RESUMO
AIM: The objective of this study was to investigate the effect of citicoline administration on epidural fibrosis which is a frequent complication of lumbar disc surgery with no effective treatment or preventive surgical technique. MATERIAL AND METHODS: Sixty Sprague-Dawley female rats undergoing L4-5 right hemilaminotomy and annular fenestration were arranged in three groups: rats in Group 1 (control group) and Group 2 (topical citicoline group) were applied 0,9% saline and 100 µM citicoline on surgical area, respectively, while rats in Group 3 (systemic citicoline group) received 600 µmol/kg citicoline intraperitoneally. Rats were sacrificed four weeks later and their vertebral colons were removed en bloc. Groups were evaluated according to histological criteria and results were compared using statistical tools. RESULTS: Compared with control group, significantly less epidural fibrosis, dural adhesion, fibroblast cell density, foreign body reaction, and medulla spinalis retraction were observed in groups treated with topical and systemic citicoline (groups 2 and 3) (p < 0,001). No significant difference was found with regard to measured parameters between two treatment groups (p > 0,05). CONCLUSION: Our study demonstrates for the first time in the literature that citicoline may be effective for preventing postoperative epidural fibrosis. However, its mechanism of action and clinical effectiveness must be further investigated.
Assuntos
Citidina Difosfato Colina/uso terapêutico , Espaço Epidural/patologia , Procedimentos Neurocirúrgicos/efeitos adversos , Nootrópicos/uso terapêutico , Complicações Pós-Operatórias/prevenção & controle , Animais , Contagem de Células , Cicatriz/patologia , Citidina Difosfato Colina/administração & dosagem , Discotomia , Feminino , Fibroblastos , Fibrose , Reação a Corpo Estranho/patologia , Injeções Intraperitoneais , Disco Intervertebral/patologia , Laminectomia , Nootrópicos/administração & dosagem , Ratos , Ratos Sprague-Dawley , Coluna Vertebral/patologia , Aderências Teciduais/patologiaRESUMO
It is rare for a patient with a dermoid cyst (DC) to present with taste dysfunction. A 58-year-old man presented with an altered sense of taste. Magnetic resonance imaging of the brain showed a mass lesion in the right insula with compression effect. The tumour was resected and was found to be a DC. The postoperative course was uneventful, and the patient resumed his usual taste sensation within the early postoperative period. To the best of our knowledge, this is the first report of a sylvian cistern DC that presented with dysgeusia.
