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1.
Sci Prog ; 106(2): 368504231172617, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37254509

RESUMO

Wire coating is widely used for electrical insulation to protect the wire from electric shock, prevent electrical leakage, and ensure that the electrical current flows smoothly. In this investigation, a pressurized coating die is used to explore the PTT fluid as a polymer material for wire in a magnetic field. The flow field, flow rate, temperature profile, thickness of the wire coating, volume flow rate, and shear stress are all given exact solutions. Graphs were used to illustrate the effects of certain important technical parameters, including flow rate, wire coating thickness, shear stress, and pressure gradient. It has been noted that as the values of X, Deborah number, and ratio of radii are improved, the volume and thickness of the coated wire rise. The Deborah number has a higher volume flow than the X and radii ratios. A reference to existing literature is made in order to support the validity of the current study.

2.
Cureus ; 14(11): e31036, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36475135

RESUMO

Background During and after the coronavirus disease 2019 (COVID-19) pandemic, there was a significant increase in the demand for aesthetic procedures nationwide. We believe that one of the factors contributing to this increase was the use of video conferencing apps. Therefore, the purpose of this study was to analyze the aesthetic concerns that were identified by video conferencing. Methodology In Saudi Arabia, an observational, cross-sectional study was conducted from February to April, 2022. An online survey was used to assess the aesthetic concerns raised by video conferencing. The survey addressed multiple aspects, including demographic data, information on video call utilization, the attentional focus of the participants during video calls, and new appearance concerns identified on video calls. Results The survey successfully captured 432 adult participants. More than 85% of participants disliked at least one character of their appearance during video conferencing. The skin color type (based on the Fitzpatrick scale), time spent on video calls, and visual focus during the virtual meeting were significantly correlated with self-perception of new disliked features. Conclusion Video conferencing showed a significant statistical correlation with identified disliked facial/body features in both genders. People with skin color type III were less likely to perceive a disliked feature through video conferencing applications. The likelihood of having a disliked feature was significantly higher among individuals who spent up to one hour per day using video calls. Additionally, those who mainly paid attention to their face or body during virtual meetings were more likely to have disliked features.

3.
Comput Math Methods Med ; 2022: 3599827, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36404912

RESUMO

Human immunodeficiency virus (HIV) infection affects the immune system, particularly white blood cells known as CD4+ T-cells. HIV destroys CD4+ T-cells and significantly reduces a human's resistance to viral infectious diseases as well as severe bacterial infections, which can lead to certain illnesses. The HIV framework is defined as a system of nonlinear first-order ordinary differential equations, and the innovative Galerkin technique is used to approximate the solutions of the model. To validate the findings, solve the model employing the Runge-Kutta (RK) technique of order four. The findings of the suggested techniques are compared with the results obtained from conventional schemes such as MuHPM, MVIM, and HPM that exist in the literature. Furthermore, the simulations are performed with different time step sizes, and the accuracy is measured at various time intervals. The numerical computations clearly demonstrate that the Galerkin scheme, in contrast to the Runge-Kutta scheme, provides incredibly precise solutions at relatively large time step sizes. A comparison of the solutions reveals that the obtained results through the Galerkin scheme are in fairly good agreement with the RK4 scheme in a given time interval as compared to other conventional schemes. Moreover, having performed various numerical tests for assessing the efficiency and computational cost (in terms of time) of the suggested schemes, it is observed that the Galerkin scheme is noticeably slower than the Runge-Kutta scheme. On the other hand, this work is also concerned with the path tracking and damped oscillatory behaviour of the model with a variable supply rate for the generation of new CD4+ T-cells (based on viral load concentration) and the HIV infection incidence rate. Additionally, we investigate the influence of various physical characteristics by varying their values and analysing them using graphs. The investigations indicate that the lateral system ensured more accurate predictions than the previous model.


