Memory-induced absolute negative mobility.

Non-Markovian systems form a broad area of physics that remains greatly unexplored despite years of intensive investigations. The spotlight is on memory as a source of effects that are absent in their Markovian counterparts. In this work, we dive into this problem and analyze a driven Brownian particle moving in a spatially periodic potential and exposed to correlated thermal noise. We show that the absolute negative mobility effect, in which the net movement of the particle is in the direction opposite to the average force acting on it, may be induced by the memory of the setup. To explain the origin of this phenomenon, we resort to the recently developed effective mass approach to dynamics of non-Markovian systems.

Effective mass approach to memory in non-Markovian systems.

Recent pioneering experiments on non-Markovian dynamics done, e.g., for active matter have demonstrated that our theoretical understanding of this challenging yet hot topic is rather incomplete and there is a wealth of phenomena still awaiting discovery. It is related to the fact that typically for simplification the Markovian approximation is employed and as a consequence the memory is neglected. Therefore, methods allowing to study memory effects are extremely valuable. We demonstrate that a non-Markovian system described by the Generalized Langevin Equation (GLE) for a Brownian particle of mass M can be approximated by the memoryless Langevin equation in which the memory effects are correctly reproduced solely via the effective mass M^{*} of the Brownian particle which is determined only by the form of the memory kernel. Our work lays the foundation for an impactful approach which allows one to readily study memory-related corrections to Markovian dynamics.

Temperature anomalies of oscillating diffusion in ac-driven periodic systems.

We analyze the impact of temperature on the diffusion coefficient of an inertial Brownian particle moving in a symmetric periodic potential and driven by a symmetric time-periodic force. Recent studies have revealed the low-friction regime in which the diffusion coefficient shows giant damped quasiperiodic oscillations as a function of the amplitude of the time-periodic force [I. G. Marchenko et al., Chaos 32, 113106 (2022)1054-150010.1063/5.0117902]. We find out that when temperature grows the diffusion coefficient increases at its minima; however, it decreases at the maxima within a finite temperature window. This curious behavior is explained in terms of the deterministic dynamics perturbed by thermal fluctuations and mean residence time of the particle in the locked and running trajectories. We demonstrate that temperature dependence of the diffusion coefficient can be accurately reconstructed from the stationary probability to occupy the running trajectories.

Mechanism for giant enhancement of transport induced by active fluctuations.

Understanding the role of active fluctuations in physics is a problem in statu nascendi appearing both as a hot topic and a major challenge. The reason for this is the fact that they are inherently nonequilibrium. This feature opens a landscape of phenomena yet to be explored that are absent in the presence of thermal fluctuations alone. Recently a paradoxical effect has been briefly communicated in which a free-particle transport induced by active fluctuations in the form white Poisson shot noise can be enormously boosted when the particle is additionally subjected to a periodic potential. In this work we considerably extend the original predictions and investigate the impact of statistics of active noise on the occurrence of this effect. We construct a toy model of the jump-relaxation process that allow us to identify different regimes of the free-particle transport boost and explain their corresponding mechanisms. Moreover, we formulate and interpret the conditions for statistics of active fluctuations that are necessary for the emergence of giant enhancement of the free-particle transport induced by the periodic potential. Our results are relevant not only for microscopic physical systems but also for biological ones such as, e.g., living cells where fluctuations generated by metabolic activities are active by default.

Periodic potential can enormously boost free-particle transport induced by active fluctuations.

Active fluctuations are detected in a growing number of systems due to self-propulsion mechanisms or collisions with an active environment. They drive the system far from equilibrium and can induce phenomena that are forbidden at equilibrium states by, e.g., fluctuation-dissipation relations and detailed balance symmetry. Understanding their role in living matter is emerging as a challenge for physics. Here we demonstrate a paradoxical effect in which a free-particle transport induced by active fluctuations can be boosted by many orders of magnitude when the particle is additionally subjected to a periodic potential. In contrast, within the realm of only thermal fluctuations, the velocity of a free particle exposed to a bias is reduced when the periodic potential is switched on. The presented mechanism is significant for understanding nonequilibrium environments such as living cells, where it can explain from a fundamental point of view why spatially periodic structures known as microtubules are necessary to generate impressively effective intracellular transport. Our findings can be readily corroborated experimentally, e.g., in a setup comprising a colloidal particle in an optically generated periodic potential.

