Neonatal Hearing Screening Associated with Congenital Syphilis and HIV.

Introduction: Hearing is fundamental for the development of newborns. The Universal Neonatal Hearing Screening (UNHS) in Brazil seeks to detect hearing loss early to minimize the impact on the child's hearing health. Some coping with underreporting of Sexually Transmitted Infections (STIs), such as congenital syphilis and HIV, are important, considering these situations are correlated with neonatal hearing loss. Objective: To assess the prevalence of congenital syphilis and HIV in newborns from two maternity hospitals in Greater Florianópolis and the impact on hearing, based on the results of the UNHS retest from 2018 to 2022. Methods: Retrospective cross-sectional study with secondary data of newborns treated at a SUS Hearing Health Care Service (SASA) between 2018 and 2022, referred for OAE and BAEP retests. Results: Of the 1211 newborns referred for retesting, 283 presented the investigated infections. Of these, 170 were diagnosed with congenital syphilis (59.86%), 105 were diagnosed with HIV (36.67%), and 8 with both infections (2.82%). When performing the retest, one newborn did not present a satisfactory auditory result, and the others passed when the OAE and BAEP tests were observed. Conclusion: UNHS is effective, and retests are fundamental in the screening and proper monitoring of the hearing health of newborns. Public health guidelines are evidenced, contributing to neonatal health and hearing health screening.

Hearing and Language Skills in Children Using Hearing Aids: Experimental Intervention Study.

INTRODUCTION: Hearing loss in childhood compromises a child's auditory, linguistic, and social skill development. Stimulation and early intervention through therapy and the use of personal sound amplification devices (PSAPs) are important for improving communication. PURPOSE: To verify the effectiveness of speech therapy intervention on the auditory and linguistic skills of Brazilian children aged between 6 and 8 years using PSAPs. METHODS: Experimental study analyzing the intervention process in children aged between 6 and 8 years with mild to severe bilateral hearing loss and prelingual deafness who are PSAP users. Diagnostic information was analyzed, and assessments and interventions were carried out using the Glendonald Auditory Screening Procedure (GASP), a phoneme discrimination test with figures (TFDF), an expressive language category classification test, and an Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS) questionnaire. RESULTS: Sixteen children participated in the study; they were divided into a control group (CG) of six children and an intervention group (IG) of ten children. All research subjects underwent two protocol application sessions, and the IG underwent six speech therapy intervention sessions. In the IT-MAIS, the CG had a 9% increase in score, and the IG had an increase of 3% after intervention. The TFDF obtained a 5% increase in the IG in terms of phonemic discrimination ability. The expressive language category classification tests and GASP were considered not sensitive enough to modify the parameters of auditory and linguistic skills. CONCLUSIONS: The study found a significant improvement amongst the IG in the TFDF protocol and an increase in IT-MAIS scores in both groups.

Risk for Severe Illness and Death among Pediatric Patients with Down Syndrome Hospitalized for COVID-19, Brazil.

Down syndrome is the most common human chromosomal disorder. Whether Down syndrome is a risk factor for severe COVID-19 outcomes in pediatric patients remains unclear, especially in low-to-middle income countries. We gathered data on patients <18 years of age with SARS-CoV-2 infection from a national registry in Brazil to assess the risk for severe outcomes among patients with Down syndrome. We included data from 14,684 hospitalized patients, 261 of whom had Down syndrome. After adjustments for sociodemographic and medical factors, patients with Down syndrome had 1.8 times higher odds of dying from COVID-19 (odds ratio 1.82, 95% CI 1.22-2.68) and 27% longer recovery times (hazard ratio 0.73, 95% CI 0.61-0.86) than patients without Down syndrome. We found Down syndrome was associated with increased risk for severe illness and death among COVID-19 patients. Guidelines for managing COVID-19 among pediatric patients with Down syndrome could improve outcomes for this population.

Does cognitive impairment precede self-reported poor hearing? Results from the English longitudinal study of ageing.

OBJECTIVE: To investigate whether cognitive impairment precedes self-reported poor hearing in adults aged 50 and older over a 14-year period. DESIGN: Biennial longitudinal study. STUDY SAMPLE: The data came from the English Longitudinal Study of Ageing carried out in England between 2002 and 2016, with 11,391 individuals aged 50 years and older. For this study, ELSA participants who had a positive perception of hearing at the beginning of the analysis in 2002 (n = 8,895) were eligible. The dependent variable was self-reported poor hearing, and the exposure measure was cognitive impairment. The analyses were performed using Generalised Estimation Equations and adjusted for gender, age, educational level, household wealth, smoking, alcohol consumption, depressive symptoms, ADL/IADL disability, physical activity level, diabetes, and cardiovascular disease. RESULTS: The results showed 33% increased odds of self-reported poor hearing in individuals with cognitive impairment. In the fully adjusted model, individuals who presented cognitive impairment in the previous wave had, over time, 10% increased odds (95% CI: 1.02; 1.19) of presenting self-reported poor hearing. CONCLUSIONS: The exposure to cognitive impairment was associated with a subsequent self-reported poor hearing. These data represent important tools for improving cognitive and hearing impairment diagnosis and treatment.

