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1.
Yonsei Med J ; 65(7): 406-412, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38910303

RESUMO

PURPOSE: Robotic single-site plus one-port myomectomy (RSOM) was designed to reduce the number of incision sites for greater cosmetic satisfaction of patients while retaining the benefits of conventional robotic multi-site myomectomy (CRM). Robotic single-site plus two-port myomectomy (RSTM) eliminated one port relative to conventional CRM, and RSOM achieved the same advantage with respect to RSTM. This study aimed to compare RSOM with RSTM in terms of their respective methodologies and surgical outcomes. MATERIALS AND METHODS: The medical records of 230 patients who had undergone RSOM and 146 patients who had undergone RSTM were reviewed. The groups' surgical outcomes were compared using propensity score matching (PSM) analysis. RESULTS: In the total data, RSOM had a shorter operative time (135.1±57.4 min vs. 149.9±46.2 min, p=0.009) and a shorter hospital stay (5.2±0.5 days vs. 5.4±0.7 days, p=0.033) relative to RSTM. The PSM analysis showed that there were no statistically significant intergroup differences in the patients' baseline characteristics. Regarding the surgical outcomes, the RSOM group showed shorter operative time (129.2±49.3 min vs. 148.7±46.3 min, p=0.001) compared to the RSTM group. CONCLUSION: Compared with RSTM, RSOM was associated with shorter operative time. Additionally, more detailed comparative and prospective studies are needed to evaluate RSOM relative to RSTM.


Assuntos
Duração da Cirurgia , Pontuação de Propensão , Procedimentos Cirúrgicos Robóticos , Miomectomia Uterina , Humanos , Feminino , Miomectomia Uterina/métodos , Adulto , Procedimentos Cirúrgicos Robóticos/métodos , Tempo de Internação , Resultado do Tratamento , Pessoa de Meia-Idade , Estudos Retrospectivos , Leiomioma/cirurgia , Neoplasias Uterinas/cirurgia
2.
J Robot Surg ; 18(1): 270, 2024 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-38926240

RESUMO

Fibroids are the most common benign tumours of the uterus, often requiring surgery when symptomatic. This study aims to investigate the impact of surgery using two methods, laparoscopy and laparotomy, on the thickness and vascularity of the uterine myometrium at the site of myomectomy scar (comparing sonographic features at the surgical scar site, including thickness, vascularity, and the extent of fibrotic tissue, in both open and laparoscopic surgical approaches). In this clinical trial, 100 women with type 2-5 fibroids and clinical symptoms, seeking surgery et al. Zahra Hospital, were enrolled in two groups: laparoscopy and laparotomy. Inclusion criteria were a maximum fibroid size of 8 cm and, in the case of multiple fibroids, a maximum of three, with the largest being 8 cm. 6 months post-surgery, sonographic assessments of the myomectomy scar site were compared between both groups. Participants showed no significant differences in demographic and obstetric factors. The most common clinical symptom (87%) in both groups was abnormal uterine bleeding (AUB). The mean hospital stay duration was statistically significantly lower in the laparoscopy group at 1.64 (SD 0.56) compared to 1.89 (SD 0.58) in the laparotomy group (p = 0.028). Additionally, the decrease in haemoglobin levels was 0.89 (SD 0.92) and 1.87 (SD 2.24) units, respectively, which showed a statistically significant difference (p = 0.003). The duration of surgery was significantly shorter in the laparotomy group (p = 0.001). Abdominal pressure was not observed in the laparoscopy group, while 12% of the laparotomy group reported complaints (p = 0.013). Based on the results obtained in this study, it can be concluded that there was no difference between these two methods in terms of improving uterine thickness and associated complications. However, the decrease in haemoglobin levels and the length of hospital stay were lower in patients undergoing laparoscopy.


Assuntos
Cicatriz , Laparoscopia , Laparotomia , Leiomioma , Miométrio , Miomectomia Uterina , Neoplasias Uterinas , Humanos , Feminino , Laparoscopia/métodos , Miomectomia Uterina/métodos , Cicatriz/etiologia , Adulto , Miométrio/patologia , Miométrio/cirurgia , Laparotomia/métodos , Leiomioma/cirurgia , Leiomioma/patologia , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/patologia , Ultrassonografia , Tempo de Internação , Pessoa de Meia-Idade
3.
J Med Case Rep ; 18(1): 277, 2024 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-38867300

RESUMO

BACKGROUND: This case describes the youngest patient documented in the literature who presented with a giant hydatidiform mole, effectively addressed through conservative treatment. CASE PRESENTATION: Our department received a 20-year-old Caucasian patient who was admitted due to significant metrorrhagia in an undisclosed pregnancy. During examination, we identified a massive, highly vascularized hydatidiform mole measuring 22 cm (cm). We performed a surgical dilatation and curettage. The anatomopathological findings confirmed the presence of a complete hydatidiform mole (CHM). Following the established guidelines, we conducted weekly monitoring of human chorionic gonadotropin (hCG). Unfortunately, the patient discontinued the follow-up and became pregnant again before achieving hCG negativation. CONCLUSION: This case suggests that conservative treatment is a viable option regardless of the size of gestational trophoblastic disease (GTD), especially when the preservation of fertility is a crucial consideration, as effectively demonstrated in our case.


