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1.
Artigo em Inglês | MEDLINE | ID: mdl-39324366

RESUMO

PURPOSE: This study aimed to compare the range of motion (ROM), surgical outcomes, and patient-reported outcome measures (PROMs) following anterior cruciate ligament (ACL) reconstruction outcomes in patients 60 years or older at the time of surgery to 40- to 59-year-old patients. METHODS: In this retrospective cohort study from 2015 to 2022, a 3:1 propensity match was performed to match late adulthood patients (≥60 years old) undergoing ACL reconstruction with middle adulthood (40-59 years old) ACL reconstruction patients. Patients were matched based on sex, ACL graft utilized and concomitant procedures performed during ACL reconstruction. Statistical analysis compared demographics, preoperative injury management, surgical outcomes, PROMs, and minimal clinical important difference (MCID) and substantial clinical benefit (SCB) achievement rates for all ACL reconstruction patients included. RESULTS: Twenty late adulthood and 60 middle adulthood patients who underwent ACL reconstruction were included in the final cohort. Patients who were 60 years or older experienced no difference in reoperation rate (n.s.), incidence of retears (n.s.) or ROM (n.s.) at 1 year post-operatively. There were also no differences in International Knee Documentation Committee (ΔIKDC) (31.3 ± 19.1 vs. 34.2 ± 18.2, n.s.) or ΔPCS-12 (12.4 ± 9.8 vs. 12.9 ± 10.8, n.s.) scores at 1 year post-operatively. Furthermore, the younger and older patient cohorts demonstrated similar rates of achieving the MCID (80.0% vs. 83.3%, n.s.) and SCB (50.0% vs. 61.7%, n.s.) scores for IKDC. CONCLUSION: Patients 60 years or older and 40- to 59-year-old patients demonstrated similar outcomes after undergoing ACL reconstruction with allograft. This study concludes that ACL reconstruction in late adulthood can still be a successful treatment option and should allow surgeons to feel more comfortable when performing indicated surgical intervention for older patients who experience an ACL tear. LEVEL OF EVIDENCE: Level III, Therapeutic III, retrospective cohort study.

2.
Games Health J ; 2024 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-39069966

RESUMO

Purpose: Although the health benefits of behavioral interventions for older adults are well studied, research focused on intervention acceptability in older adult populations is less established and is needed. This mixed methods study investigated older adults' perceptions of training interventions. Methods: Community-dwelling older adults (N = 41) were randomized into three groups (cognitive, physical, and exergame) and completed 20 in-lab training sessions over 10 weeks. At every fifth session, participants provided feedback on their perceived gains across functional domains, enjoyment of and motivation to complete training, and aspects they most and least enjoyed regarding study participation. Results: Based on the multivariate analysis of variance, perceived cognitive and everyday function gains did not vary by training group. However, physical and exergame groups perceived greater improvement in physical function than the cognitive training group (P < 0.001). Enjoyment of and motivation to complete training did not vary by training group. Exploratory qualitative coding results suggest that participants across groups most enjoyed social interaction and feelings of improvement. Participants least enjoyed traveling to the study site and engaging in aspects of training (e.g., specific games, structure or duration of training). Conclusion: These findings highlight the importance of incorporating meaningful social engagement and balancing the challenge of training components with goal attainment when working with older adults, regardless of the intervention type. Future research and practice should consider salient aspects of the participant experience (e.g., social connection, accessible locations or remote options) when designing interventions for older adults.

3.
Int J Public Health ; 69: 1606499, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38961855

RESUMO

Objectives: We aimed to assess later-life health responses to childhood and lifetime adversity in a cohort of rural, Black South African adults. Methods: We performed ordinary least squares regression using two waves of data from Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI) to estimate a decline in cognitive, mental, and physical health over approximately 3 years. Our analytic sample consisted of 1,993 women and 1,496 men. Results: Associations between several types of adversity and health outcomes point to declines in health. At the same time, many adverse experiences are associated with improvements in cognitive, mental, and physical health in later life. The direction of the association varied by type of exposure, health outcome, and gender. Conclusion: In populations exposed to many adversities during life, specific adverse experiences may sometimes be associated with greater improvements (and not just greater decline) in health in later life. Further research is needed to unpack the mechanisms at play in these populations.


