2D PtRhPb Mesoporous Nanosheets with Surface-Clean Active Sites for Complete Ethanol Oxidation Electrocatalysis.

The development of active and selective metal electrocatalysts for complete ethanol oxidation reaction (EOR) into desired C1 products is extremely promising for practical application of direct ethanol fuel cells. Despite some encouraging achievements, their activity and selectivity remain unsatisfactory. In this work, it is reported that 2D PtRhPb mesoporous nanosheets (MNSs) with anisotropic structure and surface-clean metal site perform perfectly for complete EOR electrocatalysis in both three-electrode and two-electrode systems. Different to the traditional routes, a selective etching strategy is developed to produce surface-clean mesopores while retaining parent anisotropy quasi-single-crystalline structure without the mesopore-forming surfactants. This method also allows the general synthesis of surface-clean mesoporous metals with other compositions and structures. When being performed for alkaline EOR electrocatalysis, the best PtRhPb MNSs deliver remarkably high activity (7.8 A mg-1) and superior C1 product selectivity (70% of Faradaic efficiency), both of which are much better than reported electrocatalysts. High performance is assigned to multiple structural and compositional synergies that not only stabilized key OHads intermediate by surface-clean mesopores but also separated the chemisorption of two carbons in ethanol by adjacent Pt and Rh sites, which facilitate the oxidation cleavage of stable C─C bond for complete EOR electrocatalysis.

A photoactivatable upconverting nanodevice boosts the lysosomal escape of PROTAC degraders for enhanced combination therapy.

PROteolysis TArgeting Chimeras have received increasing attention due to their capability to induce potent degradation of various disease-related proteins. However, the effective and controlled cytosolic delivery of current small-molecule PROTACs remains a challenge, primarily due to their intrinsic shortcomings, including unfavorable solubility, poor cell permeability, and limited spatiotemporal precision. Here, we develop a near-infrared light-controlled PROTAC delivery device (abbreviated as USDPR) that allows the efficient photoactivation of PROTAC function to achieve enhanced protein degradation. The nanodevice is constructed by encapsulating the commercial BRD4-targeting PROTACs (dBET6) in the hollow cavity of mesoporous silica-coated upconversion nanoparticles, followed by coating a Rose Bengal (RB) photosensitizer conjugated poly-L-lysine (PLL-RB). This composition enables NIR light-activatable generation of cytotoxic reactive oxygen species due to the energy transfer from the UCNPs to PLL-RB, which boosts the endo/lysosomal escape and subsequent cytosolic release of dBET6. We demonstrate that USDPR is capable of effectively degrading BRD4 in a NIR light-controlled manner. This in combination with NIR light-triggered photodynamic therapy enables an enhanced antitumor effect both in vitro and in vivo. This work thus presents a versatile strategy for controlled release of PROTACs and codelivery with photosensitizers using an NIR-responsive nanodevice, providing important insight into the design of effective PROTAC-based combination therapy.

Self-Regenerating Photothermal Agents for Tandem Photothermal and Thermodynamic Tumor Therapy.

Small molecule-based photothermal agents (PTAs) hold promising future for photothermal therapy; however, unexpected inactivation exerts negative impacts on their application clinically. Herein, a self-regenerating PTA strategy is proposed by integrating 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS•+) with a thermodynamic agent (TDA) 2,2'-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH). Under NIR laser, the photothermal effect of ABTS•+ accelerates the production of alkyl radicals by AIPH, which activates the regeneration of ABTS•+, thus creating a continuous positive feedback loop between photothermal and thermodynamic effects. The combination of ABTS•+ regeneration and alkyl radical production leads to the tandem photothermal and thermodynamic tumor therapy. In vitro and in vivo experiments confirm that the synergistic action of thermal ablation, radical damage, and oxidative stress effectively realizes tumor suppression. This work offers a promising approach to address the unwanted inactivation of PTAs and provides valuable insights for optimizing combination therapy.

Calcium Carbonate-Based Nanoplatforms for Cancer Therapeutics: Current State of Art and Future Breakthroughs.

