Resistance training and hormone replacement increase MMP-2 activity, quality and quantity of bone in ovariectomized rats
Motriz (Online)
; 23(4): e1017107, 2017. tab, graf, ilus
Article
en En
| LILACS
| ID: biblio-895018
Biblioteca responsable:
BR33.1
ABSTRACT
AIMS:
The aim of the present study was to investigate the influence of resistance training (RT) and hormone replacement (HR) on MMP-2 activity, biomechanical and physical properties bone of ovariectomized (OVX) rats.METHODS:
Sprague-Dawley female rats were grouped into six experimental groups (n = 11 per group) sham-operated sedentary (SHAM Sed), ovariectomized sedentary (OVX Sed), sham-operated resistance training (SHAM RT), ovariectomized resistance training (OVX RT), ovariectomized sedentary hormone replacement (OVX Sed-HR), and ovariectomized resistance training hormone replacement (OVX RT-HR). HR groups received implanted silastic capsules with a 5% solution of 17ß-estradiol (50 mg 17ß-estradiol/ml of sunflower oil). In a 12-week RT period (27 sessions; 4-9 climbs) the animals climbed a 1.1 m vertical ladder with weights attached to their tails. Biomechanical and physical bone analyses were performed using a universal testing machine, and MMP-2 activity analysis was done by zymography.RESULTS:
Bone density and bone mineral content was higher in the RT and HR groups. The MMP-2 activity was higher in the RT and HR groups. The biomechanical analysis (stiffness, fracture load and maximum load) demonstrated better bone tissue quality in the RT associated with HR.CONCLUSION:
The RT alone as well as when it is associated with HR was efficient in increasing MMP-2 activity, biomechanical and biophysical properties bone of ovariectomized rats.(AU)Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Osteoporosis
/
Ovariectomía
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Terapia de Reemplazo de Hormonas
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Metaloproteasas
/
Estradiol
/
Estrógenos
/
Entrenamiento de Fuerza
Límite:
Animals
Idioma:
En
Revista:
Motriz (Online)
Asunto de la revista:
EducaÆo F¡sica e Treinamento
/
Medicina Esportiva
/
Medicina F¡sica e ReabilitaÆo
Año:
2017
Tipo del documento:
Article
/
Project document
País de afiliación:
Brasil