RESUMO
Unilateral absence of a pulmonary artery (UAPA) is an uncommon congenital anomaly. Among the rarer conditions, UAPA with lung cancer has been previously reported in 13 cases; however, there remains controversy regarding the surgical approach and precautions. Herein, we present a case study of a 56-year-old female patient who was incidentally diagnosed with a nodule in the right lower lobe of the lung during a routine physical examination and subsequently found to have an absent right pulmonary artery upon preoperative evaluation. A wedge resection of the right lower lobe was performed as treatment. Postoperative pathology confirmed invasive adenocarcinoma (pT1N0M0). We provide a narrative review of existing literature on these patients and discuss optimal surgical management strategies.
Assuntos
Adenocarcinoma de Pulmão , Achados Incidentais , Neoplasias Pulmonares , Pneumonectomia , Artéria Pulmonar , Humanos , Feminino , Artéria Pulmonar/cirurgia , Artéria Pulmonar/anormalidades , Artéria Pulmonar/diagnóstico por imagem , Pessoa de Meia-Idade , Neoplasias Pulmonares/cirurgia , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/patologia , Adenocarcinoma de Pulmão/cirurgia , Adenocarcinoma de Pulmão/diagnóstico por imagem , Adenocarcinoma de Pulmão/patologia , Resultado do Tratamento , Adenocarcinoma/cirurgia , Adenocarcinoma/diagnóstico por imagem , Adenocarcinoma/patologia , Adenocarcinoma/complicações , Malformações Vasculares/cirurgia , Malformações Vasculares/diagnóstico por imagem , Malformações Vasculares/complicações , Cirurgia Torácica Vídeoassistida , Invasividade Neoplásica , Estadiamento de NeoplasiasRESUMO
Purpose To determine the prevalence of clinically relevant extracardiac findings at cardiac CT and MRI examinations from a multicenter, multinational MR/CT registry and the relationship of prevalence with examination indications and patient characteristics. Materials and Methods This was a retrospective analysis of data from the European Society of Cardiovascular Radiology MR/CT Registry. Data from 208 506 cardiac CT examinations (median patient age, 66 years [IQR, 55-77]; 121 617 [58.33%] male patients) and 228 462 cardiac MRI examinations (median patient age, 57 years [IQR, 42-69]; 145 792 [63.81%] male patients) entered into the registry between January 2011 and November 2023 were analyzed. Clinically relevant extracardiac findings were defined as findings requiring follow-up examinations or influencing clinical management. The association of examination indication and patient characteristics, including age, with prevalence of extracardiac findings was evaluated using incidence rate ratios (IRRs) derived from multivariable Poisson regression models. Results The prevalence of clinically relevant extracardiac findings was 3.28% (6832 of 208 506) at cardiac CT and 1.50% (3421 of 228 462) at cardiac MRI examinations. Extracardiac findings were more common at CT examinations performed for transcatheter aortic valve replacement (IRR, 2.07; P < .001) and structural heart disease (IRR, 1.44; P < .001) compared with CT performed for coronary artery disease (IRR, 1; reference). Extracardiac findings were more common at MRI examinations performed for myocarditis (IRR, 1.36; P < .001) and structural heart disease (IRR, 1.16; P < .001) than for coronary artery disease. Older patient age was also significantly associated with higher prevalence of extracardiac findings, with an IRR for both CT and MRI examinations of 1.02 (P < .001). Conclusion Data from the multicenter, multinational MR/CT registry indicate that clinically relevant extracardiac findings are present at cardiovascular CT and MRI examinations, and the prevalence of these findings is associated with examination indication and patient age. Keywords: Cardiac Imaging Techniques, Incidental Findings, MRI, CT Angiography, CT, Heart Disease Supplemental material is available for this article. © RSNA, 2024.
Assuntos
Imageamento por Ressonância Magnética , Sistema de Registros , Humanos , Masculino , Pessoa de Meia-Idade , Idoso , Europa (Continente)/epidemiologia , Estudos Retrospectivos , Feminino , Adulto , Achados Incidentais , Tomografia Computadorizada por Raios X , Prevalência , Técnicas de Imagem CardíacaRESUMO
The patent ductus arteriosus is a vascular structure that connects the proximal descending aorta to the main pulmonary artery near the origin of the left pulmonary artery. The persistence of ductal patency after the first weeks of life is abnormal. In adults, it is most often an isolated finding but it may be associated with other congenital anomalies. Its repercussions depend on the size of the duct, varying from the absence of signs and symptoms to Eisenmenger's syndrome. Echocardiography is the keystone of diagnosis. Multimodal imaging allows precise anatomical characterization. Treatment with percutaneous placement of a closure device is recommended based on ultrasound parameters and right heart catheterization.
