Assigning a social status from face adornments: an fMRI study.

For at least 150,000 years, the human body has been culturally modified by the wearing of personal ornaments and probably by painting with red pigment. The present study used functional magnetic resonance imaging to explore the brain networks involved in attributing social status from face decorations. Results showed the fusiform gyrus, orbitofrontal cortex, and salience network were involved in social encoding, categorization, and evaluation. The hippocampus and parahippocampus were activated due to the memory and associative skills required for the task, while the inferior frontal gyrus likely interpreted face ornaments as symbols. Resting-state functional connectivity analysis clarified the interaction between these regions. The study highlights the importance of these neural interactions in the symbolic interpretation of social markers on the human face, which were likely active in early Homo species and intensified with Homo sapiens populations as more complex technologies were developed to culturalize the human face.

Anatomic features in SCAD assessed by CCT: A propensity score matching case control study.

PURPOSE: Spontaneous coronary artery dissection (SCAD) may occur in middle age population without any cardiovascular risk factor. We retrospectively evaluated anatomic features of 11 patients with SCAD using a coronary arteries computed tomography (CCT), compared to age and sex balanced patients who underwent CCT. MATERIAL AND METHODS: CCT was performed in 11 patients (7 females and 4 males) as follow-up in patients with SCAD (left anterior descending - LAD or circumflex artery - Cx) and compared, using the propensity score matching analysis, with 11 healthy patients. Several anatomic features were evaluated: Left main (LM) length, angle between descending coronary artery (LAD) and its first branch, angle between LAD and LM, distance from the annulus to RCA (a-RCA distance) and LM (a-LM distance) ostia and their ratio; ratio between LM length and length a-LM and tortuosity score of the vessel with SCAD. A fluid dynamic analysis has been performed to evaluate the effects on shear stress of vessels wall. RESULTS: LM length was significantly shorter in patients with SCAD versus healthy subjects (P=0.01) as well as LM length/a-LM (P=0.03) and the angle between LAD and the first adjacent branch was sharper (P<0.01). Tortuosity score showed a statistically significant difference between groups (P<0.001). Fluid dynamic analysis demonstrates that, in SCAD group, an angle<90 degree is present at the first bifurcation and it can be a cause of increased strain on vessel wall in patients with high tortuosity of coronary artery. CONCLUSION: Tortuosity and angle between the LAD and the adjacent arterial branch combined may determine increased shear stress on the vessel wall that increases the risk of SCAD.

Last Interglacial Iberian Neandertals as fisher-hunter-gatherers.

Marine food-reliant subsistence systems such as those in the African Middle Stone Age (MSA) were not thought to exist in Europe until the much later Mesolithic. Whether this apparent lag reflects taphonomic biases or behavioral distinctions between archaic and modern humans remains much debated. Figueira Brava cave, in the Arrábida range (Portugal), provides an exceptionally well preserved record of Neandertal coastal resource exploitation on a comparable scale to the MSA and dated to ~86 to 106 thousand years ago. The breadth of the subsistence base-pine nuts, marine invertebrates, fish, marine birds and mammals, tortoises, waterfowl, and hoofed game-exceeds that of regional early Holocene sites. Fisher-hunter-gatherer economies are not the preserve of anatomically modern people; by the Last Interglacial, they were in place across the Old World in the appropriate settings.

Neuroimaging supports the representational nature of the earliest human engravings.

The earliest human graphic productions, consisting of abstract patterns engraved on a variety of media, date to the Lower and Middle Palaeolithic. They are associated with anatomically modern and archaic hominins. The nature and significance of these engravings are still under question. To address this issue, we used functional magnetic resonance imaging to compare brain activations triggered by the perception of engraved patterns dating between 540 000 and 30 000 years before the present with those elicited by the perception of scenes, objects, symbol-like characters and written words. The perception of the engravings bilaterally activated regions along the ventral route in a pattern similar to that activated by the perception of objects, suggesting that these graphic productions are processed as organized visual representations in the brain. Moreover, the perception of the engravings led to a leftward activation of the visual word form area. These results support the hypothesis that these engravings have the visual properties of meaningful representations in present-day humans, and could have served such purpose in early modern humans and archaic hominins.

