Remediation on antimony-contaminated soil from mine area using zero-valent-iron doped biochar and their effect on the bioavailability of antimony.

Due to the bioavailability and trophic web movement of antimony, the overexploitation of antimony mine resulted in antimony contamination that harmed the ecology nearby, raising concerns for public health. Whereas, most researches focused on the removal of antimony in the aqueous instead of the immobilization of antimony in the soil. Herein, the immobilized performance of biochar (BC) loaded with nano zero-valent iron (nZVI-BC) on antimony in the soil near the smelting area was researched through pot experiments for the first time, and its stabilization mechanism on antimony was investigated by valent state variation of antimony. The results demonstrated that BC restricted the cation exchange capacity and catalase activity in the soil. Whereas nZVI-BC had a favorable and negative impact on two variables, respectively. While the exchangeable speciation of antimony fell both from 15% to 2% after adding the BC and nZVI-BC, nZVI-BC showed more stable immobilization capacity on antimony over time than BC, whose exchangeable speciation only marginally rose (2% to 6%). The electron attraction force between nZVI-BC and antimony was also intensified owing to the oxidation-reduction process, which was considered as the stabilizing principle of nZVI-BC on antimony in soil. Furthermore, the decreased bioaccumulation factor for the perennial ryegrass (0.46 to 0.21) and Galinsoga parviflora Cav. (0.26 to 0.17) stated that the BC effectively mitigated the bioaccumulation risk of antimony.

Combination of prostate volume and apparent diffusion coefficient can stratify patients with a PI-RADS score of 3 to reduce unnecessary prostate biopsies.

BACKGROUND: Nowadays, there are many patients who undergo unnecessary prostate biopsies after receiving a prostate imaging reporting and data system (PI-RADS) score of 3. Our purpose is to identify cutoff values of the prostate volume (PV) and minimum apparent diffusion coefficient (ADCmin) to stratify those patients to reduce unnecessary prostate biopsies. METHODS: Data from 224 qualified patients who received prostate biopsies from January 2019 to June 2023 were collected. The Mann-Whitney U test was used to compare non-normal distributed continuous variables, which were recorded as median (interquartile ranges). The correlation coefficients were calculated using Spearman's rank correlation analysis. Categorical variables are recorded by numbers (percentages) and compared by χ2 test. Both univariate and multivariate logistic regression analysis were used to determine the independent predictors. The receiver-operating characteristic curve and the area under the curve (AUC) were used to evaluate the diagnostic performance of clinical variables. RESULTS: Out of a total of 224 patients, 36 patients (16.07%) were diagnosed with clinically significant prostate cancer (csPCa), whereas 72 patients (32.14%) were diagnosed with any grade prostate cancer. The result of multivariate analysis demonstrated that the PV (p < 0.001, odds ratio [OR]: 0.952, 95% confidence interval [95% CI]: 0.927-0.978) and ADCmin (p < 0.01, OR: 0.993, 95% CI: 0.989-0.998) were the independent factors for predicting csPCa. The AUC values of the PV and ADCmin were 0.779 (95% CI: 0.718-0.831) and 0.799 (95% CI: 0.740-0.849), respectively, for diagnosing csPCa. After stratifying patients by PV and ADCmin, 24 patients (47.06%) with "PV < 55 mL and ADCmin < 685 µm2/s" were diagnosed with csPCa. However, only one patient (1.25%) with PV ≥ 55 mL and ADCmin ≥ 685 µm2/s were diagnosed with csPCa. CONCLUSIONS: In this study, we found the combination of PV and ADCmin can stratify patients with a PI-RADS score of 3 to reduce unnecessary prostate biopsies. These patients with "PV ≥ 55 mL and ADCmin ≥ 685 µm2/s" may safely avoid prostate biopsies.

Creating a novel multiparametric magnetic resonance imaging-based biopsy strategy for reducing unnecessary prostate biopsies: a retrospective cohort study.

Background: The overdiagnosis of prostate cancer (PCa) caused by unnecessary prostate biopsy has become a worldwide problem that urgently requires a solution. We aimed to reduce the unnecessary prostate biopsies and increase the detection rate of clinically significant PCa (csPCa) by creating a novel multiparametric magnetic resonance imaging (mpMRI)-based strategy. Methods: A total of 1,194 eligible patients who underwent transperineal prostate biopsies from January 2018 to December 2022 were included in this retrospective study. Of these patients, 1,080 who received prostate biopsies from January 2018 to July 2022 were regarded as cohort 1 for primary analysis, and 114 patients who received prostate biopsies from August 2022 to December 2022 were collected in cohort 2 for validation. All the mpMRI images were quantitatively evaluated by the Prostate Imaging Reporting and Data System version 2.1 (PI-RADS v. 2.1). The diagnostic performances were assessed through the receiver operating characteristic (ROC) curve and area under the curve (AUC) and were compared with the DeLong test. Cancer diagnosis-free survival analysis was performed using the Kaplan-Meier method and log-rank test. The primary endpoint of this study was clinically significant PCa with an International Society of Urological Pathology (ISUP) grade ≥2. Results: In cohort 1, the results of ROC curves demonstrated that the PI-RADS score had a higher diagnostic accuracy (AUC =0.898 for any-grade PCa; AUC =0.917 for csPCa) than did the other clinical variables (P<0.001). Under the novel mpMRI-based biopsy strategy, all patients with PI-RADS 1 can safely avoid prostate biopsy. For patients with PI-RADS 2, prostate biopsy should be considered for patients with prostate-specific antigen density (PSAD) ≥0.3 ng/mL2 and prostate volume <65 mL. As for patients with PI-RADS 3, structured surveillance programs can be a viable option if PSAD <0.3 ng/mL2 and prostate volume ≥65 mL. Finally, patients with a PI-RADS score of 4 and 5 should undergo prostate biopsy due to the high probability of clinically significant PCa. In the validation analysis of cohort 2, 48 patients were placed into a biopsy-spared group with no csPCa cases, while 66 patients were placed in a biopsy-needed group, with an csPCa detection rate of 50.0%. Overall, the novel strategy demonstrated a sensitivity, specificity, positive predictive value, and negative predictive value of 98.9%, 57.5%, 50.5%, and 99.2%, respectively, for diagnosing csPCa. Conclusions: An mpMRI-based biopsy strategy can effectively avoid about 40% of prostate biopsies and maintain a high detection rate for clinically significant PCa. It can further provide valuable guidance for patients and physicians in considering the necessity of prostate biopsy.

