Prepubertal development of rat prostate and seminal vesicle following chemical sympathectomy with guanethidine
Braz. j. med. biol. res
; 26(6): 639-46, Jun. 1993. tab, graf
Article
en En
| LILACS
| ID: lil-148717
Biblioteca responsable:
BR1.1
ABSTRACT
1. The internal genital organs of prepubertal, 21-day old male Wistar rats were sympathectomized by ip injection of guanethidine (G), at doses of 5 mg/kg per day (N = 10) or 10 mg/kg per day (N = 10), for 20 days. Controls (N = 10) received saline. 2. Plasma testosterone level (measured by radioimmunoassay) decreased significantly in sympathectomized rats from 4.11 +/- 0.57 to 1.76 +/- 0.37 ng/ml (5 mg/kg G) and to 1.17 +/- 0.26 ng/ml (10 mg/kg G). Plasma levels of luteinizing and follicle-stimulating hormones and of prolactin were unaltered. 3. Chemical denervation caused a significant decrease in ventral prostate wet weight from 74.3 +/- 5.5 to 59.3 +/- 4.7 mg (5 mg/kg G) and to 54.6 +/- 4.1 mg (10 mg/kg G) and in seminal vesicle wet weight from 36.5 +/- 6.8 to 31.7 +/- 5.2 mg (5 mg/kg G) and to 21.3 +/- 1.6 mg (10 mg/kg G). 4. The potential secretory activity of the prostate (measured in terms of fructose content) decreased significantly in guanethidine-treated rats from 0.38 +/- 0.02 to 0.30 +/- 0.02 mg/g (5 mg/kg G) and to 0.20 +/- 0.02 mg/g (10 mg/kg G). The seminal vesicle fructose content (0.33 +/- 0.04 mg/g for controls), however, was not altered by chemical denervation. 5. Our data suggested that sympathetic neurons may be involved in the control of LH receptors, at least in the prepubertal phase of sexual development. They may also be directly related to growth and secretory activity of the male accessory sex glands
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Próstata
/
Vesículas Seminales
/
Simpatectomía Química
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1993
Tipo del documento:
Article
/
Congress and conference