Dosimetric and chemical characteristics of Fricke gels based on PVA matrices cross-linked with glutaraldehyde.

Fricke gel radiochemical sensors based on various matrices have been studied for decades as 3D dosimeters for radiotherapy. Despite their many appealing features, progressive aging and blurring of the signal have prevented the widespread use of these dosimeters, so far. We have addressed these shortcomings and hereby present our development of a Fricke gel based on a chemically cross-linked PVA matrix. We investigated the influence of several parameters of the polymeric matrix on sensitivity, diffusion coefficient and spontaneous oxidation of the proposed gel dosimeter. Based on these findings, we optimized the gel compositions. Our new gel formulation combines transparency, high sensitivity and simple production method, typical of gels based on natural polymers, with low diffusion coefficient and slow spontaneous oxidation typical of PVA gels made by freezing-thawing.

Advanced readout methods for superheated emulsion detectors.

Superheated emulsions develop visible vapor bubbles when exposed to ionizing radiation. They consist in droplets of a metastable liquid, emulsified in an inert matrix. The formation of a bubble cavity is accompanied by sound waves. Evaporated bubbles also exhibit a lower refractive index, compared to the inert gel matrix. These two physical phenomena have been exploited to count the number of evaporated bubbles and thus measure the interacting radiation flux. Systems based on piezoelectric transducers have been traditionally used to acquire the acoustic (pressure) signals generated by bubble evaporation. Such systems can operate at ambient noise levels exceeding 100 dB; however, they are affected by a significant dead time (>10 ms). An optical readout technique relying on the scattering of light by neutron-induced bubbles has been recently improved in order to minimize measurement dead time and ambient noise sensitivity. Beams of infra-red light from light-emitting diode (LED) sources cross the active area of the detector and are deflected by evaporated bubbles. The scattered light correlates with bubble density. Planar photodiodes are affixed along the detector length in optimized positions, allowing the detection of scattered light from the bubbles and minimizing the detection of direct light from the LEDs. A low-noise signal-conditioning stage has been designed and realized to amplify the current induced in the photodiodes by scattered light and to subtract the background signal due to intrinsic scattering within the detector matrix. The proposed amplification architecture maximizes the measurement signal-to-noise ratio, yielding a readout uncertainty of 6% (±1 SD), with 1000 evaporated bubbles in a detector active volume of 150 ml (6 cm detector diameter). In this work, we prove that the intensity of scattered light also relates to the bubble size, which can be controlled by applying an external pressure to the detector emulsion. This effect can be exploited during the readout procedure to minimize shadowing effects between bubbles, which become severe when the latter are several thousands. The detector we used in this work is based on superheated C-318 (octafluorocyclobutane), emulsified in 100 µm ± 10% (1 SD) diameter drops in an inert matrix of approximately 150 ml. The detector was operated at room temperature and ambient pressure.

Estrogen receptor ß controls proliferation of enteric glia and differentiation of neurons in the myenteric plexus after damage.