Assuntos
Nível de Saúde , Saúde Mental , Humanos , Masculino , Feminino , África do Sul , Estudos Longitudinais , Pessoa de Meia-Idade , Idoso , Cognição , Adulto , Experiências Adversas da Infância/estatística & dados numéricos , População Rural
4.
Aging Ment Health ; 28(10): 1326-1333, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-38444324

RESUMO

OBJECTIVES: Resilience during old age reflects the capacity to adapt to changes and challenges associated with normative aging and is an important component of successful aging. Belief in the incremental theory of intelligence and personality could help older adults maintain cognitive functioning and social engagement, which may further contribute to their resilience. The current study investigated how implicit theories of intelligence and personality affected older adults' resilience and examined cognitive functioning and social participation as two mediators. METHOD: A total of 108 older adults aged 60-92 were recruited and completed relevant scales and cognitive tasks. Path analyses were conducted to estimate the expected mediation model. RESULTS: The incremental theory of intelligence, but not personality, was positively related to older adults' resilience. Both cognitive functioning and social participation mediated the effect of the implicit theory of intelligence in the model without covariates. When background variables were controlled, the mediation effect of cognitive functioning remained significant, while the link between the implicit theory of intelligence and social participation was weakened. CONCLUSION: Older adults' implicit theory of intelligence plays a significant role in fostering resilience in late adulthood, especially through maintaining older adults' cognitive functioning.


Assuntos
Cognição , Inteligência , Personalidade , Resiliência Psicológica , Participação Social , Humanos , Idoso , Masculino , Feminino , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Participação Social/psicologia , Envelhecimento/psicologia
5.
Curr Opin Psychol ; 55: 101730, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38006625

RESUMO

In this review, we argue that in late adulthood adults adjust their goals at three levels to cope with age-related challenges: At the highest level, they narrow their goal systems by selectively pursuing fewer goals from important life domains that are mutually supportive, by abandoning goals, and by focusing on agency protection. At the mid-level of individual goals, older adults show changes in goal content, goal importance, goal orientation, and goal focus, indicating, for example, a relative increase in intrinsic goals. Finally, but worthy of future investigation, older adults may show adjustments on the level of means and strategies for goal pursuit. Individual differences in such adaptations also contribute to differences in goal commitment, well-being, and psychopathology in late adulthood.


Assuntos
Objetivos , Motivação , Humanos , Idoso , Adulto , Individualidade , Psicopatologia
6.
Curr Opin Psychol ; 55: 101731, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38007918

RESUMO

Meta-analytic evidence shows that most personality traits tend to increase through early adulthood and middle age but decrease in late adulthood, whereas Emotional Stability continues to increase throughout late adulthood. We propose that these normative patterns of personality development can be explained by motivational theories of aging. Specifically, decreases in Extraversion, Agreeableness, Conscientiousness, and Openness to Experience may reflect a reduced capacity to control one's environment, whereas continued increases in Emotional Stability reflect increases in individual's ability to compensate and cope with age-graded losses. Pairing motivational theories of aging with longitudinal evidence in personality science provides an explanation for empirical patterns of personality trait development and raises interesting possibilities to promote healthy aging.


Assuntos
Desenvolvimento da Personalidade , Personalidade , Pessoa de Meia-Idade , Humanos , Adulto , Emoções , Envelhecimento/psicologia , Transtornos da Personalidade
7.
Aging Ment Health ; : 1-10, 2023 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-37993410

RESUMO

Objectives: The goal of the present study was to investigate whether forgiveness played a mediating role in the relationships between gerotranscendence and wisdom among people in late adulthood. Method: The study included 416 participants aged 60 to 75 years. The following measures were used: the Gerotranscendence Scale Type 2 (GST2), the Heartland Forgiveness Scale and the Self-Assessed Wisdom Scale (SAWS). To verify the hypothesis, a longitudinal three-wave field study was conducted. Results: The results suggest that an increase in gerotranscendence is associated with an increase in forgiveness and wisdom. In addition, greater willingness to forgive co-occurs with higher levels of wisdom. Moreover, dispositional forgiveness mediates the relationship between gerotranscendence and wisdom - a higher gerotranscendence leads to a higher wisdom through an increase in forgiveness. Conclusion: The results of our research add to the knowledge of the mechanism of the relationship between gerotranscendence and wisdom and support the thesis that late adulthood presents individuals with new challenges and opportunities for creative personal development.

