A long-term evaluation of the CIN-lesions. A clinicopathological study.

Among patients treated over a 20-year period cytological screening demonstrated a high-grade cervical dyscariosis (III-V Papanicolaou group) in 565 (2.3%) cases. In a group of 159 of these patients, all with cervical erythroplasia, a detailed study was possible and punch-biopsy (without colposcopy) was performed. Comparative analysis of cytology and pre-operative histology revealed good correlation. The patients in whom punch-biopsy demonstrated high-grade CIN and also those with negative histology, but with dyscariosis permanently occurring in cervicovaginal smears, underwent surgical treatment (conization). The results of histology in the punch-biopsies and in the surgical specimens of the cervix were discordant, mostly in low-grade CIN. Most patients are alive and well and remain in permanent clinical control. Conclusion--Cytology is a useful method of selecting the high-risk patients, who should subsequently be followed clinically, by cytology and histology. Surgical treatment seems to prevent invasive cancer: however these patients should remain under permanent control.

[Morphological and clinical evaluation of non-epithelial and mixed neoplasms of the female reproductive organs. II. Leiomyosarcoma]. / Ocena morfologiczno-kliniczna zlosliwych nienablonkowych i mieszanych nowotworów narzadu rodnego. II. Miesniak gladkokomórkowy miesakowaty.

Among 12886 malignant neoplasms of female sex organ 34 leiomyosarcoma were found. Average age of suffering women was 50 years. Metrorrhagia and lower abdominal pain were most common symptoms reported. Surgical treatment was supplemented with radiotherapy. Significant impact on prognosis showed: number of mitoses, number of bizarre and giant cells, massive necrosis and hyalinization. Efficient early diagnosis these neoplasms still awaits improvement.

Gross body composition changes in patients with cancer of the uterine cervix treated with irradiation.

Gross body composition studies done on a group of 11 women with cervical cancer before and after completion of radiotherapy revealed moderate compositional changes. There was after irradiation a tendency towards weight loss, connected with some increase of relative total body water content and also its extracellular fraction. The weight loss was due to a decrease of body fat and cell mass, whereas extracellular spaces tended to increase. There was a tendency towards a drop in plasma sodium concentration and an increase of its total content in extracellular water. A significant drop of the potassium serum concentration was observed.