Injury to the enteric nervous system (ENS) can cause several gastrointestinal (GI) disorders including achalasia, irritable bowel syndrome, and gastroparesis. Recently, a subpopulation of enteric glial cells with neuronal stem/progenitor properties (ENSCs) has been identified in the adult ENS. ENSCs have the ability of reconstituting the enteric neuronal pool after damage of the myenteric plexus. Since the estrogen receptor ß (ERß) is expressed in enteric glial cells and neurons, we investigated whether a selective ERß agonist, LY3201, can influence neuronal and glial cell differentiation. Myenteric ganglia from the murine muscularis externa were isolated and cultured in either glial cell medium or neuronal medium. In glial cell medium, the number of glial progenitor cells (Sox10+) was increased by fourfold in the presence of LY3201. In the neuronal medium supplemented with an antimitotic agent to block glial cell proliferation, LY3201 elicited a 2.7-fold increase in the number of neurons (neurofilament+ or HuC/D+). In addition, the effect of LY3201 was evaluated in vivo in two murine models of enteric neuronal damage and loss, namely, high-fat diet and topical application of the cationic detergent benzalkonium chloride (BAC) on the intestinal serosa, respectively. In both models, treatment with LY3201 significantly increased the recovery of neurons after damage. Thus, LY3201 was able to stimulate glial-to-neuron cell differentiation in vitro and promoted neurogenesis in the damaged myenteric plexus in vivo. Overall, our study suggests that selective ERß agonists may represent a therapeutic tool to treat patients suffering from GI disorders, caused by excessive neuronal/glial cell damage.

NEW DEVELOPMENTS AND APPLICATIONS OF SUPERHEATED EMULSIONS: WARHEAD VERIFICATION AND SPECIAL NUCLEAR MATERIAL INTERDICTION.

In recent years, neutron detection with superheated emulsions has received renewed attention thanks to improved detector manufacturing and read-out techniques, and thanks to successful applications in warhead verification and special nuclear material (SNM) interdiction. Detectors are currently manufactured with methods allowing high uniformity of the drop sizes, which in turn allows the use of optical read-out techniques based on dynamic light scattering. Small detector cartridges arranged in 2D matrices are developed for the verification of a declared warhead without revealing its design. For this application, the enabling features of the emulsions are that bubbles formed at different times cannot be distinguished from each other, while the passive nature of the detectors avoids the susceptibility to electronic snooping and tampering. Large modules of emulsions are developed to detect the presence of shielded special nuclear materials hidden in cargo containers 'interrogated' with high energy X-rays. In this case, the enabling features of the emulsions are photon discrimination, a neutron detection threshold close to 3 MeV and a rate-insensitive read-out.

Application of a Bonner sphere spectrometer for the determination of the angular neutron energy spectrum of an accelerator-based BNCT facility.

Experimental activities are underway at INFN Legnaro National Laboratories (LNL) (Padua, Italy) and Pisa University aimed at angular-dependent neutron energy spectra measurements produced by the (9)Be(p,xn) reaction, under a 5MeV proton beam. This work has been performed in the framework of INFN TRASCO-BNCT project. Bonner Sphere Spectrometer (BSS), based on (6)LiI (Eu) scintillator, was used with the shadow-cone technique. Proper unfolding codes, coupled to BSS response function calculated by Monte Carlo code, were finally used. The main results are reported here.

Development of anthropomorphic hand phantoms for personal dosimetry in 90Y-Zevalin preparation and patient delivering.

Anthropomorphic tissue-equivalent hand phantoms were achieved to measure the extremity dose involved in Zevalin (90)Y-labelling and patient delivering procedure for radioimmunotherapy treatment of non-Hodgkin lymphoma. The extremity doses to hands and wrists of operators were measured by using thermoluminescent detectors mounted on the developed phantoms. Measurements of chest- and lens-equivalent doses performed on a Rando phantom are also reported.

Transient global amnesia as the first symptom of primary antiphospholipid syndrome: a case report.

We describe the case of a 45-year-old woman who had drawn our attention for some recent episodes of transient global amnesia that, upon further examination, resulted from ischemic events caused by multiple arterial thrombosis (bilateral internal carotid occlusion, significant stenosis of the right external carotid, mild stenosis of the right vertebral artery, right anterior cerebral artery occlusion and severe stenosis of the anterior descending coronary artery) due to primary antiphospholipid syndrome. Revascularisation of either carotid was not attempted. A percutaneous intervention in the anterior descending coronary artery stenosis was performed successfully. Due to severe arterial thrombosis, the patient was discharged with only duplex antiplatelet treatment and subcutaneous anticoagulant therapy, since immunotherapy is not indicated in primary APS. The occurrence of transient global amnesia should raise the suspicion of APS.