Assuntos
Mola Hidatiforme , Neoplasias Uterinas , Humanos , Mola Hidatiforme/patologia , Mola Hidatiforme/diagnóstico , Mola Hidatiforme/cirurgia , Mola Hidatiforme/diagnóstico por imagem , Feminino , Gravidez , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/patologia , Neoplasias Uterinas/diagnóstico , Adulto Jovem , Dilatação e Curetagem , Gonadotropina Coriônica/sangue
4.
Int J Hyperthermia ; 41(1): 2365974, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38880503

RESUMO

PURPOSE: To investigate the feasibility, safety and efficacy of high intensity focused ultrasound ablation (HIFU) as a preoperative treatment for challenging hysteroscopic myomectomies. MATERIALS AND METHODS: A total of 75 patients diagnosed with types 0-III of uterine fibroids were enrolled. Based on the Size, Topography, Extension of the base, Penetration and lateral Wall position (STEPW) classification scoring system, 25 cases with a score ≥ 5 points were treated with HIFU followed by hysteroscopic myomectomy (HIFU + HM group), whereas 50 cases with a score < 5 points were treated with hysteroscopic myomectomy (HM group). RESULTS: The median preoperative STEPW score was 7 in the HIFU + HM group and 2 in the HM group. The average non-perfused volume (NPV) ratio achieved in fibroids after HIFU was 86.87%. Patients in the HIFU + HM group underwent hysteroscopic myomectomy one to four days after HIFU, and downgrading was observed in 81.81% of fibroids. The operation time for patients in the HIFU + HM group was 73 min and the success rate of myomectomy in a single attempt was 60%. The volume of distention medium used during the operation was greater in the HIFU + HM group than in the HM group (15,500 ml vs. 7500 ml). No significant difference was observed between the two groups in terms of intraoperative blood loss, the incidence of intraoperative and postoperative complications, menstrual volume score, or uterine fibroid quality of life score. CONCLUSION: HIFU can be utilized as a preoperative treatment for large submucosal fibroids prior to hysteroscopic myomectomy. HIFU offers a novel approach in the management of this subset of patients.


Assuntos
Ablação por Ultrassom Focalizado de Alta Intensidade , Histeroscopia , Leiomioma , Miomectomia Uterina , Humanos , Feminino , Ablação por Ultrassom Focalizado de Alta Intensidade/métodos , Adulto , Miomectomia Uterina/métodos , Histeroscopia/métodos , Pessoa de Meia-Idade , Leiomioma/cirurgia , Leiomioma/terapia , Estudos de Viabilidade , Resultado do Tratamento , Neoplasias Uterinas/cirurgia
5.
J Int Med Res ; 52(6): 3000605241255810, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38886867

RESUMO

Pelvic masses frequently originate from the pelvic cavity and are often associated with uterine, ovarian, or intestinal disorders. This report describes the case of a patient with a pelvic mass diagnosed as a retroperitoneal dermoid cyst at our hospital. We analyzed this case and conducted a literature review, to mitigate the risk of misdiagnosis and enhance the treatment of retroperitoneal masses.


Assuntos
Adenomioma , Cisto Dermoide , Neoplasias Retroperitoneais , Neoplasias Uterinas , Humanos , Feminino , Cisto Dermoide/cirurgia , Cisto Dermoide/complicações , Cisto Dermoide/diagnóstico , Cisto Dermoide/patologia , Neoplasias Retroperitoneais/patologia , Neoplasias Retroperitoneais/complicações , Neoplasias Retroperitoneais/diagnóstico por imagem , Neoplasias Retroperitoneais/diagnóstico , Neoplasias Retroperitoneais/cirurgia , Neoplasias Uterinas/patologia , Neoplasias Uterinas/complicações , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/diagnóstico por imagem , Adenomioma/patologia , Adenomioma/cirurgia , Adenomioma/complicações , Adenomioma/diagnóstico , Adenomioma/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Adulto
6.
BMJ Case Rep ; 17(6)2024 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-38862186