Assuntos
Infecções por HIV , Humanos , Carga Viral , Linfócitos T CD4-Positivos
5.
ACS Omega ; 7(37): 33432-33442, 2022 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-36157759

RESUMO

The growth of hybrid nanofluids can be connected to their enhanced thermal performance as pertains to the dynamics of automobile coolant among others. In addition to that, the thermal characteristics of water-based nanofluids carrying three different types of nanoparticles are incredible. Keeping in view this new idea, the current investigation explores ternary hybrid nanofluid flow over a stretching sheet. Joule heating and viscous dissipation are addressed in the heat equation. Three distinct kinds of nanoparticles, namely, magnesium oxide, copper, and MWCNTs, are suspended in water to form a ternary hybrid nanofluid with the combination MgO-Cu-MWCNTs-H2O. To stabilize the flow of the ternary hybrid nanofluid, transverse magnetic and electric fields have been considered in the fluid model. The production of entropy has been analyzed for the modeled problem. A comparative study for ternary, hybrid, and traditional nanofluids has also been carried out by sketching statistical charts. The equations that govern the problem are shifted to dimension-free format by employing transformable variables, and then they are solved by the homotopy analysis method (HAM). It has been revealed in this work that the flow of fluid opposes by magnetic parameter and supports by electric field the volumetric fraction of ternary hybrid nanofluid, while thermal profiles are gained by the growing values of these parameters. Boosting values of the electric field, magnetic parameters, and Eckert number support the Bejan number and oppose the production of entropy. Statistically, it has been established in this work that a ternary hybrid nanofluid has a higher thermal conductivity than hybrid or traditional nanofluids.

6.
Comput Intell Neurosci ; 2022: 1200611, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36072714

RESUMO

In this paper, the Ridge Regression method is employed to estimate the shape parameter of the Lomax distribution (LD). In addition to that, the approaches of both classical and Bayesian are considered with several loss functions as a squared error (SELF), Linear Exponential (LLF), and Composite Linear Exponential (CLLF). As far as Bayesian estimators are concerned, informative and noninformative priors are used to estimate the shape parameter. To examine the performance of the Ridge Regression method, we compared it with classical estimators which included Maximum Likelihood, Ordinary Least Squares, Uniformly Minimum Variance Unbiased Estimator, and Median Method as well as Bayesian estimators. Monte Carlo simulation compares these estimators with respect to the Mean Square Error criteria (MSE's). The result of the simulation mentioned that the Ridge Regression method is promising and can be used in a real environment. where it revealed better performance the than Ordinary Least Squares method for estimating shape parameter.


Assuntos
Projetos de Pesquisa , Teorema de Bayes , Simulação por Computador , Análise dos Mínimos Quadrados , Método de Monte Carlo
7.
Sci Rep ; 12(1): 15577, 2022 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-36114201

RESUMO

Due to their unique microstructures, micropolar fluids have attracted enormous attention for their industrial applications, including convective heat and mass transfer polymer production and rigid and random cooling particles of metallic sheets. The thermodynamical demonstration is an integral asset for anticipating the ideal softening of heat transfer. This is because there is a decent connection between mathematical and scientific heat transfers through thermodynamic anticipated outcomes. A model is developed under the micropolar stream of a non-Newtonian (3rd grade) liquid in light of specific presumptions. Such a model is dealt with by summoning likeness answers for administering conditions. The acquired arrangement of nonlinear conditions is mathematically settled using the fourth-fifth order Runge-Kutta-Fehlberg strategy. The outcomes of recognized boundaries on liquid streams are investigated in subtleties through the sketched realistic images. Actual amounts like Nusselt number, Sherwood number, and skin-part coefficient are explored mathematically by tables. It is observed that the velocity distribution boosts for larger values of any of [Formula: see text], [Formula: see text], and declines for larger [Formula: see text] and Hartmann numbers. Furthermore, the temperature distribution [Formula: see text] shows direct behavior with the radiation parameter and Eckert number, while, opposite behavior with Pr, and K. Moreover, the concentration distribution shows diminishing behavior as we put the higher value of the Brownian motion number.

