be modified to healthier versions by blending different vegetable oils. Therefore, in this study, an oil blend with health-protective and promoting fatty acid combinations was investigated to bring down the progression of cardiac and other metabolic diseases. Methodology: A bio-efficacy trial was performed to investigate the therapeutic potential of an oil blend in 30 hyperlipidemic rats. Five rats were allocated to each group (coconut, flaxseed, olive, sunflower, and blended oil) for 42 days and were compared with the initial values of hyperlipidemic rats. Methodological investigations were performed for the body weight, naso-anal length, various obesity indices, visceral fat accumulation, blood and serum, cardiovascular risk indices, and echocardiograph. Results: Blended oil consumption indicated significant reductions of 53.12% in body fat content (3.98 ± 0.96), 6.82% in Lee index (289.60 ± 8.27), 16.84% in BMI (0.15 ± 0.003), 57.37% in total cholesterol (52.00 ± 9.03), 68.57% in triacylglycerides (99.00 ± 9.19), 61.16% in atherogenic index (0.88 ± 0.12), and 58.72% in coronary risk index (2.88 ± 0.12), when compared with the initial values. Conclusion: Blended oil consumption has significantly reduced various obesity indices, improved lipid profile, and provided significant protection against cardiovascular risk indices. Moreover, the results of blended oil indicated significant health protective ameliorations in electrocardiographs. Its regular consumption could help to reduce the onset of obesity and metabolic diseases.

10.
Food Chem ; 464(Pt 1): 141669, 2024 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-39423547

RESUMO

The effect of cold plasma (CP) treatment in promoting the covalent grafting of ovalbumin (OVA) with gallic acid (GA) were investigated, along with identifying the binding sites in the OVA-GA complex and exploring its potential for reducing the antigenicity of OVA. The results showed that the GA content of 22.97 ± 1.27 mg/g in OVA-GA complex was obtained following 60 s of CP treatment. Using LC-MS/MS, four regions (T52-R59, V201-K207, I279-R285, and V281-K291) were identified, containing 12 GA binding sites in the OVA-GA complex. Additionally, a significant reduction in IgE binding capacity (70.83 ± 0.90 %) was observed, as confirmed by ELISA analysis. The masking/steric-hindrance effect on linear epitopes and the disruption of conformational epitopes of OVA as a result of GA grafting may be the key factors leading to the reduction in OVA antigenicity. This study highlights that promoting the grafting of polyphenols onto proteins using CP treatment is an effective strategy for reducing the antigenicity of protein allergens.

11.
Talanta ; 282: 127007, 2024 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-39406101

RESUMO

Fenfluramine, an appetite suppressant used for weight loss, can cause significant harm if overdosed. The unauthorized addition of fenfluramine to slimming foods has raised concerns. Currently, no rapid screening method is available for the quick detection of fenfluramine in the field. This study proposes six new haptens with varying spacer arm lengths and hydrophobicity, promising to elicit antibodies capable of being highly specific and strongly binding to fenfluramine. The study found that highly hydrophobic haptens with long spacer arms favored the generation of highly sensitive antibodies. Key interaction forces for antibody recognition of fenfluramine were revealed by intrinsic molecular mechanisms. Based on the above results, monoclonal antibody for fenfluramine was prepared and an ultrasensitive icELISA method with heterologous coating strategies was developed in slimming foods. The IC50 of the method was 6.25 ng/mL, the linear detection range was 0.47-83.51 ng/mL and the detection limit was 0.10 ng/mL. Recovery rates in tea bags, tablets, capsules, coffee, and beverages ranged from 96.56 % to 108.90 %. The method was successfully applied to blind samples, showing strong correlation with HPLC-MS/MS results. Thus, the developed method is suitable for identifying fenfluramine adulteration in slimming foods.

