Persistence of Leishmania antigen in C57B1/6j inbred mice infected with Leishmania (Leishmania) amazonensis
Rev. Assoc. Med. Bras. (1992, Impr.)
; 45(3): 225-8, jul.-set. 1999. ilus
Article
en En
| LILACS
| ID: lil-241200
Biblioteca responsable:
BR1.1
ABSTRACT
Purpose. To develop an animal model for studying mucocutaneous leishmaniasis. Methods. The hind footpad of C57B1/6j inbred mice was experimentally infected with 10(7) Leishmania (Leishmania) amazonensis promastigote and the skin was studied through ligh and electron transmission microscopy and immunohistochemistry (PAP) techniques. Results. There were morphological evidences of cellular immune mechanisms and hypersensitivity reaction after eight weeks of infection and metastasis and well shaped parasites at ultrastructural level by fifty-one weeks post infection. Relapse of infection with mucosa lesions occurred around the 50th week after inoculation. Conclusion. The use of this animal model in long term follow up could be an useful experimental model for human mucocutaneous leishmaniasis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Piel
/
Leishmaniasis Mucocutánea
/
Leishmania
/
Antígenos de Protozoos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Rev. Assoc. Med. Bras. (1992, Impr.)
Asunto de la revista:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
MEDICINA
Año:
1999
Tipo del documento:
Article