8.
Lett Appl Microbiol ; 75(4): 967-981, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-35716384

RESUMO

This study was done to find exopolysaccharide (EPS)-producing lactic acid bacteria (LAB) against foodborne pathogens. Isolated LAB were screened to find the ones with the ability to produce antibacterial EPS against foodborne pathogens. Among tested EPSs, EPS of AS20(1) isolate showed inhibitory effects on the growth of Listeria monocytogenes (MIC = 0·935 mg ml-1 , MBC = 0·935 mg ml-1 ), Yersinia enterocolitica (MIC = 12·5 mg ml-1 , MBC = 50 mg ml-1 ) and Bacillus cereus (MIC = 6·25 mg ml-1 , MBC = 12·5 mg ml-1 ). According to 16S rRNA sequencing, AS20(1) showed the closest similarity to Lacticaseibacillus paracasei (100%). This antibacterial EPS showed negligible toxicity (4·4%-5·2%) against red blood cells. Lacticaseibacillus paracasei AS20(1) showed probiotic properties, including high acid resistance, hydrophobicity (47·5%), autoaggregation and coaggregation with foodborne pathogens. Also, L. paracasei AS20(1) showed no haemolysis activity and antibiotic resistance. Characterization of antibacterial EPS revealed that it is a heteropolysaccharide with various functional groups, amorphous structure, and smooth surface, sheet and compact structure, which can be suitable for food packaging. L. paracasei AS20(1) and its antimicrobial EPS can be used to make functional food.


Assuntos
Lacticaseibacillus paracasei , Lactobacillales , Probióticos , Antibacterianos/farmacologia , Lactobacillales/genética , Probióticos/química , RNA Ribossômico 16S/genética
9.
Micromachines (Basel) ; 14(1)2022 Dec 25.
Artigo em Inglês | MEDLINE | ID: mdl-36677110

RESUMO

The present computational model is built to analyze the energy and mass transition rate through a copper and cobalt ferrite water-based hybrid nanofluid (hnf) flow caused by the fluctuating wavy spinning disk. Cobalt ferrite (CoFe2O4) and copper (Cu) nanoparticles (nps) are incredibly renowned in engineering and technological research due to their vast potential applications in nano/microscale structures, devices, materials, and systems related to micro- and nanotechnology. The flow mechanism has been formulated in the form of a nonlinear set of PDEs. That set of PDEs has been further reduced to the system of ODEs through resemblance replacements and computationally solved through the parametric continuation method. The outcomes are verified with the Matlab program bvp4c, for accuracy purposes. The statistical outputs and graphical evaluation of physical factors versus velocity, energy, and mass outlines are given through tables and figures. The configuration of a circulating disk affects the energy transformation and velocity distribution desirably. In comparison to a uniform interface, the uneven spinning surface augments energy communication by up to 15%. The addition of nanostructured materials (cobalt ferrite and copper) dramatically improves the solvent physiochemical characteristics. Furthermore, the upward and downward oscillation of the rotating disc also enhances the velocity and energy distribution.

10.
Exp Toxicol Pathol ; 67(9): 435-41, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26095745

RESUMO

The role of Balanites aegyptiaca (B. aegyptiaca) on development and growth of Ehrlich Ascitic carcinoma (EAC) and metastasis (liver and spleen) was evaluated. Balanite (400mg/kg; 10mg in 0.1ml/mouse) was given daily over a period of two weeks started 24h before intraperitoneal injection of EAC (2×10(6)/once). The present study deals with the effect of B. aegyptiaca on the growth of transplantable ascetic tumor, life span of EAC-bearing mice, hepatocellular and splenic histology. Antioxidant and biochemical changes as well as p53 genes expression were recorded. B. aegyptiaca extracts inhibited tumor growth and proliferation in ascetic fluid through a significant decrease in tumor volume, total cell volume, and viable cell count and prolonged the life span of mice. Also, it significantly decreased the levels of lipid peroxidation and increased SOD, CAT levels and P53 expression. Also, balanite inhibited either tumor invaded/or affected hepatic and splenic tissue. This result gives a new insight on beneficial effect of B. aegyptiaca in primary and secondary loci of Ehrlich Ascitic tumor through its antioxidant effect.