12.
Heliyon ; 10(18): e36445, 2024 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-39315182

RESUMO

Objectives: To comprehensively analyze the copper metabolism in Breast cancer, we established a prognostic signature for breast cancer (BC) related to copper metabolism. Methods: Copper metabolism-related genes were sourced from previous literatures and were selected by the Univariate Cox regression. Cu-enrichment scores were calculated via ssGSEA. Differentially expressed genes were identified with limma between high and low Cu-enrichment scores group, then we used the Random Survival Forest and LASSO to build the CuScore for BC. Kaplan-Meier analysis, ROC curves, and Cox regression were used to evaluate CuScore. Genomic mutations were analyzed with GISTIC. Immune cells were examined using ESTIMATE, ssGSEA and TIMER. Enrichment analysis used clusterProfiler and GSVA. The GDSC database and oncoPredict package analyzed chemotherapeutic sensitivity. MMP13 was selected for in vitro assays. Results: Four copper metabolism-related genes (UBE2D2, SLC31A1, ATP7A, and MAPK1) with prognostic value were identified. Higher expression levels of these genes were associated with higher Cu-enrichment scores, a factor of malignancy in breast cancer. Among 115 differentially expressed genes, 19 prognostic genes were identified, with three (CEACAM5, MMP13, and CRISP3) highlighted by Random Survival Forest and LASSO. Higher CuScores correlated with worse prognoses and were effective in predicting breast cancer outcomes. CuScore and metastasis were independent prognostic factors. Tumor-infiltrating immune cells were associated with lower CuScores. GO-GSEA analysis indicated six immune-related pathways might be regulated by CuScore. Patients with higher CuScores had lower TMB and were more sensitive to Sapitinib and LCL161, while those with lower CuScores might respond better to anti-PD1 therapy. High MMP13 expression in breast cancer was linked to malignancy, affecting cell proliferation and migration. Conclusion: The identified copper metabolism-related gene signature has the potential to predict prognosis and guide clinical treatment for BC. Among these genes, MMP13 may act as a malignant factor in BC.

13.
Curr Res Food Sci ; 9: 100831, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39281340

RESUMO

During the fermentation of ripened pu-erh tea (RPT), the composition of lipids and other compounds changes significantly. In this study, we conducted industrial fermentation of RPT and observed that the levels of water extract, tea polyphenols, free amino acids, catechins, caffeine, rutin, theophylline, luteolin, and myricetin decreased, while the level of soluble sugar increased. Additionally, the levels of gallic acid, quercetin, ellagic acid, and kaempferol first increased and then decreased during fermentation. We identified a total of 731 lipids, which were classified into seven categories using a lipomics method. Among these lipids, 85 with relatively high contents decreased, while 201 lipids with low contents increased after fermentation. This led to an overall decrease in the sum contents of lipids and dominant lipids, including glycerophospholipids and saccharolipids. We also detected 33 medium- and long-chain fatty acids, with α-linolenic acid (881.202 ± 12.13-1322.263 ± 19.78 µg/g), palmitic acid (797.275 ± 19.56-955.180 ± 30.49 µg/g), and linoleic acid (539.634 ± 15.551-706.869 ± 12.14 µg/g) being the predominant ones. Coenzymes Q9 (62.76-63.57 µg/g) and Q10 (50.82-59.33 µg/g) were also identified in the fermentation process. Our findings shed light on the changes in lipids during the fermentation of RPT and highlight the potential bio-active compounds, such as α-linolenic acid, linoleic acid, Coenzymes Q9, and Q10, in ripened pu-erh tea. This contributes to a better understanding of the fermentation mechanism for RPT.

14.
Front Plant Sci ; 15: 1432875, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39323530

RESUMO

Introduction: Oilseed flax (Linum usitatissimum L.) yields are phosphate (P) fertilizer-limited, especially in the temperate semiarid dryland regions of North China. However, there are limited studies on the effects of P-fertilizer inputs on plant growth and soil microorganisms in flax planting systems. Methods: To address this gap, a field experiment was conducted with four treatments: no P addition and application of 40, 80, and 120 kg P ha-¹, respectively. The aim was to investigate the influence of various P fertilizer inputs on yield, plant dry matter, P use efficiency, as well as the population of soil arbuscular mycorrhizal fungi (AMF) and bacteria in dryland oilseed flax. Results: Our results show that the P addition increased the dry matter, and the yield of oilseed increased by ~200% at 120 kg P ha-1 addition with inhibition on the growth of AMF hyphae. The moderate P supply (80 kg ha-1) was adequate for promoting P translocation, P use efficiency, and P recovery efficiency. Soil pH, available P, and available K significantly (p< 0.05) promoted the abundance of the dominant taxa (Acidobacteria_GP6, Sphingobacteria and Bacteroidetes). In addition, it is imperative to comprehend the mechanism of interaction between phosphorus-fertilizer inputs and microbiota in oilseed flax soil. Discussion: This necessitates further research to quantify and optimize the moderate phosphorus supply, regulate soil microbes to ensure high phosphorus utilization, and ultimately establish a sustainable system for oilseed flax cultivation in the local area.

