Pan-cancer Comprehensive Analysis Identified EGFR as a Potential Biomarker for Multiple Tumor Types.

The epidermal growth factor receptor (EGFR) has been extensively studied for its critical role in the development and progression of various malignancies. In this comprehensive pan-cancer analysis, we investigated the potential of EGFR as a biomarker across multiple tumor types; a comprehensive analysis of EGFR gene mutation and copy number variation was conducted using cBioPortal and other tools. Utilizing multi-omics datasets from The Cancer Genome Atlas (TCGA), we analyzed EGFR's expression patterns, prognostic implications, genetic mutations, and molecular interactions in different cancers. Our findings revealed frequent dysregulation of EGFR in several tumor types, including lung cancers and glioblastoma multiforme. High EGFR expression was consistently associated with poor clinical outcomes, such as reduced overall survival, disease-free survival, and progression-free survival. Genetic alteration analysis indicated a high frequency of EGFR mutations and copy number variations, particularly in glioblastoma multiforme. Additionally, our study suggests a complex relationship between EGFR expression and cancer-associated fibroblast infiltration, which may contribute to an immunosuppressive tumor microenvironment. These findings underscore the clinical relevance of EGFR as a prognostic biomarker and therapeutic target, emphasizing the need for further research and the development of targeted therapies to enhance patient outcomes in cancers with EGFR alterations. The co-expression network of EGFR with genes and proteins involved in cell cycle regulation and mitotic control provided insights into the molecular mechanisms of oncogenesis.

The Implications of Sanctions on Civilian Mental Health and Quality of life Iranian: An overview.

BACKGROUND: The Islamic Republic of Iran has been under sanctions since 1979. These sanctions were further reinforced between the years 2005 and 2012. This study utilizes available data from Iran post-sanctions to review the impact of economic sanctions on both the mental health and the quality of life of Iranian citizens. METHODS: A comprehensive scoping review was conducted to identify studies examining the impact of sanctions on health in Iran. Searches were initiated in 2012 using PubMed/Medline, Embase, Web of Science, Scopus, and the Scientific Information Database (Iranian Database) with keywords such as sanctions, implications, mental health, quality of life, civilian mental health, and Iran. Subsequent to the screening process, secondary reports and letters to the editor were excluded. Only original studies-those collecting data via observation, interviews, surveys, experiments, or literature reviews-were retained for analysis. In addition to these search strategies, reference scanning was undertaken to identify additional articles pertinent to the scope of the current study. This thorough approach facilitated the discovery of relevant and significant articles exploring the effects of sanctions against Iran on the mental health and overall well-being of its civilian population. Following the search, duplicate articles were meticulously identified and removed by the authors. Data were subsequently extracted and summarized, focusing on study characteristics and the observed effects of sanctions on civilian mental health and quality of life in Iran. RESULT: Out of 165 items identified in the preliminary search, ten articles met the inclusion criteria. These selected articles highlighted the pronounced effects of sanctions on various health-related domains. CONCLUSION: Since 2012, Iran has been subject to intensified sanctions. There is evidence to suggest that the economic sanctions, imposed by Western nations, and have exerted a negative and detrimental impact on the health of individual Iranians.

Cachexia in tuberculosis in South-East Asian and African regions: knowledge gaps and untapped opportunities.

Tuberculosis (TB) and cachexia are clinical entities that have a defined relationship, making them often found together. TB can lead to cachexia, while cachexia is a risk factor for TB. This article reviews cachexia in Tuberculosis patients in Southeast Asian and African regions by conducting a comprehensive literature search across electronic databases such as PubMed, Google Scholar, and Research Gate between 2013 and 2024 using keywords including 'Africa', 'cachexia', 'prevalence', 'implications', 'tuberculosis', and 'Southeast Asia. This article utilized only studies that satisfied the inclusion criteria, revealing knowledge gaps and untapped opportunities for cachexia in TB across Southeast Asian and African regions. Many Southeast Asian and Western Pacific patients initially receive a tuberculosis diagnosis. Sub-Saharan African countries are among the 30 high TB burden nations, according to the WHO. Food inadequacy and heightened energy expenditure can impair the immune system, leading to latent TB and subsequently, active infection. Symptoms needing attention: shortness of breath, productive cough, hyponatremia at 131 mmol/l, hypoalbuminemia at 2.1 g/dl, elevated aspartate transaminase at 75 U/l, increased lactate dehydrogenase at 654, and normocytic anemia. Comorbidities, such as kidney disease, cardiovascular disease, and asthma, can influence the nutritional status of individuals with TB. While efforts like screening, contact tracing, and utilizing gene Xpert to detect TB cases were implemented, only a few proved effective. It is essential to conduct further studies, including RCTs, in Southeast Asia and Africa to evaluate and manage cachexia in TB patients.

