RESUMO
In 2023, it was 50 years since the first statin was isolated from fungi and its structure determined. This finding is a fascinating parallel story to the discovery of penicillin.
Assuntos
Inibidores de Hidroximetilglutaril-CoA Redutases , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Doenças Cardiovasculares/prevenção & controle , História do Século XX , História do Século XXIRESUMO
Skin renewal is characterised by progenitor cells at the epidermal basal layer dividing and differentiating, yet the identity and properties of these progenitors remain poorly understood. In a new study, Tudorita Tumbar and colleagues identify, for the first time in vivo in the mouse epidermis, a distinct population of non-self-renewing progenitor cells that exhibit biphasic transit-amplifying behaviour. To find out more about the story behind the paper, we caught up with first author Sangeeta Ghuwalewala, penultimate author David Shalloway and corresponding author Tudorita (Doina) Tumbar, Professor of Molecular Biology and Genetics at Cornell University, USA.
Assuntos
Células-Tronco , Animais , Camundongos , Células-Tronco/citologia , Células-Tronco/metabolismo , História do Século XXI , História do Século XX , Humanos , Biologia do Desenvolvimento/históriaRESUMO
Jean-Paul (JP) Vincent is Group Leader at the Francis Crick Institute, London. His lab is interested in understanding how cells communicate to form organs during development. In 2024, he was awarded the British Society for Developmental Biology (BSDB) Waddington medal, which honours outstanding research performance and services to the developmental biology community. This interview was conducted at the 2024 BSDB and Genetics Society Joint Spring Meeting in Warwick, UK, where JP was presented with the medal.
Assuntos
Distinções e Prêmios , Biologia do Desenvolvimento , Biologia do Desenvolvimento/história , História do Século XXI , Humanos , História do Século XX , Londres , Animais , Reino UnidoRESUMO
Twenty-five years ago, in 1998, the HLA Informatics Group of the Anthony Nolan Research Institute released the IMGT/HLA Database. Since this time, this online resource has acted as the repository for the numerous variant sequences of HLA alleles named by the WHO Nomenclature Committee for Factors of the HLA System. The IPD-IMGT/HLA Database has provided a stable, highly accessible, user-friendly repository for this work. During this time, the technology underlying HLA typing has undergone significant changes. Next generation sequencing (NGS) has superseded previous methodologies of HLA typing and can generate large amounts of high-resolution sequencing data. This has resulted in a drastic increase in the number and complexity of sequences submitted to the database. The challenge for the IPD-IMGT/HLA Database has been to maintain the highest standards of curation, while supporting the core set of tools and functionality to our users with increased numbers of submissions and sequences. Traditional methods of accessing and presenting data have been challenged and new methods utilising new computing technologies have had to be developed to keep pace and support a shifting user demographic.
Assuntos
Bases de Dados Genéticas , Antígenos HLA , Sequenciamento de Nucleotídeos em Larga Escala , Teste de Histocompatibilidade , Humanos , Antígenos HLA/genética , Antígenos HLA/classificação , Teste de Histocompatibilidade/métodos , Sequenciamento de Nucleotídeos em Larga Escala/métodos , Alelos , Software , História do Século XXI , História do Século XX , Biologia Computacional/métodosRESUMO
The term "urticaria" was first introduced by William Cullen in the eighteenth century. Urticaria is a common mast cell-mediated cutaneous disease presenting with pruritic wheals, angioedema, or both. It is classified as acute (≤6 weeks) or chronic (>6 weeks) and as spontaneous (no definite triggers) or inducible (definite and subtype-specific triggers). The international urticaria guideline on the definition, classification, diagnosis, and management of urticaria is revised every 4 years. The global network of Urticaria Centers of Reference and Excellence, the biggest and most active consortium of urticaria specialists, offers physicians and patients several research, educational, and digital care initiatives.