Enhanced adsorption for trivalent antimony by nano-zero-valent iron-loaded biochar: performance, mechanism, and sustainability.

The discharge of tailing leachate and metallurgical wastewater has led to an increasing trend of water pollution. In this study, nZVI-modified low-temperature biochar was used to adsorb Sb(III) from water. The adsorption capacity and speed of nZVI-BC were better than those of BC, and the best adsorption effect was observed for 4nZVI-BC, with 93.60 mg·g-1 maximum adsorptive capacity, which was 208.61% higher than the original BC. The Langmuir and Temkin models were well fitted (R2 ≥ 0.99), and PSO was more in line with the 4nZVI-BC adsorption process, indicating that the adsorption was a monolayer physico-chemical adsorption. The combination of XRD, FTIR, and XPS characterization demonstrated that the adsorption mechanism predominantly included redox reactions, complexation, and electrostatic interactions. The thermodynamic results demonstrated that 4nZVI-BC adsorption on Sb(III) was a spontaneous endothermic process. Additionally, the order of the influence of interfering ions on 4nZVI-BC was CO32- > H2PO4- > SO42- > Cl-. After three repeated uses and adsorption-desorption, the adsorption ratio of Sb(III) by 4nZVI-BC was still as high as 90% and 65%, respectively. This study provides a theoretical reference for the exploration and development of Sb(III) removal technologies for aquatic environments.

Trivalent antimony removal using carbonaceous nanomaterial loaded with zero-valent bimetal (iron/copper) and their effect on seed growth.

As rapid industrial and social growth, antimony mines are the overexploited, leading to the accumulation of trivalent antimony in the aquatic environment near smelters, which harm human health. To eradicate trivalent antimony from water, an innovative nanomaterial in the form of sludge biochar loaded with zero-valent bimetal was synthesized using a liquid-phase reduction method. The adsorption performance of the nanomaterial for trivalent antimony was investigated based on a series of adsorption experiments using sludge biochar, nano zero-valent iron biochar, and nano zero-valent bimetal biochar. The results showed that the optimal adsorption performance of the three nanomaterials for trivalent antimony, considering the economic practicability, was highlighted at solution pH of 3 and 0.05 g of nanomaterial. Additionally, the maximum adsorption capacity of sludge biochar, nano zero-valent iron biochar, and nano zero-valent bimetal biochar is 3.89 mg g-1 at 35 °C, 32.01 mg g-1 at 25 °C, 50.96 mg g-1 at 25 °C, respectively. The adsorption process of sludge biochar is endothermic, resulting in an increase in the adsorption capacity with increasing temperature, whereas the exothermic reaction contributes to decrease in the adsorption capacity at increasing temperature for the other two carbon nanomaterials. The inhibitory effect of coexisting ions was in the order: Al3+ > NH4+ > Na+ > K+; CO32- > CH3COO- > H2PO4- > S2-. Additionally, nanomaterials promoted seed germination and growth. Investigation of the adsorption mechanism using X-ray photoelectron spectroscopy showed that trivalent antimony was oxidised to pentavalent antimony, and Fe(III) was reduced to Fe(II). The formed primary battery formed by copper ions and iron acclerated electron transfer and improved the adsorption rate. This implied that trivalent antimony could be removed through the synergistic action of the adsorption behaviour and redox reaction. Therefore, the biochar loaded with the zero-valent bimetal serves as a pathway for eradicating trivalent antimony.

Plasmon-modulated bistable four-wave mixing signals from a metal nanoparticle-monolayer MoS2 nanoresonator hybrid system.

We present a study for the impact of exciton-phonon and exciton-plasmon interactions on bistable four-wave mixing (FWM) signals in a metal nanoparticle (MNP)-monolayer MoS2 nanoresonator hybrid system. Via tracing the FWM response we predict that, depending on the excitation conditions and the system parameters, such a system exhibits 'U-shaped' bistable FWM signals. We also map out bistability phase diagrams within the system's parameter space. Especially, we show that compared with the exciton-phonon interaction, a strong exciton-plasmon interaction plays a dominant role in the generation of optical bistability, and the bistable region will be greatly broadened by shortening the distance between the MNP and the monolayer MoS2 nanoresonator. In the weak exciton-plasmon coupling regime, the impact of exciton-phonon interaction on optical bistability will become obvious. The scheme proposed may be used for building optical switches and logic-gate devices for optical computing and quantum information processing.