Clinician perspectives of engaging parents in behavioural interventions: a thematic analysis in Aotearoa New Zealand.

PURPOSE: Engaging parents in child-focused interventions is considered important for intervention effectiveness but is rarely investigated in behaviour analysis literature. METHODS: This qualitative study conducted semi-structured interviews with 13 clinicians working with parents in child-focused behavioural interventions in Aotearoa New Zealand. Interpretive description was the overarching methodology for the study, with thematic analysis utilised to analyse data. The study was guided by the research question; 'how is parent engagement understood by behavioural clinicians?' RESULTS: Three themes were developed to explain the process of parent engagement from the perspective of clinicians: (a) establishing parent context and needs, (b), developing connection and relationship, (c) facilitating behaviour change. These findings suggest that parent engagement is heavily relational and occurs over time. CONCLUSIONS: Aligned with parent engagement literature from other allied health fields, this study highlights the relational and dynamic elements of engagement within a child-focused intervention. Behaviour analysts should focus on interpersonal connections with parents at the start of intervention and may benefit from additional training to achieve this.

Behavioural clinicians understand parent engagement as heavily informed by relationship and likely to change over time.Attending carefully to parent expectations, values, learning histories, and preferences at the start of intervention will support fostering of parent engagement in child treatments.Behaviour analysts should prioritise building connection with parents before focusing on levels of parent adherence to developed interventions.

A case of intra-abdominal textiloma mimicking a mesenteric tumor.

INTRODUCTION: A textiloma or gossypiboma is a retained surgical material in the body after an operation. It may be asymptomatic or revealed by complications such as occlusion, perforation, and fistulization. CASE REPORT: We report a case of intraabdominal textiloma mimicking a mesenteric tumor. The patient has a history of open cholecystectomy. She was referred to our department for the discovery on abdominal computed tomography scan (CT-scan) of a mass in the mesentery. A laparotomy was performed observing a textiloma which was resected with part of the small intestine. The evolution was satisfactory for the patient. DISCUSSION: Intraabdominal textiloma is the most frequently observed foreign body left after a surgical procedure. They can be asymptomatic or discovered incidentally for another cause. We describe two types of immune responses, tansudative and exudative response, depending on the antigenicity of the foreign body. Surgical resection is the gold standard of treatment. CONCLUSION: Although they are rare, these foreign bodies can present real complications after an open surgery.

Long-lasting effects of post-traumatic stress disorder in Yazidi women living in Northern Iraqi camps.

The severity of post-traumatic stress disorder and its long-lasting effects among the Yazidi population has not yet been investigated. Objectives: This study evaluated the impact of PTSD severity and chronicity on physiological and anthropometric parameters in women survivors of the genocide-related events after the so-called Islamic State of Iraq and Syria (ISIS) attack in 2014. Methods: The diagnosis PTSD was assessed using PTSD Checklist for DSM-5 (PCL-5). Participants were divided into: External control (healthy individuals living outside the camps), Internal control (healthy individuals living in the camps), and PTSD group (individuals diagnosed with PTSD). The PTSD group was subdivided according to chronicity <2 years, 2-5 years, and >5 years and subdivided according to PTSD severity into "Moderate", "Severe" and "Extreme". Systolic blood pressure (SBP), diastolic blood pressure (DBP), blood oxygen saturation (SPO2) and heart rate (HR) were evaluated. Weight, height and waist circumference were measured. Body mass index (BMI) and waist-to-height ratio (WHtR) were calculated. Results: The PTSD group showed significant increases in SBP, DBP, heart rate, BMI, WC, weight, and WHtR compared to the control groups. SPO2 values decreased in the PTSD group. As the disease progressed, there were further increases in SBP, DBP, heart rate, BMI, WC, WHtR, and weight. Similar increases were observed with the severity of the disease. Conclusion: Our data indicates that a long-term impact on physiological and anthropometric parameters is present in women diagnosed with PTSD which might be aggravated by the severity and chronicity of the disease.

The impact of fuel cell vehicles deployment on road transport greenhouse gas emissions through 2050: Evidence from 15 G20 countries.

