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Lawmakers propose reducing 27 institutes to 15.
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National Institutes of Health (U.S.) , National Institutes of Health (U.S.)/economia , Estados Unidos , PolíticaRESUMO
Cleveland Clinic fined $7.6 million for alleged mismanagement of NIH grants.
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Financiamento Governamental , Instalações de Saúde , National Institutes of Health (U.S.) , China , National Institutes of Health (U.S.)/economia , Apoio à Pesquisa como Assunto , Estados Unidos , Instalações de Saúde/economia , Instalações de Saúde/éticaRESUMO
BACKGROUND: Industry payments to US cancer centers are poorly understood. METHODS: US National Cancer Institute (NCI)-designated comprehensive cancer centers were identified (n = 51). Industry payments to NCI-designated comprehensive cancer centers from 2014 to 2021 were obtained from Open Payments and National Institutes of Health (NIH) grant funding from NIH Research Portfolio Online Reporting Tools (RePORT). Given our focus on cancer centers, we measured the subset of industry payments related to cancer drugs specifically and the subset of NIH funding from the NCI. RESULTS: Despite a pandemic-related decline in 2020-2021, cancer-related industry payments to NCI-designated comprehensive cancer centers increased from $482 million in 2014 to $972 million in 2021. Over the same period, NCI research grant funding increased from $2â481â million to $2â724â million. The large majority of nonresearch payments were royalties and licensing payments. CONCLUSION: Industry payments to NCI-designated comprehensive cancer centers increased substantially more than NCI funding in recent years but were also more variable. These trends raise concerns regarding the influence and instability of industry payments.
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Institutos de Câncer , Indústria Farmacêutica , National Cancer Institute (U.S.) , National Institutes of Health (U.S.) , Apoio à Pesquisa como Assunto , Estados Unidos , Humanos , National Cancer Institute (U.S.)/economia , Indústria Farmacêutica/economia , Indústria Farmacêutica/tendências , Apoio à Pesquisa como Assunto/tendências , Apoio à Pesquisa como Assunto/economia , National Institutes of Health (U.S.)/economia , Institutos de Câncer/economia , Conflito de Interesses/economia , Antineoplásicos/economia , Neoplasias/economiaRESUMO
Research investigating the impact of barriers to care on health-related quality of life (HRQoL) among US adults with chronic inflammatory skin diseases (CISDs) is limited. In this study, we utilize multivariable-adjusted logistic regression to analyze the associations between cost barriers (e.g., delaying specialist and mental health care due to cost) and non-cost barriers (e.g., delaying care due to transportation issues and the lack of provider diversity) with HRQoL among US adults with several common CISDs in the National Institutes of Health's All of Us Research Program (AoURP). Among the 19,208 adults with CISDs included in our analysis, the prevalence of poorer HRQoL(i.e., "fair" or "poor" HRQoL) was significantly higher among adults with CISDs who experienced cost (aOR, 2.39;95% CI, 2.10-2.73) and non-cost barriers (aOR, 2.52; 95% CI, 2.20-2.88) than those with CISDs who did not experience those barriers. Since dermatologists are often the only physician caring for patients with CISDs, this study reinforces the critical role dermatologists have in addressing social determinants of health and advocating to reduce cost and non-cost barriers for their patients with CISDs.
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Acessibilidade aos Serviços de Saúde , Qualidade de Vida , Humanos , Masculino , Feminino , Estados Unidos , Estudos Transversais , Adulto , Pessoa de Meia-Idade , Acessibilidade aos Serviços de Saúde/estatística & dados numéricos , Acessibilidade aos Serviços de Saúde/economia , Doença Crônica , National Institutes of Health (U.S.)/economia , Idoso , Adulto JovemRESUMO
Drop in 21st Century Cures Act funding will slow BRAIN and All of Us projects.
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Medicina Genômica , National Institutes of Health (U.S.) , Neurociências , Apoio à Pesquisa como Assunto , Humanos , Financiamento Governamental , National Institutes of Health (U.S.)/economia , Estados Unidos , Neurociências/economia , Medicina Genômica/economiaRESUMO
Belated Senate and House compromise eliminates policy riders restricting certain studies.