With the rapid development of nanotechnology, nanomaterials have shown immense potential for antitumor applications. Nanosized calcium carbonate (CaCO3) materials exhibit excellent biocompatibility and degradability, and have been utilized to develop platform technologies for cancer therapy. These materials can be engineered to carry anticancer drugs and functional groups that specifically target cancer cells and tissues, thereby enhancing therapeutic efficacy. Additionally, their physicochemical properties can be tailored to enable stimuli-responsive therapy and precision drug delivery. This Review consolidates recent literatures focusing on the synthesis, physicochemical properties, and multimodal antitumor therapies of CaCO3-based nanoplatforms (CBN). We also explore the current challenges and potential breakthroughs in the development of CBN for antitumor applications, providing a valuable reference for researchers in the field.

Ir-Doped CuPd Single-Crystalline Mesoporous Nanotetrahedrons for Ethylene Glycol Oxidation Electrocatalysis: Enhanced Selective Cleavage of C-C Bond.

The development of highly efficient electrocatalysts for complete oxidation of ethylene glycol (EG) in direct EG fuel cells is of decisive importance to hold higher energy efficiency. Despite some achievements, their progress, especially electrocatalytic selectivity to complete oxidated C1 products, is remarkably slower than expected. In this work, we developed a facile aqueous synthesis of Ir-doped CuPd single-crystalline mesoporous nanotetrahedrons (Ir-CuPd SMTs) as high-performance electrocatalyst for promoting oxidation cleavage of C-C bond in alkaline EG oxidation reaction (EGOR) electrocatalysis. The synthesis relied on precise reduction/co-nucleation and epitaxial growth of Ir, Cu and Pd precursors with cetyltrimethylammonium chloride as the mesopore-forming surfactant and extra Br- as the facet-selective agent under ambient conditions. The products featured concave nanotetrahedron morphology enclosed by well-defined (111) facets, single-crystalline and mesoporous structure radiated from the center, and uniform elemental composition without any phase separation. Ir-CuPd SMTs disclosed remarkably enhanced electrocatalytic activity and excellent stability as well as superior selectivity of C1 products for alkaline EGOR electrocatalysis. Detailed mechanism studies demonstrated that performance improvement came from structural and compositional synergies, which kinetically accelerated transports of electrons/reactants within active sites of penetrated mesopores and facilitated oxidation cleavage of high-energy-barrier C-C bond of EG for desired C1 products. More interestingly, Ir-CuPd SMTs performed well in coupled electrocatalysis of anode EGOR and cathode nitrate reduction, highlighting its high potential as bifunctional electrocatalyst in various applications.

Self-induced electron attraction center formation with pyrophosphorylation strategy for photocatalytic hydrogen evolution.

An integral approach towards augmenting the performance of photocatalytic hydrogen production lies in the induction of charge transfer mediators within the material matrix itself, thereby facilitating swift and efficient charge transfer processes. Here, CoTiO3 is induced to grow its electronic attraction center, CoP3, through a high-temperature phosphatization strategy. CoP3 acts as the active reduction site for the hydrogen evolution reaction and enhances the photocatalytic performance of the pristine catalyst. Compared with pure CoTiO3, the PCTO7 hybrid catalyst with the electronic attraction center CoP3 exhibits a superior photocatalytic performance and good stability. Experimental results show that the hydrogen evolution performance of the PCTO7 hybrid catalyst reaches 56.52 µmol, which is 78 times higher than that of the single catalyst CoTiO3 (0.72 µmol). These results demonstrate that the hybrid catalyst with the self-induced electronic attraction center has a higher light absorption capacity, faster charge carrier dynamics and improved photogenerated charge carrier separation and transfer than pure CoTiO3, resulting in excellent redox capability. DFT calculations provide evidence supporting the topological metal properties of CoP3 as the electron sink center. This study provides a feasible approach for enhancing the photocatalytic performance of a pristine catalyst employing a high-temperature phosphatization-induced electron sink center.

Highly efficient capture of iodine vapor by [Mo3S13]2- intercalated layered double hydroxides.

