RESUMO
Mitochondria serve as the primary site for aerobic respiration within cells, playing a crucial role in maintaining cellular homeostasis. To maintain homeostasis and meet the diverse demands of the cells, mitochondria have evolved intricate systems of quality control, mainly including mitochondrial dynamics, mitochondrial autophagy (mitophagy) and mitochondrial biogenesis. The kidney, characterized by its high energy requirements, is particularly abundant in mitochondria. Interestingly, the mitochondria display complex behaviors and functions. When the kidney is suffered from obstructive, ischemic, hypoxic, oxidative, or metabolic insults, the dysfunctional mitochondrial derived from the defects in the mitochondrial quality control system contribute to cellular inflammation, cellular senescence, and cell death, posing a threat to the kidney. However, in addition to causing injury to the kidney in several cases, mitochondria also exhibit protective effect on the kidney. In recent years, accumulating evidence indicated that mitochondria play a crucial role in adaptive repair following kidney diseases caused by various etiologies. In this article, we comprehensively reviewed the current understanding about the multifaceted effects of mitochondria on kidney diseases and their therapeutic potential.
RESUMO
Herein, we have successfully synthesized two rubidium antimony (III) oxalates, namely, Rb2Sb(C2O4)2.5(H2O)3 and RbSb2(C2O4)F5, utilizing a low-temperature hydrothermal method. These two compounds share a similar chemical composition, consisting of Sb3+ cations with active lone pair electrons, alkali metal Rb+ ions, and planar π-conjugated C2O42- anions. However, they exhibit different symmetries, Rb2Sb(C2O4)2.5(H2O)3 is centrosymmetric (CS), while RbSb2(C2O4)F5 is noncentrosymmetric (NCS), which should be caused by the presence of F- ions. Notably, the NCS compound, RbSb2(C2O4)F5, demonstrates a moderate second-harmonic generation (SHG) response, approximately 1.3 times that of KH2PO4 (KDP), and exhibits a large birefringence of 0.09 at 546 nm. These characteristics indicate that RbSb2(C2O4)F5 holds promising potential as a nonlinear optical material for ultraviolet (UV) applications. Detailed structural analysis and theoretical calculations confirm that the excellent optical properties arise from the synergistic effects between Sb3+ cations with SCALP and planar π-conjugated [C2O4]2- groups.
RESUMO
Improvisational behavior is an individual's spontaneous and creative behavior in the face of emergencies, using existing material and emotional resources to respond quickly and effectively to uncertain situations. Despite increasing interest in this behavior, its antecedents remain unclear, with particular ambiguity regarding the relationship between empowering leadership and employee improvisational behavior. The present article addresses this ambiguity with the theory of reasoned action to examine whether the impact of empowering leadership on employees' improvisational behavior is determined by employees' attitudes toward such behavior. In this study, a multi-source design was adopted, and data (339 valid samples) were collected from five Internet companies in China's Jiangsu and Zhejiang provinces. Hierarchical regression and bootstrapping methods were used to test the hypotheses. The results reveal that (1) employees' promotion focus moderates the relationship between empowering leadership and improvisational behavior and (2) employees' willingness to take risks mediates the moderating effect of promotion focus. Our findings demonstrate employees' attitudinal utility in explaining when improvisational behavior is most likely to occur under empowering leadership.
RESUMO
In this paper, nanostructured molybdenum selenide (MoSe2) with composited phases are synthesized by hydrothermal method, and the products are modified by metal anoparticles to improve the gas sensing performance. Microstructure characterization shows that few layered 1T/2H-MoSe2nanosheets have been successfully prepared. Both the morphology and component of nanosheets could be tuned by the reaction parameters. It is shown the MoSe2-based nanomaterials have excellent selectivity to nitrogen dioxide (NO2) according to gas sensing properties measurement. The sensitivity of 1T/2H-MoSe2nanosheets modified by Cu nanoparticles is 17.73 (50 ppm NO2) at the optimal operating temperature, which is the highest compared with other samples. The sensors also exhibit rapid response/recovery time and high stability. The sensing mechanism of MoSe2nanosheets toward NO2is investigated based on the first-principles calculation. The results suggest the modification by metal nanoparticles could significantly improve the adsorption energy and charge transfer between gas molecule and MoSe2. This work demonstrates a promising guidance for the design of new NO2gas sensing materials and devices.
RESUMO
In this paper, nanostructured Molybdenum Selenide (MoSe2) with composited phases are synthesized by hydrothermal method, and the products are modified by metal anoparticles to improve the gas sensing performance. Microstructure characterization shows that few layered 1T/2H-MoSe2 nanosheets have been successfully prepared. Both the morphology and composition of nanosheets could be tuned by the reaction parameters. It is shown the MoSe2-based nanomaterials have excellent selectivity to Nitrogen dioxide (NO2) according to gas sensing properties measurement. The sensitivity of 1T/2H-MoSe2 nanosheets modified by Cu nanoparticles is 17.73 (50 ppm NO2) at the optimal operating temperature, which is the highest compared with other samples. The sensors also exhibit rapid response/recovery time and high stability. The sensing mechanism of MoSe2 nanosheets toward NO2 is investigated based on the first-principles calculation. The results suggest the modification by metal nanoparticles could significantly improve the adsorption energy and the charge transfer between gas molecule and MoSe2. This work demonstrates a promising guidance for the design of new NO2 gas sensing materials and devices.