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Pesquisa Biomédica , Orçamentos , National Institutes of Health (U.S.) , National Institutes of Health (U.S.)/economia , Políticas , Estados Unidos , Mutação com Ganho de Função , Pesquisa Biomédica/economia , Pesquisa Biomédica/tendênciasRESUMO
Improving patient care is top priority for head of world's largest biomedical research funder.
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Pesquisa Biomédica , National Institutes of Health (U.S.) , Assistência ao Paciente , Humanos , Pesquisa Biomédica/economia , National Institutes of Health (U.S.)/economiaRESUMO
Importance: Surgeon-scientists are uniquely positioned to facilitate translation between the laboratory and clinical settings to drive innovation in patient care. However, surgeon-scientists face many challenges in pursuing research, such as increasing clinical demands that affect their competitiveness to apply for National Institutes of Health (NIH) funding compared with other scientists. Objective: To examine how NIH funding has been awarded to surgeon-scientists over time. Design, Setting, and Participants: This cross-sectional study used publicly available data from the NIH RePORTER (Research Portfolio Online Reporting Tools Expenditures and Results) database for research project grants awarded to departments of surgery between 1995 and 2020. Surgeon-scientists were defined as NIH-funded faculty holding an MD or MD-PhD degree with board certification in surgery; PhD scientists were NIH-funded faculty holding a PhD degree. Statistical analysis was performed from April 1 to August 31, 2022. Main Outcome: National Institutes of Health funding to surgeon-scientists compared with PhD scientists, as well as NIH funding to surgeon-scientists across surgical subspecialties. Results: Between 1995 and 2020, the number of NIH-funded investigators in surgical departments increased 1.9-fold from 968 to 1874 investigators, corresponding to a 4.0-fold increase in total funding (1995, $214 million; 2020, $861 million). Although the total amount of NIH funding to both surgeon-scientists and PhD scientists increased, the funding gap between surgeon-scientists and PhD scientists increased 2.8-fold from a $73 million difference in 1995 to a $208 million difference in 2020, favoring PhD scientists. National Institutes of Health funding to female surgeon-scientists increased significantly at a rate of 0.53% (95% CI, 0.48%-0.57%) per year from 4.8% of grants awarded to female surgeon-scientists in 1995 to 18.8% in 2020 (P < .001). However, substantial disparity remained, with female surgeon-scientists receiving less than 20% of NIH grants and funding dollars in 2020. In addition, although there was increased NIH funding to neurosurgeons and otolaryngologists, funding to urologists decreased significantly from 14.9% of all grants in 1995 to 7.5% in 2020 (annual percent change, -0.39% [95% CI, -0.47% to -0.30%]; P < .001). Despite surgical diseases making up 30% of the global disease burden, representation of surgeon-scientists among NIH investigators remains less than 2%. Conclusion and Relevance: This study suggests that research performed by surgeon-scientists continues to be underrepresented in the NIH funding portfolio, highlighting a fundamental need to support and fund more surgeon-scientists.
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Pesquisa Biomédica , Cirurgiões , Estados Unidos , Humanos , Feminino , Estudos Transversais , Cirurgiões/economia , National Institutes of Health (U.S.)/economia , Bases de Dados FactuaisAssuntos
Pesquisa Biomédica , COVID-19 , Coronavirus , Organização do Financiamento , National Institutes of Health (U.S.) , Humanos , Pesquisa Biomédica/economia , Pesquisa Biomédica/legislação & jurisprudência , Pesquisa Biomédica/tendências , COVID-19/epidemiologia , COVID-19/transmissão , COVID-19/virologia , National Institutes of Health (U.S.)/economia , National Institutes of Health (U.S.)/legislação & jurisprudência , Política , Estados Unidos , Zoonoses Virais/epidemiologia , Zoonoses Virais/transmissão , Zoonoses Virais/virologia , AnimaisAssuntos
Ensaios Clínicos como Assunto , Terapia por Exercício , National Institutes of Health (U.S.) , Síndrome de COVID-19 Pós-Aguda , Apoio à Pesquisa como Assunto , Humanos , National Institutes of Health (U.S.)/economia , National Institutes of Health (U.S.)/organização & administração , Síndrome de COVID-19 Pós-Aguda/terapia , Apoio à Pesquisa como Assunto/métodos , Apoio à Pesquisa como Assunto/organização & administração , Estados Unidos , Terapia por Exercício/efeitos adversosRESUMO
This study examines practices related to trial registration and results submission in ClinicalTrials.gov and publication of pediatric clinical trials funded by the National Institutes of Health.