Assuntos
Antineoplásicos Fitogênicos/uso terapêutico , Balanites/química , Carcinoma de Ehrlich/tratamento farmacológico , Neoplasias Hepáticas/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Neoplasias Esplênicas/tratamento farmacológico , Animais , Antineoplásicos Fitogênicos/administração & dosagem , Antineoplásicos Fitogênicos/isolamento & purificação , Carcinoma de Ehrlich/patologia , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Feminino , Frutas/química , Neoplasias Hepáticas/secundário , Camundongos , Extratos Vegetais/administração & dosagem , Extratos Vegetais/isolamento & purificação , Neoplasias Esplênicas/secundário , Resultado do Tratamento , Proteína Supressora de Tumor p53/genética
11.
J Family Med Prim Care ; 4(1): 132-4, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25811005

RESUMO

We report a 16-year-old Jordanian female who presented with bleeding from both eyes of sudden onset. Her physical examination was remarkable for blood pouring from both eyes, and normal otherwise examination including eye and nose examination. During hospital stay, it was noted that "bleeding" occurred only when alone in the room. She later was seen to prick her finger tips of the left hand with her right hand using a hair clip. She denied any psychological problems, and later did not show for follow-up. Munchausen syndrome as a cause of bleeding is discussed.

13.
Can J Vet Res ; 77(2): 150-7, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24082408

RESUMO

The objective of this study was to characterize the highly elevated levels of clotting factor VIII (FVIII) in camel plasma. Whole blood was collected from healthy camels and factor VIII clotting activity (FVIII:C) assays were conducted using both the clotting and the chromogenic techniques. The anticoagulant citrate phosphate dextrose adenine (CPDA) produced the highest harvest of FVIII:C, the level of plasma factor VIII, compared to heparin:saline and heparin:CPDA anticoagulants. Camel FVIII can be concentrated 2 to 3 times in cryoprecipitate. There was a significant loss of camel FVIII when comparing levels of FVIII in camel plasma after 1 h of incubation at 37°C (533%), 40°C (364%), and 50°C (223%). Thrombin generation of camel plasma is comparable to that of human plasma. It was concluded that camel plasma contains very elevated levels of FVIII:C, approaching 8 times the levels in human plasma, and that these elevated levels could not be attributed to excessive thrombin generation. Unlike human FVIII:C, camel FVIII:C is remarkably heat stable. Taken together, these unique features of camel FVIII could be part of the physiological adaptation of hemostasis of the Arabian camel in order to survive in the hot desert environment.


L'objectif de la présente étude était de caractériser les niveaux très élevés du facteur de coagulation VIII (FVIII) dans le plasma de chameau. Du sang entier a été prélevé de chameaux en santé et des épreuves d'activité de coagulation du facteur VIII (FVIII:C) ont été effectuées en utilisant des techniques chromogéniques et de coagulation. L'anticoagulant citrate phosphate dextrose adénine (CPDA) a permis la récolte la plus élevée de FVIII:C, le niveau plasmatique de facteur VIII, comparativement aux anticoagulants héparine:saline et héparine CPDA. Le FVIII de chameau peut être concentré 2 à 3 fois dans des cryoprécipités. Il y avait une perte significative de FVIII de chameau lorsque l'on comparait les niveaux de FVIII dans le plasma de chameau après 1 h d'incubation à 37 °C (533 %), 40 °C (364 %), et 50 °C (223 %). La génération de thrombine dans le plasma de chameau est comparable à celle dans le plasma humain. Il a été conclu que le plasma de chameau contient des niveaux très élevés de FVIII:C, atteignant près de 8 fois le niveau dans le plasma humain, et que ces niveaux élevés ne pouvaient pas être attribué à une génération excessive de thrombine. Comparativement au FVIII:C humain, le FVIII:C de chameau est très stable à la chaleur. Prises dans leur ensemble, ces caractéristiques uniques du FVIII de chameau pourraient faire partie de l'adaptation physiologique de l'hémostase du chameau arabe afin de lui permettre de survivre dans l'environnement chaud du désert.(Traduit par Docteur Serge Messier).


