Genetic epidemiology of infectious disease
Ciênc. cult. (Säo Paulo)
; 51(3/4): 191-8, maio-ago. 1999. tab
Article
en En
| LILACS
| ID: lil-254742
Biblioteca responsable:
BR1.1
RESUMO
The genetic mechanisms involved in the variability of the human response to the infection of some organisms are critically reviewed. For leprosy and leishmaniasis there seems to exist no simple and general mechanism. The Mitsuda reaction, however, seems to be the most important phenotype measuring the human response to M. leprae. Several genes are known to affect the resistance/susceptibility to malaria. Studies on this disease should take into account all of this variability and be particularly cautious regarding the natural history of the population under study in order to establish the relative importance of given genes on a given population subject to a give epidemic. The sole parasitic disease that did not show discrepancies among studies is schistosomiasis, indicating the importance of a single additive gene that, ultimately, acts on the individualïs capacity to build and efficient eosinophilia. Future studies should focus on general mechanisms as well as on explanations of the existent disparities between studies.
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Colección:
01-internacional
Base de datos:
LILACS
Contexto en salud:
3_ND
Problema de salud:
3_helminthiasis
/
3_leprosy
/
3_malaria
/
3_neglected_diseases
/
3_schistosomiasis
/
3_zoonosis
Asunto principal:
Enfermedades Transmisibles
Tipo de estudio:
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Ciênc. cult. (Säo Paulo)
Asunto de la revista:
CIENCIA
Año:
1999
Tipo del documento:
Article