Giant oscillations of diffusion in ac-driven periodic systems.

We revisit the problem of diffusion in a driven system consisting of an inertial Brownian particle moving in a symmetric periodic potential and subjected to a symmetric time-periodic force. We reveal parameter domains in which diffusion is normal in the long time limit and exhibits intriguing giant damped quasiperiodic oscillations as a function of the external driving amplitude. As the mechanism behind this effect, we identify the corresponding oscillations of difference in the number of locked and running trajectories that carry the leading contribution to the diffusion coefficient. Our findings can be verified experimentally in a multitude of physical systems, including colloidal particles, Josephson junction, or cold atoms dwelling in optical lattices, to name only a few.

Conundrum of weak-noise limit for diffusion in a tilted periodic potential.

The weak-noise limit of dissipative dynamical systems is often the most fascinating one. In such a case fluctuations can interact with a rich complexity, frequently hidden in deterministic systems, to give rise to phenomena that are absent for both noiseless and strong fluctuations regimes. Unfortunately, this limit is also notoriously hard to approach analytically or numerically. We reinvestigate in this context the paradigmatic model of nonequilibrium statistical physics consisting of inertial Brownian particles diffusing in a tilted periodic potential by exploiting state-of-the-art computer simulations of an extremely long timescale. In contrast to previous results on this longstanding problem, we draw an inference that in the parameter regime for which the particle velocity is bistable the lifetime of ballistic diffusion diverges to infinity when the thermal noise intensity tends to zero, i.e., an everlasting ballistic diffusion emerges. As a consequence, the diffusion coefficient does not reach its stationary constant value.

Arcsine law and multistable Brownian dynamics in a tilted periodic potential.

Multistability is one of the most important phenomena in dynamical systems, e.g., bistability enables the implementation of logic gates and therefore computation. Recently multistability has attracted a greatly renewed interest related to memristors and graphene structures, to name only a few. We investigate tristability in velocity dynamics of a Brownian particle subjected to a tilted periodic potential. It is demonstrated that the origin of this effect is attributed to the arcsine law for the velocity dynamics at the zero temperature limit. We analyze the impact of thermal fluctuations and construct the phase diagram for the stability of the velocity dynamics. It suggests an efficient strategy to control the multistability by changing solely the force acting on the particle or temperature of the system. Our findings for the paradigmatic model of nonequilibrium statistical physics apply to, inter alia, Brownian motors, Josephson junctions, cold atoms dwelling in optical lattices, and colloidal systems.

Energy of a free Brownian particle coupled to thermal vacuum.

Experimentalists have come to temperatures very close to absolute zero at which physics that was once ordinary becomes extraordinary. In such a regime quantum effects and fluctuations start to play a dominant role. In this context we study the simplest open quantum system, namely, a free quantum Brownian particle coupled to thermal vacuum, i.e. thermostat in the limiting case of absolute zero temperature. We analyze the average energy [Formula: see text] of the particle from a weak to strong interaction strength c between the particle and thermal vacuum. The impact of various dissipation mechanisms is considered. In the weak coupling regime the energy tends to zero as [Formula: see text] while in the strong coupling regime it diverges to infinity as [Formula: see text]. We demonstrate it for selected examples of the dissipation mechanisms defined by the memory kernel [Formula: see text] of the Generalized Langevin Equation. We reveal how at a fixed value of c the energy E(c) depends on the dissipation model: one has to compare values of the derivative [Formula: see text] of the dissipation function [Formula: see text] at time [Formula: see text] or at the memory time [Formula: see text] which characterizes the degree of non-Markovianity of the Brownian particle dynamics. The impact of low temperature is also presented.

Colossal Brownian yet non-Gaussian diffusion in a periodic potential: Impact of nonequilibrium noise amplitude statistics.