8.
Prev Sci ; 24(5): 799-807, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37249730

RESUMO

The interdisciplinary field of prevention science was founded on the premise of a lifespan developmental model. Prevention scientists have developed a strong set of tools and intervention technologies for understanding and potentially modifying risk and protective factors through early adulthood. However, there is a demographic imperative to apply prevention science principles to health issues in middle and late adulthood. The articles in this special issue utilize a variety of methods to investigate important scientific questions about how theories, methodologies, and interventions applied in the science of prevention can be usefully integrated into the study of health and wellness in middle and late adulthood. More specifically, contributions (1) highlight current empirical research that draws on lifespan developmental science to address the unique prevention and intervention needs in middle and late adulthood, (2) illustrate the opportunities and challenges of a lifespan approach to prevention science with special attention to middle and late adulthood, and (3) identify additional areas that prevention science can contribute to advancements in middle and late adulthood. These articles provide a glimpse into the challenges and opportunities at the intersection of prevention science and gerontology. As a field, we have much room to grow in leveraging innovative tools, approaches, and efforts to best support older adults' physical, mental, and social health, particularly for diverse and under-served populations.


Assuntos
Longevidade , Humanos , Idoso , Adulto , Fatores de Proteção
9.
Prev Sci ; 24(5): 808-816, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37166533

RESUMO

This commentary on the special issue of Prevention Science, "Toward a Lifespan Prevention Science: A Focus on Middle and Late Adulthood" reviews the studies included in the issue, compares findings, and makes recommendations for future directions in this emerging field. Articles in this issue addressed a number of the key elements of prevention science, including identifying proximal and distal risk and protective factors that play a role in middle and late adult health and well-being, providing preliminary evidence for a preventive intervention to moderate stress reactivity, and proposing a theoretical approach to preventing substance misuse across the lifespan. Our commentary centers around three critical areas for mid and later life prevention science: the importance of theory building, a focus on alcohol and its role in midlife health, and health disparities. Each of the articles in this issue touched on at least one of these areas. We conclude that a focus on prevention in mid and later life has strong potential, and further research is needed.


Assuntos
Disparidades nos Níveis de Saúde , Nível de Saúde , Fatores de Proteção , Adulto , Humanos
10.
J Gerontol Soc Work ; 66(2): 221-238, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-35791671

RESUMO

Caregiving can be physically challenging and emotionally draining for older caregivers. The existing research on physical and emotional strain mainly focuses on the general caregiver population. Using the Stress Process Model, this study aims to expand on existing caregiving literature by identifying correlates of physical and emotional strain among older caregivers. Hierarchical OLS regressions were performed on data selected from the 2015 Caregiving in the U.S. Survey (N = 701). Several risk factors for physical strain and emotional strain were identified: Assistance with ADLs and IADLs, the number of health problems of the care recipient, and the receipt of formal support were positively associated with physical and emotional strain. Moreover, providing care to parents/parents-in-law was associated with higher levels of emotional strain than providing care to non-relatives. The number of care recipients was positively associated with emotional strain. Older African Americans experienced lower levels of physical strain than their white counterparts. The findings uncover the individual differences among older caregivers and provide insights into how these differences uniquely influence caregiving strain. Moreover, the study identifies a risk and protective profile of caregiving strain, which can help practitioners direct services and resources to older caregivers who are particularly at risk for caregiving strain.


