Composición genética de la población chilena: distribución de polimorfismos de DNA mitocondrial en grupos originarios y en la población mixta de Santiago / Genetic composition of the chilean population: analysis of mitochondrial DNA polymorphisms
Rev. méd. Chile
; 130(2): 125-131, feb. 2002. tab
Article
en Es
| LILACS
| ID: lil-313174
Biblioteca responsable:
CL1.1
RESUMO
Background:
The analysis of mitochondrial DNA restriction site polymorphisms assigns most Latin American aborigines to four haplogroups. These are characterized by determined polymorphic restriction sites and a deletion of 9 base pairs in the intergenic region V.Aim:
To study the distribution of mitochondrial DNA haplogroups in Chilean aboriginal groups, as well as in the mixed population of Santiago. Material andmethods:
One hundred twenty Aymara subjects and 23 Atacame-o subjects from the Northern part of Chile and 162 randomly chosen subjects residing in Santiago were studied. DNA was extracted from peripheral lymphocytes. Mitochondrial DNA was amplified by means of polymerase chain reaction.Results:
The frequency of haplogroup B decreases from north to south. Aymaras in the north have the highest frequency (64 percent) and it is absent among the Yamanas (previously studied) in the extreme South. Haplogroups C and D show an inverse tendency. It is noteworthy that 84 percent of mitochondrial haplogroups of the mixed population of Santiago are of Amerindian origin whereas the Y-chromosomes are mainly European.Conclusions:
The peculiar distribution of haplotypes indicate that the population of Santiago is the result of an asymmetric mating system in which the females ancestors were mainly Amerindian and the male ancestors mainly European
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Polimorfismo Genético
/
ADN Mitocondrial
Límite:
Humans
País/Región como asunto:
America do sul
/
Chile
Idioma:
Es
Revista:
Rev Med Chil
/
Rev. méd. Chile
/
Rev. méd. Chile (En línea)
/
Revista médica de Chile
Asunto de la revista:
MEDICINA
Año:
2002
Tipo del documento:
Article
/
Project document
País de afiliación:
Chile