RESUMO

Disseminated peritoneal leiomyomatosis (DPL) is a rare and benign clinical entity. It is also known as leiomyomatosis peritonealis disseminata (LPD). Here, we report and discuss a case of a primiparous woman in her early 40s who presented with heavy, prolonged, painful menses and heaviness in her lower abdomen. She underwent a laparoscopic myomectomy for a fibroid uterus, 12 months ago for similar complaints. On workup, she was diagnosed with DPL. We performed a total abdominal hysterectomy with bilateral salpingectomy, low anterior resection with stapled colorectal anastomosis and excision of peritoneal tumour deposits in consortium with the gastrosurgery team. Her postoperative period was uneventful, and the patient was discharged on postop day 6. Her histopathology report was consistent with leiomyoma; the follow-up period was uneventful.


Assuntos
Histerectomia , Neoplasias Peritoneais , Humanos , Feminino , Neoplasias Peritoneais/diagnóstico , Neoplasias Peritoneais/cirurgia , Neoplasias Peritoneais/patologia , Adulto , Leiomioma/cirurgia , Leiomioma/diagnóstico , Leiomioma/patologia , Leiomiomatose/cirurgia , Leiomiomatose/patologia , Leiomiomatose/diagnóstico , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/patologia , Diagnóstico Diferencial , Miomectomia Uterina , Salpingectomia
7.
J Int Med Res ; 52(6): 3000605241258572, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38869107

RESUMO

We herein report a rare case of simultaneous intrauterine molar pregnancy and tubal pregnancy. A woman of childbearing age who had never been pregnant underwent an ultrasound examination 70 days after the onset of menopause. She had a history of ovulation induction. The ultrasound findings suggested a partial hydatidiform mole. She was then pathologically confirmed to have a complete hydatidiform mole after uterine suction dilation and curettage. On postoperative day 4, an ultrasound examination before discharge showed an inhomogeneous mass in the left adnexal region with mild lower abdominal pain. On postoperative day 17, the blood human chorionic gonadotropin level did not drop as expected, and a follow-up examination still indicated a mass in the left adnexal region. We were unable to rule out an ectopic hydatidiform mole. Hysteroscopy with laparoscopic exploration of the left adnexal mass and salpingotomy suggested a diagnosis of intrauterine hydatidiform mole combined with left tubal pregnancy.


Assuntos
Mola Hidatiforme , Gravidez Tubária , Humanos , Feminino , Gravidez , Mola Hidatiforme/cirurgia , Mola Hidatiforme/diagnóstico , Mola Hidatiforme/diagnóstico por imagem , Mola Hidatiforme/patologia , Gravidez Tubária/cirurgia , Gravidez Tubária/diagnóstico , Gravidez Tubária/diagnóstico por imagem , Gravidez Tubária/sangue , Adulto , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/diagnóstico por imagem , Neoplasias Uterinas/patologia , Gravidez Heterotópica/cirurgia , Gravidez Heterotópica/diagnóstico , Gravidez Heterotópica/diagnóstico por imagem , Ultrassonografia
8.
J Radiol Case Rep ; 18(1): 1-7, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38910588

RESUMO

This case report discusses a diagnosis of uterine torsion in an 84-year-old woman who presented with five days of right lower quadrant abdominal pain, nausea, vomiting, constipation, and poor intake. Computed tomography (CT) imaging demonstrated a whorled configuration at the junction of the cervix and lower uterine segment, with the left gonadal vein crossing midline, and two previously known right leiomyomas now appearing on the left. These findings were consistent with the diagnosis of uterine torsion. She then underwent an urgent exploratory laparotomy, and the uterus was found to be dextroverted 270 degrees, with dark mottled purple tissue and engorged vessels. A supracervical hysterectomy and bilateral salpingo-oopherectomy were performed. Final pathology demonstrated extensive necrosis. This case reviews the classic presentation and imaging findings for the rare diagnosis of uterine torsion and options for management of both non-gravid and gravid patients.