The earliest evidence for the use of human bone as a tool.

We report on the analysis of three human cranial fragments from a Mousterian context at the site of La Quina (France), which show anthropogenic surface modifications. Macroscopic and microscopic analyses, including SEM observation, demonstrate that the modifications visible on one of these fragments are similar to those produced on bone fragments used experimentally to retouch flakes. The microscopic analysis also identified ancient scraping marks, possibly resulting from the cleaning of the skull prior to its breakage and utilisation of a resulting fragment as a tool. The traces of utilisation and the dimensions of this object are compared to those on a sample of 67 bone retouchers found in the same excavation area and layer. Results show that the tool size, as well as the dimensions and location of the utilised area, fall well within the range of variation observed on faunal shaft fragments from La Quina that were used as retouchers. This skull fragment represents the earliest known use of human bone as a raw material and the first reported use of human bone for this purpose by hominins other than modern humans. The two other skull fragments, which probably come from the same individual, also bear anthropogenic surface modifications in the form of percussion, cut, and scraping marks. The deliberate versus unintentional hypotheses for the unusual choice of the bone are presented in light of contextual information, modifications identified on the two skull fragments not used as tools, and data on bone retouchers from the same layer, the same site, and other Mousterian sites.

Angle and energy differential neutron spectrometry for the SPES BNCT facility.

An accelerator-driven thermal neutron facility for boron neutron capture therapy of skin melanoma is currently under construction at the Legnaro National Laboratories, Italy. The installation relies on the production of neutrons from a thick beryllium target bombarded with 5 MeV protons. A complete set of double differential data, i.e. angle- and energy-differential neutron spectra produced by the beryllium target, is necessary for the Monte Carlo-based design of the installation. For this purpose, double differential fluence measurements are currently performed with the "BINS" neutron spectrometer using 5 MeV protons at the "CN" Van de Graaf accelerator. This spectrometer uses a superheated emulsion of dichlorotetrafluoroethane which is sequentially operated at 25, 30, 35, 40, 45, 50 and 55 degrees C and thus provides a series of seven sharp thresholds covering the 0.1-10 MeV neutron energy interval. Deconvolution of the data is performed with the code "MAXED", which is based on the maximum entropy principle. The analysis of our first neutron spectrometry measurements at angles of 0 degrees, 40 degrees, 80 degrees and 120 degrees supports the viability of the BINS spectrometry method for the generation of the required double differential data.

Comparison of double dosimetry algorithms for estimating the effective dose in occupational dosimetry of interventional radiology staff.

'Double dosimetry' i.e. measurement with two dosemeters, one located above the protective apron and one under has been recommended in interventional radiology (IR) to determine the effective dose to staff. Several algorithms have been developed to calculate the effective dose from the readings of the two dosemeters, but there is no international consensus on what is the best algorithm. In this work, a few of the most recently developed algorithms have been tested in typical IR conditions. The effective dose and personnel dosemeter readings were obtained experimentally by using thermoluminescent dosemeters in and on a Rando-Alderson phantom provided with a lead apron. In addition, the effective dose and personnel dosemeter readings were calculated by the Monte Carlo method for the same irradiation geometry. The results suggest that most of the algorithms overestimate effective dose in the selected IR conditions, but there is also a risk of underestimation by using the least conservative algorithms. Two of the algorithms seem to comply best with the chosen criteria of performance, i.e. no underestimation, minimum overestimation and close estimation of effective dose in typical IR conditions. However, it might not be justified to generalise the results. It is recommended that whenever personnel doses approach or exceed the dose limit, IR conditions should be further investigated and the possibility of over- or under-estimation of effective dose by the algorithm used should be considered.

