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The relationship between erythema nodosum and prognosis in systemic sarcoidosis: a retrospective cohort study
Yıldırım, Elif Afacan; Öztürk, Perihan Aladaǧ; Adıșen, Esra; Köktürk, Nurdan.
Afiliación
  • Yıldırım, Elif Afacan; Gazi University. Faculty of Medicine. Department of Dermatology. Ankara. TR
  • Öztürk, Perihan Aladaǧ; Gazi University. Faculty of Medicine. Department of Dermatology. Ankara. TR
  • Adıșen, Esra; Gazi University. Faculty of Medicine. Department of Dermatology. Ankara. TR
  • Köktürk, Nurdan; Gazi University. Faculty of Medicine. Department of Pulmonary Medicine. Ankara. TR
An. bras. dermatol ; An. bras. dermatol;97(5): 606-611, Sept.-Oct. 2022. tab
Article en En | LILACS-Express | LILACS | ID: biblio-1403161
Biblioteca responsable: BR1.1
ABSTRACT
Abstract

Background:

Erythema Nodosum (EN) is the most common skin manifestation in sarcoidosis and has often been associated with a good prognosis.

Objectives:

To compare the clinical characteristics and treatment-related features in patients with sarcoidosis according to whether or not EN was seen as a presenting symptom at the time of diagnosis.

Methods:

A 20-year single-center retrospective study was performed. The following two groups were identified one group with EN as one of the presenting symptoms at the time of diagnosis of sarcoidosis (EN group) and a second group without EN as a presenting symptom at diagnosis (non-EN group). The clinical characteristics and treatment modalities were collected from the medical records.

Results:

A total of 122 patients (31 in the EN group, 91 in the non-EN group) were included. Radiological stages of pulmonary disease were significantly lower in the EN group. Articular involvement was more common in the EN group (p = 0.001), whereas other systemic organ involvements (p = 0.025), especially neurological involvement (p = 0.036), were significantly more common in the non-EN group. In the EN group, a higher percentage of patients were managed without systemic therapy (71.0% vs. 54.9%) and spontaneous remission was more frequent (25.0% vs. 14.1%), however, this wasn't statistically significant. Study

limitations:

Retrospective design.

Conclusions:

The lower radiological stage of pulmonary sarcoidosis and lower frequency of systemic organ involvement in patients with EN augment the prognostic value of EN highlighted in the literature. However, this study couldn't confirm that the patients with EN would need less systemic therapy in the course of their disease.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: An. bras. dermatol Asunto de la revista: DERMATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Turquía

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: An. bras. dermatol Asunto de la revista: DERMATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Turquía
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