Le canal artériel persistant est une structure vasculaire qui connecte l'aorte descendante proximale au tronc pulmonaire commun près de l'origine de l'artère pulmonaire gauche. La persistance du canal artériel après les premières semaines de vie est anormale. Chez l'adulte, il s'agit le plus souvent d'une découverte isolée, mais qui peut être associée à d'autres anomalies congénitales. Ses répercussions dépendent de la taille et de la morphologie du canal, variant de l'absence de signes et symptômes à un syndrome d'Eisenmenger pour les formes les plus sévères. L'échocardiographie est la clé de voûte du diagnostic. L'imagerie multimodale permet une caractérisation anatomique précise. Le traitement par mise en place par voie percutanée d'un dispositif de fermeture est recommandé en fonction des paramètres échographiques et du cathétérisme cardiaque droit.
Assuntos
Permeabilidade do Canal Arterial , Achados Incidentais , Humanos , Permeabilidade do Canal Arterial/diagnóstico por imagem , Permeabilidade do Canal Arterial/diagnóstico , Adulto , Feminino , EcocardiografiaRESUMO
BACKGROUND Chylous ascites is defined as the development of lipid-rich ascitic fluid in the peritoneal cavity. The formation of chylous ascites revolves around non-portal-based and portal-based etiologies, and the diagnosis is made via paracentesis revealing an elevated triglyceride level and milky-white appearance. Chylous ascites is often reported as a postoperative complication in surgical procedures, but it has also been documented in cases of cirrhosis, malignancy, and tuberculosis. However, chylous ascites is rarely seen in chronic pancreatitis and non-cirrhotic portal hypertension. This report presents the case of a 65-year-old man with a history of necrotizing pancreatitis and portal hypertension amidst an incidental finding of chylous ascites upon elective umbilical hernia repair. CASE REPORT We present the case of a patient with chylous ascites discovered during hernia repair. A 65-year-old man with no alcohol or tobacco use and a history of recurrent episodes of acute necrotizing pancreatitis was admitted for umbilical hernia repair. However, upon entering the abdominal cavity, an enlarging mass of ascitic fluid was encountered and tracked into the hernia sac. The fluid was drained via paracentesis and cytology revealed chylous ascites. The patient was discharged in stable condition and was advised to consume a high-protein, low-fat diet. Postoperative computed topography (CT) demonstrated an unchanged necrotic mass in the head of the pancreas. CONCLUSIONS This report demonstrates that when dealing with unexpected findings, it is important to consider the existence of multiple pathologies as the driving cause. We describe a complex cause of chylous ascites, along with a review of the literature on the relationship between chylous ascites and chronic pancreatitis.
Assuntos
Ascite Quilosa , Hérnia Umbilical , Herniorrafia , Pancreatite Necrosante Aguda , Humanos , Ascite Quilosa/etiologia , Masculino , Idoso , Hérnia Umbilical/cirurgia , Hérnia Umbilical/complicações , Pancreatite Necrosante Aguda/complicações , Pancreatite Necrosante Aguda/etiologia , Pancreatite Necrosante Aguda/cirurgia , Achados IncidentaisAssuntos
Aneurisma Coronário , Achados Incidentais , Dor de Ombro , Humanos , Dor de Ombro/etiologia , Dor de Ombro/diagnóstico por imagem , Aneurisma Coronário/complicações , Aneurisma Coronário/diagnóstico por imagem , Aneurisma Coronário/diagnóstico , Dor nas Costas/etiologia , Masculino , Pessoa de Meia-IdadeRESUMO