15.
Colloids Surf B Biointerfaces ; 245: 114260, 2024 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-39305549

RESUMO

Unlike traditional drug carriers, sequential drug delivery systems can release different drugs in order, with the first released drug providing a prerequisite for the later released drug to maximize its function, thereby achieving stronger anti-tumor effects. Herein we constructed a temporal sequential system designated TPZ@MSN/HIF-1α siRNA@PDA@GOx (MTRPG) in which mesoporous silica nanoparticles were used as cores to load hypoxia induced chemotherapy drug tirapazamine (TPZ) and gene targeted nucleic acid drug HIF-1α siRNA, polydopamine (PDA) as acid -responsive coating as well as to realize photothermal therapy, and glucose oxidase (GOx) as the outermost layer to achieve starvation therapy and construct a deepened hypoxia to activate TPZ. Through in vitro and in vivo experiments, we demonstrated that the first released glucose oxidase catalyzed the oxidation of glucose, achieving starvation treatment while reducing the acidic environment and further exacerbating hypoxia in tumor cells. The reduced acidic conditions enabled the degradation of PDA, resulting in the release of loaded HIF-1α siRNA and TPZ. At the same time, PDA could also exert photothermal therapy under 808 nm near-infrared (808 nm NIR) laser irradiation. The later released hypoxia induced chemotherapy drug TPZ amplifies its anti-tumor activity under intensified hypoxia conditions. Meanwhile, the released HIF-1α siRNA interfered with the up-regulated HIF-1α induced by the deepened hypoxia condition, which caused hypoxia tolerance in tumors, reduced its expression activity, and achieved synergistic killing of tumor cells with chemotherapy. This work provides an effective multimodal synergistic therapy strategy to promote tumor therapeutic index, which may possess a promising future in clinical application.

16.
ChemSusChem ; : e202401197, 2024 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-39243173

RESUMO

Developing efficient and durable electrocatalyst for seawater splitting is crucial in hydrogen production. Herein, a multi-scale design strategy was employed to fabricate ruthenium clusters modification carbon layer-encapsulated nickel-cobalt-phosphorus (Ru/C/NiCoP) nanoneedles electrocatalyst supported on nickel foam (NF). We demonstrated that Ru/C/NiCoP/NF exhibited exceptional oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) performances, with low overpotential, Tafel slope and superior stability. Furthermore, the electrocatalytic mechanism of Ru/C/NiCoP was elucidated through the combination of ex-situ and in-situ characterizations, along with comprehensive electrochemical tests. Strikingly, Ru clusters and the carbon layer engendered robust electronic interaction reaction, accelerated the charge transfer rate, provided more active sites, and enhanced intrinsic catalytic activity, thus substantially promoting the OER kinetics and HER reaction steps as well as stability. In addition, the two-electrode system constructed with Ru/C/NiCoP/NF achieved current density of 10 mA cm-2 in both pure water and seawater at ultra-low potential of 1.46/1.47 V, with Faraday efficiency close to 100%. Even at higher current density of 100 mA cm-2, the required driving voltage remained low at 1.75/1.77 V, maintaining stable operation for 150 h, outperforming most reported non-noble catalysts. This innovative strategy provides facile and versatile approach for developing advanced electrocatalysts in seawater electrolysis application.