Assuntos
Leiomioma , Pós-Menopausa , Tomografia Computadorizada por Raios X , Anormalidade Torcional , Neoplasias Uterinas , Humanos , Feminino , Leiomioma/cirurgia , Leiomioma/diagnóstico por imagem , Leiomioma/complicações , Leiomioma/patologia , Idoso de 80 Anos ou mais , Anormalidade Torcional/diagnóstico por imagem , Anormalidade Torcional/cirurgia , Neoplasias Uterinas/diagnóstico por imagem , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/complicações , Neoplasias Uterinas/patologia , Doenças Uterinas/diagnóstico por imagem , Doenças Uterinas/cirurgia , Doenças Uterinas/patologia , Histerectomia , Diagnóstico Diferencial
9.
Arch Esp Urol ; 77(4): 345-352, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38840276

RESUMO

BACKGROUND: This study aims to determine the effect of pelvic floor function exercise on the improvement of lower urinary tract symptoms in patients with uterine fibroid surgery. METHODS: The clinical data of 188 patients who underwent uterine fibroid surgery in our hospital from February 2020 to December 2022 were retrospectively analysed. The patients were divided into a control group and an observation group according to the nursing methods recorded in the data. The observation group received targeted nursing combined with pelvic floor function exercise based on routine intervention. General demographic data, disease and surgery-related characteristics of the patients were collected. Propensity score matching was used to balance the baseline data of the two groups. Lower urinary tract symptoms, pelvic floor function, pelvic floor muscle strength and quality of life were compared between the two groups after matching. RESULTS: A total of 130 patients were included in the two groups, and their baseline data were not statistically significant. At 3 months after the operation, the total incidence of lower urinary tract symptoms in the observation group (10.77%) was lower than that in the control group (30.77%, p < 0.05). Before the intervention, the pelvic floor function, pelvic floor muscle strength and quality of life scores of the two groups were basically the same (p > 0.05). At 3 months after the operation, the pelvic floor function score of the observation group was lower than that of the control group, but the pelvic floor muscle strength index and quality of life score of the observation group were higher than those of the control group (p < 0.05). CONCLUSIONS: Targeted nursing combined with pelvic floor function exercise for patients with uterine fibroids surgery can prevent the occurrence of lower urinary tract symptoms and improve the pelvic floor function, pelvic floor muscle strength and quality of life of patients and is thus worthy of promotion.


Assuntos
Terapia por Exercício , Leiomioma , Sintomas do Trato Urinário Inferior , Diafragma da Pelve , Neoplasias Uterinas , Humanos , Feminino , Leiomioma/cirurgia , Estudos Retrospectivos , Sintomas do Trato Urinário Inferior/etiologia , Sintomas do Trato Urinário Inferior/prevenção & controle , Adulto , Pessoa de Meia-Idade , Neoplasias Uterinas/cirurgia , Terapia por Exercício/métodos , Complicações Pós-Operatórias/prevenção & controle , Complicações Pós-Operatórias/etiologia , Qualidade de Vida
10.
Medicina (Kaunas) ; 60(6)2024 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-38929485

RESUMO

Uterine fibroids (leiomyomas and myomas) are the most common benign gynecological condition in patients presenting with abnormal uterine bleeding, pelvic masses causing pressure or pain, infertility and obstetric complications. Almost a third of women with fibroids need treatment due to symptoms. OBJECTIVES: In this review we present all currently available treatment modalities for uterine fibroids. METHODS: An extensive search for the available data regarding surgical, medical and other treatment options for uterine fibroids was conducted. REVIEW: Nowadays, treatment for fibroids is intended to control symptoms while preserving future fertility. The choice of treatment depends on the patient's age and fertility and the number, size and location of the fibroids. Current management strategies mainly involve surgical interventions (hysterectomy and myomectomy hysteroscopy, laparoscopy or laparotomy). Other surgical and non-surgical minimally invasive techniques include interventions performed under radiologic or ultrasound guidance (uterine artery embolization and occlusion, myolysis, magnetic resonance-guided focused ultrasound surgery, radiofrequency ablation of fibroids and endometrial ablation). Medical treatment options for fibroids are still restricted and available medications (progestogens, combined oral contraceptives andgonadotropin-releasing hormone agonists and antagonists) are generally used for short-term treatment of fibroid-induced bleeding. Recently, it was shown that SPRMs could be administered intermittently long-term with good results on bleeding and fibroid size reduction. Novel medical treatments are still under investigation but with promising results. CONCLUSIONS: Treatment of fibroids must be individualized based on the presence and severity of symptoms and the patient's desire for definitive treatment or fertility preservation.


