Administration of Vaccine Preservative Thimerosal Produces Impairment in Rat Liver
Braz. arch. biol. technol
; Braz. arch. biol. technol;64: e21190689, 2021. tab, graf
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LILACS-Express
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| ID: biblio-1350263
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ABSTRACT
Abstract The present research was planned to analyze the toxic effects of thimerosal on rat liver. Mercury and mercury compounds are universally known toxicants for animals and humans. Thimerosal is widely used in the vaccines as a preservative which contains 49.6% mercury. Twenty-four adult male albino rats were distributed into four groups (n=6). The first group was considered as a control group. While, second, third and fourth groups were intoxicated with 0.5, 10 and 50 µg/kg thimerosal (i.m.) respectively. After 30 days, rats were slaughtered to analyze the liver tissues. The results of the experiment exposed that thimerosal instigated significant (p<0.05) increase in alanine transaminase (ALT), alkaline phosphatase (ALP) and aminotransferase (AST) levels. Catalase (CAT), superoxide dismutase (SOD), peroxidase (POD) activities and Glutathione (GSH) and protein levels were significantly (p<0.05) reduced. Furthermore, significant increases in Hydrogen peroxide (H2O2), thiobarbituric acid reactive substances (TBARS) level and DNA damage was observed. Histopathological study revealed severe damages, e.g. fatty alterations, deterioration of lobular structure and degeneration of nuclei in hepatic tissues of thimerosal treated rats. Results of present investigation revealed that thimerosal induces hepatotoxicity at different levels.
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1
Colección:
01-internacional
Base de datos:
LILACS
Idioma:
En
Revista:
Braz. arch. biol. technol
/
Braz. arch. biol. technol. (Online)
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Brazilian archives of biology and technology (Impresso)
Asunto de la revista:
BIOLOGIA
Año:
2021
Tipo del documento:
Article
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Project document
País de afiliación:
Pakistán
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Arabia Saudita
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Estados Unidos