1.
Cancer
; 68(5 Suppl): 1176-7, 1991 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1913502
2.
Cancer
; 58(7): 1426-7, 1986 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3742462
RESUMO
Nitrosoureas are alkylating agents that have been associated with the development of a preleukemic syndrome, secondary acute nonlymphocytic leukemia and a variety of acute and delayed toxicities. Nitrosoureas have activity in the treatment of primary malignant brain tumors. The authors report a patient who developed bone marrow myelofibrosis three years following treatment with radiation therapy and oral CCNU. This is the first case of marrow fibrosis associated with the use of a nitrosourea. Bone marrow myelofibrosis may be another delayed treatment effect of this class of drugs.