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1.
Sci Rep ; 14(1): 15820, 2024 Jul 09.
Artigo em Inglês | MEDLINE | ID: mdl-38982162

RESUMO

Recent studies on fibular osteotomy for varus gonarthrosis and possible subsequent biomechanical changes have attracted increasing attention to the topic. Existing studies have focused mainly on proximal fibular osteotomy with short follow-up periods. The aim of this study was to investigate changes in the alignment of the coronal plane of the ankle and knee joints in patients who underwent vascularized fibula graft harvest (VFGH). The evaluation was based on functional outcomes and radiological measurements.In the comparison between the VFGH side and the contralateral side, no significant differences in the knee inclination (KI) or talar inclination (TI) angle, knee medial clear space (K-MCS) or ankle medial clear space (A-MCS) distance were noted. However, a significant difference in the hip knee (HKA) angle was observed between the operated and nonoperated sides (0.3° ± 1.8° and 1.5° ± 1.9°, respectively [p = 0.019]). Statistically significant differences in both the knee society score (KSS) and the AOFAS scores were found between the ipsilateral donor limb and the contralateral healthy limb. Although the contralateral healthy side had better clinical scores than the VFGH side, the outcomes of the VFGH side were still satisfactory or excellent.


Assuntos
Articulação do Tornozelo , Fíbula , Articulação do Joelho , Humanos , Fíbula/transplante , Fíbula/cirurgia , Masculino , Feminino , Pessoa de Meia-Idade , Articulação do Joelho/cirurgia , Adulto , Articulação do Tornozelo/cirurgia , Transplante Ósseo/métodos , Extremidade Inferior/cirurgia , Extremidade Inferior/irrigação sanguínea , Osteotomia/métodos , Resultado do Tratamento , Coleta de Tecidos e Órgãos/métodos , Idoso
2.
BMC Musculoskelet Disord ; 25(1): 525, 2024 Jul 09.
Artigo em Inglês | MEDLINE | ID: mdl-38982406

RESUMO

Pediatric ankle injuries are common; ankle epiphyseal fractures are also common in children. But isolated distal epiphyseal fibular fractures of the distal fibula are clinically rare. We describe one unusual case of an adolescent with a completely displaced Salter-Harris type II distal fibular epiphyseal fracture. The attempt of closed reduction failed, and the patient required open reduction and internal fixation. The localized periosteum and the superior peroneal retinaculum were avulsed from the distal fibular metaphysis, with the peroneal tendons underneath exposed but no obvious subluxation. To the best of our knowledge, this combination of injuries has not been previously reported.


Assuntos
Epífises , Fíbula , Fixação Interna de Fraturas , Humanos , Fíbula/lesões , Fíbula/cirurgia , Fíbula/diagnóstico por imagem , Adolescente , Fixação Interna de Fraturas/métodos , Epífises/lesões , Epífises/cirurgia , Epífises/diagnóstico por imagem , Masculino , Resultado do Tratamento , Fraturas Ósseas/cirurgia , Fraturas Ósseas/diagnóstico por imagem , Fraturas do Tornozelo/cirurgia , Fraturas do Tornozelo/diagnóstico por imagem , Redução Aberta/métodos , Feminino
3.
Microsurgery ; 44(5): e31213, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-39011824

RESUMO

INTRODUCTION: Complex open long bone fractures present a multidisciplinary surgical challenge. Various treatment options are discussed with no consensus. Fibula flaps (FF) are frequently used in maxillofacial surgery, however their use in limb injuries is less common. With the tremendous improvement in microsurgery, orthoplastic surgery gained importance. Our retrospective study aims to assess the long-term results and the quality of life of the patients operated by FF for complex traumatic limb reconstruction. PATIENTS AND METHODS: We conducted an observational mono centric retrospective study from the year 2011 to the year 2021. Patients operated for complicated traumatic limb fractures using FF were included in the study. Not only long-term clinical results were evaluated, but also Patient-reported outcome measures (PROM). These included the Lower Extremity Functional Scale (LEFS), Quick Disabilities of the Arm, shoulder and hand (Qdash), and the Visual Analogue Scale (VAS). The statistical analysis was done using the R Software. RESULTS: Twenty patients were included in our study. 80% achieved complete union with no re fracture rate at a median follow-up of 41 months. All of the patients (n = 4) who underwent amputation were smokers (p = .09), were operated for lower limb fractures (p = .54), and were males (p = 1). The length of hospital stay was associated with an increased duration to complete bony union (p = .01, coefficient = 2.88). At the end of follow-up, the LEFS median score was 67 for the total population and 63.5 for the lower limb reconstructed sub group. CONCLUSION: VFF is an important tool in the armamentarium of orthoplastic surgeons. Encouraging long term functional and clinical outcomes were obtained in patients with complex traumatic limb fractures.