From the swollen LDH, bulky [Mo3S13]2- anions are facilely introduced into the LDH interlayers to assemble the Mo3S13-LDH composite, which exhibits excellent iodine capture performance and good irradiation resistance. The positive-charged LDH layers may disperse the [Mo3S13]2- uniformly within the interlayers, providing abundant adsorption sites for effectively trapping iodine. The Mo-S bond serving as a soft Lewis base has strong affinity to I2 with soft Lewis acidic characteristic, which is conducive to improvement of iodine capture via physical sorption. Besides, chemisorption has a significant contribution to the iodine adsorption. The S22-/S2- in [Mo3S13]2- can reduce the I2 to [I3]- ions, which are facilely fixed within the LDH gallery in virtue of electrostatic attraction. Meanwhile, the S22-/S2- themselves are oxidized to S8 and SO42-, while Mo4+ is oxidized (by O2 in air) to Mo6+, which combines with SO42- forming amorphous Mo(SO4)3. With the collective interactions of chemical and physical adsorption, the Mo3S13-LDH demonstrates an extremely large iodine adsorption capacity of 1580 mg/g. Under γ radiation, the structure of Mo3S13-LDH well maintains and iodine adsorption capability does not deteriorate, indicating the good irradiation resistance. This work provides an important reference to tailor cost-effective sorbents for trapping iodine from radioactive nuclear wastes.

[Sn2S6]4- Anion-Intercalated Layered Double Hydroxides for Highly Efficient Capture of Iodine.

The development of low-cost and high-efficiency iodine sorbents is of great significance for the control of nuclear pollution. In this work, we intercalate the tin sulfide cluster of [Sn2S6]4- to Mg/Al-type layered double hydroxides to obtain Sn2S6-LDH, which exhibits highly efficient capture performance of iodine vapor and iodine in solutions. The dispersion effect of the positively charged LDH layers contributes to the adequate exposure of [Sn2S6]4- anions, providing plentiful adsorption sites. For iodine vapor, Sn2S6-LDH showed an extremely large iodine capture capacity of 2954 mg/g with a large contribution from physisorption. For iodine in solutions, a significantly large sorption capacity of 1308 mg/g was achieved. During iodine capture, I2 molecules were reduced to I- ions (by S2- in [Sn2S6]4-), which then reacted with Sn4+ to form SnI4, where the molar amount of captured iodine is 4-fold that of Sn. Besides, the as-reduced I- combined with I2 again to generate [I3]-, which then entered the LDH interlayers to maintain electric neutrality. While reducing iodine, S2- itself in [Sn2S6]4- was oxidized to S8, which further combined with SnI4 to form a novel compound of SnI4(S8)2. The excellent iodine capture capability endows Sn2S6-LDH with a promising application in trapping radioactive iodine.

Single-atom nanozymes: classification, regulation strategy, and safety concerns.

Nanozymes, nanomaterials possessing enzymatic activity, have been studied extensively by researchers. However, their complex composition, low density of active sites, and inadequate substrate selectivity have hindered the maturation and widespread acceptance of nanozymes. Single-atom nanozymes (SAzymes) with atomically dispersed active sites are leading the field of catalysis due to their exceptional performance. The maximum utilization rate of atoms, low cost, well-defined coordination structure, and active sites are the most prominent advantages of SAzymes that researchers favor. This review systematically categorizes SAzymes based on their support type and describes their specific applications. Additionally, we discuss regulation strategies for SAzyme activity and provide a comprehensive summary of biosafety challenges associated with these enzymes.

An elaborate biomolecular keypad lock based on electrochromism of viologen derivatives and bioelectrocatalytic reduction of CO2 at supramolecular hydrogel film electrodes.

Herein, the short peptide N-fluorenemethoxycarbonyl diphenylalanine (Fmoc-FF) was used to immobilize both diallyl viologen (DAV) and the enzyme formate dehydrogenase (FDH) to form Fmoc-FF/DAV/FDH supramolecular hydrogel films on an electrode surface by a simple solvent-controlled self-assembly method. The DAV component in the films exhibited multiple properties, such as electrochromism and electrofluorochromism, and acted as an electrochemical mediator. A high efficiency of bioelectrocatalytic reduction of CO2 to formate (HCOO-) was obtained by the natural FDH enzyme and the artificial coenzyme factor DAV both immobilized in the same films. The supramolecular hydrogel films with CO2, voltage and light as stimulating factors and current, fluorescence and UV-vis extinction as responsive signals, were further applied for the construction of complex biomolecular logic systems and information encryption. A 3-input/7-output biomolecular logic gate and several logic devices, including an encoder/decoder, a parity checker, and a keypad lock, were constructed. Especially, the biomolecular keypad lock with 3 types of signals as outputs significantly enhanced the security level of information encryption. In this work, a supramolecular self-assembly interface was simply fabricated with complex biomolecular computational functions using immobilized molecules as the computational core, greatly broadening the application range of supramolecular hydrogel films and providing an idea for new designs of bioinformation encryption through the use of a simple film system.

