Assuntos
Proteínas de Ligação a DNA/genética , Fibrossarcoma/congênito , Recidiva Local de Neoplasia , Receptor trkC/genética , Proteínas Repressoras , Coxa da Perna , Fatores de Transcrição/genética , Translocação Genética , Amputação Cirúrgica , Fusão Gênica Artificial , Terapia Combinada , Fibrossarcoma/genética , Fibrossarcoma/cirurgia , Humanos , Recém-Nascido , Cariotipagem , Masculino , Metástase Neoplásica , Proteínas Proto-Oncogênicas c-ets , Variante 6 da Proteína do Fator de Translocação ETSRESUMO
Hepatosplenic gamma-delta (gammadelta) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch-preparation of the spleen.
Assuntos
Cromossomos Humanos Par 7/genética , Cromossomos Humanos Par 8/genética , Isocromossomos/genética , Neoplasias Hepáticas/genética , Linfoma de Células T/genética , Neoplasias Esplênicas/genética , Trissomia/genética , Criança , Citometria de Fluxo , Humanos , Hibridização in Situ Fluorescente , Neoplasias Hepáticas/patologia , Linfoma de Células T/patologia , Masculino , Receptores de Antígenos de Linfócitos T gama-delta/genética , Neoplasias Esplênicas/patologiaRESUMO
The karyotype of a cystic partially differentiated nephroblastoma (CPDN) was found to be 51, XY, +7, +8, +12, +13, +17. A review of the literature disclosed three other cytogenetically analyzed CPDNs. As in this case, they were all hyperdiploid. The only chromosomal anomaly common to all four cases was trisomy 12, suggesting this chromosome might have a pathogenetic role. Earlier reports had tentatively attributed this role to chromosome 8.
Assuntos
Cromossomos Humanos Par 12 , Diploide , Doenças Renais Císticas/patologia , Neoplasias Renais/patologia , Trissomia , Tumor de Wilms/patologia , Diferenciação Celular , Humanos , Lactente , Doenças Renais Císticas/genética , Neoplasias Renais/genética , Masculino , Tumor de Wilms/genéticaRESUMO
In children with constipation the usefulness of passage time along the large bowel was assessed, limiting the number of performed rectal enemas. The preliminary results suggest that it is possible to answer the clinician's questions - whether the passage time is prolonged, and if so, to determine in what segment of the large bowel. This method may be treated as a screening test in the diagnosis of constipation in children.
Assuntos
Constipação Intestinal/diagnóstico , Trânsito Gastrointestinal/fisiologia , Adolescente , Criança , Pré-Escolar , Constipação Intestinal/fisiopatologia , Constipação Intestinal/terapia , Enema , HumanosRESUMO
We report the cytogenetic analysis of a choroid plexus papilloma, a benign tumor, with a modal number of 56 chromosomes. In our review of the few reported karyotypes of choroid plexus tumors, we found no predictive relationship between the karyotype and the pathologic diagnosis or outcome.
Assuntos
Neoplasias do Plexo Corióideo/genética , Glioma/genética , Neoplasias do Plexo Corióideo/patologia , Glioma/patologia , Humanos , Lactente , Cariotipagem , Imageamento por Ressonância Magnética , MasculinoRESUMO
In the present study HPV 16 DNA was discovered in the cervical cancer tissue and in blood of women with cancer. In the blood of patients with advanced cancer the HPV appeared in granulocytes and was anchored to the lymphocytic membrane. It may be therefore concluded that the presence of HPV 16 DNA in the blood of women with cervical cancer reduced immunocompetence.
