The impact of an expanded genetic testing program and selective oophorectomy on the incidence of ovarian cancer in West Pomerania.

The aim of the study was to evaluate the impact of a regional population-based genetic testing program on the incidence of ovarian cancer in West Pomerania. Between 1999 and 2010, a total of 37,552 women ages 35 to 70 were tested for three BRCA1 founder mutations at the outpatient genetics clinic of the Pomeranian Medical University in Szczecin, Poland. A total of 641 women were found to carry a mutation (1.7%) and of these, 220 had a prophylactic oophorectomy (34.3%). A total of 12 women had an occult cancer diagnosed at the time of prophylactic oophorectomy (5.5%). We estimate that 26 more ovarian cancers would have been diagnosed by January 2015 in the absence of these oophorectomies and that an additional 25 cancers will be prevented in the future (total 51). During this period, 1611 ovarian cancers were diagnosed in the region; therefore we estimate that approximately 1.6% of ovarian cancers were prevented between 1999 and 2015 by our genetic testing program. We conclude that the prophylactic oophorectomies performed between 1999 and 2010 as a result of widespread BRCA1 mutation testing have reduced the incidence of ovarian cancer in Pomerania by a small amount (about 1.6%), and that the impact of genetic testing will increase in the coming years.

Soybean meal enriched with microelements by biosorption--a new biological feed supplement for laying hens. Part I. Performance and egg traits.

The aim of the study was to evaluate the effect of soybean meal enriched with Cu(II), Zn(II), Fe(II) and Cr(III) by biosorption on egg traits (egg weight, eggshell strength, eggshell thickness, yolk colour, albumen height) and performance of laying hens. Also, the effect of increased microelement doses in biological form on egg quality parameters and hens performance was investigated. A consumer questionnaire was undertaken to evaluate the organoleptic parameters of the eggs. Generally, our study showed that in the groups fed with the new biological supplement, egg quality parameters improved, including eggshell strength, eggshell thickness, albumen height and yolk colour. The biological form of microelements also improved the feed conversion rate, especially in the group fed with a biological form of Cr(III). Moreover, the new supplement improved organoleptic parameters of the eggs, in comparison to the inorganic form of microelements as well as to chelate. Enriched soybean meal could constitute an alternative for currently used feed additives with microelements.