Primary hyperparathyroidism (PHPT) due to ectopic parathyroid adenoma is a rare case of hypercalcemia in the pediatric population. Herein, a rare case of PHPT due to ectopic intrathymic parathyroid adenoma was described in an asymptomatic 15-year-old girl who had incidental diagnosis based on laboratory abnormalities but experienced a 3-month postoperative course of persistently elevated parathyroid hormone (PTH) and hypercalcemia following the initial unsuccessful parathyroidectomy operation carried out in a non-parathyroid expert center. The curative surgical treatment was accomplished only after the patient was reoperated with video-assisted thoracoscopic surgery (VATS) thymectomy by the surgeon experienced in parathyroid surgery with implementation of the combined imaging modalities for accurate localization of ectopic adenoma including 99mTc sestamibi (MIBI) plus neck and thoracic computed tomography (CT) and the appropriate surgical strategies including intraoperative intact PTH monitoring and frozen section diagnosis. Before the reoperation (VATS thymectomy), laboratory findings showed elevated PTH (1,171 ng/L; reference range: 21.80 ng/L-87.5 ng/L) and hypercalcemia (13.4 mg/dL; reference range: 8.4 mg/dL-10.2 mg/dL). The preoperative PTH levels were 94 ng/L at 5 min after thymectomy and 78 ng/L at 10 min. The PTH and calcium levels were 54.3 ng/L and 8.47 mg/dL, respectively, on postoperative day 1 and were 34.2 ng/L and 8.1 mg/dL on postoperative day 2. The patient was discharged on postoperative day 2 without any complications. In conclusion, our findings indicate the likelihood of isolated primary hyperparathyroidism to be incidentally diagnosed based solely on laboratory abnormalities with no specific clinical manifestations in the pediatric age. In addition, using combined imaging modalities (such as MIBI and CT) in accurate localization of ectopic parathyroid adenoma and implementation of surgery by experienced surgeons along with intraoperative intact PTH monitoring and frozen section diagnosis seem crucial to ensure the curative surgical treatment.
Assuntos
Adenoma , Hiperparatireoidismo Primário , Achados Incidentais , Neoplasias das Paratireoides , Humanos , Feminino , Adolescente , Hiperparatireoidismo Primário/cirurgia , Hiperparatireoidismo Primário/diagnóstico , Hiperparatireoidismo Primário/complicações , Neoplasias das Paratireoides/cirurgia , Neoplasias das Paratireoides/complicações , Neoplasias das Paratireoides/diagnóstico , Neoplasias das Paratireoides/patologia , Adenoma/cirurgia , Adenoma/complicações , Adenoma/diagnóstico , Adenoma/patologia , Paratireoidectomia , Timectomia , Cirurgia Torácica VídeoassistidaRESUMO
A 3-year-old neutered male standard poodle mix dog was presented because of acute onset vomiting, increased respiratory effort, hyporexia, and progressive lethargy. On physical examination, intermittent tachycardia, tachypnea with mildly increased respiratory effort, and bilateral ventral muffled lung sounds were noted. Thoracic and abdominal computed tomography with contrast revealed a peritoneal pericardial diaphragmatic hernia (PPDH) with herniation of the liver and gallbladder, moderate abdominal lymphadenopathy, and mild pleural effusion. The dog underwent an emergency laparotomy and median sternotomy. Right ventral PPDH with a herniated, necrosed, and nonviable quadrate liver lobe and gallbladder; 2 suspected right ventricular (RV) aneurysms; and generalized mesenteric and portal lymphadenopathy were present. The affected liver lobe and gallbladder were removed; suspected aneurysms were managed by placing 2 purse-string sutures around the lesions and anchoring a pericardial flap over the aneurysms. The dog developed a ventricular arrhythmia postoperatively. Due to the arrhythmia and intraoperative findings of suspected aneurysms, echocardiography was performed and revealed focal RV systolic dysfunction, left ventricular systolic dysfunction, mild left ventricular dilation, and a hyperechoic area on the RV free wall, consistent with the purse string. An angiotensin-convertingenzyme (ACE) inhibitor was prescribed for left ventricular dilation. The dog was discharged 4 d postoperatively and was doing well 12 mo postoperatively. To our knowledge, this is the first report of a PPDH and suspected concurrent RV wall aneurysm in a dog successfully treated with a purse string and pericardial flap. Key clinical message: An RV aneurysm is extremely rare yet can be life-threatening in small animals. Early detection and treatment may minimize the risk of aneurysm rupture and sudden death.