Assuntos
Fíbula , Retalhos de Tecido Biológico , Procedimentos de Cirurgia Plástica , Humanos , Masculino , Estudos Retrospectivos , Feminino , Adulto , Fíbula/transplante , Procedimentos de Cirurgia Plástica/métodos , Pessoa de Meia-Idade , Seguimentos , Retalhos de Tecido Biológico/transplante , Resultado do Tratamento , Fraturas Expostas/cirurgia , Qualidade de Vida , Adulto Jovem , Medidas de Resultados Relatados pelo Paciente , Idoso , Microcirurgia/métodos
4.
Artigo em Inglês | MEDLINE | ID: mdl-38996216

RESUMO

INTRODUCTION: The purpose of this systematic review and meta-analysis was to provide an update of the recent literature comparing clinical outcomes of surgically treated fibular fractures using intramedullary nailing (IMN) with open reduction and internal plate fixation (ORIF). METHODS: A literature search reporting clinical outcomes after IMN or ORIF of the distal fibula was conducted on PubMed. Inclusion criteria consisted of original studies; studies focusing on clinical outcomes after IMN or IMN and ORIF published before May 11, 2022; studies with at least 5 patients; and studies reporting union rates, complication rates, and patient-reported outcomes such as American Orthopaedic Foot and Ankle Society (AOFAS) and Olerud-Molander scores. RESULTS: Of 2,394 studies identified, a total of 29 studies (4 LOE-I, 2 LOE-II, 6 LOE-III, 17 LOE-IV) were included consisting of 1,850 IMN patients and 514 plate patients. The pooled mean age of IMN patients was 58 years (95% confidence interval [CI], 54 to 62, I2 = 42%) versus 57 years (95% CI, 53 to 62, I2 = 49%) in ORIF. Union rates for IMN patients revealed a 99% union rate (95% CI, 0.98 to 1.00, I2 = 20%) versus 97% union rate for ORIF patients (95% CI, 0.94 to 0.99, I2 = 0%). Studies that compared IMN with ORIF revealed no difference in union rates (risk ratio [RR] = 0.99, 95% CI, 0.96 to 1.02, I2 = 0%). IMN patients showed a 15% complication rate (95% CI, 0.09 to 0.23, I2 = 89%), whereas plate patients had a complication rate of 30% (95% CI, 0.18 to 0.46, I2 = 63%). When comparing studies with both treatments, IMN patients had a significantly lower risk of complications (RR = 0.49, 95% CI, 0.29 to 0.82, I2 = 50%). The IMN group trended toward a higher mean AOFAS and Olerud-Molander score than the plate group by 4.53 (95% CI, -14.58 to 23.65, I2 = 85%) and 3.54 (95% CI, -2.32 to 9.41, I2 = 76%) points, respectively. CONCLUSION: Current literature reveals near equivalence in union rates and a markedly lower risk of complications when comparing IMN with plate fixation. While IMN patients had higher AOFAS and Olerud-Molander scores, these differences were not statistically significant. Notably, subgroup analyses indicated that rates of symptomatic implant and removal of implant were comparable between IMN and ORIF, which may indicate that wound-related complications were reduced in the minimally invasive IMN technique. While the high cost of IMN implants remains a barrier to their widespread adoption, the long-term benefits of reducing complications, specifically associated with wound complications in high-risk populations, may greatly improve quality of care for patients with distal fibula fractures. Additional research and cost-effectiveness analyses are warranted to fully assess the long-term benefits and economic feasibility of using IMN fixation for distal fibula fractures. LEVEL OF EVIDENCE: Therapeutic Level IV.