Assuntos
Leiomioma , Humanos , Leiomioma/terapia , Leiomioma/cirurgia , Feminino , Neoplasias Uterinas/terapia , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/complicações , Histerectomia/métodos , Embolização da Artéria Uterina/métodos , Miomectomia Uterina/métodos
11.
BMC Womens Health ; 24(1): 308, 2024 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-38783282

RESUMO

BACKGROUND: Cervical mullerian adenosarcoma is a rare uterine sarcoma, especially in young women. Its pathological features are low-grade malignant tumors with bidirectional differentiation, and the degree of malignancy is similar to that of low-grade endometrial stromal sarcoma. This paper reports the case of a young asexual patient who has been closely followed up after tumor resection and has not had any recurrences. CASE PRESENTATION: A 20-year-old, young asexual woman was diagnosed with cervical mullerian adenosarcoma with sarcomatous overgrowth (MASO). Cervical tumor resection was performed after admission, and the resection margin was negative. After the operation, she refused to undergo secondary surgery due to fertility requirements and did not receive adjuvant treatment. The patient was closely followed up after the operation and has not yet relapsed. CONCLUSION: A young woman with cervical MASO did not receive adjuvant treatment after cervical tumor resection. For women with fertility requirements, close follow-ups should be conducted after the operation to guard against tumor recurrence and radical tumor resection should be performed as early as possible after the patient no longer requires their fertility.


Assuntos
Adenossarcoma , Neoplasias do Colo do Útero , Neoplasias Uterinas , Humanos , Feminino , Adenossarcoma/cirurgia , Adenossarcoma/patologia , Adenossarcoma/diagnóstico , Adulto Jovem , Neoplasias do Colo do Útero/cirurgia , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/diagnóstico , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/patologia , Neoplasias Uterinas/complicações , Neoplasias Uterinas/diagnóstico , Comportamento Sexual
12.
Braz J Med Biol Res ; 57: e13549, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38716986

RESUMO

Expanding uterine masses can be the cause of pregnancy loss and add technical difficulties to uterus evacuation due to the intense anatomical distortion of the endocervical canal and uterine cavity. The literature is scarce in the peculiarities of the management of missed abortions in uterus with important distorted anatomies. We report a case of a primigravida patient who presented a rapid and expressive increase of abdominal volume due to a giant uterine mass, evolving to miscarriage. Ultrasound can be a useful tool, allowing visualization of the endocervical path and uterine cavity, helping to perform uterine evacuation in the presence of anatomical distortion without compromising the reproductive future. To the best of our knowledge, no such case has been previously reported.


Assuntos
Aborto Espontâneo , Neoplasias Uterinas , Humanos , Feminino , Neoplasias Uterinas/diagnóstico por imagem , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/patologia , Gravidez , Adulto , Ultrassonografia , Complicações Neoplásicas na Gravidez/diagnóstico por imagem , Complicações Neoplásicas na Gravidez/patologia , Complicações Neoplásicas na Gravidez/cirurgia , Leiomioma/diagnóstico por imagem , Leiomioma/cirurgia , Leiomioma/patologia
13.
J Int Med Res ; 52(5): 3000605241252238, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38759222

RESUMO

An accessory cavitated uterine mass (ACUM) is a very rare obstructive genital malformation characterized by pelvic pain and severe dysmenorrhea. It is easily mistaken for other obstructive genital malformations in women, such as cystic uterine adenomyosis or cystic degeneration of uterine fibroids. This case report describes a 30-year-old patient with a huge uterine cornual mass. Successful resection was performed by surgical excision, and the lesion was diagnosed as an ACUM. Given the rarity of a giant ACUM, this report also includes a brief review of the relevant literature.


Assuntos
Útero , Humanos , Feminino , Adulto , Útero/anormalidades , Útero/cirurgia , Útero/patologia , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/patologia , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/diagnóstico por imagem , Imageamento por Ressonância Magnética , Resultado do Tratamento , Dismenorreia/etiologia , Dismenorreia/cirurgia , Dismenorreia/diagnóstico
14.
Trials ; 25(1): 343, 2024 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-38790029