As global concern over the negative impacts of global warming, primarily caused by using passenger vehicles (PVs), the transition to hydrogen fuel cell vehicles (HFCVs) is an essential alternative for reducing greenhouse (GHG) emissions. This research employs a bottom-up approach to analyze road vehicle fleet's GHG emissions. We calculated GHG emissions from PVs in 15 Group of Twenty (G20) countries based on four scenarios adopting the global HFCVs from 2024 to 2050. This paper introduces business-as-usual (BaU), moderate, aggressive, and non-HFCVs scenario. The results show that the aggressive scenario has the highest sales, estimated between 62,000 and 29.48 million vehicles by 2050, with global hydrogen market penetration rates 48.48%. Building on countries' respective national strategies, the findings highlight China and India as the leading markets for hydrogen demand, with Germany and Japan also showing significant interest. The aggressive scenario further demonstrates that transitioning from internal combustion engine vehicles (ICEVs) to battery electric vehicles (BEVs), plug-in hybrid electric vehicles (PHEVs), and HFCVs can significantly reduce annual GHG emissions. Ultimately, this study finds that the transition to HFCVs could reduce emissions by up to 67.09% by 2050.

Awareness of COPD in low-and middle-income countries and implications for treatment.

INTRODUCTION: COPD is the 3rd leading cause of death worldwide, affecting an estimated 212.3 million people. More than 80% of this burden occurs in low- and middle-income countries. One of the major reasons for this growing burden, is the lack of awareness of COPD among all levels. AREAS COVERED: In this review article, we studied the level of awareness of COPD among lay people, health care providers and policy makers in the LMICs. Search engines including Google Scholar, PubMed, and Scopus were used for relevant articles. Articles spanning from 1990 to March 2024 were screened on COPD awareness in LMICs and its treatment implications using a combination of key words. EXPERT OPINION: We report that the overall awareness of COPD is low at all levels. There are several reasons such as poverty, illiteracy, societal beliefs, cultural beliefs, and misconceptions. This is associated with increase in suffering, deaths, and economic loss, due to poor adaption correct prescription and compliance to treatment. And very little is being done to improve the current status. COPD needs to be highlighted in the national programs in LMICs.

Recent Southern Hemisphere Lamprimine Stag Beetle in Cretaceous Burmese Amber and Its Biogeographic Implications (Coleoptera: Lucanidae).

A new stag beetle fossil, Prostreptocerus burmiticus Yu & Cai gen. et sp. nov., is described based on a single male specimen. This is the first representative of the subfamily Lampriminae (Coleoptera: Scarabaeoidea: Lucanidae) from mid-Cretaceous Burmese amber. The new species is distinctive among Lucanidae due to its well-developed, right-angled mandible, frons featuring a pair of large protuberances, a coarse and sparsely punctate elytral disc, and large tubercles on the humeri. Prostreptocerus Yu & Cai is placed within Lampriminae based on several key characteristics. Morphologically, it is most similar to the extant Streptocerus Fairmaire, 1850. The current distribution of Streptocerus and Lampriminae is primarily restricted to the Southern Hemisphere, suggesting that this lineage is ancient and existed on Gondwanaland, which has significant geographical implications. This discovery extends the fossil record of Lampriminae and provides additional evidence for the existence of sexual dimorphism and potential combat behavior in Mesozoic lucanids. Additionally, Electraesalopsis Bai, Zhang & Qiu, 2017, previously placed as Lucanidae incertae sedis, shares many characteristics with Prostreptocerus Yu & Cai and is also assigned to Lampriminae based on a suite of traits.

Improving environmental and economic sustainability of cutlery manufacturing in a developing nation through energy reduction and energy transition initiatives.

Manufacturing industries are vital for economic development, but they cause significant environmental damages. As there are scarce research studies for this industrial sector from developing countries, this article reports a comprehensive environmental and economic analyses for cutlery manufacturing in Pakistan. SimaPro 9.5 was used as a modelling software tool, while ReCiPe 2016 methods were used to evaluate various midpoint and endpoint environmental impacts. Various economic indicators were used to evaluate the economic performance of different alternative scenarios. The results revealed that injection molding process, due to its energy-intensive nature caused the most environmental impacts as compared to other manufacturing processes. Global warming and terrestrial ecotoxicity were the most affected impact categories with values of 11.8 kg CO2 eq and 12.0 kg 1,4-DCB, respectively. Meanwhile, at endpoint level, human health category was most damaged as compared to others. Based on technical process intervention and energy transition, four different alternative scenarios were developed. In comparison with baseline scenario, the alternative scenario with double-cavity mold resulted in a reduction of more than 30% for various impact categories. The other three alternatives were grounded on the use of solar energy (50% or 100%) and injection mold with double or single cavity. Overall, the alternative scenario with 50% solar energy and double-cavity mold was the best solution that showed more than 50% reduction in most of the impact categories, less than 3-year payback time, 2.12 million (Pakistani Rupees) net present value, and 36.3% of return on investment. This study clearly shows the importance of renewable energy resources and simple changes in process technology for improving sustainability performance. The relevant stakeholders can effectively use the results and methodology of this study as a reference and guide for future research and practical interventions, especially in developing countries.