Hernie diaphragmatique péritonéale péricardique avec découverte fortuite d'anévrismes suspects de la paroi ventriculaire droite chez un chienUn chien croisé caniche standard mâle castré âgé de 3 ans a été présenté en raison de vomissements aigus, d'efforts respiratoires accrus, d'hyporexie et de léthargie progressive. À l'examen physique, une tachycardie intermittente, une tachypnée avec effort respiratoire légèrement accru et des bruits pulmonaires étouffés ventraux bilatéraux ont été notés. Une tomodensitométrie thoracique et abdominale avec contraste a révélé une hernie diaphragmatique péritonéale péricardique (HDPP) avec hernie du foie et de la vésicule biliaire, une lymphadénopathie abdominale modérée et un épanchement pleural léger. Le chien a subi une laparotomie d'urgence et une sternotomie médiane. Une HDPP ventrale droite avec un lobe hépatique carré et une vésicule biliaire herniés, nécrosés et non viables; 2 anévrismes du ventricule droit (VD) suspectés; et une adénopathie mésentérique et portale généralisée étaient présents. Le lobe hépatique et la vésicule biliaire affectés ont été retirés; les anévrismes suspectés ont été gérés en plaçant 2 sutures en bourse autour des lésions et en ancrant un lambeau péricardique sur les anévrismes. Le chien a développé une arythmie ventriculaire postopératoire. En raison de l'arythmie et des résultats peropératoires d'anévrismes suspectés, une échocardiographie a été réalisée et a révélé un dysfonctionnement systolique focal du VD, un dysfonctionnement systolique du ventricule gauche, une légère dilatation du ventricule gauche et une zone hyperéchogène sur la paroi libre du VD, compatible avec la bourse. Un inhibiteur de l'enzyme de conversion de l'angiotensine (ECA) a été prescrit pour la dilatation du ventricule gauche. Le chien a obtenu son congé 4 jours après l'opération et se portait bien 12 mois après l'opération. À notre connaissance, il s'agit du premier rapport d'une HDPP et d'un anévrisme concomitant suspecté de la paroi du VD chez un chien traité avec succès par une suture en bourse et un lambeau péricardique.Message clinique clé :Un anévrisme du ventricule droit est extrêmement rare, mais peut mettre la vie en danger chez les petits animaux. Une détection et un traitement précoces peuvent minimiser le risque de rupture d'anévrisme et de mort subite.(Traduit par Dr Serge Messier).
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Doenças do Cão , Animais , Cães , Masculino , Doenças do Cão/cirurgia , Doenças do Cão/diagnóstico , Hérnia Diafragmática/veterinária , Hérnia Diafragmática/cirurgia , Aneurisma Cardíaco/veterinária , Aneurisma Cardíaco/cirurgia , Aneurisma Cardíaco/diagnóstico por imagem , Achados IncidentaisRESUMO
Noninfectious aortitis is occasionally detected incidentally, either on imaging or on histopathologic review after open thoracic aortic surgery. It can present as a clinically asymptomatic, seemingly focal lesion, as diffuse inflammation throughout several aortic segments but sparing the branch vessels, or as a manifestation of a widespread systemic condition. Treatment differs based on etiology, so once identified, all patients with aortitis need a thorough evaluation, laboratory tests, complete large-vessel imaging, and a referral to a vasculitis expert. All patients with aortitis are at high risk of future vascular complications and should be followed with serial clinical evaluations and imaging.
Assuntos
Aorta Torácica , Aortite , Achados Incidentais , Humanos , Aortite/diagnóstico , Aorta Torácica/diagnóstico por imagemRESUMO
A male patient in his 20s with a history of bilateral congenital cataracts and nystagmus presented to the genetic eye disease clinic at Moorfields Eye Hospital to enquire about genetic testing for family decision-making and access to preimplantation genetic testing. He had a history of lensectomy with best-corrected visual acuities of logMAR 0.60 and 1.00 in the right and left eye. Whole genome sequencing (WGS) was conducted, which included targeted analysis of a panel of 115 lens-related genes and incidental findings, for which patients are unable to opt-out. Genetic testing identified the causative variant c.134T>C (p.Leu45Pro) in the CRYGC gene. A pathogenic variant in BRCA2 was also identified as a secondary finding. This was unexpected given the absence of a strong family history of breast or ovarian cancer. This case illustrates the importance of genetic counselling and informing patients about the implications of incidental findings that arise from WGS.
