RESUMO
In the present study, we report the preparation of antifungal and non-cytotoxic polymer nanocomposites with potential application in biomedical materials. Dodecanethiol-protected silver nanoparticles (AgNPs-DDT) were synthesized by a reduction/precipitation method and dispersed in chloroform to obtain stable colloidal dispersions. PBAT-based nanocomposites containing 0.25, 0.5 and 2â¯wt% AgNPs-DDT were prepared by casting method. The incorporation of AgNPs-DDT in PBAT matrix resulted in nanocomposites which combine improved mechanical performance and antifungal properties with a non-cytotoxic characteristic.
Assuntos
Antifúngicos/farmacologia , Nanopartículas Metálicas/química , Nanocompostos/química , Poliésteres/química , Prata/química , Compostos de Sulfidrila/química , Varredura Diferencial de Calorimetria , Candida albicans/efeitos dos fármacos , Morte Celular/efeitos dos fármacos , Linhagem Celular , Elasticidade , Humanos , Testes de Sensibilidade Microbiana , Nanocompostos/ultraestrutura , Tamanho da Partícula , Reologia , ViscosidadeRESUMO
Poly(lactic acid) nanocomposites were prepared with three synthetic fluoromicas in a twin-screw extruder. Sodium and two organomodified synthetic fluoromicas at different compositions were used. The effect of mica type and composition on the rheological behavior of the nanocomposites was evaluated. The sodium fluoromica did not have a significant effect on the poly(lactic acid) rheological properties, while addition of the organophilic micas to poly(lactic acid) has a strong effect on the rheology, showing a pronounced shear thinning behavior. The dynamic rheological studies revealed that the nanocomposites with organomica have a higher viscosity and more pronounced elastic properties than neat poly(lactic acid). Both storage and loss moduli increased with mica content.