Assuntos
Placas Ósseas , Fíbula , Fixação Intramedular de Fraturas , Fraturas Ósseas , Humanos , Fíbula/lesões , Fíbula/cirurgia , Fixação Intramedular de Fraturas/métodos , Fraturas Ósseas/cirurgia , Fixação Interna de Fraturas/métodos , Resultado do Tratamento , Complicações Pós-Operatórias , Pessoa de Meia-Idade
5.
Oral Oncol ; 156: 106945, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39002300

RESUMO

OBJECTIVES: This study aimed to compare the risk of osteoradionecrosis and implant survival in oral cancer patients undergoing immediate dental implants during jaw reconstruction, termed "Jaw in a Day" (JIAD), with those receiving no implants or delayed implants (non-JIAD). PATIENTS & METHODS: Clinicopathologic data were collected from prospectively enrolled JIAD patients (n = 10, 29 implants) and retrospectively from non-JIAD patients (n = 117, 86 implants). Survival analyses were performed to assess implant survival and osteoradionecrosis-free survival. RESULTS: Osteoradionecrosis occurred in 0 % of JIAD cases compared to 19.3 % in non-JIAD cases without implants and 71.4 % in non-JIAD cases with delayed implants (p = 0.008). Osteoradionecrosis-free survival was significantly better in the JIAD group than the non-JIAD group (p = 0.0059). Implants in the JIAD group all survived regardless of radiation therapy (29/29, 100 %) and 95.1 % (58/61) of implants survived in delayed implants in non-irradiated fibula without radiotherapy. Meanwhile, only 11 of 25 implants placed in irradiated fibula flaps survived, even when the implants were placed after a median time interval of 624 days after radiotherapy, and none of them were earlier than 360 days. The survival analysis revealed a significant difference (p < 0.0001). CONCLUSION: JIAD appears to offer superior outcomes in terms of implant survival and osteoradionecrosis prevention compared to delayed implant placement. Placing implants in irradiated fibula, even after years, significantly poses high risk of implant failure and osteoradionecrosis. JIAD represents a promising approach for optimal rehabilitation, particularly in oral cancer patients requiring postoperative radiotherapy. Proper positioning and orientation of implants and flaps are crucial for implant survival.


Assuntos
Implantes Dentários , Fíbula , Retalhos de Tecido Biológico , Osteorradionecrose , Humanos , Osteorradionecrose/cirurgia , Osteorradionecrose/etiologia , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Fíbula/cirurgia , Fíbula/transplante , Estudos Retrospectivos , Procedimentos de Cirurgia Plástica/métodos , Neoplasias Bucais/cirurgia , Neoplasias Bucais/radioterapia , Adulto , Arcada Osseodentária , Estudos Prospectivos
6.
Sci Rep ; 14(1): 14538, 2024 06 24.
Artigo em Inglês | MEDLINE | ID: mdl-38914709

RESUMO

Minimally invasive plate osteosynthesis is the most commonly used minimally invasive surgery technique for tibial fractures, possibly involving single or dual plate methods. Herein, we performed a finite element analysis to investigate plate strength according to the plate type, length, and presence of a fibula by constructing a three-dimensional tibia model. A thickness of 20 mm was cut 50 mm distal from the lateral plateau, and the ligaments were created. Plates were modeled with lengths of 150, 200, and 250 mm and mounted to the tibia. Screws were arranged to avoid overlapping in the dual plating. The von-Mises stress applied to the plates was measured by applying a load of 1 body weight. Dual plates showed the least stress with low displacement, followed by medial and lateral plates. As the plate length increased, the average stress gradually decreased, increasing plate safety. The difference in the influence of the fibula depending on the presence of proximal fibula osteotomy showed that the average stress increased by 35% following proximal fibula osteotomy in the D1(Plate type: Dual plate, Medial plate length: 150 mm, Lateral plate length: 200 mm, Non Proximal fibula osteotomy) and D1P(Plate type: Dual plate, Medial plate length: 150 mm, Lateral plate length: 200 mm, Proximal fibula osteotomy) models, confirming the necessity of the fibula model. There is no consensus guideline for treatment of this kind of fracture case. A single fracture plate can decrease the risk of skin damage, ligament damage, and wound infection, but because of its design, it cannot provide sufficient stability and satisfactory reduction of the condylar fragment, especially in cases of comminution or coronal fracture. So, these results will help clinicians make an informed choice on which plate to use in patients with tibial fractures.


