RESUMO
OBJECTIVE: An imbalance in the pro- and anti-inflammatory cytokines may be responsible for periodontal breakdown through immune responses. This study aimed to determine the total amount, concentration and ratio of interleukin (IL)-11 and IL-17 in gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients. MATERIALS AND METHODS: Forty CP patients and 20 healthy controls (C) were included. The CP group was divided into two subgroups in line with the probing depth (PD) in GCF-sampling sites (CPa: PD >or= 5 mm, CPb: PD Assuntos
Periodontite Crônica/imunologia
, Líquido do Sulco Gengival/imunologia
, Interleucina-11/análise
, Interleucina-17/análise
, Adulto
, Idoso
, Periodontite Crônica/etiologia
, Índice de Placa Dentária
, Feminino
, Hemorragia Gengival/imunologia
, Humanos
, Masculino
, Pessoa de Meia-Idade
, Perda da Inserção Periodontal/imunologia
, Índice Periodontal
, Bolsa Periodontal/imunologia
RESUMO
The aim of this study was to evaluate the periodontal health status of lead-exposed apprentices and to search the correlation between clinical periodontal parameters and either blood lead or oxidative stress/damage indices in erythrocytes. Sixty male subjects were recruited for this study (30 apprentices and 30 controls). The periodontal health status was determined with gingival index, plaque index, gingival bleeding time index, probing depth, and clinical attachment level records. Additionally, blood lead level and indices of oxidative stress (glutathione peroxidase, superoxide dismutase), catalase activities and damage (malondialdehyde concentration) in erythrocytes were determined. The results showed that lead level was significantly higher in apprentices than in controls (P < 0.05). None of the clinical periodontal parameters and oxidative stress/damage indices were significantly different between the groups (P > 0.05). Significant correlation between plaque index and catalase, probing depth and superoxide dismutase, clinical attachment level and superoxide dismutase, and clinical attachment level and malondialdehyde in apprentices group (P < 0.05), and gingival bleeding time index and glutathione peroxidase in control group were found (P < 0.05). In multiple regression analysis, there were statistically significant associations between gingival index and working status, family income and either probing depth or clinical attachment level (P < 0.05). The results of this study showed significant association between the clinical periodontal parameters and oxidative stress/damage indices in apprentices indirectly exposed to low levels of lead.
Assuntos
Automóveis , Chumbo/toxicidade , Exposição Ocupacional/efeitos adversos , Doenças Periodontais/epidemiologia , Adolescente , Estudos de Casos e Controles , Eritrócitos/efeitos dos fármacos , Indicadores Básicos de Saúde , Humanos , Masculino , Doenças Periodontais/induzido quimicamente , Análise de RegressãoRESUMO
BACKGROUND: The aim of the present study was to evaluate gingival crevicular fluid (GCF) leptin levels and the influence of long-term and heavy smoking on GCF leptin levels in patients with chronic periodontitis. METHODS: In this study, 143 individuals were divided into three groups: non-smokers (NS), smokers (S), and control (C). Three subgroups of NS and S were grouped as follows: a) probing depth (PD)