Correlation between GDF-15 gene polymorphism and the formation of collateral circulation in acute ST-elevation myocardial infarction
Rev. Assoc. Med. Bras. (1992, Impr.)
; Rev. Assoc. Med. Bras. (1992, Impr.);63(12): 1049-1054, Dec. 2017. tab, graf
Article
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| LILACS
| ID: biblio-896328
Biblioteca responsable:
BR1.1
ABSTRACT
Summary Objective:
To explore the correlation between growth differentiation factor 15 (GDF-15) -3148C/G polymorphism and the formation of collateral circulation in acute ST-elevation myocardial infarction (STEMI) in Han population of Taiyuan area.Method:
The present study included 92 STEMI patients and 56 normal controls based on coronary angiography; STEMI group was divided into collateral group and non-collateral group according to Rentrop's grading method. Polymerase chain reaction (PCR) and DNA sequencing methods were used to detect and analyze the GDF-15 -3148C/G polymorphism in all participants.Results:
There was significant difference in GDF-15 -3148C/G CC and GC distribution between STEMI group and control group (p=0.009); the allele frequencies between these two groups were also significant different (p=0.016); and the risk genotype for STEMI was CC with increased OR=2.660. For STEMI group, GDF-15 -3148C/G CC and GC distribution was also significantly different between patients with and without collateral (p=0.048), and CC genotype significantly promote the formation of collateral circulation. However, there were no significant differences in allele frequencies between these two subgroups of STEMI.Conclusion:
There was correlation between GDF-15-3148C/G polymorphism and the formation of collateral circulation in patients with acute STEMI.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Polimorfismo Genético
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Circulación Colateral
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Factor 15 de Diferenciación de Crecimiento
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Infarto del Miocardio con Elevación del ST
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Rev Assoc Med Bras
/
Rev. Assoc. Med. Bras. (1992, Impr.)
/
Rev. Assoc. Méd. Bras. (1992, Online)
/
Revista da Associação Médica Brasileira (1992. Impresso)
Asunto de la revista:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
MEDICINA
Año:
2017
Tipo del documento:
Article
País de afiliación:
China