Assuntos
Placas Ósseas , Fíbula , Análise de Elementos Finitos , Fixação Interna de Fraturas , Fraturas da Tíbia , Fraturas da Tíbia/cirurgia , Humanos , Fíbula/cirurgia , Fíbula/lesões , Fixação Interna de Fraturas/métodos , Fixação Interna de Fraturas/instrumentação , Estresse Mecânico , Fenômenos Biomecânicos , Tíbia/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos
7.
Iowa Orthop J ; 44(1): 93-98, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38919371

RESUMO

Background: Fibular hemimelia is the most common congenital long bone deficiency. It is often associated with femoral and tibial deficiencies which result in a clinically evident leg length discrepancy. The primary soft tissue concern is ACL/PCL deficiency. If treatment includes bony lengthening, joint stability is imperative to avoid complications. In this study, we detail a novel technique for long bone lengthening and ACL reconstruction in a single, cohesive surgery. This consolidates the need for multiple procedures and offers improved limb length symmetry and knee stability for this patient population. Clinical outcomes of pediatric patients with hemimelia who underwent either femoral or tibial lengthening with PRECICE® nail and concomitant ACL reconstruction are presented. Methods: After IRB approval, we identified five patients with complex fibular hemimelia who underwent ACL reconstruction and concomitant lengthening with at least two years of follow-up. Two patients (40%) presented with congenital short femur, and three (60%) with congenital short tibia. In each case, ACL reconstruction and either femoral or tibial guided growth via PRECICE® nail were performed. Operative techniques involving both soft tissue and bony methodology are described in detail. Results: All patients had objective improvement in knee stability as assessed both intra and post operatively, as well as successful intermedullary lengthening without complications related to joint stability. Three patients had minor complications unrelated to joint stability that did not interfere with overall result. Conclusion: Fibular hemimelia associated with hypoplasia of bony and soft tissue structures can be successfully addressed with concomitant ligamentous reconstruction at the time of implantation of lengthening devices. This addresses knee instability and reduces both number of operative procedures and potential complications related to joint instability while pursuing bony lengthening. Level of Evidence: V.


Assuntos
Reconstrução do Ligamento Cruzado Anterior , Alongamento Ósseo , Ectromelia , Fíbula , Humanos , Estudos Retrospectivos , Ectromelia/cirurgia , Masculino , Feminino , Fíbula/cirurgia , Fíbula/anormalidades , Criança , Reconstrução do Ligamento Cruzado Anterior/métodos , Alongamento Ósseo/métodos , Resultado do Tratamento , Adolescente , Tíbia/cirurgia , Tíbia/anormalidades , Fêmur/cirurgia , Fêmur/anormalidades
8.
BMC Musculoskelet Disord ; 25(1): 479, 2024 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-38890706

RESUMO

BACKGROUND: This work aimed to investigate the change in fingerprint depth and the recovery rule of fingerprint biological recognition function after repairing finger abdominal defects and rebuilding fingerprint with a free flap. METHOD: From April 2018 to March 2023, we collected a total of 43 cases of repairing finger pulp defects using the free flap of the fibular side of the great toe with the digital nerve. After surgery, irregular follow-up visits were conducted to observe fingerprint clarity, perform the ninhydrin test or detect visible sweating with the naked eye. We recorded fingerprint clarity, nail shape, two-point discrimination, cold perception, warm perception and fingerprint recognition using smartphones. The reconstruction process of the repaired finger was recorded to understand the changes in various observation indicators and their relationship with the depth of the fingerprint. The correlation between fingerprint depth and neural repair was determined, and the process of fingerprint biological recognition function repair was elucidated. RESULT: All flaps survived, and we observed various manifestations in different stages of nerve recovery. The reconstructed fingerprint had a clear fuzzy process, and the depth changes of the fingerprint were consistent with the changes in the biological recognition function curve. CONCLUSION: The free flap with the digital nerve is used to repair finger pulp defects. The reconstructed fingerprint has a biological recognition function, and the depth of the fingerprint is correlated with the process of nerve repair. The fingerprint morphology has a dynamic recovery process, and it can reach a stable state after 6-8 months.


Assuntos
Traumatismos dos Dedos , Retalhos de Tecido Biológico , Lesões dos Tecidos Moles , Humanos , Masculino , Feminino , Adulto , Retalhos de Tecido Biológico/transplante , Retalhos de Tecido Biológico/inervação , Pessoa de Meia-Idade , Traumatismos dos Dedos/cirurgia , Lesões dos Tecidos Moles/cirurgia , Adulto Jovem , Recuperação de Função Fisiológica , Procedimentos de Cirurgia Plástica/métodos , Dedos do Pé/cirurgia , Dedos do Pé/inervação , Dedos/inervação , Dedos/cirurgia , Resultado do Tratamento , Fíbula/transplante , Fíbula/cirurgia , Adolescente , Idoso
9.
J Orthop Surg Res ; 19(1): 333, 2024 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-38835085

