Onset of analgesia for liquigel ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg, and placebo in the treatment of postoperative dental pain.

Ibuprofen is a peripherally acting nonsteroidal anti-inflammatory drug indicated fo ranalgesia, antipyresis, and various arthritic conditions. A solubilized 200 mg liquigel formulation of ibuprofen has been shown to have a more rapid rate of absorption compared with ibuprofen 200 mg tablets. Ibuprofen liquigels have a kinetic profile similar to ibuprofen suspension, with both a higher Cmax and an earlier tmax than any solid tablet. The objective of this single-dose, double-blind, triple-dummy, parallel-group study was to assess the time to onset of relief and overall analgesic efficacy of liquigel ibuprofen 400 mg, ketoprofen 25 mg compared with acetaminophen 1000 mg, and placebo in 239 patients with moderate or severe pain following third molar extractions. Treatments were compared over 6 hours using standard scales for pain intensity and relief and stopwatch onset of meaningful relief. All active treatments provided meaningful relief significantly faster compared with placebo. Ibuprofen provided significantly faster relief compared with acetaminophen and ketoprofen. By the end of the study (6 h), onset of meaningful relief was achieved by 36%, 99%, 96%, and 88% of the patients in the placebo, ketoprofen, ibuprofen, and acetaminophen groups, respectively. The median times to onset of relief were > 6 hours for placebo, 25.5 minutes for ketoprofen, 24.2 minutes for ibuprofen, and 29.9 minutes for acetaminophen. In addition, both ibuprofen and ketoprofen showed statistical superiority over acetaminophen at earlier time points on the time-effect curves for pain relief and pain intensity difference. Consistent results were seen with respect to the 6-hour summary efficacy variables: the three active treatments were significantly better than placebo, and ibuprofen was significantly better than both acetaminophen and ketoprofen. Liquigel ibuprofen 400 mg was shown to provide faster relief and superior overall efficacy compared with ketoprofen 25 mg, acetaminophen 1000 mg, and placebo. No serious adverse effects were reported in this single-dose study.

Angioplastia transluminal percutanea (ATP). Comienzo de un estudio y perspectivas. / Percutaneous transluminal angioplasty (PTA). The beginning of a study and perspectives

La angioplastia transluminal percutanea (ATP), permite la dilatacion de una estenosis o la desobstruccion vascular por medio del cateterismo. Tecnica introducida por Dotter en 1964, en los ultimos anos ha experimentado gran difusion mundial a raiz del uso del cateter de Gruntzig. Practicamente en todos los territorios vasculares se han efectuado angioplastias, siendo sus indicaciones y resultados a largo plazo, todavia no totalmente definidos. Sin embargo el metodo ha sido aceptado y sus buenos resultados comprobados, cuando la cirugia no permite realizar procedimientos de revascularizacion o estos involucran un importante riesgo para el enfermo.Nuestro interes es que el primer caso exitoso de ATP realizado en nuestro pais, sea el comienzo de un trabajo a largo plazo para valorar las posibilidades de dicho metodo terapeutico

Enfermedad de Hodgkin primitiva de pulmon. / Primary Hodkin's disease of the lung

La enfermedad de Hoddgkin primitiva del pulmon es poco frecuente. En una serie de 72 enfermos tratados en los ultimos 10 anos, un solo paciente presento esta forma de inicio. Se analizan aspectos epidemiologicos, etiopatogenicos diagnosticos y terapeuticos. Se destaca la dificuldad en establecer el diagnostico frente a patologias mas frecuentes como lo es el neoplasma de pulmon y se consideran las formas de afectacion pulmonar en la Enfermedade de Hodgkin