Identification of neprilysin as a potential target of arteannuin using computational drug repositioning
Braz. J. Pharm. Sci. (Online)
; 53(2): e16087, 2017. tab, graf
Article
en En
| LILACS
| ID: biblio-839493
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT The discovery of arteannuin (qinghaosu) in the 20th Century was a major advance for medicine. Besides functioning as a malaria therapy, arteannuin is a pharmacological agent in a range of other diseases, but its mechanism of action remains obscure. In this study, the reverse docking server PharmMapper was used to identify potential targets of arteannuin. The results were checked using the chemical-protein interactome servers DRAR-CPI and DDI-CPI, and verified by AutoDock Vina. The results showed that neprilysin (also known as CD10), a common acute lymphoblastic leukaemia antigen, was the top disease-related target of arteannuin. The chemical-protein interactome and docking results agreed with those of PharmMapper, further implicating neprilysin as a potential target. Although experimental verification is required, this study provides guidance for future pharmacological investigations into novel clinical applications for arteannuin.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Contexto en salud:
3_ND
Problema de salud:
3_malaria
Asunto principal:
Simulación por Computador
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Neprilisina
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Artemisininas
Tipo de estudio:
Diagnostic_studies
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Guideline
Idioma:
En
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
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Teraputica
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Toxicologia
Año:
2017
Tipo del documento:
Article
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Project document
País de afiliación:
China