Assuntos
Proteína BRCA2 , Catarata , Achados Incidentais , Sequenciamento Completo do Genoma , Humanos , Catarata/genética , Catarata/congênito , Catarata/diagnóstico , Masculino , Proteína BRCA2/genética , Adulto , Testes Genéticos/métodosRESUMO
INTRODUCTION: Gastric antral vascular ectasia is an uncommon clinical disease that affects elder people and is characterized by severe chronic upper gastrointestinal bleeding mainly affecting the gastric antrum. It is generally unusual among patients undergoing maintenance hemodialysis for chronic kidney disease. CASE PRESENTATION: Here, we aim to present an uncommon case of incidental diagnosis of the gastric antral vascular ectasia and erosive gastritis in a 71-year-old Hindu male patient belonging to the Gurung ethnicity of Nepal undergoing maintenance hemodialysis due to chronic kidney disease. The patient presented with a history of melena and fatigue. On investigation, a low hemoglobin level of 7.3 gm% was used for blood transfusion. The patient was on regular hemodialysis after admission at our institution. Upper gastrointestinal bleeding was suspected after analyzing patient's history and investigations. Therefore, an upper gastrointestinal endoscopy was performed that showed linear ectatic punctuate lesions radiating from the body of the stomach to the antrum, and hence, an incidental diagnosis of the gastric antral vascular ectasia was made. Initial fluid resuscitation, iron therapy, and a triple regimen were administered. Proper management with argon plasma coagulation therapy was scheduled at another institution due to lack of respective facilities in our institution. DISCUSSION: Gastric antral vascular ectasia is an unusual cause of upper gastrointestinal bleeding, primarily affecting the gastric antrum and pylorus with rare cases affecting the duodenum, jejunum, and gastric fundus. It is generally associated with other chronic disease conditions. Several hypotheses have been proposed for the pathogenesis of gastric antral vascular ectasia, especially its association with chronic kidney disease, as in our case, which is considered to be rare. Management varies from medical to endoscopic interventions to even surgery. CONCLUSION: Prompt proper diagnosis and treatment for the gastric antral vascular ectasia should be sought, as it is frequently misdiagnosed or missed during upper gastrointestinal endoscopy. Our case report presents a case of gastric antral vascular ectasia in chronic kidney disease undergoing maintenance hemodialysis, which is quite uncommon, as literature has suggested the same point.
Assuntos
Ectasia Vascular Gástrica Antral , Hemorragia Gastrointestinal , Achados Incidentais , Insuficiência Renal Crônica , Humanos , Masculino , Ectasia Vascular Gástrica Antral/diagnóstico , Ectasia Vascular Gástrica Antral/complicações , Ectasia Vascular Gástrica Antral/terapia , Idoso , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/terapia , Insuficiência Renal Crônica/diagnóstico , Hemorragia Gastrointestinal/etiologia , Hemorragia Gastrointestinal/terapia , Nepal , Diálise Renal , Gastrite/diagnóstico , Gastrite/complicações , Gastrite/terapia , Coagulação com Plasma de Argônio , Melena/etiologiaRESUMO
Cholecystoenteric fistula is a rare complication of cholelithiasis, occurring in 3%-5% of patients with cholelithiasis. The symptoms are typically minimal and vague, with either acute or subacute presentations, rarely leading to bowel obstruction, and occasionally manifesting as chronic abdominal pain. In this case, a male patient in his early 30s presented with epigastric and right hypochondrial pain. On evaluation, he was diagnosed with gallstone disease and adenomyomatosis of the gallbladder. During laparoscopic cholecystectomy, a cholecystocolonic fistula was unexpectedly discovered. The fistula was managed laparoscopically using ENDOLOOP (prelooped chromic catgut ligature) ligation of the fistulous tract. The patient recovered without complications and was discharged on the third postoperative day. This case emphasises the importance of intraoperative vigilance and demonstrates a successful minimally invasive management approach.
Assuntos
Fístula Biliar , Colecistectomia Laparoscópica , Achados Incidentais , Fístula Intestinal , Humanos , Masculino , Colecistectomia Laparoscópica/métodos , Fístula Intestinal/cirurgia , Fístula Intestinal/complicações , Fístula Intestinal/diagnóstico , Adulto , Fístula Biliar/cirurgia , Fístula Biliar/diagnóstico , Doenças do Colo/cirurgia , Doenças do Colo/diagnóstico , Ligadura/métodos , Colelitíase/cirurgia , Colelitíase/complicações , Cálculos Biliares/cirurgia , Cálculos Biliares/complicaçõesRESUMO
In the context of cystic lesions of the pancreas and their paucisymptomatic symptoms, we present the case of a 33-year-old woman with epigastric pain and nonspecific abdominal discomfort. Computed tomography and magnetic resonance imaging were performed, with the finding of a lesion at the level of the head-uncinate process of the pancreas, compatible with a solid pseudopapillary neoplasm of the pancreas. The procedure was performed with a cephalic pancreaticoduodenectomy of Whipple, without incident. After 18 months of follow-up, the disease remains free. It is worth highlighting the importance of images prior to therapeutic planning, due to the proximity of the tumor to the celiac artery in the hepatic artery´s origin.