RESUMO

BACKGROUND: Knee osteoarthritis (KOA) represents a widespread degenerative condition among adults that significantly affects quality of life. This study aims to elucidate the biomechanical implications of proximal fibular osteotomy (PFO), a proposed cost-effective and straightforward intervention for KOA, comparing its effects against traditional high tibial osteotomy (HTO) through in-silico analysis. METHODS: Using medical imaging and finite element analysis (FEA), this research quantitatively evaluates the biomechanical outcomes of a simulated PFO procedure in patients with severe medial compartment genu-varum, who have undergone surgical correction with HTO. The study focused on evaluating changes in knee joint contact pressures, stress distribution, and anatomical positioning of the center of pressure (CoP). Three models are generated for each of the five patients investigated in this study, a preoperative original condition model, an in-silico PFO based on the same original condition data, and a reversed-engineered HTO in-silico model. RESULTS: The novel contribution of this investigation is the quantitative analysis of the impact of PFO on the biomechanics of the knee joint. The results provide mechanical evidence that PFO can effectively redistribute and homogenize joint stresses, while also repositioning the CoP towards the center of the knee, similar to what is observed post HTO. The findings propose PFO as a potentially viable and simpler alternative to conventional surgical methods for managing severe KOA, specifically in patients with medial compartment genu-varum. CONCLUSION: This research also marks the first application of FEA that may support one of the underlying biomechanical theories of PFO, providing a foundation for future clinical and in-silico studies.


Assuntos
Simulação por Computador , Fíbula , Articulação do Joelho , Osteoartrite do Joelho , Osteotomia , Pressão , Humanos , Osteotomia/métodos , Osteoartrite do Joelho/cirurgia , Osteoartrite do Joelho/fisiopatologia , Fíbula/cirurgia , Articulação do Joelho/cirurgia , Articulação do Joelho/fisiopatologia , Articulação do Joelho/diagnóstico por imagem , Tíbia/cirurgia , Tíbia/diagnóstico por imagem , Análise de Elementos Finitos , Fenômenos Biomecânicos , Masculino , Feminino , Pessoa de Meia-Idade , Adulto
10.
BMC Musculoskelet Disord ; 25(1): 466, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38879480

RESUMO

BACKGROUND: Traumatic proximal tibiofibular fracture and dislocation (PTFD) have been rarely studied and are easily missed in clinical practice. PTFD is considered a marker of severely traumatized knees. The purpose of this study was to retrospectively analyze the incidence and impact of PTFD in traumatized knees with vascular injury. METHODS: Patients with knee trauma and vascular injury were included from January 2022 to October 2023. X-rays and CT scans of included patients were retrospectively analyzed to determine the presence of PTFD. Patients were further divided into PTFD group and non-PTFD group for further comparative analysis. RESULTS: A total of 27 patients (28 limbs) were included. Incidence of PTFD was 39.3% (11/28) in traumatic knee with vascular injury, including 8 anterolateral dislocations and 3 posteromedial dislocations. PTFD group had significantly more limbs with open injuries compared with non-PTFD group (10/11 VS 7/17, p<0.05). Amputation rate of PTFD group was as high as 40% (4/10), compared to 23.5% (4/17) in non-PTFD group. However, the difference between two groups was not statistically significant (p>0.05). CONCLUSIONS: PTFD was easily overlooked or missed. In traumatized knees with vascular injury, incidence of PTFD was high. The presence of PTFD might indicate severe knee trauma and the possibility of open injury. Although there was no significant difference compared with non-PTFD group, PTFD group had a relatively high amputation rate of 40%.


Assuntos
Fíbula , Luxação do Joelho , Fraturas da Tíbia , Humanos , Masculino , Feminino , Estudos Retrospectivos , Adulto , Pessoa de Meia-Idade , Fraturas da Tíbia/diagnóstico por imagem , Fraturas da Tíbia/epidemiologia , Luxação do Joelho/epidemiologia , Luxação do Joelho/diagnóstico por imagem , Fíbula/lesões , Fíbula/diagnóstico por imagem , Incidência , Adulto Jovem , Tomografia Computadorizada por Raios X , Lesões do Sistema Vascular/epidemiologia , Lesões do Sistema Vascular/diagnóstico por imagem , Lesões do Sistema Vascular/etiologia , Amputação Cirúrgica/estatística & dados numéricos , Idoso , Traumatismos do Joelho/diagnóstico por imagem , Traumatismos do Joelho/epidemiologia , Adolescente
11.
BMJ Case Rep ; 17(6)2024 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-38914523

RESUMO

A man in his early 70s with right Takakura stage IIIB varus ankle osteoarthritis underwent medial opening wedge supramalleolar osteotomy with inframalleolar correction as joint preserving procedure. We also performed anteroinferior tibiofibular ligament (AITFL) resection with fibular shortening valgisation osteotomy to enhance the talar tilt correction. Postoperative decrease in talar tilt with dramatic symptom improvement was achieved. Performing the AITFL resection with fibular shortening valgisation osteotomy plus concomitant supramalleolar osteotomy and inframalleolar correction for Takakura stage IIIB varus ankle osteoarthritis resulted in successful improvement in talar tilt by making room for the valgus deviation of the talus.