RESUMO

BACKGROUND: The oral gonadotropin-releasing hormone antagonist relugolix, which temporarily stops menstruation, is used to treat heavy menstrual bleeding, pelvic pressure, and low back pain in women with uterine fibroids. Treatment can also help women recover from low hemoglobin levels and possibly shrink the fibroids. However, evidence of preoperative use of relugolix before laparoscopic myomectomy is limited. Nevertheless, the treatment could reduce interoperative blood loss, decrease the risk of developing postoperative anemia, and shorten the operative time. Thus, we aim to test whether 12-week preoperative treatment with relugolix (40 mg orally, once daily) is similar to or not worse than leuprorelin (one injection every 4 weeks) to reduce intraoperative blood loss. METHODS: Efficacy and safety of preoperative administration of drugs will be studied in a multi-center, randomized, open-label, parallel-group, noninferiority trial enrolling premenopausal women ≥ 20 years of age, diagnosed with uterine fibroids and scheduled for laparoscopic myomectomy. Participants (n = 80) will be recruited in the clinical setting of participating institutions. The minimization method (predefined factors: presence or absence of fibroids ≥ 9 cm and the International Federation of Gynecology and Obstetrics [FIGO] type 1-5 fibroids) with randomization is used in a 1:1 allocation. Relugolix is a 40-mg oral tablet taken once a day before a meal, for 12 weeks, up to the day before surgery. Leuprorelin is a 1.88 mg, or 3.75 mg subcutaneous injection, given in three 4-week intervals during patient visits before the surgery. For the primary outcome measure of intraoperative bleeding, the blood flow is collected from the body cavity, surgical sponges, and collection bag and measured in milliliters. Secondary outcome measures are hemoglobin levels, myoma size, other surgical outcomes, and quality-of-life questionnaire responses (Kupperman Konenki Shogai Index and Uterine Fibroid Symptoms-Quality of Life). DISCUSSION: Real-world evidence will be collected in a clinical setting to use pre-treatment with an oral gonadotropin-releasing hormone antagonist to reduce intraoperative bleeding in women who undergo laparoscopic myomectomy. TRIAL REGISTRATION: jRCTs031210564 was registered on 19 January 2022 in the Japan Registry of Clinical Trials ( https://jrct.niph.go.jp ).


Assuntos
Laparoscopia , Leiomioma , Leuprolida , Estudos Multicêntricos como Assunto , Pré-Menopausa , Miomectomia Uterina , Neoplasias Uterinas , Humanos , Feminino , Leiomioma/cirurgia , Leiomioma/tratamento farmacológico , Leuprolida/uso terapêutico , Leuprolida/administração & dosagem , Miomectomia Uterina/efeitos adversos , Neoplasias Uterinas/cirurgia , Resultado do Tratamento , Cuidados Pré-Operatórios/métodos , Estudos de Equivalência como Asunto , Antineoplásicos Hormonais/uso terapêutico , Antineoplásicos Hormonais/administração & dosagem , Adulto , Perda Sanguínea Cirúrgica/prevenção & controle , Hormônio Liberador de Gonadotropina/antagonistas & inibidores , Fatores de Tempo , Ensaios Clínicos Controlados Aleatórios como Assunto , Compostos de Fenilureia , Pirimidinonas
15.
Health Aff (Millwood) ; 43(5): 740-742, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38709964

RESUMO

An African American woman with uterine fibroids is advised to get a hysterectomy, despite the availability of less life-altering options.


Assuntos
Negro ou Afro-Americano , Histerectomia , Leiomioma , Neoplasias Uterinas , Humanos , Feminino , Histerectomia/métodos , Leiomioma/cirurgia , Neoplasias Uterinas/cirurgia , Pessoa de Meia-Idade
16.
BMC Womens Health ; 24(1): 294, 2024 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-38762488

RESUMO

OBJECTIVE: To report the long-term re-intervention of patients with uterine fibroids after ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation and to analyse the influencing factors of re-intervention in patients in the NPVR ≥ 80% group. MATERIALS AND METHODS: Patients with a single uterine fibroid who underwent USgHIFU at our hospital from January 2012 to December 2019 were enrolled. The patients were divided into four groups according to different nonperfusion volume ratio (NPVR). Kaplan-Meier survival curve was used to analyse long-term re-intervention in different NPVR groups, and Cox regression was used to analyse the influencing factors of re-intervention in the NPVR ≥ 80% group. MAIN RESULTS: A total of 1,257 patients were enrolled, of whom 920 were successfully followed up. The median follow-up time was 88 months, and the median NPVR was 85.0%. The cumulative re-intervention rates at 1, 3, 5, 8 and 10 years after USgHIFU were 3.4%, 11.8%, 16.8%, 22.6% and 24.1%, respectively. The 10-year cumulative re-intervention rate was 37.3% in the NPVR < 70% group, 31.0% in the NPVR 70-79% group, 18.2% in the NPVR 80-89% group and 17.8% in the NPVR ≥ 90% group (P < 0.05). However, no difference was found between the group of NPVR 80-89% and the group of NPVR ≥ 90% (P = 0.499). Age of patients and signal intensity on T2-weighted imaging (T2WI) of tumours were found to be independent risk factors for long-term re-intervention in the NPVR ≥ 80% group. A younger age and greater signal intensity on T2W images corresponded to a greater risk of re-intervention. CONCLUSION: USgHIFU, an alternative treatment for uterine fibroids, has reliable long-term efficacy. NPVR ≥ 80% can be used as a sign of technical success, which can reduce re-intervention rates. However, an important step is to communicate with patients in combination with the age of patients and the signal intensity on T2WI of fibroids. TRIAL REGISTRATION: This retrospective study was approved by the ethics committee at our institution (Registration No. HF2023001; Date: 06/04/2023). The Chinese Clinical Trial Registry provided full approval for the study protocol (Registration No. CHiCTR2300074797; Date: 16/08/2023).