En el contexto de las lesiones quísticas del páncreas y su clínica paucisintomática, se presenta el caso de una mujer de 33 años que inicia estudio por epigastralgia y molestias abdominales. Se realizan tomografía computarizada y resonancia magnética, con hallazgo de una lesión a nivel de la cabeza-proceso uncinado del páncreas, compatible con una neoplasia pseudopapilar sólida del páncreas. Se interviene realizando duodenopancreatectomía cefálica de Whipple, que transcurre sin incidencias. Tras 18 meses de seguimiento, persiste libre de enfermedad. Cabe destacar la importancia de las imágenes previas a la planificación terapéutica, por la proximidad de la tumoración al tronco celíaco en la salida de la arteria hepática.
Assuntos
Carcinoma Papilar , Achados Incidentais , Imageamento por Ressonância Magnética , Neoplasias Pancreáticas , Pancreaticoduodenectomia , Tomografia Computadorizada por Raios X , Humanos , Feminino , Adulto , Neoplasias Pancreáticas/cirurgia , Neoplasias Pancreáticas/diagnóstico por imagem , Neoplasias Pancreáticas/diagnóstico , Carcinoma Papilar/cirurgia , Carcinoma Papilar/patologia , Carcinoma Papilar/diagnóstico por imagem , Carcinoma Papilar/diagnóstico , Dor Abdominal/etiologiaRESUMO
INTRODUCTION: Gastrointestinal stromal tumors (GIST) are rare, reported incidence is between 10 to 15 cases per million of habitants. They are usually located in the stomach (56%), small intestine (32%), colon-rectum (6%), and esophagus (<1%). Its symptoms include nausea, vomiting and abdominal fullness; 30% are asymptomatic. Incidental finding during abdominal surgery or imaging studies is common. Resection with negative margins is the standard treatment. CASE REPORT: A 69-year-old female patient who debuted with massive digestive tract bleeding, requiring surgical treatment. A tumor was detected at jejunum compatible with a GIST.
INTRODUCCIÓN: Los tumores del estroma gastrointestinal (GIST) son poco frecuentes, con una incidencia de 10 a 15 casos por millón de habitantes. Suelen localizarse en el estómago (56%), el intestino delgado (32%), el colon-recto (6%) y el esófago (< 1%). Sus síntomas incluyen náusea, vómito y plenitud abdominal; el 30% son asintomáticos. Es común su hallazgo incidental durante una cirugía abdominal o en estudios de imagen. La resección con márgenes negativos es el tratamiento estándar. CASO CLÍNICO: Mujer de 69 años que debuta con hemorragia masiva de tubo digestivo, requiriendo tratamiento quirúrgico. Se detecta un tumor de yeyuno compatible con GIST.
Assuntos
Hemorragia Gastrointestinal , Tumores do Estroma Gastrointestinal , Neoplasias do Jejuno , Humanos , Tumores do Estroma Gastrointestinal/complicações , Tumores do Estroma Gastrointestinal/cirurgia , Feminino , Idoso , Hemorragia Gastrointestinal/etiologia , Neoplasias do Jejuno/complicações , Neoplasias do Jejuno/cirurgia , Achados IncidentaisRESUMO
BACKGROUND: Adrenal masses are found in up to 5%-7% of adults. The 2016 European guidelines on the management of adrenal incidentalomas have standardised the workup of these patients, but evidence of their impact on clinical practice is lacking. METHODS: Retrospective review of clinical presentation, radiological characteristics, and final diagnosis of a large cohort of patients with adrenal masses referred to a tertiary care centre 1998-2022. Sub-analysis compares outcomes before and after implementing the 2016 guidelines. RESULTS: A total of 1397 patients (55.7% women; median age 60 years [interquartile range {IQR}, 49-70]) were included. Incidental discovery was the most frequent mode of presentation (63.7%) and 30.6% of patients had masses ≥ 4â cm (median 2.9â cm [IQR, 1.9-4.7]). Unenhanced computed tomography Hounsfield units (HU) were available for 763 patients; of these, 32.9% had heterogeneous masses or >20 HU. The most common diagnoses were adrenocortical adenoma (56.0%), phaeochromocytoma (12.7%), adrenocortical carcinoma (10.6%), and metastases (5.7%). At multivariable analysis, significant predictors of malignancy included >20 HU or heterogeneous density (odds ratio [OR] 28.40), androgen excess (OR 27.67), detection during cancer surveillance (OR 11.34), size ≥ 4â cm (OR 6.11), and male sex (OR 3.06). After implementing the 2016 guidelines, the number of adrenalectomies decreased (6.1% pre-2016 vs 4.5% post-2016) and the number of patients discharged increased (4.4% pre-2016 vs 25.3% post-2016) for benign non-functioning adrenal masses. CONCLUSION: Implementing the 2016 guidelines positively impacted clinical practice, reducing unnecessary surgeries and increasing the discharge rate for benign adrenal masses, thereby preserving healthcare resources and patient burden.
