MRI features and tumor-infiltrating CD8 + T cells-based nomogram for predicting meningioma recurrence risk.

OBJECTIVE: This study was based on MRI features and number of tumor-infiltrating CD8 + T cells in post-operative pathology, in predicting meningioma recurrence risk. METHODS: Clinical, pathological, and imaging data of 102 patients with surgically and pathologically confirmed meningiomas were retrospectively analyzed. Patients were divided into recurrence and non-recurrence groups based on follow-up. Tumor-infiltrating CD8 + T cells in tissue samples were quantitatively assessed with immunohistochemical staining. Apparent diffusion coefficient (ADC) histogram parameters from preoperative MRI were quantified in MaZda. Considering the high correlation between ADC histogram parameters, we only chose ADC histogram parameter that had the best predictive efficacy for COX regression analysis further. A visual nomogram was then constructed and the recurrence probability at 1- and 2-years was determined. Finally, subgroup analysis was performed with the nomogram. RESULTS: The risk factors for meningioma recurrence were ADCp1 (hazard ratio [HR] = 0.961, 95% confidence interval [95% CI]: 0.937 ~ 0.986, p = 0.002) and CD8 + T cells (HR = 0.026, 95%CI: 0.001 ~ 0.609, p = 0.023). The resultant nomogram had AUC values of 0.779 and 0.784 for 1- and 2-years predicted recurrence rates, respectively. The survival analysis revealed that patients with low CD8 + T cells counts or ADCp1 had higher recurrence rates than those with high CD8 + T cells counts or ADCp1. Subgroup analysis revealed that the AUC of nomogram for predicting 1-year and 2-year recurrence of WHO grade 1 and WHO grade 2 meningiomas was 0.872 (0.652) and 0.828 (0.751), respectively. CONCLUSIONS: Preoperative ADC histogram parameters and tumor-infiltrating CD8 + T cells may be potential biomarkers in predicting meningioma recurrence risk. CLINICAL RELEVANCE STATEMENT: The findings will improve prognostic accuracy for patients with meningioma and potentially allow for targeted treatment of individuals who have the recurrent form.

T2-Weighted Imaging and Apparent Diffusion Coefficient Histogram Parameters Predict Meningioma Consistency.

RATIONALE AND OBJECTIVES: Preoperative prediction of meningioma consistency is of great clinical value for risk stratification and surgical approach selection. However, to date, objective quantitative criteria for predicting meningioma consistency have not been developed. This study aimed to investigate the predictive value of magnetic resonance imaging (MRI) T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) histogram parameters for meningioma consistency. MATERIALS AND METHODS: We retrospectively analyzed the clinical, preoperative MRI, and pathological data of 103 patients with histopathologically confirmed meningiomas. Histogram parameters (mean, variance, skewness, kurtosis, Perc.01%, Perc.10%, Perc.50%, Perc.90%, and Perc.99%) were calculated automatically on the whole tumor using MaZda software. Chi-square test, Mann-Whitney's U test, or independent samples t-test was used to compare clinical, conventional MRI features, and histogram parameters between soft and hard meningiomas. Receiver operating characteristic curve and binary logistic regression analysis were employed to assess the predictive performance of T2WI and ADC histogram parameters. RESULTS: Tumor enhancement was the only conventional MRI feature that was statistically different between soft and hard meningiomas. ADCmean, ADCp1, ADCp10, and ADCp50 among ADC histogram parameters, and T2mean, T2p1, T2p10, T2p50, T2p90, and T2p99 among T2WI histogram parameters showed statistically significant differences between soft and hard meningiomas (all P < 0.05). We found that all combined variables (combinedall) had the best accuracy in predicting meningioma consistency, with area under the curve, sensitivity, specificity, accuracy, positive predictive, and negative predictive values of 0.873 (0.804-0.941), 88.89%, 67.50%, 80.58%, 81.20%, and 79.40%, respectively. Among them, combinedT2 is the most beneficial for predicting meningioma consistency. CONCLUSION: CombinedT2 demonstrated better predictive performance for meningioma consistency than combinedADC. T2WI and ADC histogram parameters may be imaging markers for predicting meningioma consistency.

Whole-tumor histogram analysis of multi-parametric MRI for differentiating brain metastases histological subtypes in lung cancers: relationship with the Ki-67 proliferation index.