Neighbourhood walkability and mental health in older adults: A cross-sectional analysis from EpiFloripa Aging Study.

This study aims to analyse the association between walkability index and depressive symptoms and cognitive impairment and test the mediating role of moderate-vigorous physical activity (MVPA) in this relationship among older adults from Florianópolis, Brazil. This is cross-sectional research with data from the third wave of the EpiFloripa Aging cohort study, conducted in 2017-2019. Depressive symptoms were assessed using the short version of the Geriatric Depression Scale (GDS), and cognitive impairment, using the Mini-Mental State Examination (MMSE) scales. The neighbourhood environment was assessed using a walkability index, which considered 500-m network buffers around the participants' homes. Binary logistic regression analysis the association between the walkability index (quartile) and mental health outcomes (yes vs. no). Structural equation modelling evaluated the mediation between the walkability index and cognitive impairment by MVPA with an estimator of dichotomous variables. 1,162 people participated in the study (61.5% women, average age = 73.1). Older adults residing in places with a high and highest walkability index were 38% and 44% less likely to have cognitive impairment, respective. There was no association between depressive symptoms and walkability index in crude nor adjusted analysis. Engaging in MVPA had a partial but not significant effect (14%; p = 0.087), showing a tendency for this relationship to be partially explained by the greater engagement in physical activities in places with greater walkability. Policy planning to prevent and reduce the risks of cognitive impairment should consider factors of the physical environment as determinants in older adults.

Effects of Noise and Chemical Exposure on Peripheral and Central Auditory Pathways in Normal-hearing Workers.

Objectives: To assess the effects of noise and chemical exposure on peripheral and central auditory pathways in normal-hearing workers exposed to chemicals or high noise levels and compare the groups with each other and with workers not exposed to either of these agents. Methods: A total of 54 normal-hearing workers were divided into three groups (chemical, noise, control) and submitted to the following assessments: conventional and extended high-frequency pure-tone audiometry; transient and distortion-product otoacoustic emissions, the inhibitory effect of the efferent auditory pathway; and Staggered Spondaic Word (SSW) and Pitch Pattern Sequence (PPS) test. Results: There were no significant differences between the groups in extended high-frequency hearing thresholds. Significantly lower amplitudes were observed in the noise group for otoacoustic emissions. There were significantly more absences of the inhibitory effect of the efferent system in the noise group. There was no difference between the groups in the SSW test, while in PPS, the noise group performed worse than the control group. Conclusion: These findings suggest that noise exposure produced deleterious effects on the workers' peripheral and central auditory systems, despite their normal hearing thresholds. The chemical group did not have significantly different results from those of the control group. It is important that individuals exposed to noise or chemicals have their auditory pathways monitored with complementary assessments.

Is pregnancy a risk factor for in-hospital mortality in reproductive-aged women with SARS-CoV-2 infection? A nationwide retrospective observational cohort study.

OBJECTIVE: To examine the effect of pregnancy on coronavirus disease 2019 (COVID-19) -related in-hospital mortality in women of reproductive age (between 15 and 45 years), with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection confirmed with polymerase chain reaction tests, adjusted for factors such as co-infection and intervention that were not considered in existing literature. METHODS: Data gathered from a nationwide database in Brazil were analyzed using multivariate logistic regression and multivariate Cox regression. Adjusted odds ratios and hazard ratios of independent factors associated with in-hospital death were calculated. RESULTS: A total of 97 712 women were included in the study. After the adjustment for sociodemographic factors, epidemiologic characteristics, pre-existing medical conditions, and intervention, pregnant women were found to be associated with lower risk for in-hospital mortality as well as longer survival time compared with non-pregnant women. When covariates of intervention were omitted from the analysis, pregnancy did not appear to be a significant factor associated with mortality. CONCLUSION: With the adjustment for intervention that was shown to be an independent factor associated with mortality, pregnancy appeared to have a favorable effect on SARS-CoV-2 infection. Given the immunosuppressed state of pregnancy, this finding is in line with the hypothetical protective role of a weaker immune response that inhibits the production of proinflammatory cytokine.

Ototoxic effects of hydroxychloroquine.

OBJECTIVE: To present scientific evidence based on a systematic review of the literature (PRISMA), aiming to systematize evidence of the ototoxic effects of hydroxychloroquine (HCQ). METHODS: The studies were selected using a combination based on the Medical Subject Headings (MeSH). The databases searched were MEDLINE (PubMed), LILACS, SciELO, and BIREME, encompassing articles from January 2010 to May 2020, with no restrictions of language and place of publication. RESULTS: A total of 148 articles with the potential to be included were retrieved. Of these, two answered the research question, which consisted of seeking evidence of the ototoxic effects of hydroxychloroquine. These studies scored 11 in their quality assessment with the modified protocol by Pithon et al.13. CONCLUSIONS: The studies reported possible ototoxicity of HCQ. Audiovestibular changes, such as hearing loss, peripheral vestibular syndrome, and tinnitus were evidenced in patients submitted to HCQ. The improvement in the audiological examinations and the regression in the vestibular syndrome after stopping the treatment with HCQ are strong arguments in favor of the ototoxicity caused by this medication. However, there are still divergences about the relationship between ototoxic effects and the use of HCQ.