Intercalation of salicylaldoxime into layered double hydroxide: Ultrafast and highly selective uptake of uranium from different water systems via versatile binding modes.

We report the first example of MgAl layered double hydroxide intercalated with salicylaldoxime (SA-LDH) which exhibits excellent uranium (U(VI)) capture performance. In U(VI) aqueous solutions, the SA-LDH shows a tremendous maximum U(VI) sorption capacity (qmU) of 502 mg·g-1, surpassing most known sorbents. For the aqueous solution with an initial U(VI) concentration (C0U) of âˆ¼ 10 ppm, ≥99.99 % uptake is achieved in a wide pH range of 3-10. At C0U âˆ¼ 20 ppm, >99 % uptake is reached within only 5 min, and pseudo-second-order kinetics rate constant (k2) of 44.9 g·mg-1·min-1 reaches the record value, placing the SA-LDH amongst the fastest U adsorbing materials reported to date. In contaminated seawater with 35 ppm of U while highly concentrated metal ions of Na+, Mg2+, Ca2+, and K+, the SA-LDH still displays exceptionally high selectivity and ultrafast extraction for UO22+, giving >95 % uptake of U(VI) within 5 min, and the k2 value of 0.308 g·mg-1·min-1 for seawater surpasses most reported values for aqueous solutions. Versatile binding modes toward U by SA-LDH, including complexation (UO22+ with SA- and/or CO32-), ion exchange and precipitation, contribute to the preferable uptake of U at different concentrations. X-ray absorption fine structure (XAFS) analyses demonstrate that one uranyl ion (UO22+) binds to two SA- anions and two H2O molecules forming 8-coordinated configuration. The U coordinates with O atom of the phenolic hydroxyl group and N atom of the -CN-O- group of SA-, forming a stable six-membered ring motif, which endows the fast and robust capture of U. The wonderful uranium trapping ability makes the SA-LDH among the best adsorbent used for uranium extraction from various solution systems including seawater.

Oxygen-generating biocatalytic nanomaterials for tumor hypoxia relief in cancer radiotherapy.

Radiotherapy (RT), the most commonly used treatment method in clinics, shows unique advantages such as strong penetration, high energy intensity, and low systemic side effects. However, in vivo tumor hypoxia seriously hinders the therapeutic effect of RT. Hypoxia is a common characteristic of locally advanced solid tumor microenvironments, which leads to the proliferation, invasion and metastasis of tumor cells. In addition, oxygen consumption during RT will further aggravate tumor hypoxia, causing a variety of adverse side effects. In recent years, various biocatalytic nanomaterials (BCNs) have been explored to regulate and reverse tumor hypoxia microenvironments during RT. In this review, the most recent efforts toward developing oxygen-generating BCNs in relieving tumor hypoxia in RT are focused upon. The classification, engineering nanocatalytical activity of oxygen-generating BCNs and combined therapy based on these BCNs are systematically introduced and discussed. The challenges and prospects of these oxygen-generating BCNs in RT applications are also summarized.

Recent advances in g-C3N4-based photo-enzyme catalysts for degrading organic pollutants.

In recent years, photocatalytic reactions have shown great potential in degrading organic pollutants because of their simple operation and no secondary pollution. Graphitic carbon nitride (g-C3N4) is one of the most frequently used photocatalyst materials in the field of photocatalysis because it is a form of photocatalytic material with facile synthesis, no metal, visible light response, and strong stability. Enzyme-catalyzed degradation has received extensive attention due to its broad selectivity, high efficiency, and environmental friendliness. Horseradish peroxidase (HRP), one of several oxidoreductases utilized for pollutant degradation, has a wide range of applications due to its mild reaction conditions and high stability. Exploring efficient platforms for immobilizing g-C3N4 and HRP to develop photo-enzyme-coupled catalysis is an attractive practical topic. The coupling effect of g-C3N4 and HRP improves the carrier separation efficiency and generates more active species, which finally realize the solar-driven non-selective destruction of organic pollutants. We describe the alteration of g-C3N4 and the immobilization of HRP in detail in this study, and we outline recent developments in the photo-enzyme coupling of g-C3N4 and HRP.

Co-immobilized bienzyme of horseradish peroxidase and glucose oxidase on dopamine-modified cellulose-chitosan composite beads as a high-efficiency biocatalyst for degradation of acridine.

