Does shift-and-persist strategy buffer career choice anxiety and affect career exploration?

OBJECTIVE: The transition from school to the workforce is important for concrete future planning. During this period, people are more likely to experience psychological health problems, such as anxiety and feelings of hopelessness and helplessness. In particular, job hunting in individuals with low socioeconomic status (SES) leads to various impulsive behaviors and physical and psychological problems due to a scarcity of economic and time resources. There is a lack of research examining career education and intervention approaches that consider the backgrounds of those experiencing adversities and difficulties due to low SES. Considering these situations, we examined whether shift-and-persist coping strategies (S-P) could buffer the career choice anxiety of individuals with low SES and improve career exploration. RESULTS: The results from 311 students who preparing/doing for job hunting showed a negative association between S-P and career choice anxiety and a positive association with career exploration. There are no significant effects of the direct link between SES to career exploration and the indirect link between SES and career exploration via career choice anxiety. There was also no buffering effect of S-P use on the above mediating process.

Total Synthesis of (+)-Neopeltolide by the Macrocyclization/Transannular Pyran Cyclization Strategy.

An 11-step synthesis of (+)-neopeltolide was developed. The C1-C7 carboxylic acid and the C8-C16 alcohol were prepared, each in six steps, from (R)- and (S)-epichlorohydrin, respectively. After esterification, our tandem macrocyclization/transannular pyran cyclization strategy was applied to a stereocontrolled construction of the neopeltolide macrolactone. The side chain was synthesized in six steps from ethyl 4-oxazolecarboxylate through palladium-catalyzed cross-couplings. A Mitsunobu reaction of the neopeltolide macrolactone and the side chain completed the synthesis.

Tandem Macrolactone Synthesis: Total Synthesis of (-)-Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy.

Tetrahydropyran-containing macrolactones were synthesized by integrating Meyer-Schuster rearrangement, macrocyclic ring-closing metathesis, and transannular oxa-Michael addition under gold and ruthenium catalysis. Single-step access to a variety of 14- to 20-membered macrolactones containing a tetrahydropyran ring was possible from readily available linear precursors in good yields and with moderate to excellent diastereoselectivity. A 13-step synthesis of (-)-exiguolide, an anticancer marine macrolide, showcased the feasibility of our tandem reaction sequence for macrolactone synthesis and also demonstrated the power of transannular reactions for rapid assembly of the tetrahydropyran rings of the target natural product.