RESUMO
Urinary levels of 1-hydroxypyrene in a general adult population group are studied. Experimental data are not normally distributed; statistical analysis required a base 10 logarithmic transformation of data. The concentrations of urinary 1-hydroxypyrene measured were expressed as microgram g-1 urinary creatinine and are comparable with those reported by other authors, both for smoker and non-smoker subgroups. Multiple regression analysis shows that, for smokers, the number of cigarettes smoked per day and the body mass index (BMI) significantly influence the levels of urinary 1-hydroxypyrene expressed as microgram g-1 urinary creatinine, whereas no personal or behavioural variable (age, sex, alcohol consumption, dietary intake of pyrene, BMI) modified the 1-hydroxypyrene levels for non-smokers.
Assuntos
Exposição Ambiental , Mutagênicos/análise , Pirenos/efeitos adversos , Pirenos/análise , Urina/química , Adulto , Idoso , Consumo de Bebidas Alcoólicas , Biomarcadores/urina , Índice de Massa Corporal , Estudos de Coortes , Creatinina/urina , Dieta , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mutagênicos/metabolismo , Pirenos/metabolismo , Valores de Referência , Análise de Regressão , FumarRESUMO
Determination of MCPA, (2-methyl-4-chlorophenoxy) acetic acid, in urine has been improved by a preliminary TLC cleanup followed by HPLC with fluorescence detection. This procedure is suitable for routine analysis and has been applied with good results to an epidemiological investigation. Time required for each determination may be somewhat longer, but the proposed cleanup technique increases the specificity.