Assuntos
Articulação do Tornozelo , Osteoartrite , Osteotomia , Humanos , Masculino , Osteoartrite/cirurgia , Osteoartrite/diagnóstico por imagem , Osteotomia/métodos , Articulação do Tornozelo/cirurgia , Articulação do Tornozelo/diagnóstico por imagem , Idoso , Resultado do Tratamento , Fíbula/cirurgia , Fíbula/diagnóstico por imagem
12.
In Vivo ; 38(4): 1537-1545, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38936931

RESUMO

Fibula osteoseptocutaneous flap has been widely used for oncologic bony reconstruction of both the mandible and maxilla. Early and late morbidities of the donor side such as leg weakness, ankle instability, limited ankle mobility, tibial stress fractures or incision area pain are well documented; however, there is a lack of information about the effects of fibula grafting on patient quality of life. To address this issue, a scoping literature search in the PubMed electronic database was performed to identify all relevant studies and reviews in the period between 2010 and 2022. The potential discomforts after free fibula grafting and their impact on different domains of everyday living were identified and evaluated. The present literature review indicates that donor site morbidity can negatively impact patients' quality of life, albeit generally classified as minor. However, the functional and aesthetic benefits of oromandibular reconstruction clearly outweigh the associated sequelae. Nevertheless, the authors of this review highlight the importance of a comprehensive clinical evaluation of the donor site besides the recipient site during follow-up examinations. This would help to subjectively evaluate the functional and esthetical limitations of a patient's site and promptly detect morbidities that could lead to long-term complications.


Assuntos
Fíbula , Reconstrução Mandibular , Procedimentos de Cirurgia Plástica , Qualidade de Vida , Humanos , Fíbula/transplante , Procedimentos de Cirurgia Plástica/métodos , Reconstrução Mandibular/métodos , Transplante Ósseo/métodos , Mandíbula/cirurgia , Retalhos de Tecido Biológico
13.
Development ; 151(13)2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38828852

RESUMO

The cellular and genetic networks that contribute to the development of the zeugopod (radius and ulna of the forearm, tibia and fibula of the leg) are not well understood, although these bones are susceptible to loss in congenital human syndromes and to the action of teratogens such as thalidomide. Using a new fate-mapping approach with the Chameleon transgenic chicken line, we show that there is a small contribution of SHH-expressing cells to the posterior ulna, posterior carpals and digit 3. We establish that although the majority of the ulna develops in response to paracrine SHH signalling in both the chicken and mouse, there are differences in the contribution of SHH-expressing cells between mouse and chicken as well as between the chicken ulna and fibula. This is evidence that, although zeugopod bones are clearly homologous according to the fossil record, the gene regulatory networks that contribute to their development and evolution are not fixed.


Assuntos
Animais Geneticamente Modificados , Galinhas , Proteínas Hedgehog , Animais , Proteínas Hedgehog/metabolismo , Proteínas Hedgehog/genética , Galinhas/genética , Camundongos , Evolução Biológica , Embrião de Galinha , Ulna , Regulação da Expressão Gênica no Desenvolvimento , Fíbula/metabolismo , Rádio (Anatomia)/metabolismo , Humanos , Extremidades/embriologia
14.
Oral Oncol ; 156: 106910, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38943871

