Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy?
Acta cir. bras
; 32(7): 515-522, July 2017. tab, graf
Article
en En
| LILACS
| ID: biblio-886219
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the effects of mesenchymal stem cells on liver regeneration in rats following a 70% hepatectomy.Methods:
Forty rats were subjected to 70% hepatectomy and then ~106 mesenchymal stem cells (test group), or saline solution (control group), were infused into their livers via the portal vein. Each treatment group was divided into early and late subgroups (euthanized 3 d and 5 d following the operation, respectively). Group comparisons of Albumin, aminotransaminases (AST, ALT), and Alcaline Phosphatase (AP) levels, proliferative index (ki-67+ straining), and mitotic cell counts were conducted.Results:
No significant differences in liver regeneration rate, number of mitoses, proliferative index, or serum levels of albumin, AST, or AP were observed. ALT levels were higher in the test group than in the control group (p<.05).Conclusions:
Mesenchymal stem-cell therapy did not improve liver regeneration rate 3 d or 5 d after 70% hepatectomy in rats. Likewise, the therapy appeared not to affect liver function, proliferative index, or number of mitoses significantly.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Trasplante de Células Madre Mesenquimatosas
/
Hepatectomía
/
Regeneración Hepática
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2017
Tipo del documento:
Article
País de afiliación:
Brasil