Detection of 10 commonly used pharmaceuticals in reef-building stony corals from shallow (5-12 m) and deep (30-40 m) sites in the Red Sea.

Although pharmaceutically-active compounds (PhACs) are increasingly being found to be present in marine environments, their presence in coral reefs, already under threat from various stressors, has remains unexplored. This study focused on PhAC presence in two stony-coral genera, collected from different depths and sites in the Red Sea. The findings reveal the presence of ten different PhACs, with elevated concentrations detected in corals from shallow sites and in areas with heavy human activity. Notably, all samples contained at least one PhAC, with the antibiotic sulfamethoxazole being the most prevalent compound, detected in 93% of the samples, at concentrations ranging from 1.5 to 2080 ng/g dry weight (dw) tissue, with an average concentration of 106 ng/g dw. These findings underscore the urgent need for conservation initiatives aimed at protecting coral-reef ecosystems from the escalating threat of anthropogenic contamination, including such potential risks as the development of antibiotic resistance in marine organisms and the disruption of critical spawning synchrony among coral populations.

Proteomic changes in the solitary ascidian Herdmania momus following exposure to the anticonvulsant medication carbamazepine.

The increasing use of pharmaceuticals in human and veterinary medicine, along with their poor removal rates at wastewater treatment facilities is resulting in the chronic release of pharmaceutically-active compounds (PhACs) into the marine environment, where they pose a threat to non-target organisms. A useful approach, as applied in the current study for assessing the effects of PhACs on non-target organisms, is the proteomic approach: the large-scale study of an organism's proteins. Using 'shotgun' proteomics, we identified differentially-expressed proteins based on peptide fragments in the solitary ascidian, Herdmania momus, following a 14-day laboratory experimental exposure to the PhAC carbamazepine (CBZ), an anticonvulsant and antidepressant medication, frequently detected in the aquatic environment. Individuals were exposed to environmentally relevant concentrations: 5 or 10 µg/L of CBZ, in addition to a control treatment. Out of 199 identified proteins, 24 were differentially expressed (12%) between the treatment groups, and thus can potentially be developed as biomarkers for CBZ contamination. Ascidians' phylogenetic position within the closest sister group to vertebrates presents an advantage in examining the pathological effects of PhACs on vertebrate-related organs and systems. Together with the world-wide distribution of some model ascidian species, and their ability to flourish in pristine and polluted sites, they provide a promising tool through which to study the extent and effects of PhAC contamination on marine organisms.

Consciously monitored grasping is vulnerable to perceptual intrusions.

The idea of functional differentiation between vision-for-action and vision-for-perception has been supported by evidence from different domains. According to this account, perception is based on consciously accessible, relative representations, whereas vision-for-action is performed in an analytic, automatic manner. Support for this idea comes from studies that showed that unlike perception, grasping movements are refractory to illusions and to Weber's law. Yet, interactions between the systems may occur when an action is performed in a less automated fashion. To test this idea, we asked participants to monitor their fingers apertures in flight and to halt their movement for a short duration when they felt that their aperture reached a maximum amount. The results showed that movements in the monitored condition were biased by the Ponzo illusion and showed atypical adherence to Weber's law. These results show that action and perception are more likely to interact when movements are performed in a controlled manner.

Assessing pharmaceutical contamination along the Mediterranean and Red Sea coasts of Israel: Ascidians (Chordata, Ascidiacea) as bioindicators.

Global increase in the use of pharmaceutically-active compounds (PhACs), and their insufficient removal in wastewater treatment plants, have resulted in their continuous release into the marine environment. We investigated the use of the solitary ascidians Herdmania momus, Microcosmus exasperatus, and Styela plicata as bioindicators of three common PhACs in the Israeli coastal waters: Bezafibrate, carbamazepine and diclofenac. Both the Mediterranean and the Red-Sea coasts were found contaminated with PhACs, detected at all 11 sampling sites, with four sites contaminated with all three studied PhACs. Diclofenac was most frequent, present in nine of the 11 sites with concentrations reaching 51.9 ng/g of dry weight sample (dw). Bezafibrate and carbamazepine reached concentrations of 47.8 ng/g dw and 14.3 ng/g dw, respectively. The alarming detection of such high concentrations of PhACs in ascidians along Israel's coasts demonstrates both the extent of PhACs contamination in the region, and the potential of ascidians as bioindicators, and emphasizes the urgent need for additional research into PhAC contamination sources and effects.