Progressive encephalomyelitis with rigidity and myoclonus: a pediatric case report and literature review.

BACKGROUND: Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare and life-threatening autoimmune disease of the central nervous system. So far, only ten cases of PERM have been reported in children worldwide, including the one in this study. CASE PRESENTATION: We report a case of an 11-year-old boy with PERM with an initial presentation of abdominal pain, skin itching, dysuria, urinary retention, truncal and limb rigidity, spasms of the trunk and limbs during sleep, deep and peripheral sensory disturbances, and dysphagia. A tissue-based assay using peripheral blood was positive, demonstrated by fluorescent staining of mouse cerebellar sections. He showed gradual and persistent clinical improvement after immunotherapy with intravenous immunoglobulin, steroids, plasmapheresis and rituximab. CONCLUSIONS: We summarized the diagnosis and treatment of a patient with PERM and performed a literature review of pediatric PERM to raise awareness among pediatric neurologists. A better comprehension of this disease is required to improve its early diagnosis, treatment, and prognosis.

Fully Unsupervised Deepfake Video Detection Via Enhanced Contrastive Learning.

Nowadays, Deepfake videos are widely spread over the Internet, which severely impairs the public trustworthiness and social security. Although more and more reliable detectors have recently sprung up for resisting against that new-emerging tampering technique, some challengeable issues still need to be addressed, such that most of Deepfake video detectors under the framework of the supervised mechanism require a large scale of samples with accurate labels for training. When the amount of the training samples with the true labels are not enough or the training data are maliciously poisoned by adversaries, the supervised classifier is probably not reliable for detection. To tackle that tough issue, it is proposed to design a fully unsupervised Deepfake detector. In particular, in the whole procedure of training or testing, we have no idea of any information about the true labels of samples. First, we novelly design a pseudo-label generator for labeling the training samples, where the traditional hand-crafted features are used to characterize both types of samples. Second, the training samples with the pseudo-labels are fed into the proposed enhanced contrastive learner, in which the discriminative features are further extracted and continually refined by iteration on the guidance of the contrastive loss. Last, relying on the inter-frame correlation, we complete the final binary classification between real and fake videos. A large scale of experimental results empirically verify the effectiveness of our proposed unsupervised Deepfake detector on the benchmark datasets including FF++, Celeb-DF, DFD, DFDC, and UADFV. Furthermore, our proposed well-performed detector is superior to the current unsupervised method, and comparable to the baseline supervised methods. More importantly, when facing the problem of the labeled data poisoned by malicious adversaries or insufficient data for training, our proposed unsupervised Deepfake detector performs its powerful superiority.