Mesenchymal Stem/Stromal cells in solid tumor Microenvironment: Orchestrating NK cell remodeling and therapeutic insights.

Mesenchymal stem/stromal cells (MSCs), originating from normal tissues, possess the capacity to home to tumor sites and differentiate into tumor-associated MSCs (TA-MSCs), which are instrumental in shaping an immunosuppressive milieu within tumors. Natural killer (NK) cells, integral to the innate immune system, are endowed with the ability to eradicate target cells autonomously, serving as an immediate defense against neoplastic growths. Nonetheless, within the tumor microenvironment (TME), NK cells often exhibit a decline in both their numerical presence and functionality. TA-MSCs have been shown to exert profound inhibitory effects on the functions of tumor-infiltrating immune cells, notably NK cells. Understanding the mechanisms by which TA-MSCs contribute to NK cell dysfunction is critical for the advancement of immune surveillance and the enhancement of tumoricidal responses. This review summarizes existing literature on NK cell modulation by TA-MSCs within the TME and proposes innovative strategies to augment antitumor immunity.

Detection and health implications of phthalates in tea beverages in market: Application of novel solid-phase microextraction fibers.

Assessment and control of emerging organic pollutants in food have become critical for global food safety and health. The European Union has set standards for certain emerging organic pollutants, such as phthalic acid esters (PAEs) in food. Because of being endocrine disruptors, PAEs are toxic and carcinogenic to humans. Release of PAEs from packaging materials poses a potential risk to human health and causes environmental pollution. In this study, a highly sensitive analytical method for the detection of PAE contents in tea beverages was established using hydroxyl-functionalized covalent organic frameworks (COFs) as solid-phase microextraction (SPME) coating. Results indicate that functionalization with hydroxyl groups enhances the adsorption of PAEs. The proposed method exhibits a wide linear range (1-20,000 ng L-1), low limits of detection (> 0.048 ng L-1), and satisfactory recovery (72.8 %-127.3 %). To investigate the PAE contamination in beverages, contamination levels of six typical PAEs and their health impacts were surveyed across various brands/types/packaging materials of tea beverages sold in China. Results of the hazard quotient and hazard index approaches suggest no or extremely low health concerns regarding PAE levels. We observe that hydroxyl groups functionalized on COFs enhance the adsorption of PAEs. Moreover, an important outcome of this study is development of an efficient and sensitive direct detection method for PAEs in complex tea matrices, providing a reliable approach for the assessment of PAEs in other complex matrices.

Co-worker phubbing: A qualitative exploration of smartphone use during work breaks.

INTRODUCTION: The present study qualitatively explores co-worker "phubbing" (from "phone" and "snubbing") during communal work breaks. Phubbing, or ignoring others by paying attention to one's phone, has been linked to a range of negative interpersonal and intrapersonal outcomes. Although most research has targeted private relationships, there are indications that lateral work relationships may be similarly affected, with potential consequences at the individual, group, and organizational levels. METHODS: Interviews were conducted with 25 Swedish employees in the electrical trade (n = 13) and health care (n = 12), groups that typically work alongside colleagues and regularly take communal breaks. The interviews were analyzed using thematic analysis. RESULTS: Five main themes were identified: (1) phubbing as a social barrier, (2) the socially integrated smartphone, (3) intentional and unintentional phubbing, (4) navigating phubbing norms, and (5) generational differences in phubbing behavior and attitudes. CONCLUSION: The findings indicate that work break phubbing could potentially undermine interpersonal aspects of the psychosocial work environment. However, this was also seen as contingent on social norms and individual needs and preferences. Discussing phubbing in the workplace may be a way of mitigating negative effects by bridging disparate expectations.

Federated systems for automated infection surveillance: a perspective.