Last year, Bialas et al. [Phys. Rev. E 102, 042121 (2020)] studied an overdamped dynamics of nonequilibrium noise driven Brownian particle dwelling in a spatially periodic potential and discovered a novel class of Brownian, yet non-Gaussian diffusion. The mean square displacement of the particle grows linearly with time and the probability density for the particle position is Gaussian; however, the corresponding distribution for the increments is non-Gaussian. The latter property induces the colossal enhancement of diffusion, significantly exceeding the well known effect of giant diffusion. Here, we considerably extend the above predictions by investigating the influence of nonequilibrium noise amplitude statistics on the colossal Brownian, yet non-Gaussian diffusion. The tail of amplitude distribution crucially impacts both the magnitude of diffusion amplification and the Gaussianity of the position and increments statistics. Our results carry profound consequences for diffusive behavior in nonequilibrium settings such as living cells in which diffusion is a central transport mechanism.

Colossal Brownian yet non-Gaussian diffusion induced by nonequilibrium noise.

We report on Brownian, yet non-Gaussian diffusion, in which the mean square displacement of the particle grows linearly with time, and the probability density for the particle spreading is Gaussian like, but the probability density for its position increments possesses an exponentially decaying tail. In contrast to recent works in this area, this behavior is not a consequence of either a space- or time-dependent diffusivity, but is induced by external nonthermal noise acting on the particle dwelling in a periodic potential. The existence of the exponential tail in the increment statistics leads to colossal enhancement of diffusion, drastically surpassing the previously researched situation known as "giant" diffusion. This colossal diffusion enhancement crucially impacts a broad spectrum of the first arrival problems, such as diffusion limited reactions governing transport in living cells.

Tunable particle separation via deterministic absolute negative mobility.

Particle isolation techniques are in the spotlight of many areas of science and engineering. In food industry, a harmful bacterial activity can be prevented with the help of separation schemes. In health care, isolation techniques are used to distinguish cancer and healthy cells or in therapy for Alzheimer's and Parkinson's diseases. We consider a cloud of Brownian particles of different sizes moving in a periodic potential and subjected to an unbiased driving as well as a constant force. We reveal an efficient separation strategy via the counterintuitive effect of negative mobility when particles of a given size are transported in a direction opposite to the applied constant force. We demonstrate a tunable separation solution in which size of the particle undergoing separation may be controlled by variation of the parameters of the external force applied to the system. This approach is an important step towards the development of point-of-care lab-on-a-chip devices.

Diffusion in a biased washboard potential revisited.

The celebrated Sutherland-Einstein relation for systems at thermal equilibrium states that spread of trajectories of Brownian particles is an increasing function of temperature. Here, we scrutinize the diffusion of underdamped Brownian motion in a biased periodic potential and analyze regimes in which a diffusion coefficient decreases with increasing temperature within a finite temperature window. Comprehensive numerical simulations of the corresponding Langevin equation performed with unprecedented resolution allow us to construct a phase diagram for the occurrence of the nonmonotonic temperature dependence of the diffusion coefficient. We discuss the relation of the later effect with the phenomenon of giant diffusion.

Tunable Mass Separation via Negative Mobility.

A prerequisite for isolating diseased cells requires a mechanism for effective mass-based separation. This objective, however, is generally rather challenging because typically no valid correlation exists between the size of the particles and their mass value. We consider an inertial Brownian particle moving in a symmetric periodic potential and subjected to an externally applied unbiased harmonic driving in combination with a constant applied bias. In doing so, we identify a most efficient separation scheme which is based on the anomalous transport feature of negative mobility, meaning that the immersed particles move in the direction opposite to the acting bias. This work is the first of its kind in demonstrating a tunable separation mechanism in which the particle mass targeted for isolation is effectively controlled over a regime of nearly 2 orders of mass magnitude upon changing solely the frequency of the external harmonic driving. This approach may provide mass selectivity required in present and future separation of a diversity of nano- and microsized particles of either biological or synthetic origin.

Partition of energy for a dissipative quantum oscillator.

We reveal a new face of the old clichéd system: a dissipative quantum harmonic oscillator. We formulate and study a quantum counterpart of the energy equipartition theorem satisfied for classical systems. Both mean kinetic energy Ek and mean potential energy Ep of the oscillator are expressed as Ek = 〈εk〉 and Ep = 〈εp〉, where 〈εk〉 and 〈εp〉 are mean kinetic and potential energies per one degree of freedom of the thermostat which consists of harmonic oscillators too. The symbol 〈...〉 denotes two-fold averaging: (i) over the Gibbs canonical state for the thermostat and (ii) over thermostat oscillators frequencies ω which contribute to Ek and Ep according to the probability distribution [Formula: see text] and [Formula: see text], respectively. The role of the system-thermostat coupling strength and the memory time is analysed for the exponentially decaying memory function (Drude dissipation mechanism) and the algebraically decaying damping kernel.