RESUMO

BACKGROUND: Different fibula osteocutaneous free flap (FOCFF) configurations have been described with a double-skin paddle (DSP) to address composite through-and-through oromandibular defects: division of the skin paddle using different perforators (div-FOCFF) or a de-epithelialized DSP FOCFF (deEpi-FOCFF). This study aimed to compare the surgical outcomes using these two methods (deEpi-FOCFF/div-FOCFF). METHODS: Patients who underwent segmental mandibulectomy and reconstruction with a DSP FOCFF between 2011 and 2014 were included. We compared postoperative outcomes of patients undergoing reconstruction with deEpi-FOCFF versus div-FOCFF implementing propensity score matching. RESULTS: Of the 245 patients, 156 cases (78 pairs) were 1:1 matched. Demographic and oncologic variables were comparable between groups. The average age was 57.68 years. A higher number of perforators per flap was evident in the div-FOCFF group (p < 0.001). The deEpi-FOCFF group exhibited a higher total flap loss rate when compared to the div-FOCFF group (15 % versus 5 % p = 0.03). On multivariate analysis, number of perforators per flap (OR 0.31, p = 0.02), using the deEpi-FOCFF (OR 3.88, p = 0.03), and an increased reconstructive time (OR 1.01, p = 0.01) independently affected the likelihood of free flap failure. CONCLUSION: If the number and location of perforators are optimal, div-FOCFF improves reconstructive outcomes for composite oromandibular defects versus the deEpi-FOCFF.


Assuntos
Fíbula , Retalhos de Tecido Biológico , Pontuação de Propensão , Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Fíbula/transplante , Idoso , Procedimentos de Cirurgia Plástica/métodos , Adulto , Mandíbula/cirurgia , Estudos Retrospectivos , Resultado do Tratamento
15.
JBJS Case Connect ; 14(2)2024 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-38913790

RESUMO

CASE: We describe 2 case studies, involving a 10-year-old girl with an aneurysmal bone cyst and a 12-year-old adolescent boy with Ewing sarcoma. The patient with Ewing sarcoma was previously managed with wide surgical excision and fibular graft reconstruction and subsequently experienced significant graft resorption, hardware failure, and fracture 24 months after operation. A revision limb salvage attempt was undertaken. In both cases, fibular strut grafts were harvested and fixed with intramedullary k-wires to recreate the medial and lateral columns of the distal humeral triangle. CONCLUSION: The technique achieved complete osseous integration, structural support, and functional restoration of the elbow in both cases, with good functional outcomes.


Assuntos
Neoplasias Ósseas , Fíbula , Úmero , Sarcoma de Ewing , Humanos , Criança , Masculino , Fíbula/transplante , Fíbula/cirurgia , Feminino , Sarcoma de Ewing/cirurgia , Neoplasias Ósseas/cirurgia , Úmero/cirurgia , Transplante Ósseo/métodos , Cistos Ósseos Aneurismáticos/cirurgia , Cistos Ósseos Aneurismáticos/diagnóstico por imagem , Procedimentos de Cirurgia Plástica/métodos
16.
Med Eng Phys ; 129: 104185, 2024 07.
Artigo em Inglês | MEDLINE | ID: mdl-38906579

RESUMO

The aim of this work is to investigate in-silico the biomechanical effects of a proximal fibular osteotomy (PFO) on a knee joint with different varus/valgus deformities on the progression of knee osteoarthritis (KOA). A finite element analysis (FEA) of a human lower extremity consisting of the femoral, tibial and fibular bones and the cartilage connecting them was designed. The FEA was performed in a static standing primitive position to determine the contact pressure (CP) distribution and the location of the center of pressure (CoP). The analysis examined the relationship between these factors and the degree of deformation of the hip-knee angle in the baseline condition. The results suggested that PFO could be a simple and effective surgical treatment for patients with associated genu varum. This work also reported that a possible CP homogenization and a CoP correction can be achieved for medial varus deformities after PFO. However, it reduced its effectiveness for tibial origin valgus misalignment and worsened in cases of femoral valgus misalignment.


Assuntos
Simulação por Computador , Análise de Elementos Finitos , Articulação do Joelho , Osteotomia , Pressão , Humanos , Fenômenos Biomecânicos , Articulação do Joelho/cirurgia , Articulação do Joelho/fisiopatologia , Fíbula/cirurgia
18.
Oral Oncol ; 154: 106860, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38801787

RESUMO

OBJECTIVES: The deep circumflex iliac artery flap (DCIA) and vascularized fibular free flap (FFF) are mainstay flaps for maxillary defect reconstruction. This study compared the functional outcomes and success rates of these flaps to provide midface reconstruction strategies. MATERIALS AND METHODS: Maxillary defects reconstructed with DCIA or FFF at the Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology between May 2016 and May 2023 were retrospectively analyzed. The length, width, and height of the grafted bone segments; intermaxillary distance; buttress reconstruction rate (BRR); dental arch reconstruction rate (DAR); success rate; and dental implantation rate were compared. RESULTS: The DCIA and FFF groups had 33 and 27 patients, respectively. Success rate in the DCIA group was 93.94 % and 100 % in the FFF group. The DCIA length was less than that of FFF; however, the width and height were significantly larger. 87.10 % of cases in the DCIA group were classified as Brown class b and c, 51.85 % of cases in the FFF group were classified as Brown class d. The average BRR in the DCIA group was 69.89 % ± 16.05 %, which was significantly higher than that in the FFF group. A total of 38.7 % and 11.1 % patients in the DCIA and FFF groups, respectively, had completed implantation. CONCLUSION: DCIA has a greater width and height, and is more suitable for repairing Brown class b and c defects, providing sufficient bone for implantation, while the FFF is longer and more suitable for Brown class d defect reconstruction.


