1.
Chem Commun (Camb)
; 60(11): 1448-1451, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38213273
RESUMO
We present an iridium and Brønsted acid co-catalyzed enantioselective formal [4+2] cycloaddition reaction of cyclic enamides with 2-(1-hydroxyallyl)phenols. This method yields a wide range of N-unsubstituted spiro-N,O-ketals, with good efficiency (up to 94%) and excellent enantioselectivities (most >95% ee). The protocol features easy scale-up and facile product derivatization.