Genetics of COVID-19
J. pediatr. (Rio J.)
; 97(4): 378-386, July-Aug. 2021. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1287043
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract Objective This narrative, non-systematic review provides an update on the genetic aspects of the SARS-CoV-2 virus and its interactions with the human genome within the context of COVID-19. Although the main focus is on the etiology of this new disease, the genetics of SARS-CoV-2 impacts prevention, diagnosis, prognosis, and the development of therapies. Data source A literature search was conducted on MEDLINE, BioRxiv, and SciELO, as well as a manual search on the internet (mainly in 2019 and 2020) using the keywords "COVID-19," "SARS-CoV-2," "coronavirus," "genetics," "molecular," "mutation," "vaccine," "Brazil," "Brasil," and combinations of these terms. The keywords "Brazil" and "Brasil" were used to find publications that were specific to the Brazilian population's molecular epidemiology data. Articles most relevant to the scope were selected non-systematically. Data synthesis A number of publications illustrate an expanding knowledge on the genetics and genomics of SARS-CoV-2 and its implications for understanding COVID-19. Conclusions Knowledge of the SARS-CoV-2 genome sequence permits an in-depth investigation of the role its proteins play in the pathophysiology of COVID-19, which in turn will be enormously valuable for understanding the evolutionary, clinical, and epidemiological aspects of this disease and focusing on prevention and treatment.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
LILACS
Contexto en salud:
ODS3 - Meta 3.3 - Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
Tema en salud:
Neumonía
Asunto principal:
COVID-19
Tipo de estudio:
Guía de práctica clínica
/
Revisión sistemática
Límite:
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
J. pediatr. (Rio J.)
Asunto de la revista:
Pediatría
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Laboratório Genetika/BR
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