This study aims to investigate the predictive value of preoperative whole-tumor histogram analysis of multi-parametric MRI for histological subtypes in patients with lung cancer brain metastases (BMs) and explore the correlation between histogram parameters and Ki-67 proliferation index. The preoperative MRI data of 95 lung cancer BM lesions obtained from 73 patients (42 men and 31 women) were retrospectively analyzed. Multi-parametric MRI histogram was used to distinguish small-cell lung cancer (SCLC) from non-small cell lung cancer (NSCLC), and adenocarcinoma (AC) from squamous cell carcinoma (SCC), respectively. The T1-weighted contrast-enhanced (T1C) and apparent diffusion coefficient (ADC) histogram parameters of the volumes of interest (VOIs) in all BMs lesions were extracted using FireVoxel software. The following histogram parameters were obtained: maximum, minimum, mean, standard deviation (SD), variance, coefficient of variation (CV), skewness, kurtosis, entropy, and 1st-99th percentiles. Then investigated their relationship with the Ki-67 proliferation index. The skewness-T1C, kurtosis-T1C, minimum-ADC, mean-ADC, CV-ADC and 1st - 90th ADC percentiles were significantly different between the SCLC and NSCLC groups (all p < 0.05). When the 10th-ADC percentile was 668, the sensitivity, specificity, and accuracy (90.80%, 76.70% and 86.32%, respectively) for distinguishing SCLC from NSCLC reached their maximum values, with an AUC of 0.895 (0.824 - 0.966). Mean-T1C, CV-T1C, skewness-T1C, 1st - 50th T1C percentiles, maximum-ADC, SD-ADC, variance-ADC and 75th - 99th ADC percentiles were significantly different between the AC and SCC groups (all p < 0.05). When the CV-T1C percentiles was 3.13, the sensitivity, specificity and accuracy (75.00%, 75.60% and 75.38%, respectively) for distinguishing AC and SCC reached their maximum values, with an AUC of 0.829 (0.728-0.929). The 5th-ADC and 10th-ADC percentiles were strongly correlated with the Ki-67 proliferation index in BMs. Multi-parametric MRI histogram parameters can be used to identify the histological subtypes of lung cancer BMs and predict the Ki-67 proliferation index.

Partition-Based Point Cloud Completion Network with Density Refinement.

In this paper, we propose a novel method for point cloud complementation called PADPNet. Our approach uses a combination of global and local information to infer missing elements in the point cloud. We achieve this by dividing the input point cloud into uniform local regions, called perceptual fields, which are abstractly understood as special convolution kernels. The set of point clouds in each local region is represented as a feature vector and transformed into N uniform perceptual fields as the input to our transformer model. We also designed a geometric density-aware block to better exploit the inductive bias of the point cloud's 3D geometric structure. Our method preserves sharp edges and detailed structures that are often lost in voxel-based or point-based approaches. Experimental results demonstrate that our approach outperforms other methods in reducing the ambiguity of output results. Our proposed method has important applications in 3D computer vision and can efficiently recover complete 3D object shapes from missing point clouds.

SFOD-Trans: semi-supervised fine-grained object detection framework with transformer module.

As the labeling cost of object detection for medical images is very high, semi-supervised learning methods for medical images are investigated. In this paper, semi-supervised fine-grained object detection framework with transformer module (SFOD-Trans) is proposed for hepatic portal vein detection. It adopts Sparse R-CNN as the backbone. In detection model, the transformer module is introduced and contrastive loss is added to improve the performance of fine-grained object detection. In order to complete the information transfer both of labeled and unlabeled pictures, a new fusion module named normalized ROI fusion (NRF) is designed based on the characteristics of hepatic portal vein. We run a large number of experiments on a dataset of 1000 real CT scans. The results show that Average Precision (AP) and Average Recall (AR) of the proposed method reach 0.773 and 0.831 respectively with the 300 labeled and 1500 unlabeled samples. An overview of semi-supervised fine-grained object detection framework with transformer module (SFOD-Trans). There are two parallel branches to train supervised loss and semi-supervised loss respectively.

An Evolutionary Multitasking-Based Feature Selection Method for High-Dimensional Classification.