Co-immobilized bienzyme biocatalysts are attracting increasing interest in the field of wastewater treatment due to their widespread application. In this study, we successfully prepared a co-immobilized bienzyme biocatalyst by immobilizing horseradish peroxidase (HRP) and glucose oxidase (GOD) on dopamine (DA) modified cellulose (Ce)-chitosan (Cs) composite beads via covalent binding, designated as Ce-Cs@DA/HRP-GOD beads, and found that the bienzyme biocatalyst had a good ability to catalytically degrade acridine in wastewater. SEM, EPR, FTIR, and XRD were used to characterise the structure and properties of the Ce-Cs@DA/HRP-GOD beads. The co-immobilized bienzyme biocatalyst with a small amount of HRP exhibited better degradation efficiency for acridine (99.5%, 8 h) in simulated wastewater compared to the Ce-Cs@DA/HRP (93.8%, 8 h) and Ce-Cs@DA/GOD (15.8%, 8 h) beads alone. In addition, a reusability study showed that the co-immobilized bienzyme biocatalyst maintained a degradation rate of 61.2% after six cycles of acridine degradation. The good biodegradability and reusability of the biocatalyst might be due to the synergistic effect of bienzyme HRP-GOD, including the strong covalent bonding. Accordingly, the co-immobilized bienzyme biocatalyst based on the cascade reaction may pave the way for efficient and eco-friendly treatment of industrial wastewater.

Layered double hydroxide intercalated with dimethylglyoxime for highly selective and ultrafast uptake of uranium from seawater.

In this study, we demonstrate the first example of a MgAl layered double hydroxide intercalated by a ketoxime compound (dimethylglyoxime, DMG), that is, MgAl-DMG-LDH (abbr. DMG-LDH), which exhibits excellent capture of uranium (U(VI)) both at high (ppm) and low (ppb) concentrations. The as-formed DMG-LDH shows an enormous maximum U(VI) sorption capacity (qUm) of 380 mg g-1 and an exceptionally rapid sorption rate (k2 = 2.97 g mg-1 min-1), reaching a high uptake of 99.14% within 5 min. For natural and contaminated seawater with high concentrations of Na+, Ca2+, Mg2+ and K+ concomitant cations, the DMG-LDH still can trap ∼85% U, displaying highly effective sorption toward U. The interaction mechanism between UO22+ and DMG2- provides an important reference for the development of highly effective capture of U(VI) by ketoxime materials. The DMG-LDH is currently the best ketoxime material for uranium extraction from nuclear waste and seawater.

Constructing combinational and sequential logic devices through an intelligent electrocatalytic interface with immobilized MoS2 quantum dots and enzymes.

Stable molybdenum disulfide quantum dots (MoS2 QDs) were synthesized using a simple method and embedded into chitosan (Chit) films with glucose oxidase (GOD) on the surface of a polyaniline (PANI) pre-electrodeposited ITO electrode, designated as Chit-MoS2-GOD/PANI. At the prepared film electrode, the fluorescence property of MoS2 QDs as well as the catalytic properties of MoS2 QDs and GOD were well maintained and could be reversibly regulated by external stimuli, such as pH, potential, and the concentrations of glucose and ascorbic acid (AA) in the solution. By controlling the redox state of PANI with an externally applied voltage, the color of the film electrode switched between violet blue and nearly transparent, simultaneously quenching/dequenching the fluorescence signals from MoS2 QDs through FÓ§ster resonance energy transfer (FRET). The electrocatalytic signals toward hydrogen peroxide (H2O2), a product formed by biocatalysis between glucose and GOD, could be tuned through the catalytic capacity of MoS2 QDs in the films. Thus, an intelligent platform was built based on the film electrode with pH, potential, glucose and AA as inputs and UV-vis extinction (E), photoluminescent intensity (PL), and amperometric current (I) as outputs. Combinational logic operations such as a 4-input/5-output logic network and sequential logic operations such as a keypad lock and a reprogrammable delay/data (D) flip flop was first simulated in a biocomputing system with the film-modified electrode. This work demonstrated the construction of a multiple stimulus-responsive system with dual-functional nanomaterials and provided a new approach for sequential logic operations for further applications in the information storage.

Correction: Recent developments of a co-immobilized laccase-mediator system: a review.

[This corrects the article DOI: 10.1039/D1RA05104K.].

The confinement effect of layered double hydroxides on intercalated pyromellitic acidic anions and highly selective uranium extraction from simulated seawater.