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Neoplasias das Glândulas Suprarrenais , Centros de Atenção Terciária , Humanos , Feminino , Masculino , Pessoa de Meia-Idade , Neoplasias das Glândulas Suprarrenais/terapia , Neoplasias das Glândulas Suprarrenais/diagnóstico , Neoplasias das Glândulas Suprarrenais/diagnóstico por imagem , Neoplasias das Glândulas Suprarrenais/epidemiologia , Estudos Retrospectivos , Idoso , Feocromocitoma/terapia , Feocromocitoma/diagnóstico , Feocromocitoma/epidemiologia , Tomografia Computadorizada por Raios X , Adulto , Adrenalectomia , Guias de Prática Clínica como Assunto , Achados Incidentais , Adenoma Adrenocortical/diagnóstico , Adenoma Adrenocortical/terapia , Adenoma Adrenocortical/epidemiologiaRESUMO
BACKGROUND Incidental findings of renal infarct secondary to thrombosis in acutely ill patients present a unique challenge in diagnosis. We present a case of idiopathic renal infarct to highlight its workup and management and encourage further investigation of renal infarctions. CASE REPORT A 68-year-old woman with a past medical history of diet-controlled diabetes, hypertension, and hyperlipidemia presented to the Emergency Department (ED) for abdominal pain. She was found to be in diabetic ketoacidosis with pyelonephritis, so she was admitted to the Intensive Care Unit (ICU) for insulin and dextrose drip. Due to her abdominal pain, she underwent computed tomography (CT) of her abdomen and pelvis with contrast. This revealed multifocal infarcts of her right kidney with noncalcified thrombus at the proximal right renal artery. Subsequent CT angiography confirmed a right renal artery thrombus. She was started on subcutaneous enoxaparin and downgraded to basic level of care. Her history was negative for prior thrombosis, hypercoagulable state, and abdominal trauma. Echocardiogram and limited hypercoagulable workup were largely unremarkable. A multidisciplinary team evaluated the patient and recommended no surgical intervention. Following downgrade from the ICU, the patient was transitioned from enoxaparin to apixaban. She was discharged with plans for anticoagulation for 6 months, aspirin daily, and repeat CT angiogram abdomen/pelvis in 1 month. CONCLUSIONS This case illustrates the difficulties in elucidating the cause of incidental renal thrombosis in an acutely ill patient. Diagnostic workup is limited in the inpatient setting, but therapeutic anticoagulation remains the standard of treatment regardless of etiology.