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Ensaios Clínicos como Assunto , Disseminação de Informação , National Institutes of Health (U.S.) , Criança , Humanos , National Institutes of Health (U.S.)/economia , Sistema de Registros , Estados Unidos , Ensaios Clínicos como Assunto/economiaAssuntos
COVID-19 , National Institutes of Health (U.S.) , Apoio à Pesquisa como Assunto , Criança , Humanos , COVID-19/complicações , COVID-19/economia , Administração Financeira , National Institutes of Health (U.S.)/economia , Apoio à Pesquisa como Assunto/economia , Apoio à Pesquisa como Assunto/organização & administração , Estados UnidosRESUMO
Importance: Women have made substantial advancements in academic surgery, but research funding disparities continue to hamper their progress, and current literature on the status of National Institutes of Health (NIH) funding awarded to women surgeon-scientists appears to be conflicting. Objective: To examine gender-based differences in NIH funding awarded to surgeon-scientists by comparing total grant amounts awarded and the distribution of grants by gender and research type. Design, Setting, and Participants: This cross-sectional study was performed using a previously created database of NIH-funded surgeons from 2010 to 2020. Active physician data from the Association of American Medical Colleges were used to calculate total surgeon populations. This study was performed at the NIH using the NIH internal data platform, iSearch Grants. A total of 715 men and women surgeon-scientists funded by the NIH in 2010 and 1031 funded in 2020 were included in the analysis. Main Outcomes and Measures: The main outcome was the number of women among the total number of surgeons who received NIH grants and the total grant amounts awarded to them. Bivariate χ2 analyses were performed using population totals and substantiated by z tests of population proportions. Results: This study included 715 physicians (n = 579 men [81.0%]) in 2010 and 1031 physicians (n = 769 men [74.6%]) in 2020. In 2020, women comprised 27.4% of the surgical workforce and 25.4% of surgeons with research funding in the US, but they received only 21.7% of total NIH research funding awarded to all surgeons. The number of funded women surgeon-scientists, however, significantly increased from 2010 to 2020 (262 [25.4%] in 2020 vs 136 [19.0%] in 2010; P < .001) as did their funding ($189.7 million [21.7%] in 2020 vs $75.9 million [12.3%] in 2010; P < .001). Furthermore, the proportion of US women surgeons overall with NIH funding significantly increased in 2020 vs 2010 (0.7% vs 0.5%; P < .001). Basic science, clinical outcomes, and clinical trial R01 grants also increased among women surgeon-scientists. Women and men K grant holders had a similar mean (SD) number of R01 application attempts before success (2.7 [3.01] vs 2.3 [3.15]; P = .60) and similar K-to-R award conversion rates (23.5% vs 26.7%; P = .55). Conclusions and Relevance: This cross-sectional study found an increasing number of women surgeon-scientists receiving NIH funding in 2020 vs 2010 as well as increases in the median grant amounts awarded. Although these results are promising, a discrepancy remains in the proportion of women in the surgical workforce compared with those funded by the NIH and the total grant amounts awarded to them.
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Pesquisa Biomédica , Cirurgiões , Masculino , Estados Unidos , Feminino , Humanos , Estudos Transversais , National Institutes of Health (U.S.)/economia , Cirurgiões/economia , Bases de Dados FactuaisRESUMO
House of Representatives measure catalyzed in part by suspicions that Wuhan lab leak led to pandemic.
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Pesquisa Biomédica , Centers for Disease Control and Prevention, U.S. , National Institutes of Health (U.S.) , Pesquisa Biomédica/economia , Centers for Disease Control and Prevention, U.S./economia , China , Laboratórios/economia , National Institutes of Health (U.S.)/economia , Estados UnidosRESUMO
Patient groups, hospitals urge continued support for the Undiagnosed Diseases Network.