Feature selection (FS) is an important data preprocessing technique in data mining and machine learning, which aims to select a small subset of information features to increase the performance and reduce the dimensionality. Particle swarm optimization (PSO) has been successfully applied to FS due to being efficient and easy to implement. However, most of the existing PSO-based FS methods face the problems of trapping into local optima and computationally expensive high-dimensional data. Multifactorial optimization (MFO), as an effective evolutionary multitasking paradigm, has been widely used for solving complex problems through implicit knowledge transfer between related tasks. Inspired by MFO, this study proposes a novel PSO-based FS method to solve high-dimensional classification via information sharing between two related tasks generated from a dataset. To be specific, two related tasks about the target concept are established by evaluating the importance of features. A new crossover operator, called assortative mating, is applied to share information between these two related tasks. In addition, two mechanisms, which are variable-range strategy and subset updating mechanism, are also developed to reduce the search space and maintain the diversity of the population, respectively. The results show that the proposed FS method can achieve higher classification accuracy with a smaller feature subset in a reasonable time than the state-of-the-art FS methods on the examined high-dimensional classification problems.

Multi-Scale Capsule Attention Network and Joint Distributed Optimal Transport for Bearing Fault Diagnosis under Different Working Loads.

In recent years, intelligent fault diagnosis methods based on deep learning have developed rapidly. However, most of the existing work performs well under the assumption that training and testing samples are collected from the same distribution, and the performance drops sharply when the data distribution changes. For rolling bearings, the data distribution will change when the load and speed change. In this article, to improve fault diagnosis accuracy and anti-noise ability under different working loads, a transfer learning method based on multi-scale capsule attention network and joint distributed optimal transport (MSCAN-JDOT) is proposed for bearing fault diagnosis under different loads. Because multi-scale capsule attention networks can improve feature expression ability and anti-noise performance, the fault data can be better expressed. Using the domain adaptation ability of joint distribution optimal transport, the feature distribution of fault data under different loads is aligned, and domain-invariant features are learned. Through experiments that investigate bearings fault diagnosis under different loads, the effectiveness of MSCAN-JDOT is verified; the fault diagnosis accuracy is higher than that of other methods. In addition, fault diagnosis experiment is carried out in different noise environments to demonstrate MSCAN-JDOT, which achieves a better anti-noise ability than other transfer learning methods.

Heartbeats Classification Using Hybrid Time-Frequency Analysis and Transfer Learning Based on ResNet.

The classification of heartbeats is an important method for cardiac arrhythmia analysis. This study proposes a novel heartbeat classification method using hybrid time-frequency analysis and transfer learning based on ResNet-101. The proposed method has the following major advantages over the afore-mentioned methods: it avoids the need for manual features extraction in the traditional machine learning method, and it utilizes 2-D time-frequency diagrams which provide not only frequency and energy information but also preserve the morphological characteristic within the ECG recordings, and it owns enough deep to make better use of performance of CNN. The method deploys a hybrid time-frequency analysis of the Hilbert transform (HT) and the Wigner-Ville distribution (WVD) to transform 1-D ECG recordings into 2-D time-frequency diagrams which were then fed into a transfer learning classifier based on ResNet-101 for two classification tasks (i.e., 5 heartbeat categories assigned by the ANSI/AAMI standard (i.e., N, V, S, Q and F) and 14 original beat kinds of the MIT/BIH arrhythmia database). For 5 heartbeat categories classification, the results show the F1-score of N, V, S, Q and F categories are F N 0.9899, F V 0.9845, F S 0.9376, F Q 0.9968, F F 0.8889, respectively, and the overall F1-score is 0.9595 using the combination data balancing. The results show the average values for accuracy, sensitivity, specificity, predictive value and F1-score on test set for 14 beat kinds the MIT-BIH arrhythmia database are 99.75%, 91.36%, 99.85%, 90.81% and 0.9016, respectively. Compared with other methods, the proposed method can yield more accurate results.

Practical Model for Energy Consumption Analysis of Omnidirectional Mobile Robot.