Evaluation of the calibration procedure of active personal dosemeters for interventional radiology.

An overview of the use of active personal dosemeters (APD) in interventional radiology is presented. It is based on the work done by the working package 7 of the CONRAD coordinated action supported by the EC within the frame of the 6th FP. This study was done in collaboration with the working package 4 of CONRAD to deal with the calculations required for studying the new calibration facility. The main requirements of the standard for the APD and the difficulties caused by the use of pulsed radiations are presented through the results of an intercomparison organised in a realistic calibration facility similar to the workplace situation in interventional radiology. The main characteristics of this facility are presented.

Overview of double dosimetry procedures for the determination of the effective dose to the interventional radiology staff.

In interventional radiology, for an accurate determination of effective dose to the staff, measurements with two dosemeters have been recommended, one located above and one under the protective apron. Such 'double dosimetry' practices and the algorithms used for the determination of effective dose were reviewed in this study by circulating a questionnaire and by an extensive literature search. The results indicated that regulations for double dosimetry almost do not exist and there is no firm consensus on the most suitable calculation algorithms. The calculation of effective dose is mainly based on the single dosemeter measurements, in which either personal dose equivalent, directly, (dosemeter below the apron) or a fraction of personal dose equivalent (dosemeter above the apron) is taken as an assessment of effective dose. The most recent studies suggest that there might not be just one double dosimetry algorithm that would be optimum for all interventional radiology procedures. Further investigations in several critical configurations of interventional radiology procedures are needed to assess the suitability of the proposed algorithms.

A new neutron monitor and extended conversion coefficients for HP(10).

A new personal dose equivalent monitor for neutrons, the 'HpSLAB', is introduced. The device consists of a 30x30x15 cm3 polymethyl-methacrylate slab hosting a superheated drop detector embedded at a depth of 10 mm. The personal dose equivalent monitor was characterised experimentally with fast neutron calibrations in the 0.144-14.8 MeV range and numerically with Monte Carlo simulations. In order to evaluate the performance of the device, its response was compared to the fluence-to-directional dose equivalent conversion coefficients, hp(10;alpha,E). Since published coefficients only cover neutron angles of incidence up to 75 degrees, a new extended set of coefficients was computed for angles of incidence up to 180 degrees. The method used in these calculations was the very same used in the generation of the dose equivalent coefficients recommended by International Commission on Radiological Protection publication 74. The response of the HpSLAB follows with good approximation the trend of the conversion coefficients for monoenergetic neutrons above approximately 0.5 MeV. The device was extensively tested in broad-spectrum workplace-fields encountered at nuclear installations and its response was on average within a factor 1.4 of the reference personal dose equivalent values, regardless of angle and energy distribution of the neutron fluence.

Neutron area survey instrument measurements in the EVIDOS project.

Neutron survey instruments have been exposed at all the measurement locations used in the EVIDOS project. These results have an important impact in the interpretation of the results from the project, since operationally the survey instrument will be used for an initial assessment of and routine monitoring of the ambient dose equivalent dose rate. Additionally, since the response of these instruments is in some cases very well characterised, their systematic deviations from the reference quantities provide an important verification of the determination of those quantities.

Application of workplace correction factors to dosemeter results for the assessment of personal doses at nuclear facilities.

Ratios of H(p)(10) and H*(10) were determined with reference instruments in a number of workplace fields within the nuclear industry and used to derive workplace-specific correction factors. When commercial survey meter results together with these factors were applied to the results of the locally used personal dosemeters their results improved and became within 0.7 and 1.7 of the reference values or better depending on the response of the survey meter. A similar result was obtained when a correction was determined with a prototype reference instrument for H(p)(10) after adjustment of its response. Commercially available survey instruments both for photon and neutron H*(10) measurements agreed with the reference instruments in most cases to within 0.5-1.5. Those conclusions are derived from results reported within the EC supported EVIDOS contract.