Oxygen-rich pyromellitic acidic anions (PMA4-) have been intercalated into MgAl-layered double hydroxides to fabricate the MgAl-PMA-LDH (abbr. PMA-LDH) composite exhibiting excellent adsorption performance toward uranium (U(VI)). Benefiting from the large number of functional groups of -COO-, the PMA-LDH displays an extremely large maximum U adsorption capacity (qUm) of 352 mg g-1 and an ultra-fast sorption rate, reaching uptakes of ∼97% within 30 min and >99% in 1 h at the initial U concentration (CU0) of 113 ppm. Over a very wide pH range of 5-11, high U removals (>93%) are achieved at CU0 = 105 ppm. Moreover, in the presence of highly concentrated competitive ions, ultra-high selectivity of UO22+ is observed, giving a very large distribution coefficient (Kd) of ∼106 mL g-1. Moreover, the PMA-LDH exhibits effective capture of UO22+ in contaminated simulated seawater, showing high uptakes of >93% at CU0 ∼ 10 ppm and >98% at CU0 ∼ 100 ppm. The dispersion effect of LDH layers may contribute to the increase of U adsorption capacity, and the confinement effect of LDH is conducive to the improvement of sorption selectivity toward U. The exploration of the interaction mechanism of UO22+ with PMA4- confined within the LDH gallery offers an important basis for the fabrication of new kinds of organic/inorganic hybrid materials. The PMA-LDH is a highly effective adsorbent which can be applied to uranium extraction from seawater and uranium disposal in nuclear wastewater.

Multistage Photoactivatable Zinc-Responsive Nanodevices for Monitoring and Regulating Dysfunctional Islet ß-Cells.

The dysfunctional islet ß-cell triggered by excessive deposition of Zn2+ constituted a striking indicator of the occurrence of diabetic disease. However, it remained a formidable challenge to reflect the real-time function of ß-cell by monitoring the Zn2+ content. Herein, multistage photoactivatable Zn2+-responsive nanodevice (denoted as AD2@USD1) was presented for sensing, regulating, and evaluating Zn2+ levels in dysfunctional islet ß-cells. The photoactivated signatures on the satellite shell layer of the nanodevices and the internally loaded chelating factors effectively identified and intervened in the real-time concentration of Zn2+, the photothermal feedback component decorated on the inner core permitted the assessment of the post-intervention Zn2+ levels, achieving an integrated intervention and prognostic assessment in response to the abnormal islet ß-cell function induced by Zn2+ deposition. In this way, one strategy for sensing and regulating islet ß-cell function-oriented to Zn2+ was established. Our study introduced AD2@USD1 as a tool for effectively sensing, adjusting, and assessing the Zn2+ level in islet ß-cells with abnormalities, gaining a potential breakthrough in the treatment of diabetes.

Biodegradable MoO x @MB incorporated hydrogel as light-activated dressing for rapid and safe bacteria eradication and wound healing.

Wounds infected with drug-resistant bacteria are hard to treat, which remains a serious problem in clinical practice. An innovative strategy for treating wound infections is thus imperative. Herein, we describe the construction of a nanocomposite from biocompatible poly(vinyl alcohol) (PVA)/polyethylene glycol (PEG) hydrogel loaded biodegradable MoO x nanoparticles (NPs) and photosensitizer methylene blue (MB), denoted as MoO x @MB-hy. By incorporating MoO x @MB NPs, the nanocomposite hydrogel can act as a photoactivated wound dressing for near-infrared-II 1064 nm and 660 nm laser synergetic photothermal-photodynamic therapy (PTT-PDT). The key to PTT-induced heat becomes the most controllable release of MB from MoO x @MB-hy to produce more 1O2 under 660 nm irradiation. Importantly, MoO x @MB-hy can consume glutathione (GSH) and trap bacteria nearer to the distance limit of ROS damage to achieve a self-migration-enhanced accumulation of reactive oxygen species (ROS), thereby conquering the intrinsic shortcomings of short diffusion distance and lifetime of ROS. Consequently, MoO x @MB-hy has high antibacterial efficiencies of 99.28% and 99.16% against Ampr E. coli and B. subtilis within 15 min. Moreover, the light-activated strategy can rapidly promote healing in wounds infected by drug-resistant bacteria. This work paves a way to design a novel nanocomposite hydrogel dressing for safe and highly-efficient antibacterial therapy.