Automation of surveillance of infectious diseases-where algorithms are applied to routine care data to replace manual decisions-likely reduces workload and improves quality of surveillance. However, various barriers limit large-scale implementation of automated surveillance (AS). Current implementation strategies for AS in surveillance networks include central implementation (i.e. collecting all data centrally, and central algorithm application for case ascertainment) or local implementation (i.e. local algorithm application and sharing surveillance results with the network coordinating center). In this perspective, we explore whether current challenges can be solved by federated AS. In federated AS, scripts for analyses are developed centrally and applied locally. We focus on the potential of federated AS in the context of healthcare associated infections (AS-HAI) and of severe acute respiratory illness (AS-SARI). AS-HAI and AS-SARI have common and specific requirements, but both would benefit from decreased local surveillance burden, alignment of AS and increased central and local oversight, and improved access to data while preserving privacy. Federated AS combines some benefits of a centrally implemented system, such as standardization and alignment of an easily scalable methodology, with some of the benefits of a locally implemented system including (near) real-time access to data and flexibility in algorithms, meeting different information needs and improving sustainability, and allowance of a broader range of clinically relevant case-definitions. From a global perspective, it can promote the development of automated surveillance where it is not currently possible and foster international collaboration.The necessary transformation of source data likely will place a significant burden on healthcare facilities. However, this may be outweighed by the potential benefits: improved comparability of surveillance results, flexibility and reuse of data for multiple purposes. Governance and stakeholder agreement to address accuracy, accountability, transparency, digital literacy, and data protection, warrants clear attention to create acceptance of the methodology. In conclusion, federated automated surveillance seems a potential solution for current barriers of large-scale implementation of AS-HAI and AS-SARI. Prerequisites for successful implementation include validation of results and evaluation requirements of network participants to govern understanding and acceptance of the methodology.

Extended lactations in dairy cows and the effects on fertility and production.

Extending lactation length reduces the frequency of critical calving events for the cow and herewith reduces the frequency of periods with increased risk for health problems. Moreover, breeding is postponed until a moment later in lactation, which is associated with better conception rates and less days open after start of the breeding period in most studies. Potential risks of an extended lactation are that milk yield of cows at the end of the lactation may be too low which may lead to cows being overconditioned at the end of the extended lactation. Therefore, extending lactation length might not fit every cow. Individual cow characteristics like parity, milk yield level, or body condition determine the response of the cow to an extended lactation. These individual cow characteristics can be used in customized management strategies to optimize lactation length for individual cows. Customized lactation length for individual cows could limit the impact at herd level of disadvantages concerning milk losses and overconditioning and maintain benefits for improved cow health and fertility, reduced number of surplus calves and increased work satisfaction for the farmer. In conclusion, extending lactation length has interesting perspectives for health and fertility of high-producing dairy cows, although questions remain concerning management approaches to support lactation persistency of cows with an extended lactation, and consequences for calf health and development. Moreover, ongoing studies aim to develop decision support tools to select individual cows for a specific lactation length.

Endometriosis: A Comprehensive Exploration of Inflammatory Mechanisms and Fertility Implications.

Endometriosis is a prevalent gynecological disorder characterized by the ectopic growth of endometrial-like tissue outside the uterus. This condition poses significant challenges due to its chronic nature, debilitating symptoms such as pelvic pain and infertility, and substantial impact on quality of life. Central to the pathogenesis of endometriosis are inflammatory mechanisms that perpetuate tissue proliferation, adhesion formation, and immune dysregulation within the pelvic cavity. Inflammation plays a pivotal role in the development and progression of endometriosis, influencing the severity of symptoms and complications associated with the disease. Dysregulated immune responses contribute to the persistence of ectopic endometrial implants, exacerbating pelvic pain and other symptoms experienced by affected individuals. Moreover, the inflammatory milieu created by endometriotic lesions disrupts normal ovarian function, impairs follicular development, and compromises reproductive outcomes, thereby posing challenges to fertility. This review comprehensively explores the inflammatory mechanisms underlying endometriosis and their implications for fertility. Synthesizing current research and clinical insights elucidates the intricate interplay between inflammation, disease progression, and reproductive health outcomes. Understanding these complex interactions is essential for developing targeted diagnostic strategies and optimizing therapeutic approaches tailored to alleviate symptoms and improve fertility outcomes in individuals with endometriosis. Ultimately, this review aims to enhance the understanding of endometriosis pathophysiology, inform clinical practice, and stimulate further research to advance personalized care and management strategies for this challenging condition.

Specialists regulate microbial network and community assembly in subtropical seagrass sediments under differing land use conditions.