Assuntos
Anticoagulantes , Cetoacidose Diabética , Infarto , Humanos , Feminino , Cetoacidose Diabética/complicações , Cetoacidose Diabética/diagnóstico , Idoso , Infarto/diagnóstico , Infarto/etiologia , Infarto/diagnóstico por imagem , Anticoagulantes/uso terapêutico , Rim/irrigação sanguínea , Rim/diagnóstico por imagem , Enoxaparina/uso terapêutico , Trombose/diagnóstico por imagem , Trombose/diagnóstico , Trombose/etiologia , Trombose/tratamento farmacológico , Piridonas/uso terapêutico , Pirazóis/uso terapêutico , Achados IncidentaisRESUMO
Objective: To describe the prevalence of incidental malignant pathology following a hysterectomy performed for benign reasons. Method: A descriptive cross-sectional study based on hospital records. Women who underwent hysterectomy for benign reasons at a general referral hospital between 2013 and 2021 were included. Women with obstetric hysterectomy were excluded. Measured variables: age, route of hysterectomy, type of hysterectomy, histopathological diagnosis of premalignant lesion or invasive cancer, type of cancer. Analysis: Descriptive, the prevalence of preneoplastic and neoplastic conditions was estimated for the overall period. Results: Of 816 clinical records, 674 cases (87 %) met the inclusion criteria and were analyzed. The premenopausal population predominated. Twentysix cases of unexpected malignant disease were identified, yielding a prevalence of 3.8 %, and 13 cases of premalignant pathology (1.9 %). The most common origin was the cervix (40 %), followed by the ovary (33 %). Conclusions: Patients undergoing hysterectomy for benign conditions should be informed about the risk of unexpected injury. The importance of performing, in our context an adequate preoperative approach to rule out cervix uteri and ovarian cancer is emphasized. Follow-up studies of patients with unanticipated cancer are required to determine their treatment and prognosis in the region.
Objetivo: describir la prevalencia de patología maligna incidental posterior a una histerectomía por causa benigna. Método: estudio de corte transversal descriptivo, basado en registros hospitalarios. Se incluyeron mujeres a quienes se les realizó una histerectomía por causa benigna en un hospital general de referencia entre 2013 y 2021. Se excluyeron mujeres con histerectomía obstétrica. Variables medidas: edad, vía de la histerectomía, tipo de histerectomía, diagnóstico histopatológico de lesión premaligna o de cáncer invasor, tipo de cáncer. Análisis: descriptivo, se estimó la prevalencia en el periodo global de condiciones preneoplásicas y neoplásicas. Resultado: de 816 registros clínicos se analizaron 674 casos (87 %) que cumplieron los criterios de inclusión. Predominó la población premenopáusica. Se identificaron 26 casos de enfermedad maligna no anticipada para una prevalencia del 3,8 % y 13 casos de patología premaligna (1,9 %). El origen más frecuente fue el cuello uterino (40 %) seguido del ovario (33 %). Conclusiones: se debe considerar informar riesgo de lesión no esperada a las pacientes que serán sometidas a histerectomía por condición benigna. Se enfatiza la importancia de realizar una adecuada aproximación prequirúrgica, en especial para descartar cáncer de ovario y cérvix en nuestro medio. Se requieren estudios de seguimiento de las pacientes con cáncer no anticipado para determinar el tratamiento y su pronóstico en la región.
Assuntos
Histerectomia , Humanos , Feminino , Histerectomia/estatística & dados numéricos , Estudos Transversais , Adulto , Pessoa de Meia-Idade , Prevalência , Idoso , Lesões Pré-Cancerosas/patologia , Lesões Pré-Cancerosas/epidemiologia , Lesões Pré-Cancerosas/cirurgia , Adulto Jovem , Achados Incidentais , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/cirurgia , Neoplasias do Colo do Útero/epidemiologia , Neoplasias Ovarianas/patologia , Neoplasias Ovarianas/epidemiologia , Neoplasias Ovarianas/cirurgiaRESUMO
BACKGROUND: Chilaiditi's sign is an incidental radiographic finding, associated with intestinal disposition located between liver and right diaphragm. It is considered as an acquired rather than a congenital condition and the prevalence ranges from 1.18% to 2.4% according to recent adult retrospective studies. The aspects of this rare entity with regards to a 7-month-old male initially misdiagnosed as diaphragmatic hernia is discussed. CASE PRESENTATION: A 4-month-old Caucasian male was misdiagnosed with a congenital diaphragmatic hernia owing to previous hospitalization with complaints of respiratory tract infection. On admission 3 months later, he was free of any signs and symptoms of intestinal obstruction or respiratory distress. Thorax computed tomography revealed Chilaiditi's sign. A diagnostic laparoscopy was regarded necessary to evaluate the anatomical details. The most prominent finding was the lack of muscle fibers and almost transparent appearance of the medial aspect of the partially eventrated right hemidiaphragm. Owing to delicate anatomical presentation, diaphragmatic plication was considered hazardous. The patient is doing well and under follow-up. CONCLUSIONS: It is obvious that Chilaiditi's sign is not always a completely incidental finding of no consequence, and may indicate an underlying congenital diaphragmatic pathology, clearly defined by laparoscopic evaluation in this case.