Assuntos
Ablação por Ultrassom Focalizado de Alta Intensidade , Leiomioma , Neoplasias Uterinas , Humanos , Feminino , Leiomioma/cirurgia , Ablação por Ultrassom Focalizado de Alta Intensidade/métodos , Adulto , Neoplasias Uterinas/cirurgia , Pessoa de Meia-Idade , Estudos de Coortes , Resultado do Tratamento , Estudos Retrospectivos
17.
J Robot Surg ; 18(1): 184, 2024 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-38683450

RESUMO

Examine the role, benefits, and limitations of robotic surgery in myomectomies compared to laparoscopic and open surgical approaches. This review sourced data from CENTRAL, Pubmed, Medline, and Embase up until May 1, 2023. Full articles comparing clinical outcomes of robotic myomectomy with open or laparoscopic procedures were included without language restriction. Initially, 2150 records were found. 24 studies were finally included for both qualitative and quantitative analyses. Two investigators independently assessed all reports following PRISMA guidelines. Meta-analysis was conducted using the software "Review Manager Version 5.4". Risk-of-bias was assessed using the Newcastle-Ottawa scale. Sensitivity analysis was conducted, when feasible. In a comparison between robotic and laparoscopic myomectomies, no significant difference was observed in fibroid weights and the size of the largest fibroid. Robotic myomectomy resulted in less blood loss, but transfusion rates were comparable. Both methods had similar complication rates and operative times, although some robotic studies showed longer durations. Conversion rates favored robotics. Hospital stays varied widely, with no overall significant difference, and pregnancy rates were similar between the two methods. When comparing robotic to open myomectomies, open procedures treated heavier and larger fibroids. They also had greater blood loss, but the robotic approach required fewer transfusions. The complication rate was slightly higher in open procedures. Open surgeries were generally faster, postoperative pain scores were similar, but hospital stays were longer for open procedures. Pregnancy rates were comparable for both robotic and open methods. Robotic surgery offers advancement in myomectomy procedures by offering enhanced exposure and dexterity, leading to reduced blood loss and improved patient outcomes. PROSPERO registration: CRD42023462348.


Assuntos
Duração da Cirurgia , Procedimentos Cirúrgicos Robóticos , Miomectomia Uterina , Procedimentos Cirúrgicos Robóticos/métodos , Procedimentos Cirúrgicos Robóticos/estatística & dados numéricos , Humanos , Miomectomia Uterina/métodos , Feminino , Laparoscopia/métodos , Perda Sanguínea Cirúrgica/estatística & dados numéricos , Leiomioma/cirurgia , Tempo de Internação/estatística & dados numéricos , Neoplasias Uterinas/cirurgia , Resultado do Tratamento , Gravidez , Complicações Pós-Operatórias/epidemiologia , Transfusão de Sangue/estatística & dados numéricos
18.
J Med Case Rep ; 18(1): 149, 2024 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-38570807

RESUMO

BACKGROUND: The main cause of vocal cord palsy (VCP) is idiopathic impairment of the recurrent laryngeal nerve (RLN). However, solid tumors along the pathway of the RLN can also impact the nerve's function. We presented a patient with a thyroid lesion and VCP due to a bulky metastatic mass (uterine cancer) on the aortic arch field in the mediastinum. The report aims to show the significance of comorbid tumors in thyroid pathology and the importance of additional diagnostic methods in avoiding unnecessary surgeries. A patient's lifetime and the outcome of the disease were also presented. CASE PRESENTATION: A 58-year-old Ukrainian woman with a hoarse voice, intermittent dry cough, and weakness was presented to an endocrine surgeon. Thyroid pathology included signs of hypothyroidism treated with Thyroxine 112.5 µg and a nodule in the left lobe. The lesion is located on the posterior aspect of the lobe, which could probably be a cause of RLN involvement. Fine needle aspiration biopsy (FNAB) was performed twice with Bethesda category 2 result. Fibrolaryngoscopy (FLS) revealed the median position of the left vocal cord. Idiopathic, laryngeal, and thyroid causes of the VCP were excluded. Additionally, the patient displayed her anamnesis of the endometrial clear cell carcinoma following hysterectomy, external beam radiation therapy, and chemotherapy. The mediastinal metastasis was revealed sixteen years later. A chest computed tomography (CT) with intravenous contrast was done. A bulky tumor was found right under the aortic arch. Subsequently, the voice complaints reduced significantly after 4 chemotherapy courses. Cancer progression had led to the appearance of lymph node metastases on the supraclavicular region. Following six months the 60-year-old patient had passed away. CONCLUSION: A history of the disease should always be kept in mind when assessing a patient's complaints. VCP in case of thyroid pathology and previous secondary malignancy may be caused by metastatic tumor anywhere along the RLN pathway. Such a rare case shows the importance of additional methods of examination which may avoid unnecessary thyroid surgeries.