Microorganisms in the sediment play a pivotal role in the functioning and stability of seagrass ecosystems and their dynamics are influenced by the nutrient acquisition strategies of host plants. While the distinct impacts of microbial generalists and specialists on community dynamics are recognized, their distribution patterns and ecological roles within seagrass ecosystems remain largely unexplored. To address this issue, we conducted an analysis of community assembly processes and co-occurrence relationships of both microbial generalists and specialists within sediment profiles (0-100 cm) from seagrass habitats subjected to differing land use conditions. The results revealed that seagrasses in Yifeng Estuary experienced the large proportion of cultivated land and exhibited higher organic carbon content in the 0-20 cm surface sediment layer. Nitrogen-cycling bacteria were predominantly associated with seagrasses from Yifeng Estuary, whereas Vibrio spp. was more prevalent in seagrasses from Liusha Bay. Notably, seagrass Halophia beccarii (YHB) in Yifeng Estuary harbored higher niche breadths for both microbial generalist and specialist compared to Halodule uninervis (LHU) and Halophia ovalis (LHO) from Liusha Bay. Stochastic processes were pivotal in shaping seagrass sediment microbial communities, with a higher immigration rate observed in YHB, suggesting greater microbial turnover in this area. Additionally, YHB sediment presented lower drift and higher dispersal limitation among generalists compared to LHU and LHO, whereas the pattern was reversed among specialists. Specialists were found to play a crucial role in shaping microbial interactions within YHB sediment, with genera Halioglobus identified as keystone species in the network. The specialists were further found to significantly influence microbial ß-diversity in seagrass sediment directly. Overall, our findings illustrated how microbial generalists and specialists were distributed in seagrass sediments in response to land use changes and provided new insights into the potential roles of microbial regulation in degraded seagrass ecosystems.

Social Determinants of COVID-19 Pandemic Control: Participatory Learnings From Everyday Experiences in Cape Town, South Africa.

INTRODUCTION: As countries adapted their disaster responses to the COVID-19 pandemic, South Africa responded with an alert-level risk approach based on epidemiological principles that impacted all societal levels. We explored the everyday experiences of people in Cape Town whose basic needs were met and who could report on the realities of the COVID-19 pandemic control. Gaining insight into their perspectives contributes to knowledge that can inform policies and practices for managing future public health crises. METHODS: Community-Based Participatory Research principles guided the design and a series of facilitated dialogues with 18 research participants. The thematic analysis was deepened through two colloquiums with members of an overarching research consortium and a participant reflection workshop. FINDINGS: The pandemic impacted individuals, their interpersonal relationships, workplaces and communities, leading to societal processes such as stigma, virtue signalling and the subversion of mandates. The public health response had mixed reactions, with useful information about preventive measures being diluted by COVID-19 denialism and fake news. Health and other authorities were frequently perceived as out of touch with, and unresponsive to, the everyday realities of local communities. CONCLUSIONS: Our study demonstrates the connectedness of people and the need to maintain and re-establish severed connections. A holistic approach to health care and promotion from social determinants of health and a community-engaged perspective may significantly increase the outcomes of public health responses. PARTICIPANT AND PUBLIC CONTRIBUTION: People with everyday experience of the COVID-19 pandemic-including community members, healthcare workers, case managers, carers and researchers-collaborated on the study design, interview schedule, data interpretation, analysis and refinement of this article.

Current opportunities and challenges of immersive virtual reality for psychological research and application.

Immersive virtual reality (iVR), that is, digital stereoscopic 360° scenarios usually presented in head-mounted displays, has gained much popularity in medical, educational, and consumer contexts in the last years. Recently, psychological research started to utilize the theoretical and methodological advantages of iVR. Furthermore, understanding cognitive, emotional, and behavioral processes in iVR similar to real-life is a genuinely psychological, currently understudied topic. This article briefly reviews the current application of iVR in psychological research and related disciplines. The review presents empirical evidence for opportunities and strengths (e.g., realism, experimental control, effectiveness of therapeutic and educational interventions) as well as challenges and weaknesses (e.g., differences in experiencing presence, interacting with VR content including avatars, i.e., graphical representation of a person). The main part discusses areas requiring additional basic research, such as cognitive processes, socio-emotional processes during social interactions in iVR, and possible societal implications (e.g., fraud, VR-addiction). For both research and application, iVR offers a contemporary extension of the psychological toolkit, offering new avenues to investigate and enhance core phenomena of psychology such as cognition, affect, motivation, and behavior. Still, it is crucial to exercise caution in its application as excessive and careless use of iVR can pose risks to individuals' mental and physical well-being.