Four adult hemoglobin types in one mulatto family
Rev. Inst. Med. Trop. Säo Paulo
; 38(3): 201-205, May-Jun. 1996.
Article
en En
| LILACS
| ID: lil-320644
Biblioteca responsable:
BR1.1
ABSTRACT
The studied family showed the presence of four different types of hemoglobin. The family member who gave rise to this study (=propositus) presented Hb C and the hybrid Hb CG-phila. The propositus has three children, all of which have Hb AC; none of the family members showed any clinical symptoms. The investigation of the hemoglobin arose from the finding of target red cells in a blood test done during the pre-operatory examination for lower limb varicose vein stripping. The hybrid Hb CG-phila is due to two gene pairs, each of which with individual expression, determining the synthesis and the particular type subunits. The hybrid Hb CG-phila is formed by the combination velocity of the subunits alpha 2G-phila beta 2; therefore the proportion of the hybrid Hb CG-phila is lower than Hb G-phila and Hb C. The identification and molecular characterization of Hb G-phila showed the position alpha 2(68) Asn-->Lys beta 2 and Hb C showed alpha 2 beta 2(6) Glu-->Lys.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Hemoglobinas
/
Población Negra
/
Mutación
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Asunto de la revista:
MEDICINA TROPICAL
Año:
1996
Tipo del documento:
Article
País de afiliación:
Brasil