17.
Open Forum Infect Dis ; 11(9): ofae464, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39229285

RESUMO

Elevated levels of Epstein-Barr virus (EBV) gp350 and gH/gL antibodies have been associated with a lower risk of developing nasopharyngeal carcinoma (NPC), although the evidence remains inconclusive and unexplained. We conducted a longitudinal study within a high-risk Taiwanese cohort, analyzing total immunoglobulin against EBV-gp350 and -gH/gL in blood and EBV DNA shedding in saliva. Contrary to our hypothesis-that elevated levels of antibodies previously shown to be associated with a lower NPC risk should result in a decrease in EBV shedding in saliva-higher anti-gp350 antibodies at baseline were significantly associated with detectable EBV DNA in saliva at follow-up (odds ratio [OR], 1.99 [95% confidence interval {CI}, 1.03-3.97]; P = .04). Higher anti-EBV-gH/gL antibodies at baseline were not significantly associated with risk of detectable EBV DNA at follow-up (OR, 0.69 [95% CI, .35-1.32]; P = .26). These findings underscore the complexity of virus-host interactions and emphasize the need for further investigations into their role in EBV-associated diseases.

19.
Adv Mater ; : e2408118, 2024 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-39252676

RESUMO

Fast and efficient exciton utilization is a crucial solution and highly desirable for achieving high-performance blue organic light-emitting diodes (OLEDs). However, the rate and efficiency of exciton utilization in traditional OLEDs, which employ fully closed-shell materials as emitters, are inevitably limited by spin statistical limitations and transition prohibition. Herein, a new sensitization strategy, namely doublet-sensitized fluorescence (DSF), is proposed to realize high-performance deep-blue electroluminescence. In the DSF-OLED, a doublet-emitting cerium(III) complex, Ce-2, is utilized as sensitizer for multi-resonance thermally activated delayed fluorescence emitter ν-DABNA. Experimental results reveal that holes and electrons predominantly recombine on Ce-2 to form doublet excitons, which subsequently transfer energy to the singlet state of ν-DABNA via exceptionally fast (over 108 s-1) and efficient (≈100%) Förster resonance energy transfer for deep-blue emission. Due to the circumvention of spin-flip in the DSF mechanism, near-unit exciton utilization efficiency and remarkably short exciton residence time of 1.36 µs are achieved in the proof-of-concept deep-blue DSF-OLED, which achieves a Commission Internationale de l'Eclairage coordinate of (0.13, 0.14), a high external quantum efficiency of 30.0%, and small efficiency roll-off of 14.7% at a luminance of 1000 cd m-2. The DSF device exhibits significantly improved operational stability compared with unsensitized reference device.

20.
J Environ Manage ; 370: 122400, 2024 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-39255579

RESUMO

The widespread use of non-ionic surfactant nonylphenol (NP) has led to significant water pollution, posing a threat to both ecological stability and human health. However, the efficient biodegradation method and system of NP-biodegradation remain complex scientific challenges. In this study, we isolated and characterized three Pseudomonas sp. strains SW-1 (Scenedesmus quadricauda-associated), ZL-2 (Ankistrodesmus acicularis-associated), XQ-3 (Chlorella vulgaris-associated), and one NP-degrading Cupriavidus sp. strain EB-4, which exhibited the ability to utilize NP as the sole carbon source. Furthermore, four consortiums of microalgae-bacterial, S. quadricauda and SW-1 (S-SW), A. acicularis and ZL-2 (A-ZL), C. vulgaris and XQ-3 (C-XQ), S. quadricauda and EB-4 (S-EB), were constructed to investigate their biodegradability and kinetic characteristics of NP degradation from water. The consortiums showed higher degradation efficiency compared to individual microalgae or bacteria. The C-XQ consortium exhibited the highest degradation rate, removing over 94% of NP within just seven days. The first-order model with the following order of degradation rate by consortiums was C-XQ (0.3960 d-1) > S-SW (0.3506 d-1) > A-ZL (0.1968 d-1) > S-EB (0.1776 d-1). Compared with the results of our previous study, the interaction between microalgae and bacteria is not a simple additive relationship. Our findings highlight the potential of an algal-bacterial consortium for the remediation of NP-contaminated environments.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...