Assuntos
Cuidadores , Estresse Psicológico , Humanos , Idoso , Cuidadores/psicologia , Estresse Psicológico/complicações , Estresse Psicológico/epidemiologia , Família/psicologia , Inquéritos e Questionários
11.
Sci Total Environ ; 858(Pt 1): 159768, 2023 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-36309252

RESUMO

P-dichlorobenzene (p-DCB) is a volatile compound commonly used as pest repellent and air deodorant in the home and public buildings, leading to a widespread exposure in indoor environments. There has been an increasing concern about its metabolic and endocrine effects. In this study, we explored the relation between p-DCB exposure and serum levels of soluble α-Klotho, an anti-aging hormone, in US adults. A nationally representative subsample of 1485 adults 40-79 ages in the 2013-2016 National Health and Nutrition Examination Survey was analyzed for the association between p-DCB exposure, measured as urinary concentrations of 2,5-dichlorophenol (2,5-DCP), the major metabolite of p-DCB, and serum α-Klotho levels using multiple general linear models, adjusting for potential confounders. Age- and sex-specific analyses were further conducted. The weighted geometric mean of urinary 2,5-DCP was 2.43 µg/L and the weighted mean of serum α-Klotho was 831.97 pg/mL in the study participants during 2013-2016. After adjusting for potential confounders and urinary creatinine, urinary 2,5-DCP was significantly associated with decreased serum levels of α-Klotho (regression coefficient ß = -9.88; p = 0.0133) in the total study population. When age- and sex-specific analyses being conducted, a significantly inverse association was found in older adults aged 60-79 years (ß = -20.40; p = 0.0001) and in males (ß = -13.81; p = 0.0097), but not in the middle ages (40-59 years) and in females. The strongest association was observed in older (60-79 years) male participants, with a 25.43 pg/mL reduction of α-Klotho levels per 1-unit increase of 2,5-DCP concentrations (p = 0.0008). This is the first study demonstrating a relation between p-DCB exposure, measured as 2,5-DCP, and decreased α-Klotho levels in older males. Additional studies would further explore these interactions and elucidate the pathogenesis of the potential effects of p-DCB exposure on aging.


Assuntos
Clorofenóis , Pessoa de Meia-Idade , Feminino , Humanos , Masculino , Idoso , Adulto , Inquéritos Nutricionais , Clorobenzenos/metabolismo , Urinálise
12.
Behav Sci (Basel) ; 12(7)2022 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-35877284

RESUMO

BACKGROUND: A current research trend is the examination of the interplay between cognitive functioning, higher-order processes, and motor efficiency in late adulthood. However, the association between motor and cognitive functions when cognitive decline occurs has not been extensively explored. This study investigated whether gait features, functional mobility, and handgrip strength were associated with executive functions in older people with mild cognitive impairment (MCI) or dementia. METHODS: 127 older participants (Mage = 77.9 years, SD = 5.8 years) who had received a diagnosis of MCI and dementia voluntarily took part in the study. A battery of tests assessing global cognitive function, executive functions, muscular strength, functional mobility, and spatio-temporal parameters of gait was completed by the participants. RESULTS: Statistically significant correlations were obtained between global cognitive function, executive functions, and motor efficiency measures. Moreover, a series of regression analyses showed that 8-13% of the variance of several motor parameters was predicted by several executive functions. Additionally, walking, functional mobility, and global cognitive function predicted 53-71% of the variance relative to the occurrence of dementia. In conclusion, motor functioning is closely related to cognitive functioning in late adulthood. CONCLUSIONS: The assessment of muscular strength and functional mobility should be promoted in clinical settings.

13.
Aging Ment Health ; 26(12): 2348-2357, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-34670470

RESUMO

Objectives: The current study investigates the differential coping strategies and mental health consequences of food insecurity in relation to period of the lifespan (middle vs. late adulthood) and household composition (living with vs. without children).Method: Using a cross-sectional design, food-related coping strategies, anxiety (GAD-7), and depression (WHO-5) were compared among the following groups: middle adults with vs. without children, and middle adults without children vs. late adults without children. Predictive models using hierarchical linear regression examined the main effects of age and household composition with food insecurity predicting mental health; additionally, the interaction of food insecurity with age and household composition was tested in a separate model. Results: Middle-adults with and without children share similar frequencies in levels of food insecurity and coping strategies, which were significantly higher than late adults.Conclusion: The link between food insecurity and depression was stronger for middle-adults without children than late adults. Food insecurity was a stronger predictor of anxiety for middle-adults with children than those without.


