1.
Biomater Sci
; 5(1): 38-40, 2016 Dec 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27921096
RESUMO
Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.