Brownian motors in the microscale domain: enhancement of efficiency by noise.

We study a noisy drive mechanism for efficiency enhancement of Brownian motors operating on the microscale domain. It was proven [J. Spiechowicz et al., J. Stat. Mech. (2013) P02044] that biased noise η(t) can induce normal and anomalous transport processes similar to those generated by a static force F acting on inertial Brownian particles in a reflection-symmetric periodic structure in the presence of symmetric unbiased time-periodic driving. Here, we show that within selected parameter regimes, noise η(t) of the mean value 〈η(t)〉=F can be significantly more effective than the deterministic force F: the motor can move much faster, its velocity fluctuations are much smaller, and the motor efficiency increases several times. These features hold true in both normal and absolute negative mobility regimes. We demonstrate this with detailed simulations by resource to generalized white Poissonian noise. Our theoretical results can be tested and corroborated experimentally by use of a setup that consists of a resistively and capacitively shunted Josephson junction. The suggested strategy to replace F by η(t) may provide a new operating principle in which micro- and nanomotors could be powered by biased noise.

Two coupled Josephson junctions: dc voltage controlled by biharmonic current.

We study transport properties of two Josephson junctions coupled by an external shunt resistance. One of the junctions (say, the first) is driven by an unbiased ac current consisting of two harmonics. The device can rectify the ac current yielding a dc voltage across the first junction. For some values of coupling strength, controlled by an external shunt resistance, a dc voltage across the second junction can be generated. By variation of system parameters such as the relative phase or frequency of two harmonics, one can conveniently manipulate both voltages with high efficiency, e.g. changing the dc voltages across the first and second junctions from positive to negative values and vice versa.

Calprotectin (the L1 protein) during surgery in patients with rheumatoid arthritis.

Calprotectin (L1) is a major leukocyte protein which is released during activation or death of neutrophil granulocytes and monocytes. Previous studies have shown that L1 may be a useful marker of disease activity in patients with adult or juvenile rheumatoid arthritis (RA). In the present study, the plasma concentrations of L1 were analysed during shoulder-joint surgery in 16 patients with adult or juvenile RA. Decreased L1 concentrations were found 48 h postoperatively. Thereafter, the L1 concentrations were increased at 72 h, with a following decrease until day 14 postoperatively. In contrast, increased serum concentrations of both C-reactive protein (CRP) and orosomucoid (i.e. alpha 1-acid glycoprotein) were found at 48 h after surgery. Plasma samples obtained before and after surgery were analysed by gel filtration. Approximately 3/4 of the plasma L1 was found in fractions corresponding to the native molecule, while the rest was detected in higher molecular mass fractions. The distribution of L1 antigen in low and high molecular mass regions did not differ between the pre- and postoperative plasma samples. The L1 protein consists of light and heavy chains. Increased serum levels of the cystic fibrosis antigen, which is identical to L1 light chain, have been described in patients with cystic fibrosis. The existence of circulating free L1 chains was presently investigated in plasma obtained before and after surgery. After gel filtration of plasma samples, no free L1 chains were detected by use of enzyme immunoassay and dot blot.

Intraoperative autotransfusion in reconstructive hip joint surgery of patients with rheumatoid arthritis and ankylosing spondylitis.

The efficacy of a simple, low-cost device designed for intraoperative blood salvage and reinfusion, known as the Sorensen system, was studied during 24 hip joint operations in adult patients suffering from rheumatoid arthritis or ankylosing spondylitis. The total need for homologous blood was reduced to 28%, compared with a matched control group of patients who had previously undergone hip surgery by homologous blood replacement. In primary hip-replacement operations, the need for blood was met either completely by autotransfused blood or by the addition of 1 or 2 units of homologous blood. In revision arthroplasties, the maximal need for homologous blood was 6 units owing to a greater blood loss during operation. Postoperative changes in several hematologic variables measured were all very small. The autotransfusion system proved easy and safe to operate. No patients manifested complications. In our experience, the system may be considered an underutilized resource in rheumatological surgery.