Self-Reported Hearing Loss and Associated Factors in Older Adults at a Memory Clinic.

Purpose The prevalence of dementia has increased in recent years and, along with hearing loss, can negatively impact the health of older adults. The purpose of this retrospective cross-sectional study was to establish self-reported hearing loss and associated factors in older adults at a memory clinic. Method Researchers conducted a retrospective cross-sectional study on factors associated with self-reported hearing loss (i.e., lifestyle, general health, cognition, functional capacity). Data were taken from medical records of older adults (≥ 60 years old) who received care between 2017 and 2018 at a memory clinic located at the Southern Santa Catarina University in Brazil. Analysis included the Pearson chi-squared test and logistic regression, estimation of the crude and adjusted odds ratios (OR), with respective confidence intervals of 95%. Results Researchers analyzed the medical records of 257 older adults and verified a prevalence of 13.2% of these adults with self-reported hearing loss. There was a higher prevalence of the outcome (i.e., self-reported hearing loss) in older adults who reported tinnitus (35.2%), those with mild cognitive impairment (14.7%), and those who were sedentary (19.2%). After adjustment for confusion factors, tinnitus (OR = 4.63; p = .019) and sedentarism (OR = 2.89; p = .029) were still associated with the outcome. Conclusions Tinnitus and sedentarism were associated with hearing loss in older adults receiving care at a memory clinic. As a public health issue, presbycusis needs to be included in the health planning and health promotion agendas, with effective control, prevention, and treatment measures.

Universal newborn hearing screening program and perinatal and congenital infections in neonates attended in South Brazil.

OBJECTIVE: To verify the characteristics of neonates with perinatal/congenital infections (PCI) receiving care at a Universal Newborn Hearing Screening (UNHS) program of a university hospital. METHODS: A retrospective cross-sectional study was conducted with secondary data, obtained from records of neonates with diagnosis of and/or suspicion for PCI who received care between 2017 and 2019. RESULTS: The information analyzed referred to 164 neonates who attended the service and were submitted to Newborn Hearing Screening (NHS). The most prevalent infection was syphilis (67.7%), followed by HIV (20.1%). An expressive number of neonates failed NHS (11.5%). An association was verified between the cases of syphilis and HIV and older mothers (p < 0.035). CONCLUSION: An increase in the prevalence of PCI was observed, proving it to be an important indicator, whereas these infections can be prevented. In all the years analyzed, syphilis was the most recurrent RIHL. NHS is a means of early diagnosis and intervention that must necessarily be performed in the first months of the child's life.

Ototoxic effects of hydroxychloroquine

SUMMARY OBJECTIVE To present scientific evidence based on a systematic review of the literature (PRISMA), aiming to systematize evidence of the ototoxic effects of hydroxychloroquine (HCQ). METHODS The studies were selected using a combination based on the Medical Subject Headings (MeSH). The databases searched were MEDLINE (PubMed), LILACS, SciELO, and BIREME, encompassing articles from January 2010 to May 2020, with no restrictions of language and place of publication. RESULTS A total of 148 articles with the potential to be included were retrieved. Of these, two answered the research question, which consisted of seeking evidence of the ototoxic effects of hydroxychloroquine. These studies scored 11 in their quality assessment with the modified protocol by Pithon et al.13. CONCLUSIONS The studies reported possible ototoxicity of HCQ. Audiovestibular changes, such as hearing loss, peripheral vestibular syndrome, and tinnitus were evidenced in patients submitted to HCQ. The improvement in the audiological examinations and the regression in the vestibular syndrome after stopping the treatment with HCQ are strong arguments in favor of the ototoxicity caused by this medication. However, there are still divergences about the relationship between ototoxic effects and the use of HCQ.

[Understanding the elderly user of auditory prostheses]. / Compreendendo o idoso usuário de próteses auditivas.

The main goal was to identify the factors involved in the application for and use of auditory prostheses by the elderly as well as their awareness of the Policy of Care to Auditory Health. 25 elderly people of both sexes using auditory prostheses in Vitória (Espírito Santo, Brazil) were selected. They were contacted by telephone to participate in the research by answering a questionnaire. The results demonstrated that most of the elderly people interviewed (52%) use the device all day which suggests good adaptation to the process. Thirteen elderly people reported that they contacted the prosthesis company of their own accord. The advantages involved better communication and listening to TV (64%) while the difficulties were due to noisy environments; 56% were unable to understand what was being said at lectures, in church, and on the telephone, 72% reported no improvement with the prosthesis. 88% of the elderly participants are unaware of donation policies for auditory devices and 100% are unaware of this kind of service. Research and practices in health services about auditory issues still have far to go. There is a need for a change in management with the objective of putting into action policies which define the responsibilities of the State.