Assuntos
Abastecimento de Alimentos , Saúde Mental , Humanos , Adulto , Estudos Transversais , Insegurança Alimentar , Características da Família
14.
Artigo em Inglês | MEDLINE | ID: mdl-33899678

RESUMO

Recent studies have suggested that executive functions (EF) predict life satisfaction for older adults. However, the mechanism is not known. By analyzing a sample (N = 3,287, ages 32- 84 years) from the Midlife Development in the United States 2, we examined the mediational role of coping strategies in the relation between EF and life satisfaction. Both active coping and behavioral disengagement mediated the relation between EF and life satisfaction, and age significantly moderated the mediational pathways. Specifically, the positive effect of EF on active coping was more pronounced in middle-aged and older adults than in young adults. However, the negative effect of EF on behavioral disengagement was apparent only in older adults, disappeared in middle-aged adults and reversed in younger adults. Our findings underscore EF as crucial cognitive resources that facilitate the adoption of healthy coping strategies, which in turn, affect life satisfaction in middle and late adulthood.


Assuntos
Função Executiva , Satisfação Pessoal , Adaptação Psicológica , Adulto , Idoso , Idoso de 80 Anos ou mais , Nível de Saúde , Humanos , Pessoa de Meia-Idade
15.
Cereb Cortex ; 32(2): 397-407, 2022 01 10.
Artigo em Inglês | MEDLINE | ID: mdl-34255824

RESUMO

Healthy aging is typically associated with some level of cognitive decline, but there is substantial variation in such decline among older adults. The mechanisms behind such heterogeneity remain unclear but some have suggested a role for cognitive reserve. In this work, we propose the "person-based similarity index" for cognition (PBSI-Cog) as a proxy for cognitive reserve in older adults, and use the metric to quantify similarity between the cognitive profiles of healthy older and younger participants. In the current study, we computed this metric in 237 healthy older adults (55-88 years) using a reference group of 156 younger adults (18-39 years) taken from the Cambridge Center for Ageing and Neuroscience dataset. Our key findings revealed that PBSI-Cog scores in older adults were: 1) negatively associated with age (rho = -0.25, P = 10-4) and positively associated with higher education (t = 2.4, P = 0.02), 2) largely explained by fluid intelligence and executive function, and 3) predicted more by functional connectivity between lower- and higher-order resting-state networks than brain structural morphometry or education. Particularly, we found that higher segregation between the sensorimotor and executive networks predicted higher PBSI-Cog scores. Our results support the notion that brain network functional organization may underly variability in cognitive reserve in late adulthood.


Assuntos
Reserva Cognitiva , Adulto , Idoso , Envelhecimento/psicologia , Encéfalo/diagnóstico por imagem , Cognição , Humanos , Imageamento por Ressonância Magnética
16.
Front Psychol ; 12: 731017, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34659041

RESUMO

The purpose of this study was to examine multiple direct and indirect pathways of the association between older age and mental health through COVID-19-related stress perceptions, meaning in life, and forgiveness of situations. Participants were 1,382 U.S. adults who were part of the Harvard Digital Lab for the Social Sciences panel who volunteered to complete a 12 min survey in the spring of 2020. The sample had an average age of 56 years, was slightly more male (55%) than female (44%) or other (2%), mostly White (88%), well-educated (70% bachelors degree or more), and middle-income ($60,000-$75,000 annually). Measures included: COVID-19-related stress perceptions (e.g., concerns about infection, job, lack of necessities), presence of and search for meaning in life, forgiveness of situations, psychological distress, hopelessness, and optimism. A latent mental health variable was created that was comprised of psychological distress, hopelessness, and optimism. All hypothesized direct effects were in evidence, and all but one indirect effect were observed. Specifically, older age was related to better mental health through higher presence of meaning and lower search for meaning. Older age was also related to better mental health through a serial indirect pathway from lower COVID-19-related stress perceptions to higher presence of and lower search for meaning and higher forgiveness of situations to mental health. The proposed model was largely supported and confirms existing theory and research on aging, positive psychological processes, and mental health. Findings also offer new insights on the unique potential role of forgiveness of situations and its theoretical relevance to offending situations such as the COVID-19 pandemic. The present study offers a beginning for theorists, researchers, and practitioners to consider the connections between aging and mental health and the intricate interconnections between stress appraisal and positive coping resources that may serve to support it.