Assuntos
Fíbula , Retalhos de Tecido Biológico , Artéria Ilíaca , Maxila , Procedimentos de Cirurgia Plástica , Humanos , Masculino , Feminino , Estudos Retrospectivos , Pessoa de Meia-Idade , Artéria Ilíaca/cirurgia , Artéria Ilíaca/transplante , Fíbula/transplante , Procedimentos de Cirurgia Plástica/métodos , Maxila/cirurgia , Adulto , Idoso
19.
J Surg Orthop Adv ; 33(1): 53-55, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38815080

RESUMO

Common fibular nerve (CFN) injury due to ankle fracture is an underreported complication. The authors have proposed that torsional injury to the ankle can be translated along the interosseous membrane (IOM), producing tension on the CFN at the fibular neck. A 23-year-old woman presented to our clinic for left foot drop. Three months prior, the patient sustained a fall with left ankle inversion injury while running. She was diagnosed with a minor ankle fracture and placed in an orthopaedic boot. Unfortunately, her swelling worsened and one week later the patient was diagnosed with foot drop, which was further corroborated with EMG studies showing severe CFN injury localizing to the fibular neck. Because of the lack of recovery, she underwent decompression of the CFN. She experienced immediate symptomatic relief. High resolution imaging in this case supports our previous mechanism for indirect trauma to the ankle resulting in CFN injury. (Journal of Surgical Orthopaedic Advances 33(1):053-055, 2024).


Assuntos
Fraturas do Tornozelo , Imageamento por Ressonância Magnética , Nervo Fibular , Humanos , Feminino , Adulto Jovem , Nervo Fibular/lesões , Nervo Fibular/diagnóstico por imagem , Fraturas do Tornozelo/diagnóstico por imagem , Fraturas do Tornozelo/cirurgia , Traumatismos do Tornozelo/diagnóstico por imagem , Traumatismos do Tornozelo/cirurgia , Descompressão Cirúrgica , Traumatismos dos Nervos Periféricos/etiologia , Traumatismos dos Nervos Periféricos/diagnóstico por imagem , Fíbula/lesões , Fíbula/diagnóstico por imagem
20.
Jt Dis Relat Surg ; 35(2): 324-329, 2024 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-38727111

RESUMO

OBJECTIVES: This study aims to evaluate the inter-observer reliability of fibula-condyle-patella angle measurements and to compare it with other measurement techniques. PATIENTS AND METHODS: Between January 01, 2023 and January 31, 2023, a total of 108 patients (20 males, 88 females; mean age: 47.5±12.0 years; range, 18 to 72 years) who underwent X-rays using the fibula-condyle-patella angle, Insall-Salvati, Caton-Deschamps, Blackburne-Pell, and plateau-patella angle (PPA) methods were retrospectively analyzed. Knee lateral radiographs taken in at least 30 degrees of flexion and appropriate rotation were scanned. All measurements were made by two orthopedic surgeons who were blinded to measurement methods. RESULTS: Right knee patellar height measurements were conducted in 56 patients, while left knee patellar heights were assessed in 52 patients. The highest inter-observer concordance was found in the fibula-condyle-patella angle. The second highest concordance was found in the Insall-Salvati. The highest concordance correlation was found with PPA in the measurements of both researchers. CONCLUSION: The fibula-condyle-patella angle is a reliable technique with a good inter-observer reliability for measuring patellar height. We believe that this study will inspire future research to establish comprehensive reference values for clinical applications.


Assuntos
Fíbula , Variações Dependentes do Observador , Patela , Humanos , Feminino , Masculino , Fíbula/diagnóstico por imagem , Fíbula/anatomia & histologia , Adulto , Patela/diagnóstico por imagem , Patela/anatomia & histologia , Pessoa de Meia-Idade , Idoso , Estudos Retrospectivos , Adolescente , Adulto Jovem , Reprodutibilidade dos Testes , Radiografia/métodos , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/anatomia & histologia
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