The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs
Rev. Soc. Bras. Med. Trop
; 28(3): 169-77, jul.-set. 1995. graf, ilus
Article
en En
| LILACS
| ID: lil-163731
Biblioteca responsable:
BR1.1
ABSTRACT
The hemorrhagic syndrome of leptospirosis was studied in guinea pigs. The study correlates hematological, histopathological and immunohistochemical alterations in sixty animals inoculated by the intraperitoneal route with lml of the culture of virulent strain of Leptospira interrogans serovar copenhageni. Leptospirae antigens were detected by immunoperoxidase, chiefly in liver, kidney and heart muscle capillaries. Possible pathogenic mechanisms responsible for hemorrhagic syndrome are discussed with emphasis on toxic and anoxic attacks causing damage to endothelia, platelet depletion and alterations to hemostasia rates prothrombin time [PT], partial thromboplastin time [PT] and Fibrinogen concentrations. The clinical-laboratory picture is compatible with the histopathological observation of disseminated intravascular coagulation [DIC] in most of the guinea pigs from day 4 of infection.
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Hemorragia
/
Leptospirosis
Límite:
Animals
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
1995
Tipo del documento:
Article