Diet can modify autotomy behavior in rats following peripheral neurectomy.

Partial sciatic nerve ligation in rats (PSL) produces neuropathic pain disorders [Seltzer, Z., Dubner, R. and Shir, Y., Pain, 43 ( 1990) 205-18 (corrected) ]. Recently we reported that diet markedly affected the levels of these disorders. Here we questioned whether diet also affects neuropathic pain-related behavior in another model, produced by total denervation of the hindpaw following peripheral sciatic and saphenous neurectomy. Sabra rats and HA line rats were fed for 2-3 weeks preoperatively and up to 58 days postoperatively (PO) with one of five different diet formulas. We found that the autotomy behavior differed significantly between the diet groups. Surprisingly, in some diets the effects on autotomy and PSL models were different and even contrasting. Modulation of diet in humans may emerge as a novel therapy of neuropathic pain.

Dietary increase in serotonin reduces self-injurious behaviour in a Down's syndrome adult.

A 26-year-old profoundly mentally handicapped woman with Down's syndrome and severe self-injurious behaviour was treated by dietary means. Treatment consisted of regular institutional entrees, supplemented with serotonin-containing foods, and modified to ensure dietary sources of potassium each intake and low protein relative to carbohydrate. Dramatic benefit was evident the first day and, after 6 months self-hitting was still close to 90% lower than baseline rates. Relevant literature was discussed regarding why a serotonergic approach was chosen for reducing self-injury.