The four-wheeled Mecanum robot is widely used in various industries due to its maneuverability and strong load capacity, which is suitable for performing precise transportation tasks in a narrow environment. While the Mecanum wheel robot has mobility, it also consumes more energy than ordinary robots. The power consumed by the Mecanum wheel mobile robot varies enormously depending on their operating regimes and environments. Therefore, only knowing the working environment of the robot and the accurate power consumption model can we accurately predict the power consumption of the robot. In order to increase the applicable scenarios of energy consumption modeling for Mecanum wheel robots and improve the accuracy of energy consumption modeling, this paper focuses on various factors that affect the energy consumption of the Mecanum wheel robot, such as motor temperature, terrain, the center of gravity position, etc. The model is derived from the kinematic and kinetic model combined with electrical engineering and energy flow principles. The model has been simulated in MATLAB and experimentally validated with the four-wheeled Mecanum robot platform in our lab. Experimental results show that the accuracy of the model reached 95%. The results of energy consumption modeling can help robots save energy by helping them to perform rational path planning and task planning.

Extending the Frequency Range of Surface Plasmon Polariton Mode with Meta-Material.

The frequency range that surface plasmon polariton (SPP) mode exists is mainly limited by the metal material. With high permittivity dielectrics above metal surface, the SPP mode at high frequency has extremely large loss or can be cutoff, which limits the potential applications of SPP in the field of optical interconnection, active SPP devices and so on. To extend the frequency range of SPP mode, the surface mode guided by metal/dielectric multilayers meta-material has been studied based on the theory of electromagnetic field. It is demonstrated that surface mode not only could be supported by the meta-material but also extends the frequency to where conventional metal SPP cannot exist. Meanwhile, the characteristics of this surface mode, such as dispersion relation, frequency range, propagation loss and skin depth in meta-material and dielectrics, are also studied. It is indicated that, by varying the structure parameters, the meta-material guided SPP mode presents its advantages and flexibility over traditional metal one.

A Novel Mittag-Leffler Kernel Based Hybrid Fault Diagnosis Method for Wheeled Robot Driving System.

The wheeled robots have been successfully applied in many aspects, such as industrial handling vehicles, and wheeled service robots. To improve the safety and reliability of wheeled robots, this paper presents a novel hybrid fault diagnosis framework based on Mittag-Leffler kernel (ML-kernel) support vector machine (SVM) and Dempster-Shafer (D-S) fusion. Using sensor data sampled under different running conditions, the proposed approach initially establishes multiple principal component analysis (PCA) models for fault feature extraction. The fault feature vectors are then applied to train the probabilistic SVM (PSVM) classifiers that arrive at a preliminary fault diagnosis. To improve the accuracy of preliminary results, a novel ML-kernel based PSVM classifier is proposed in this paper, and the positive definiteness of the ML-kernel is proved as well. The basic probability assignments (BPAs) are defined based on the preliminary fault diagnosis results and their confidence values. Eventually, the final fault diagnosis result is archived by the fusion of the BPAs. Experimental results show that the proposed framework not only is capable of detecting and identifying the faults in the robot driving system, but also has better performance in stability and diagnosis accuracy compared with the traditional methods.

Design, implementation and application of distributed order PI control.

In this paper, a series of distributed order PI controller design methods are derived and applied to the robust control of wheeled service robots, which can tolerate more structural and parametric uncertainties than the corresponding fractional order PI control. A practical discrete incremental distributed order PI control strategy is proposed basing on the discretization method and the frequency criterions, which can be commonly used in many fields of fractional order system, control and signal processing. Besides, an auto-tuning strategy and the genetic algorithm are applied to the distributed order PI control as well. A number of experimental results are provided to show the advantages and distinguished features of the discussed methods in fairways.

[High temperature Raman spectra and structure study of stolzite-structured PbWO4 crystals and its melt].

Raman spectra of stolzite-structured PbWO4 crystal were recorded from 298 to 1 473 K. All the appearing vibrational modes were interpreted and assigned. The most intense mode at 902.7 cm(-1), which is identified as the internal mode upsilon1(Ag) of symmetrical stretching attributed to the vibration of [WO4]2- tetrahedron. Temperature dependent characteristics of the Raman spectra of the crystal were investigated. Band half-widths widened accompanied by the relative intensity decreased, and the lattice became more disorder with the increase in temperature. As being heated up to 1 398 K, PbWO4 crystals began to be melting and have completely transformed to liquid state at 1 473 K, while the internal vibrational modes of isolated [WO4]2- tetrahedron have appeared and the symmetry of vibrational modes transformed from S4 in crystal into Td of [WO4]2- in melt. It suggested that the isolated [WO4]2- structure unit exists in the melt.