17.
Int J Lang Commun Disord ; 56(4): 841-857, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-34121295

RESUMO

BACKGROUND: The ability to understand figurative language, including metaphors and proverbs, decreases with age, although the phenomenon is not universal. Cognitive capacities and education play an important role in the competence connected with figurative language use and comprehension in people during the second half of life. AIMS: To identify possible similarities and differences in task performance by subjects representing middle adulthood (40-49 and 50-59 years old) and late adulthood (60-69 and 70-92 years old). Additionally, the analyses took into account factors significantly affecting the results, that is, tasks type (metaphors versus proverbs), the way the answer is given (open-ended versus multiple choice) and types of answers (abstract and concrete). This study also aimed to identify some cognitive correlates of task completion. METHODS & PROCEDURES: A total of 86 Caucasian subjects, aged 40-92 years, participated in this study (Mwhole group = 62.37, SD = 15.53); the group included 20 subjects aged 40-49 years (Mage = 45.4; SD = 3.05), 20 aged 50-59 years (Mage = 55.50; SD = 2.64), 20 aged 60-69 years (Mage = 64.40; SD = 2.78), and 26 aged 70-92 years (Mage = 79.15; SD = 6.27). A total of 20 well-known Polish metaphors and 20 popular Polish proverbs were used to assess the level of proverb and metaphor comprehension. The Montreal Cognitive Assessment Scale and Vocabulary subtest of the Polish version of WAIS-R were applied to assess the cognitive functions. OUTCOMES & RESULTS: The results of the analyses suggest that there are differences as well as certain similarities between the groups. At 70+ years of age, the ability to explain and comprehend metaphors and proverbs decreases when compared with younger adults. In the 70+ group, the ability to grasp the meaning of both metaphors and proverbs is similar, unlike in the younger groups which present a better ability to explain and comprehend metaphors than proverbs. The conditions related to the types of tasks, that is, spontaneous interpretation and choice of responses, do not affect scores of the oldest subjects. CONCLUSIONS: The analysis of response types, that is, abstract versus concrete, shows that, compared with younger groups, people aged 70+ years tend to less frequently provide abstract explanations and more often give concrete (but correct) responses, referring to situational data or examples from everyday life. Moreover, attention, short-term/delayed memory and lexical reserve influence the ability to use and comprehend figurative language to a varied degree. WHAT THIS PAPER ADDS: What is already known on the subject Studies focusing on metaphor and proverb interpretation by people in middle and late adulthood are rather scarce, and what is more, they provide inconclusive results. Research has shown that the capacities related to attention and memory, as well as language resources and executive functions, all deteriorate in older people, which negatively affects their ability to understand metaphors and proverbs. However, varied methods are applied to assess these skills, which may explain why the related findings are inconsistent. What this paper adds to existing knowledge The novelty of this study lies in the fact that the analyses took into account the type of task (metaphors versus proverbs), the method of responding (open-ended versus multiple-choice) and the nature of the answer (abstract versus concrete). This allowed us to highlight intergroup differences and to show specific characteristics of proverb and metaphor spontaneous interpretation and choice of correct answers. The results were compared among the participants representing relatively narrow age ranges classified as middle and late adulthood. What are the potential or actual clinical implications of this work? Analysis of how people in middle and late adulthood interpret metaphors and proverbs might constitute an element of preliminary screening assessment showing whether a decrease in this capacity is in the normal range or if it reflects a serious cognitive decline. It would be worthwhile if the diagnostic process included varied task designs, that is, both metaphors and proverbs, as well as spontaneous interpretation and multiple-choice, as well as varied types of responses.