Assuntos
Camelus/sangue , Fator VIII/metabolismo , Trombina/metabolismo , Adaptação Fisiológica , Animais , Fibrinogênio/metabolismo , Temperatura Alta , Humanos , Fator de von Willebrand/metabolismo
14.
Commun Agric Appl Biol Sci ; 78(3): 585-98, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-25151835

RESUMO

The activity of heat treatments for controlling tomato black mould caused by Alternaria alternata (Fr.) Keissler and grey mould caused by Botrytis cinerea Pers. Ex. Pers. wWas tested. Spore suspension of the grey mold pathogen which was exposed to hot water treatment at 58 degrees C for 6 min., failed to germinate, whereas A. alternata failed to germinate when exposed to hot water at 58 degrees C, for 8 min. Exposing discs bearing growth of any both tested fungi to hot air at 48 degrees C for 72 h caused growth suppression for the both tested pathogens. Dipping tomato fruits in hot water at 58 degrees C for 8 min or keeping in hot air for 72 h at 40 degrees C prevented decay development in non inoculated or artificially inoculated fruits with A. alternata and B. cinerea up to 12 days when stored at 24 degrees C. The high amount of polygalacturonase (PG) and pectinmethylestrase (BME) enzymes were investigated in infected fruits by the two tested pathogens as compared by healthy ones. The culture filtrate of A. alternata had the highest protease activity, white B. cinerea was the lowest. Protease activity was higher when CD liquid medium contain casein was used.


Assuntos
Conservação de Alimentos/métodos , Doenças das Plantas/microbiologia , Solanum lycopersicum/enzimologia , Solanum lycopersicum/microbiologia , Alternaria/química , Alternaria/crescimento & desenvolvimento , Botrytis/química , Botrytis/crescimento & desenvolvimento , Armazenamento de Alimentos , Frutas/química , Frutas/enzimologia , Frutas/microbiologia , Temperatura Alta , Solanum lycopersicum/química , Peptídeo Hidrolases/metabolismo , Doenças das Plantas/prevenção & controle , Proteínas de Plantas/metabolismo , Poligalacturonase/metabolismo , Esporos Fúngicos/química , Esporos Fúngicos/crescimento & desenvolvimento , beta-Glucosidase/metabolismo
15.
Trop Anim Health Prod ; 44(7): 1535-9, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22359088

RESUMO

Serological prevalence of IgG antibodies against Rift Valley fever (RVFV) virus was investigated in 22 major localities in five different regions of Saudi Arabia where vaccination against RVF virus (RVFV) is not practiced. The study excludes the southwestern region where a major outbreak of RVF occurred in 2000 and where annual vaccination of ruminants is practiced. Sheep and goat IgG-sandwich ELISA were used to test serum samples from sheep and goats, and bovine IgG-sandwich ELISA was used to test cattle sera. A nonspecies-specific, nonantibody isotype-specific ELISA was used to test camel sera. A total of 3,480 sheep, goats, cattle and camels with no previous history of vaccination against RVFV were randomly tested. All tested animals were negative for IgG class antibodies against the virus except four out of 1,508 sheep and three out of 913 goats, which tested positive. All animals were clinically normal and no evidence was found of virus activity in the studied areas. It is, therefore, most likely that those rare positive cases, which constituted 0.002% of the total animals tested, were either false positives or vaccinates smuggled from the outbreak zone. The need for regular monitoring of animals both within the outbreak zone of 2000 and other parts of the kingdom is strongly emphasized.


Assuntos
Anticorpos Antivirais/sangue , Gado/virologia , Febre do Vale de Rift/veterinária , Vírus da Febre do Vale do Rift/imunologia , Animais , Estudos Transversais , Ensaio de Imunoadsorção Enzimática/veterinária , Feminino , Imunoglobulina G/sangue , Gado/sangue , Masculino , Prevalência , Febre do Vale de Rift/epidemiologia , Vírus da Febre do Vale do Rift/isolamento & purificação , Ruminantes/sangue , Ruminantes/virologia , Arábia Saudita/epidemiologia , Estudos Soroepidemiológicos
16.
Vector Borne Zoonotic Dis ; 11(12): 1513-20, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21923257

