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1.
PLoS One ; 13(8): e0202361, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30118505

RESUMO

Acute Kidney Injury (AKI) is the main systemic complication and cause of death in viperid envenomation. Although there are hypotheses for the development of AKI, the mechanisms involved are still not established. The aim of this study was to evaluate the clinical-laboratorial-epidemiological factors associated with AKI in victims of Bothrops sp envenomation. This is an observational study carried out at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. AKI was defined according to the guidelines of the Acute Kidney Injury Network (AKIN). Among the 186 patients evaluated, AKI was observed in 24 (12.9%) after 48 hours of admission. Stage I was present in 17 (70.8%) patients, II in 3 (12.5%) and III in 4 (16.7%). Epidemiological characterization showed predominance of men, occurrence in rural areas, aged between 16-60 years, feet as the most affected anatomical region, and time to medical assistance less than 3 hours. Hypertension and diabetes were the comorbidities identified. Most of the accidents were classified as moderate, and clinical manifestations included severe pain, mild edema, local bleeding and headache. Laboratory results showed blood uncoagulability, hypofibrinogenemia, leukocytosis, increase of creatine kinase, and high lactate dehydrogenase levels. Multivariate analysis showed an association with high LDH levels [AOR = 1.01 (95% CI = 1.01-1.01, p<0.002)], local bleeding [AOR = 0.13 (95%CI = 0.027-0.59, p<0.009)], and the presence of comorbidities [AOR = 60.96 (95%CI = 9.69-383.30; p<0.000)]. Herein, laboratory markers such as high LDH levels along with local bleeding and comorbidities may aid in the diagnosis of AKI.


Assuntos
Injúria Renal Aguda/diagnóstico , Injúria Renal Aguda/etiologia , Bothrops , Venenos de Crotalídeos , Mordeduras de Serpentes/complicações , Injúria Renal Aguda/epidemiologia , Adolescente , Adulto , Animais , Biomarcadores/sangue , Brasil/epidemiologia , Comorbidade , Humanos , Pessoa de Meia-Idade , Prognóstico , Fatores de Risco , Mordeduras de Serpentes/diagnóstico , Mordeduras de Serpentes/epidemiologia , Centros de Atenção Terciária , Adulto Jovem
2.
Rev Soc Bras Med Trop ; 49(3): 389-92, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27384843

RESUMO

Freshwater stingray injuries are a common problem in the Brazilian Amazon, affecting mostly riverine and indigenous populations. These injuries cause severe local and regional pain, swelling and erythema, as well as complications, such as local necrosis and bacterial infection. Herein, we report a case of bacterial infection and hallux necrosis, after a freshwater stingray injury in the Brazilian Amazon, which eventually required amputation. Different antimicrobial regimens were administered at different stages of the disease; however, avoiding amputation through effective treatment was not achieved.


Assuntos
Amputação Cirúrgica , Mordeduras e Picadas/complicações , Hallux/lesões , Rajidae , Adulto , Animais , Brasil , Hallux/patologia , Hallux/cirurgia , Humanos , Masculino , Necrose
3.
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;49(3): 389-392, tab, graf
Artigo em Inglês | LILACS | ID: lil-785792

RESUMO

Abstract: Freshwater stingray injuries are a common problem in the Brazilian Amazon, affecting mostly riverine and indigenous populations. These injuries cause severe local and regional pain, swelling and erythema, as well as complications, such as local necrosis and bacterial infection. Herein, we report a case of bacterial infection and hallux necrosis, after a freshwater stingray injury in the Brazilian Amazon, which eventually required amputation. Different antimicrobial regimens were administered at different stages of the disease; however, avoiding amputation through effective treatment was not achieved.


Assuntos
Humanos , Animais , Masculino , Adulto , Mordeduras e Picadas/complicações , Rajidae , Hallux/lesões , Amputação Cirúrgica , Brasil , Hallux/cirurgia , Hallux/patologia , Necrose
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