Assuntos
Idioma , Metáfora , Adulto , Idoso , Cognição , Compreensão , Humanos , Pessoa de Meia-Idade , Polônia
18.
Psychoneuroendocrinology ; 130: 105253, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34051654

RESUMO

BACKGROUND: Parent-child separation has been shown to increase the risk of a range of mental and physical health conditions later in life. Hypothalamic-pituitary-adrenal (HPA) axis dysregulation may help to explain this association. However, few studies have examined the effect of maternal separation on cortisol in late adulthood. METHODS: We examined the relationship between maternal separation in childhood and hair cortisol concentrations in late adulthood, using data from the Whitehall II study (n = 3969, mean age: 70 y, range: 60-83 y). Additionally, the role of childhood (adverse childhood experiences (ACEs), material disadvantage, and parenting), adult (marital status and social position), and health (health behaviors, cardiovascular health and medication, and depression) measures in this association were examined. Finally, we examined age of separation and reason for separation. Analysis was carried out using linear regression. RESULTS: Hair cortisol concentrations (pg/mg) among participants who reported maternal separation during childhood were higher (B=0.179, 95% CI 0.041-0.317, p = 0.01) compared to their non-separated counterparts. This effect was robust to adjustment by childhood, adult, and health measures. Among participants who reported separation, age at onset and reason for separation were not significantly associated with hair cortisol concentrations. CONCLUSION: In older age individuals, hair cortisol concentrations were higher in those who reported maternal separation during childhood. This effect was independent of a wide variety of factors suggesting that there are lifelong pathways between early life separation and HPA functioning in old age.


Assuntos
Hidrocortisona , Privação Materna , Adulto , Idoso , Humanos , Sistema Hipotálamo-Hipofisário , Poder Familiar , Sistema Hipófise-Suprarrenal , Estresse Psicológico
19.
J Transcult Nurs ; 32(3): 202-211, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-32065072

RESUMO

Introduction: This study aims to explore how older people structure the subjectivity that accompanies the development of gerotranscendence in late adulthood within a specific sociocultural context. Method: Q methodology, a common method for assessing subjectivity, was applied. Results: The four subjective frames of reference that accompany the development of gerotranscendence, represented by four corresponding Q-factors, were (a) generation awareness, (b) awareness of aging, (c) awareness of the big picture of life, and (d) awareness of temporality. Discussion: The subjective frames of reference that characterize the development of gerotranscendence in late adulthood are closely related to cultural and psychosocial environmental influences over the course of an individual's life.


Assuntos
Envelhecimento , Adulto , Idoso , Humanos , República da Coreia
20.
Cereb Cortex ; 31(3): 1719-1731, 2021 02 05.
Artigo em Inglês | MEDLINE | ID: mdl-33188411

RESUMO

Currently, several human brain functional atlases are used to define the spatial constituents of the resting-state networks (RSNs). However, the only brain atlases available are derived from samples of young adults. As brain networks are continuously reconfigured throughout life, the lack of brain atlases derived from older populations may influence RSN results in late adulthood. To address this gap, the aim of the study was to construct a reliable brain atlas derived only from older participants. We leveraged resting-state functional magnetic resonance imaging data from three cohorts of healthy older adults (total N = 563; age = 55-95 years) and a younger-adult cohort (N = 128; age = 18-35 years). We identified the major RSNs and their subdivisions across all older-adult cohorts. We demonstrated high spatial reproducibility of these RSNs with an average spatial overlap of 67%. Importantly, the RSNs derived from the older-adult cohorts were spatially different from those derived from the younger-adult cohort (P = 2.3 × 10-3). Lastly, we constructed a novel brain atlas, called Atlas55+, which includes the consensus of the major RSNs and their subdivisions across the older-adult cohorts. Thus, Atlas55+ provides a reliable age-appropriate template for RSNs in late adulthood and is publicly available. Our results confirm the need for age-appropriate functional atlases for studies investigating aging-related brain mechanisms.


Assuntos
Encéfalo/anatomia & histologia , Encéfalo/fisiologia , Idoso , Idoso de 80 Anos ou mais , Conectoma/métodos , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Descanso
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