RESUMO

In August-September 2000, an overwhelming outbreak of Rift Valley fever (RVF) struck the southwestern part of Saudi Arabia and adjoining Yemeni territories. During the outbreak, which was the first ever to be recorded outside Africa, around 40,000 animals, mostly sheep and goats, died or aborted and 883 cases, with 124 deaths, were recorded among humans in Saudi Arabia. An additional 1328 human cases, with 166 deaths, were concurrently recorded in northwestern Yemen. Vector studies in Saudi Arabia established Aedes vexans arabiensis and Culex (culex) triteniorynchus as the biological vectors of RVF virus in the region. Both of these species and several others, which could be potential vectors of the virus, occur throughout the Kingdom. Rigorous control measures were implemented, which succeeded in curtailing the infection and preventing its spread to other parts of the country. However, the virus persisted in a cryptic form in the original area of the epizootic, resulting in intermittent diagnosis of few cases throughout the past 10 years. To date, however, no evidence was found of virus activity outside that area. This review provides, from a veterinary perspective, a brief account of the events surrounding the epizootic and its present status in Saudi Arabia and emphasizes the need for vigilance, preparedness, and regular monitoring of the disease by serosurveillance methods.


Assuntos
Febre do Vale de Rift/epidemiologia , Febre do Vale de Rift/transmissão , Aedes/virologia , Animais , Controle de Doenças Transmissíveis/métodos , Culex/virologia , Surtos de Doenças , Humanos , Insetos Vetores/virologia , Febre do Vale de Rift/prevenção & controle , Febre do Vale de Rift/veterinária , Fatores de Risco , Arábia Saudita/epidemiologia , Iêmen/epidemiologia , Zoonoses/epidemiologia , Zoonoses/transmissão , Zoonoses/virologia
17.
Trop Anim Health Prod ; 43(8): 1605-10, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21637994

RESUMO

The purpose of this study was to determine the prevalence of subclinical mastitis in camels in Riyadh, Saudi Arabia and the factors influencing its incidence. A total of 740 quarter milk samples were collected from 47 camel herds belonging to Majahim, Maghatir, Shu'l, and Sufer breeds. California mastitis test (CMT) was used as a screening test for subclinical mastitis. Samples giving negative or trace CMT scores (0) were assigned to healthy quarters, while those giving positive scores of 1+ to 3+ were assigned to subclinically affected quarters. Logistic regression was used to assess the association of breed, parity, and stage of lactation with the prevalence of subclinical mastitis. Milk fat, protein, lactose, solid nonfat percentages and Na, Ca, and K concentrations were compared in CMT-positive versus healthy quarters. One third (33%) of tested quarters had subclinical mastitis based on CMT. The estimated probability of subclinical mastitis with the combined effects of breed, parity, and stage of lactation ranged from 15.8% to 54.6%. The risk of subclinical mastitis increased significantly with parity and with the early stage of lactation. The Shu'l breed had significantly higher prevalence of subclinical mastitis than other breeds. Significant decreases in protein, lactose, and solid nonfat, Ca and K concentrations and increase in Na concentrations were associated with subclinical mastitis. In conclusion, subclinical mastitis is prevalent in Saudi camels, and its incidence is influenced by breed, parity, and stage of lactation.


Assuntos
Infecções Assintomáticas/epidemiologia , Camelus/microbiologia , Mastite/veterinária , Leite/microbiologia , Doenças dos Animais/diagnóstico , Doenças dos Animais/epidemiologia , Doenças dos Animais/etiologia , Animais , Técnicas Bacteriológicas/veterinária , Feminino , Lactação , Programas de Rastreamento/veterinária , Mastite/diagnóstico , Mastite/epidemiologia , Mastite/etiologia , Prevalência , Arábia Saudita/epidemiologia , Especificidade da Espécie
18.
Immunol Invest ; 40(1): 29-38, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-20809700

