RESUMO
Ivabradine has been shown to improve heart failure with sinus tachycardia by reducing the heart rate without affecting left ventricular systolic function or blood pressure. Here we report a case of a catecholaminedependent patient, New York Heart Association (NYHA) class IV, LVEF of 18%, and low cardiac output, who was able to discontinue intravenous catecholamine by oral administration of ivabradine.
Assuntos
Baixo Débito Cardíaco , Insuficiência Cardíaca , Humanos , Ivabradina , Baixo Débito Cardíaco/tratamento farmacológico , Catecolaminas , Insuficiência Cardíaca/complicações , Insuficiência Cardíaca/tratamento farmacológico , Frequência Cardíaca/fisiologiaRESUMO
Vanishing tumor of the lung, also known as phantom tumor, is uncommonly observed in congestive heart failure. We report a case of a vanishing tumor that rapidly disappeared and reappeared in just a few minutes due to repositioning in a patient after open-heart surgery.
Assuntos
Procedimentos Cirúrgicos Cardíacos , Insuficiência Cardíaca , Neoplasias Pulmonares , Humanos , Pulmão , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Neoplasias Pulmonares/cirurgiaRESUMO
Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, is capable of inhibiting synthesis of pro-inflammatory cytokines like IFNgamma, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and T helper Type 1 cells. We observed that normal human serum, derived from a healthy individual but containing large amounts of IL-10, inhibited cytotoxic activity and interfered with granzyme B release from alloreactive cytotoxic T cell (CTL) clones in vitro, but did not affect perforin release. The addition of normal human serum containing high levels of anti-IL-10 IgG neutralized the inhibitory effects of IL-10 serum. Moreover, we have identified that cytotoxic activity and granzyme B release from an Epstein-Barr virus (EBV)-specific CTL clone was similarly inhibited in the presence of IL-10 serum, while perforin release was unaffected. Anti-IL-10 IgG serum also appeared to neutralize the inhibitory effect of IL-10 serum on an EBV-specific CTL clone.