Assuntos
Neoplasias Uterinas , Paralisia das Pregas Vocais , Feminino , Humanos , Pessoa de Meia-Idade , Metástase Linfática , Mediastino/patologia , Glândula Tireoide/patologia , Tireoidectomia/efeitos adversos , Neoplasias Uterinas/cirurgia , Paralisia das Pregas Vocais/etiologia
19.
Sci Rep ; 14(1): 9857, 2024 04 29.
Artigo em Inglês | MEDLINE | ID: mdl-38684835

RESUMO

The aim of this study was to investigate the value of diffusion-weighted imaging (DWI) as a potential non-gadolinium alternative for promptly assessing the hyperacute outcome of magnetic resonance-guided focused ultrasound (MRgFUS) treatment for uterine fibroids. In this retrospective study we included 65 uterine fibroids from 44 women, who underwent axial DWI (b-value: 800 s/mm2) and contrast-enhanced (CE) MR within 15 min post-ablation. Two blinded observers independently reviewed the DWI findings of ablated necrotic lesions and measured their volumes on DWI and CE images. The post-ablation DWI images revealed clear depiction of ablative necrotic lesions in all fibroids, which were classified into two types: the bull's eye sign (type 1) and the bright patch sign (type 2). The inter-observer intraclass correlation coefficient for classifying DWI signal types was 0.804 (p < 0.001). Volumetric analysis of ablated necrosis using DWI and CE T1-weighted imaging showed no significant variance, nor did the non-perfused volume ratios (all p > 0.05). Bland-Altman analysis revealed a mean difference of 2.38% and 1.71% in non-perfused volume ratios between DWI and CE, with 95% limits of agreement from - 19.06 to 23.82% and - 18.40 to 21.82%, respectively. The findings of this study support the potential of DWI as a viable non-gadolinium alternative for evaluating the hyperacute outcomes of MRgFUS ablation in uterine fibroids.


Assuntos
Imagem de Difusão por Ressonância Magnética , Ablação por Ultrassom Focalizado de Alta Intensidade , Leiomioma , Humanos , Feminino , Leiomioma/diagnóstico por imagem , Leiomioma/cirurgia , Leiomioma/patologia , Imagem de Difusão por Ressonância Magnética/métodos , Adulto , Pessoa de Meia-Idade , Estudos Retrospectivos , Ablação por Ultrassom Focalizado de Alta Intensidade/métodos , Resultado do Tratamento , Neoplasias Uterinas/diagnóstico por imagem , Neoplasias Uterinas/cirurgia , Neoplasias Uterinas/patologia , Meios de Contraste
20.
Medicina (Kaunas) ; 60(4)2024 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-38674255

RESUMO

Up to 70-80% of women of reproductive age may be affected with the most common uterine tumors, known as fibroids or myomas. These benign tumors are the second most prevalent cause of surgery among premenopausal women. Predictions show that the occurrence of myomas in pregnancy will increase, and that the risk of having myomas during pregnancy increases with advanced maternal age. Although most women with fibroids do not experience any symptoms during pregnancy, up to 30% of women experience problems during pregnancy, childbirth, and the puerperium. The viability of myoma excision during cesarean surgery (CS) is a contentious issue raised by the rising incidence of myomas in pregnancy and CS rates. A new surgical procedure for removing fibroids using a trans-endometrial approach, which involves making an incision through the decidua itself, has put into doubt the long-standing practice of cesarean myomectomy (CM) with a trans-serosal approach. Some authors have recently advocated for this last approach, highlighting its advantages and potential uses in real-world situations. The purpose of this paper is to critique the present approach to cesarean myomectomy by analyzing the clinical and surgical distinctions between the two approaches and providing illustrations of the CM methods.


Assuntos
Cesárea , Leiomioma , Miomectomia Uterina , Neoplasias Uterinas , Humanos , Feminino , Cesárea/métodos , Miomectomia Uterina/métodos , Gravidez , Leiomioma/cirurgia , Neoplasias Uterinas/cirurgia , Adulto , Complicações Neoplásicas na Gravidez/cirurgia , Decídua
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