RESUMO

Hepatitis C virus (HCV), a major cause of liver disease worldwide, is frequently resistant to the antiviral alpha interferon (IFN). Previous studies have shown that HCV NS5A protein induces expression of the proinflammatory interleukin-8 (IL-8) and this may affect the therapeutic outcome. The aim of the present study was to investigate the relationship among levels of IL-8 in serum of subjects with past exposure to HCV indicated by positive IgG to HCV and negative PCR, patients with chronic HCV infections and in responder to combined alfa IFN and ribavirin therapy. The study included 48 Egyptian subjects with evidence of HCV infection. They were classified according to viremia to patients with chronic hepatitis C with positive viremia and immune subjects with positive HCV IgG alone. Chronic HCV patients were followed after therapy and 16 healthy adults as control group. It was found that viral load was dependent factor for the level of IL 8 (P = 0.003) and there was significant correlation between levels of IL-8 before treatment and after treatment. The present study highlights the kinetic of serum levels of interleukin-8 in patients with chronic hepatitis C genotype 4 before and after therapy with combined alfa interferon and ribavirin. It was demonstrated that HCV infection was associated with higher levels of interleukin-8 in pretreatment and posttreatment period. Moreover, immune subjects also had higher level of interleukin-8, indicating its role in immunity to HCV infection.


Assuntos
Antivirais/uso terapêutico , Hepatite C/tratamento farmacológico , Hepatite C/imunologia , Interferon-alfa/uso terapêutico , Interleucina-8/sangue , Ribavirina/uso terapêutico , Adulto , Anticorpos Antivirais/sangue , Quimioterapia Combinada , Ensaio de Imunoadsorção Enzimática , Feminino , Hepacivirus/imunologia , Hepatite C/virologia , Humanos , Imunoglobulina G/sangue , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Resultado do Tratamento
19.
J Nanosci Nanotechnol ; 11(10): 9118-22, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22400311

RESUMO

Silicon oxynitride (SiO(X)N(Y)) thin films were deposited by plasma-enhanced chemical vapour deposition technique (PECVD) from silane (SiH4), nitrous oxide (N2O), ammonia (NH3) and nitrogen (N2) mixture. Spectroscopic ellipsometry (SE), in the range of wavelengths 450-900 nm, was used to define the film thickness and therefore the deposition rate, as well as the refractive index as a function of the N2O gaseous flow. While considering the (Si3N4, SiO2, H2 or void) heterogeneous mixture, Maxwell Garnett (MG) theory allows to fit the SE measurements and to define the volume fraction of the different phases. Finally, Rutherford Backscattering Spectrometry (RBS) results showed that x = O/Si ratio increases gradually with increasing the N2O flow, allowing the correlation of the SiO(X)N(Y) films main parameters.

20.
Ann Endocrinol (Paris) ; 70(6): 477-9, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19922902

RESUMO

Thiamine-responsive megaloblastic anemia (TRMA) is a rare autosomal recessive disorder characterized by megaloblastic anemia, diabetes mellitus and progressive sensorineural deafness. We report the cases of two infants, aged 4 and 5 months, hospitalized for diabetic ketoacidosis requiring insulin therapy. Laboratory tests revealed megaloblasic anemia, thrombocytopenia and normal thiamine level. Neurosensorial investigations showed bilateral deafness and ophthalmic involvement. Treatment with oral thiamine normalized hematological disorders and controlled diabetes; however, thiamine therapy had no impact on neurosensorial disorders.


Assuntos
Anemia Megaloblástica/diagnóstico , Anemia Megaloblástica/genética , Cetoacidose Diabética/diagnóstico , Tiamina/uso terapêutico , Anemia Megaloblástica/tratamento farmacológico , Contagem de Células Sanguíneas , Células da Medula Óssea/patologia , Diabetes Mellitus/tratamento farmacológico , Diabetes Mellitus/genética , Cetoacidose Diabética/tratamento farmacológico , Cetoacidose Diabética/genética , Feminino , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/genética , Humanos , Lactente , Insulina/uso terapêutico , Masculino , Proteínas de Membrana Transportadoras/genética , Mutação , Tiamina/sangue , Trombocitopenia/diagnóstico
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